Identification and comparative analysis of the lactoferrin and transferrin receptors among clinical isolates of gonococci.

Abstract:

:Neisseria gonorrhoeae expresses receptors for both lactoferrin (LF) and transferrin (TF). To determine whether qualitative or quantitative changes in these receptors, or both, correlate with the pattern of disease due to N. gonorrhoeae, a dot binding assay with whole cells was used to measure the absolute receptor levels expressed during iron-limited growth of strains isolated from asymptomatic patients and patients with urethritis, cervicitis, pelvic inflammatory disease and disseminated infection. Lactoferrin and transferrin receptor complexes were purified by affinity chromatography and their protein profiles were compared. The molecular weights of the LF and TF receptor complexes from a representative sample of gonococci were homogeneous. We conclude that there is no relationship between the LF and TF receptor levels and disease manifestation, auxotype or serotype.

journal_name

J Med Microbiol

authors

Lee BC,Bryan LE

doi

10.1099/00222615-28-3-199

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

199-204

issue

3

eissn

0022-2615

issn

1473-5644

journal_volume

28

pub_type

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