Abstract:
:A solid-phase radioimmunoassay was used to detect IgG antibodies against herpes-simplex virus antigens (capsid, envelope and excreted) and against measles virus antigen in serum and cerebrospinal fluid (CSF) specimens of 61 patients with no evidence of infectious or demyelinating disease of the central nervous system. Quantitative determinations of IgG and albumin in serum and CSF were also performed. Of the 61 serum and 61 CSF samples tested, 57 and 56 respectively contained antibodies against subunit antigens of herpes simplex virus. Antibody against measles virus was found in 59 serum and 47 CSF specimens. A positive correlation (P less than 0-001) was found between each of the four serum to CSF antibody ratios and the serum to CSF total IgG ratios. This indicated that the distribution of antiviral IgG antibodies in serum and CSF normally follows the distribution of total IgG. The ratios between viral antibody in serum and CSF were also correlated with albumin ratios (P less than 0-05). An inverse relation (P less than 0-001) was found between the age of the patients and their serum to CSF albumin ratios, but not their IgG ratios, suggesting that the albumin ratio is a useful indicator of a blood brain barrier lesion and that the IgG ratio should be used in evaluating disturbed antibody ratios.
journal_name
J Med Microbioljournal_title
Journal of medical microbiologyauthors
Kalimo KO,Marttila RJ,Ziola BR,Matikainen MT,Panelius Mdoi
10.1099/00222615-10-4-431subject
Has Abstractpub_date
1977-11-01 00:00:00pages
431-8issue
4eissn
0022-2615issn
1473-5644journal_volume
10pub_type
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更新日期:2006-05-01 00:00:00
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更新日期:2010-11-01 00:00:00