Abstract:
:Large-scale monitoring of resistance to 14 antimicrobial agents was performed using 103 Proteus mirabilis strains isolated from dogs in Japan. Resistant strains were analysed to identify their resistance mechanisms. Rates of resistance to chloramphenicol, streptomycin, enrofloxacin, trimethoprim/sulfamethoxazole, kanamycin, ampicillin, ciprofloxacin, cephalothin, gentamicin, cefoxitin and cefotaxime were 20.4, 15.5, 12.6, 10.7, 9.7, 8.7, 5.8, 2.9, 2.9, 1.9 and 1.9%, respectively. No resistance to ceftazidime, aztreonam or imipenem was found. Class 1 and 2 integrases were detected in 2.9 and 11.7% of isolates, respectively. Class 1 integrons contained aadB or aadB-catB-like-blaOXA10-aadA1, whereas those of class 2 contained sat-aadA1, dhfr1-sat-aadA1 or none of the anticipated resistance genes. Of five distinct plasmid-mediated quinolone-resistance (PMQR) genes, only qnrD gene was detected in 1.9% of isolates. Quinolone-resistance determining regions (QRDRs) of gyrA and parC from 13 enrofloxacin-intermediate and -resistant isolates were sequenced. Seven strains had double mutations and three had single mutations. Three of nine ampicillin-resistant isolates harboured AmpC-type β-lactamases (i.e. blaCMY-2, blaCMY-4 and blaDHA-1). These results suggest that canine Proteus mirabilis deserves continued surveillance as an important reservoir of antimicrobial resistance determinants. This is the first report, to our knowledge, describing integrons, PMQRs and QRDR mutations in Proteus mirabilis isolates from companion animals.
journal_name
J Med Microbioljournal_title
Journal of medical microbiologyauthors
Harada K,Niina A,Shimizu T,Mukai Y,Kuwajima K,Miyamoto T,Kataoka Ydoi
10.1099/jmm.0.081539-0subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1561-1567issue
Pt 11eissn
0022-2615issn
1473-5644journal_volume
63pub_type
杂志文章abstract::The intrathecal synthesis of IgM and IgG antibodies to Borrelia burgdorferi sonicate, to recombinant flagellin (41 kDa) and to a tryptic peptide of the flagellin (14-kDa fragment) was determined by ELISA in paired cerebrospinal fluid (CSF) and serum samples from 35 patients with Lyme neuroborreliosis (LNB) and in 10 p...
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journal_title:Journal of medical microbiology
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journal_title:Journal of medical microbiology
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journal_title:Journal of medical microbiology
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journal_title:Journal of medical microbiology
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journal_title:Journal of medical microbiology
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更新日期:1982-08-01 00:00:00
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journal_title:Journal of medical microbiology
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更新日期:1975-02-01 00:00:00
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doi:10.1099/jmm.0.016543-0
更新日期:2010-03-01 00:00:00
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journal_title:Journal of medical microbiology
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更新日期:1991-12-01 00:00:00
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journal_title:Journal of medical microbiology
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更新日期:1985-12-01 00:00:00
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journal_title:Journal of medical microbiology
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journal_title:Journal of medical microbiology
pub_type: 杂志文章
doi:10.1099/00222615-11-3-355
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abstract::Enteroaggregative Escherichia coli (EAEC) is an important agent of diarrhoeal diseases worldwide. The role of EAEC virulence factors in the clinical outcome of infection is not completely defined. This case-control study investigated the prevalence of EAEC, its virulence genes and the antimicrobial resistance profile ...
journal_title:Journal of medical microbiology
pub_type: 杂志文章
doi:10.1099/jmm.0.000055
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journal_title:Journal of medical microbiology
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doi:10.1099/jmm.0.46456-0
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journal_title:Journal of medical microbiology
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journal_title:Journal of medical microbiology
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journal_title:Journal of medical microbiology
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journal_title:Journal of medical microbiology
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journal_title:Journal of medical microbiology
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journal_title:Journal of medical microbiology
pub_type: 杂志文章
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更新日期:1985-08-01 00:00:00
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journal_title:Journal of medical microbiology
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journal_title:Journal of medical microbiology
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更新日期:2008-11-01 00:00:00
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journal_title:Journal of medical microbiology
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更新日期:2009-12-01 00:00:00
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journal_title:Journal of medical microbiology
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更新日期:2012-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00