Abstract:
:Certain bile acids inhibit the growth in vitro of organisms commonly found in the intestine and, in particular, anaerobic bacteria. As the importance of this effect in vivo has not been demonstrated, we investigated changes in intestinal flora in the rat after diversion of bile to the urinary bladder. Five days after operation there was an increase in numbers of Proteus sp. in the stomach, mid-jejunum and caecum and of coliform bacilli in the stomach and mid-jejunum. Lacto-bacilli were increased in the stomach. There was no change in numbers of anaerobic organisms. Similar changes in bacterial flora followed 5 days of pair feeding in control rats. Our results do not suggest a specific antibacterial effect of bile salts in the rat in vivo. The changes found are probably related to semi-starvation, because the food intake of the rats after operation was about half that of control rats having an unrestricted diet.
journal_name
J Med Microbioljournal_title
Journal of medical microbiologyauthors
Burke V,Stone DE,Beaman J,Gracey Mdoi
10.1099/00222615-10-2-241subject
Has Abstractpub_date
1977-05-01 00:00:00pages
241-4issue
2eissn
0022-2615issn
1473-5644journal_volume
10pub_type
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