Abstract：
:An oxathiolanone derivative of rutin could be produced in the stomach after the ingestion of rutin containing foods, and the oxathiolanone derivative could be hydrolysed to an oxathiolanone derivative of quercetin (quercetin-oxathiolanone) in the intestine. Quercetin-oxathiolanone as well as quercetin inhibited xanthine oxidase. Approximately 0.05μM quercetin-oxathiolanone inhibited the activity by 50%, whereas 50% inhibition by quercetin was observed at approximately 0.4μM. The results suggested that quercetin-oxathiolanone can be used as an effective inhibitor of xanthine oxidase and that the ingestion of rutin-rich foods may be useful to prevent the increase in the blood concentration of uric acid.
journal_name
Food Chemjournal_title
Food chemistryauthors
Takahama U,Koga Y,Hirota S,Yamauchi Rdoi
10.1016/j.foodchem.2010.12.009subject
Has Abstractpub_date
2011-06-15 00:00:00pages
1808-11issue
4eissn
0308-8146issn
1873-7072pii
S0308-8146(10)01607-9journal_volume
126pub_type
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