Sleep apnea-hypopnea syndrome and type 2 diabetes. A reciprocal relationship?


:Epidemiological data suggest that sleep apnea-hypopnea syndrome (SAHS) is independently associated with the development of insulin resistance and glucose intolerance. Moreover, despite significant methodological limitations, some studies report a high prevalence of SAHS in patients with type 2 diabetes mellitus (DM2). A recent meta-analysis shows that moderate-severe SAHS is associated with an increased risk of DM2 (relative risk=1.63 [1.09 to 2.45]), compared to the absence of apneas and hypopneas. Common alterations in various pathogenic pathways add biological plausibility to this relationship. Intermittent hypoxia and sleep fragmentation, caused by successive apnea-hypopnea episodes, induce several intermediate disorders, such as activation of the sympathetic nervous system, oxidative stress, systemic inflammation, alterations in appetite-regulating hormones and activation of the hypothalamic-pituitary-adrenal axis which, in turn, favor the development of insulin resistance, its progression to glucose intolerance and, ultimately, to DM2. Concomitant SAHS seems to increase DM2 severity, since it worsens glycemic control and enhances the effects of atherosclerosis on the development of macrovascular complications. Furthermore, SAHS may be associated with the development of microvascular complications: retinopathy, nephropathy or diabetic neuropathy in particular. Data are still scant, but it seems that DM2 may also worsen SAHS progression, by increasing the collapsibility of the upper airway and the development of central apneas and hypopneas.


Arch Bronconeumol


Martínez Cerón E,Casitas Mateos R,García-Río F




Has Abstract


2015-03-01 00:00:00














  • Clinical audit of patients hospitalized due to COPD exacerbation. MAG-1 Study.

    abstract:UNLABELLED:Hospitalizations for acute exacerbation of COPD (AECOPD) generate high consumption of health resources, frequent readmissions and high mortality. The MAG -1 study aims to identify critical points to improve the care process of severe AECOPD requiring hospitalization. METHODS:Observational study, with review...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,多中心研究


    authors: Escarrabill J,Torrente E,Esquinas C,Hernández C,Monsó E,Freixas M,Almagro P,Tresserras R,en nombre del equipo del Plan Director de las Enfermedades del Aparato Respiratorio (PDMAR) y del grupo colaborador del proyecto MAG-1.

    更新日期:2015-10-01 00:00:00

  • [Reference figures for pulmonary artery pressures after effective treatment of Graves' disease].

    abstract::We report the case of a 48-year-old woman with a diagnosis of pulmonary hypertension and hyperthyroidism (Graves' disease) in whom pulmonary artery pressures became normal after treatment of thyroid disease. The possible pathogenic mechanisms involved in this association include the presence of hyperdynamic heart fail...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Moraza J,Esteban C,Aburto M,Altube L,Gorordo I,Capelastegui A

    更新日期:2003-01-01 00:00:00

  • Prevalence and Mortality of Patients with Palliative Needs in an Acute Respiratory Setting.

    abstract:INTRODUCTION:NECPAL is a tool for identification of patients with advanced chronic disease in need of palliative care. The main objective of the study is to know the prevalence of patients with palliative needs in an acute respiratory ward in a Spanish tertiary hospital using NECPAL. A second objective of the study is ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Tabernero Huguet E,Ortiz de Urbina Antia B,González Quero B,Garay Llorente E,Andia Iturrate J,Pérez Fernández S,Gómez Larrauri A,Iriberri Pascual M

    更新日期:2020-09-25 00:00:00

  • [The primary ciliary dyskinesia syndrome. A frequent pathology].

    abstract::The prevalence of primary ciliary dyskinesia syndrome (PCDS) in Western countries is of 1/40,000 but is 13% in patients with bronchiectasis. The aim of this study was to determine the prevalence of PCDS in patients with bronchiectasis and sinusitis, including whether or not these patients present specific clinical sig...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Barranco MJ,Armengot M,Cardá C,Císcar MA,Peris R,Ramón M,Juan G

    更新日期:1994-01-01 00:00:00

  • Factors associated with the non-completion of conventional anti-tuberculosis treatment in Peru.

    abstract:BACKGROUND:The non-adherence to tuberculosis treatment is associated with increased infection, antibiotic resistance, increased costs and death. Our objective was to identify factors associated with lack of completion of conventional treatment for tuberculosis in Peru. PATIENTS AND METHODS:An unmatched case-control st...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Culqui DR,Munayco E CV,Grijalva CG,Cayla JA,Horna-Campos O,Alva Ch K,Suarez O LA

    更新日期:2012-05-01 00:00:00

  • Internal consistency and validity of the Spanish version of the quality of life questionnaire specific for obstructive sleep apnea: sleep apnea quality of life index.

    abstract:INTRODUCTION:The objective of the present study was to validate the Spanish version of the SAQLI, which is a health-related quality of life (HRQL) questionnaire specific for sleep apnea-hypopnea syndrome (SAHS), and to assess its sensitivity to change. MATERIAL AND METHODS:A multicenter study performed in a group of p...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Catalán P,Martínez A,Herrejón A,Martínez-García MÁ,Soler-Cataluña JJ,Román-Sánchez P,Pinel J,Blanquer R

    更新日期:2012-12-01 00:00:00

  • [Sequential double lung transplant in Kartagener's syndrome].

    abstract::Very few cases of lung transplantation have been described for patients with Kartagener's syndrome. We report the first case to be published in Spain. A 15-year-old girl with complete Kartagener's syndrome underwent sequential transplantation of both lungs. Due to the unusual distribution of the organs in this syndrom...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Lama Martínez R,Santos Luna F,Salvatierra Velázquez A,Cerezo Madueño F,Algar Algar J,Alvarez Kindelán A

    更新日期:2000-02-01 00:00:00

  • [Chest ultrasonography].

    abstract::Chest ultrasonography is a useful tool for assessing disease activity in the peripheral lung parenchyma, pleura, chest wall, diaphragm, and mediastinum. Ultrasound imaging also provides highly useful guidance in invasive diagnostic and therapeutic procedures. The main advantages of this imaging technology are the abse...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Vollmer I,Gayete A

    更新日期:2010-01-01 00:00:00

  • Advances in the diagnosis of tuberculosis infection.

    abstract::One-third of the world-wide population currently presents latent tuberculosis infection (LTI). In Spain, TB is situated as the third disease of mandatory notification. The standard technique for the diagnosis of ITL is the tuberculin test (PPD), although its most important drawback is its specificity since the protein...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Arias Guillén M

    更新日期:2011-10-01 00:00:00

  • Official Statement of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) on Electronic Cigarettes and IQOS®.

    abstract::The use of novel tobacco products, particularly the electronic cigarette (EC) and partial tobacco combustion devices (HnB systems: Heat not Burn), has increased exponentially, particularly among adolescents and young people. The health authorities and scientific societies have shown concern about issues surrounding sa...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Signes-Costa J,de Granda-Orive JI,Ramos Pinedo Á,Camarasa Escrig A,de Higes Martínez E,Rábade Castedo C,Cabrera César E,Jiménez-Ruiz CA

    更新日期:2019-11-01 00:00:00

  • [Pulmonary mycetoma].

    abstract::Ten cases of pulmonary mycetoma diagnosed in our service between 1985-1992 were retrospectively studied. Clinical methodology followed in the study is commented and the different therapeutic options are reviewed, so the literature concerning this process. The unspecificity of serum precipitins with Aspergillus is emph...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Rodríguez García JC,Baloira Villar A,García García JC,Argüelles Riera Y

    更新日期:1994-08-01 00:00:00

  • Human papillomavirus in non-small-cell lung cancer: the impact of EGFR mutations and the response to erlotinib.

    abstract::It has been suggested that human papillomavirus (HPV) could participate in the development of non-small-cell lung cancer (NSCLC). A higher HPV infection rate has been reported in the NSCLC samples from Asian non-smoker patients, with adenocarcinomas or responders to EGFR tyrosine kinase inhibitors (EGFR-TKI). We explo...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Márquez-Medina D,Gasol-Cudós A,Taberner-Bonastre MT,Samamé Pérez-Vargas JC,Salud-Salvia A,Llombart-Cussac A

    更新日期:2013-02-01 00:00:00

  • [Management of pleural disease].

    abstract::In view of the presentations in the First National Forum of Trainee Pneumologists, the present article focuses on infectious pleural effusions and on the study of possible markers of malignant disease in asbestos-exposed individuals. The yield of the distinct techniques for the diagnosis of tuberculous pleural effusio...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Rodríguez-Panadero F,Pérez MA,Moya MA,Cruz MI

    更新日期:2009-01-01 00:00:00

  • [Diseases of the diaphragm].

    abstract::The diaphragm is the main muscle involved in ventilation and is supplied exclusively by the phrenic nerves. Congenital defects of the diaphragm muscle or phrenic nerve injury cause diaphragmatic paralysis-eventration. Prognosis and treatment depend on whether involvement is unilateral or bilateral and on the patient's...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: León-Atance P,Martínez-Hernández NJ,Milla-Saba AM,Roca-Fernández J

    更新日期:2011-01-01 00:00:00

  • [The search for clinical markers of abnormal hypercoagulable states among factors that trigger venous thromboembolic disease].

    abstract::We proposed to search for markers of hypercoagulable states in function of age, sex or factors that trigger venous thromboembolic disease (VTD) in a group of patients so diagnosed. The following patient data were analyzed: age, sex and triggering factors of VTD categorized as associative-transient, permanent or unknow...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Otero Candelera R,Arenas Gordillo M,Hurtado Ayuso JE,Morales R,Monedero M,Digon J

    更新日期:1999-07-01 00:00:00

  • [Clinicopathological features of solitary fibrous tumors of the pleura: a case series and literature review].

    abstract::We assessed the clinicopathological features of solitary fibrous tumors of the pleura in a case series comprising 30 patients (20 women, 66.6%) with a mean age of 58.39 years. Forty-five percent of the cases were asymptomatic. In 70% of the cases the tumors arose in the visceral pleura. Twenty percent presented multip...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Sánchez-Mora N,Cebollero-Presmanes M,Monroy V,Carretero-Albiñana L,Herranz-Aladro M,Alvarez-Fernández E

    更新日期:2006-02-01 00:00:00

  • [Hookwire localization of pulmonary nodules for video-thorascopic surgical resection].

    abstract:OBJECTIVES:To assess the usefulness of a technique for inserting hookwires guided by computed tomography to locate and resect pulmonary nodules by video-assisted thoracoscopy. To describe the procedure and its complications. PATIENTS AND METHODS:Nine pulmonary nodules were located in nine patients. All were

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Soleto MJ,Olivera MJ,Pun YW,Moreno R,Nieto S,Caballero P

    更新日期:2002-09-01 00:00:00

  • [Clinical relevance of distal airway involvement in asthma].

    abstract::Asthma continues to be a global health problem, despite advances in diagnostic techniques and treatment. The inflammatory nature of asthma is currently indisputable, as is the involvement of the entire respiratory tree, both the proximal and most distal airways, which has been demonstrated in multiple studies. The dev...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Torrego Fernández A,Muñoz Cano RM

    更新日期:2011-04-01 00:00:00

  • [Impact of exacerbations and admissions in chronic obstructive pulmonary disease].

    abstract::During the natural history of patients with chronic obstructive pulmonary disease (COPD), an increase in symptom severity can occur, called exacerbated COPD (ECOPD), sometimes requiring hospital admission. Although there is ongoing debate on the definition of ECOPD--leading to a lack of homogeneity in the numerous stu...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Arnedillo Muñoz A

    更新日期:2010-01-01 00:00:00

  • [Prognostic factors and outcome of thymectomy in 80 cases of myasthenia gravis].

    abstract:OBJECTIVES:To analyze the results of thymectomy in our series of patients with myasthenia gravis (MG) and to study the influence of the most common prognostic factors. MATERIAL AND METHODS:Eighty MG patients over a period of 23 years underwent thymectomy consecutively in our hospital. Preoperative assessment included ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Vázquez-Pelillo J,Gil Alonso J,Díaz-Agero P,García Sánchez-Girón J,Roca Serrano R,Díez Tejedor E,Casillas Pajuelo M

    更新日期:2001-04-01 00:00:00

  • Exogenous Lipoid Pneumonia in Laryngectomy Patients: Radiological Findings.

    abstract::Exogenous lipoid pneumonia (ELP) is a rare (incidence 1.0%-2.5%), often under-diagnosed disease, caused by the aspiration and accumulation of exogenous lipids within the pulmonary alveoli. Various cases have been described due to inhalation of lubricants via the nasal passages and oropharynx, aspiration of mineral oil...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: García Latorre R,Rodríguez Díaz R,Barrios Barreto D,Ayala Carbonero A,García Gómez-Muriel MI,Gorospe Sarasúa L

    更新日期:2015-07-01 00:00:00

  • [Comparison between the 1993 and 2002 Guidelines of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) for identifying respiratory events in polysomnography tests].

    abstract:OBJECTIVE:To compare the results of applying both the 1993 and 2002 guidelines of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) to identify respiratory events during nighttime polysomnography tests. PATIENTS AND METHODS:One hundred twenty consecutive patients with medium to high suspicion of sleep ap...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Aguirregomoscorta JI,Altube L,Menéndez I,Romaní A,Basualdo LV,Vallejo G

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  • Prevalence and Determinants of COPD in Spain: EPISCAN II.

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  • [Pulmonary circulation: what has 2010 brought?].

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  • [Hemodynamic study: indications for right- and left-sided catheterization in the diagnosis and follow-up of pulmonary hypertension].

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,多中心研究


    authors: García-García JM,Rodrigo T,Casals M,Ruiz-Manzano J,Pascual-Pascual T,Caylà JA,Grupo de Trabajo del Programa Integrado de Investigación en Tuberculosis (PIITB).

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    pub_type: 杂志文章


    authors: Baltaxe E,Shulimzon T,Lieberman S,Rozenman J,Perelman M,Segel MJ

    更新日期:2016-01-01 00:00:00

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    abstract:INTRODUCTION:Persistent air leak is frustrating for both patients and physicians, above all leaks with a high risk of surgery. Insertion of endobronchial valves could be an alternative to surgery. The aim of this study is to describe our experience in these valves and analyse their efficacy in a series of patients with...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Cordovilla R,Torracchi AM,Novoa N,Jiménez M,Aranda JL,Varela G,Barrueco M

    更新日期:2015-01-01 00:00:00

  • [Clinical efficacy of moxifloxacin in the treatment of exacerbations of chronic bronchitis: a systematic review and meta-analysis].

    abstract:OBJECTIVE:As the research undertaken to date on the efficacy of the new antibiotics in the treatment of exacerbations of chronic bronchitis has taken the form of trials designed to demonstrate equivalence, we have no data on the advantages associated with the use of these new drugs with greater bactericidal activity. O...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,meta分析,评审


    authors: Miravitlles M,Molina J,Brosa M

    更新日期:2007-01-01 00:00:00

  • [Diffuse interstitial lung disease related to peribronchiolar metaplasia].

    abstract::Peribronchiolar metaplasia is a histologic lesion characterized by fibrosis and bronchiolar epithelial proliferation, affecting peribronchiolar alveolar septa and terminal bronchioles. It has been considered a nonspecific tissue reaction secondary to the action of external factors, such as tobacco smoke and microbes, ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Cano-Jiménez E,Molina-Molina M,Ramírez J,Sánchez M,Aliaga JL,Xaubet A

    更新日期:2009-01-01 00:00:00