Abstract：
:In non-small cell lung cancer, the EGFR gene mutations identify a patient sub-population with different clinical characteristics and treatment responses to those that do not have these mutations. There are mutations that derive in increased sensitive to EGFR targeted therapy, as well as mutations that result in resistance. The determination of EGFR mutations involves a change in the therapeutic approach to lung cancer patients in current clinical practice. In this article we present a case of a patient suffering from a metastatic lung adenocarcinoma with an activating mutation on diagnosis, initially responding to treatment with erlotinib, who subsequently developed a secondary resistance due to acquiring the T790M mutation in exon 20 of the EGFR gene.
journal_name
Arch Bronconeumoljournal_title
Archivos de bronconeumologiaauthors
Taus A,Vollmer I,Arriola Edoi
10.1016/j.arbres.2010.06.013subject
Has Abstractpub_date
2011-02-01 00:00:00pages
103-5issue
2eissn
0300-2896issn
1579-2129pii
S0300-2896(10)00195-Xjournal_volume
47pub_type
杂志文章abstract：:Chest ultrasound, a diagnostic technique used mainly by radiologists, is useful for managing pleural effusion. Sonography and computed tomography (CT) are complementary, although the former is more accessible to clinicians because it is safe and easy to use and because results are available quickly. We evaluated the u...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(03)75376-9
更新日期：2003-06-01 00:00:00
abstract：OBJECTIVE:To evaluate the prevalence of sleep disorders in patients awaiting kidney transplants compared to a control group. PATIENTS AND METHODS:We carried out an observational study of 23 patients on a kidney transplant waiting list in comparison with 20 healthy volunteers matched for age, sex, and body mass index (...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：
更新日期：2008-07-01 00:00:00
abstract：:Proliferating cell nuclear antigen (PCNA) is a 36 kD nuclear protein involved in DNA replication that is believed to provide an indication of proliferation in some neoplasms. This study analyzes PCNA expression in 24 cases of primary non-small cell lung cancer using monoclonal PC-10 antibodies in paraffin embedded mat...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(15)30798-5
更新日期：1996-03-01 00:00:00
abstract：INTRODUCTION:Studies on inflammation biomarkers in serum and in exhaled breath condensate (EBC) in obstructive sleep apnea (OSA) have shown conflicting results. The objective of this study is to assess EBC and serum biomarkers in OSA patients at baseline and after continuous positive airway pressure (CPAP) or upper air...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2014.02.016
更新日期：2014-10-01 00:00:00
abstract：OBJECTIVE:To analyse the results obtained in the diagnosis and staging of lung cancer (LC) by a Lung Cancer Rapid Diagnosis Unit (LC-RDU) in which real-time endobronchial ultrasound-guided transbronchial needle aspiration (RT-EBUS guided-TBNA) is performed as part of the clinical evaluation of the patient prior to trea...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2010.07.005
更新日期：2010-12-01 00:00:00
abstract：:The Clinical Notes published in 2009 serve as a resource to reflect on clinical aspects relevant to different clinical entities. Through this review an attempt is likewise made to bring the reader closer to the clinical reality of our environment. ...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：10.1016/j.arbres.2010.10.001
更新日期：2010-12-01 00:00:00
abstract：:Airway complications after lung transplant are relatively common although the rates vary according to the different studies. Pathogenesis is diverse but the principal mechanism is usually bronchus intermedius ischemia in the post-transplant period. One major complication is bronchial stenosis, with relatively frequent...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2013.12.005
更新日期：2015-02-01 00:00:00
abstract：:We report a case of pleural effusion, pericardial thickening, and pulmonary involvement in a patient with dry cough, dyspnea, edema, and changes in the skin of the lower limbs. Treatment with cabergoline (Sogilen) had been started 4 months earlier. Pleural effusion, pericardial thickening, and impaired pulmonary funct...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s1579-2129(07)60118-9
更新日期：2007-09-01 00:00:00
abstract：:Improper assessment and treatment of asthma attacks have been identified as causes of increased morbidity and mortality: several pneumological societies have therefore created and published guidelines for facilitating decision making and for preventing unnecessary failures of therapy. The objective of this study was t...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(15)30627-x
更新日期：1997-04-01 00:00:00
abstract：:Chronic obstructive pulmonary disease (COPD) is a chronic disease causing increasing healthcare costs worldwide. Another respiratory disease causing high costs and morbidity is community-acquired pneumonia (CAP). Because of the constant growth in the population with both diseases (CAP and COPD), analyzing their clinic...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：10.1016/S0300-2896(10)70024-7
更新日期：2010-01-01 00:00:00
abstract：INTRODUCTION:Neuromuscular disease (NMD) patients frequently have impaired cough. Mechanical insufflation-exsufflation (MI-E) has proven efficacy in improving airway clearance, however data related to its long-term home use is lacking. The purpose of this study was to describe indications, safety and compliance of home...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2010.04.011
更新日期：2010-08-01 00:00:00
abstract：:Chest ultrasonography is a useful tool for assessing disease activity in the peripheral lung parenchyma, pleura, chest wall, diaphragm, and mediastinum. Ultrasound imaging also provides highly useful guidance in invasive diagnostic and therapeutic procedures. The main advantages of this imaging technology are the abse...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：10.1016/j.arbres.2008.12.004
更新日期：2010-01-01 00:00:00
abstract：INTRODUCTION:Failure to rescue (FTR), defined as the mortality rate among patients suffering from postoperative complications, is considered an indicator of the quality of surgical care. The aim of this study was to investigate the risk factors associated with FTR after anatomical lung resections. METHOD:Patients unde...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2020.04.015
更新日期：2020-05-31 00:00:00
abstract：BACKGROUND:Patients with activating somatic mutations in the Epidermal Growth Factor Receptor (EGFR) have better clinical outcomes when treated with Tyrosine Kinase Inhibitors (TKI) over chemotherapy. However, the impact of the use of TKIs on overall survival outside clinical trials is not well established. OBJECTIVE:...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2017.07.012
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:To analyze the factors that determine the risk of morbidity and mortality associated with lung resection in patients with bronchogenic carcinoma. PATIENTS AND METHODS:Prospective multicenter study conducted between October 1, 1993 and September 30, 1997 in the 19 hospitals that make up the Bronchogenic Carci...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s1579-2129(07)60038-x
更新日期：2007-03-01 00:00:00
abstract：:One-third of the world-wide population currently presents latent tuberculosis infection (LTI). In Spain, TB is situated as the third disease of mandatory notification. The standard technique for the diagnosis of ITL is the tuberculin test (PPD), although its most important drawback is its specificity since the protein...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：10.1016/j.arbres.2011.06.018
更新日期：2011-10-01 00:00:00
abstract：:During the natural history of patients with chronic obstructive pulmonary disease (COPD), an increase in symptom severity can occur, called exacerbated COPD (ECOPD), sometimes requiring hospital admission. Although there is ongoing debate on the definition of ECOPD--leading to a lack of homogeneity in the numerous stu...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：10.1016/S0300-2896(10)70061-2
更新日期：2010-01-01 00:00:00
abstract：:It is unusual for pulmonologists to be familiar with the European and US regulations governing the administration of oxygen during air travel and each airline's policy in this respect. This lack of knowledge is in large part due to the scarcity of articles addressing this matter in specialized journals and the noticea...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2014.06.004
更新日期：2015-01-01 00:00:00
abstract：:Exogenous lipoid pneumonia (ELP) is a rare (incidence 1.0%-2.5%), often under-diagnosed disease, caused by the aspiration and accumulation of exogenous lipids within the pulmonary alveoli. Various cases have been described due to inhalation of lubricants via the nasal passages and oropharynx, aspiration of mineral oil...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2014.09.002
更新日期：2015-07-01 00:00:00
abstract：:Our objective was to study agreement between the compression ultrasound images taken in our respiratory medicine department and the duplex ultrasound images obtained by radiologists at our hospital for patients admitted to our ward with suspected diagnoses of venous thromboembolism.Seventy-eight consecutive patients a...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(02)75185-5
更新日期：2002-04-01 00:00:00
abstract：INTRODUCTION:Few studies have examined the 24-hour symptom profile in patients with chronic obstructive pulmonary disease (COPD). The main objective of this study was to determine daily variations in the symptoms of patients with stable COPD in Spain, compared with other European countries. METHODS:Observational study...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,多中心研究
doi：10.1016/j.arbres.2015.11.010
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:To compare the effects of a simple home pulmonary rehabilitation program and an intensive hospital-based program in terms of the exercise tolerance and health-related quality of life (HRQL) of patients with severe chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS:Patients in this prospective...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,多中心研究,随机对照试验
doi：
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVE:PLATINO project is a population-based study designed to determine the prevalence of chronic obstructive pulmonary disease (COPD) in São Paulo, Brazil; Mexico City, Mexico; Montevideo, Uruguay; Santiago de Chile, Chile; and Caracas, Venezuela. The objective of this portion of PLATINO was to describe preventive...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,多中心研究
doi：10.1016/s1579-2129(08)60016-6
更新日期：2008-02-01 00:00:00
abstract：:Pneumocephalus resulting from a subarachnoid-pleural fistula following resection of a pulmonary neoplasm is a very rare postoperative complication: we have found only 17 cases in the literature. We report the case of a 65-year-old man diagnosed with a superior sulcus tumor who underwent a left upper lobectomy and cost...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：INTRODUCTION:The objective of this analysis was the evaluation of a new national circuit used for diagnosing alpha1 antitrypsin deficiency (AATD) based on multiplex technology using online registration and mail posted samples from dried blood spots (DBS) and buccal swabs. METHODS:This is an observational, ongoing stud...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2020.04.014
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVE:To assess the effect of adequate outpatient care as defined by guidelines of the Global Initiative for Asthma (GINA) on the long-term outcome of near-fatal asthma. PATIENTS AND METHODS:Fifty-three patients who had experienced a near-fatal attack of asthma were treated according to the GINA guidelines and fol...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：
更新日期：2008-04-01 00:00:00
abstract：:Two hundred forty-eight cases of thoracic trauma arriving at our hospital between 1990 and 1992 are analyzed in this report. Injuries were only thoracic in 29% of the cases. The remaining patients presented associated lesions, mainly in the extremities, followed by head injuries. Single or multiple rib fracture, in 19...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(15)31073-5
更新日期：1994-05-01 00:00:00
abstract：:The prevalence of primary ciliary dyskinesia syndrome (PCDS) in Western countries is of 1/40,000 but is 13% in patients with bronchiectasis. The aim of this study was to determine the prevalence of PCDS in patients with bronchiectasis and sinusitis, including whether or not these patients present specific clinical sig...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(15)31145-5
更新日期：1994-01-01 00:00:00
abstract：:This article reviews the pathophysiology of the latent form of Mycobacterium tuberculosis along with its natural history and progression in infected tissues. The proposed hypotheses regarding the relationship between M tuberculosis and the associated immune response, the cause of granuloma necrosis, the tolerance of a...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：10.1016/s1579-2129(06)60110-9
更新日期：2006-01-01 00:00:00
abstract：INTRODUCTION:COPD and emphysema due to alpha-1 antitrypsin deficiency (AATD) are the first and fourth indications for lung transplantation worldwide, respectively. Despite this, there is little information regarding the health status of these patients at the time of transplantation. METHODS:Patients who received a lun...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2014.08.003
更新日期：2015-08-01 00:00:00
