Abstract:
OBJECTIVE:To compare the effects of a simple home pulmonary rehabilitation program and an intensive hospital-based program in terms of the exercise tolerance and health-related quality of life (HRQL) of patients with severe chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS:Patients in this prospective, multicenter trial were randomized to 2 groups to receive hospital or home pulmonary rehabilitation. Patients in both groups attended 2 informative sessions about the disease and 4 physical therapy sessions. Patients in the hospital group then carried out a structured exercise program while home group patients performed low intensity exercises at home without supervision. RESULTS:Twenty-eight patients were randomized to the hospital rehabilitation group and 23 to the home group. Both groups showed a similar improvement on the 6-minute walk test (mean difference, 8.7 m; P=.61). HRQOL measured with the Chronic Respiratory Questionnaire also improved in both groups, but the change was greater on the emotional function domain in the hospital rehabilitation group (mean difference between groups, 0.58 on a scale for which the smallest clinically relevant difference is 0.5 points). The benefits were maintained in both groups 6 months after the programs ended. CONCLUSIONS:This study demonstrates that the improvement in exercise tolerance achieved by COPD patients with an unsupervised home pulmonary rehabilitation program is similar to the gains of patients in an intensive hospital-based program. However, the hospital program afforded greater benefit on the HRQOL emotional function domain.
journal_name
Arch Bronconeumoljournal_title
Archivos de bronconeumologiaauthors
Güell MR,de Lucas P,Gáldiz JB,Montemayor T,Rodríguez González-Moro JM,Gorostiza A,Ortega F,Bellón JM,Guyatt Gsubject
Has Abstractpub_date
2008-10-01 00:00:00pages
512-8issue
10eissn
0300-2896issn
1579-2129pii
13126830journal_volume
44pub_type
杂志文章,多中心研究,随机对照试验abstract::It has been suggested that human papillomavirus (HPV) could participate in the development of non-small-cell lung cancer (NSCLC). A higher HPV infection rate has been reported in the NSCLC samples from Asian non-smoker patients, with adenocarcinomas or responders to EGFR tyrosine kinase inhibitors (EGFR-TKI). We explo...
journal_title:Archivos de bronconeumologia
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,实务指引
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pub_type: 临床试验,杂志文章
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