Abstract:
INTRODUCTION:The diagnosis of latent tuberculous infection (LTI) by IGRA continues to generate debate. Experience in the simultaneous use of 2 IGRA tests is scant. The aim of this study was to compare the results of 2 versions of QuantiFERON-TB Gold (In-Tube/Plus) with those of T-SPOT.TB, and to analyse the effectiveness of a dual strategy (T-SPOT.TB + QTF) for the diagnosis of LTI in an immunosuppressed population. METHODS:We conducted a prospective study (May 2015-June 2017) that included 2,999 immunosuppressed patients and/or candidates for biologics, in whom 2 simultaneous IGRA tests were performed: Group 1 (1535 patients): T-SPOT.TB + QuantiFERON-TB Gold-In-Tube (QTF-GIT); Group 2 (1464 patients): T-SPOT.TB + QuantiFERON-TB Gold Plus (QTF-Plus). RESULTS:The concordance between QTF-GIT and T-SPOT.TB was 83.19% (κ=0.532). The percentage of positive, negative, and indeterminate results were, respectively: 14.33% vs. 17.06%; 82.41% vs. 74.46%; and 3.25% vs. 8.46%. The concordance between QTF-Plus and T-SPOT.TB was 87.56% (κ=0.609). The percentage of positive, negative, and indeterminate results were, respectively: 15.02% vs. 15.36%; 82.92% vs. 79.37%; and 2.04% vs. 5.25%. Discrepancies between T-SPOT.TB and QTF-Plus were 12.43%, suggesting that 103 patients were positive and another 79 were negative due exclusively to 1 of the 2 IGRAs. CONCLUSIONS:Greater concordance was found between QTF-Plus and T-SPOT.TB than between QTF-GIT and T-SPOT.TB. However, we believe that the proportion of discrepancies between T-SPOT.TB and QTF-Plus is sufficiently important from a clinical point of view to justify the simultaneous use of 2 IGRA in this specific patient group.
journal_name
Arch Bronconeumoljournal_title
Archivos de bronconeumologiaauthors
Fernández-Blázquez A,Argüelles Menéndez P,Sabater-Cabrera C,García-García JM,Asensi Álvarez V,Palacios Gutiérrez JJ,en representación de la Red de Laboratorios de Microbiología del SESPA.doi
10.1016/j.arbres.2020.04.011subject
Has Abstractpub_date
2020-06-10 00:00:00eissn
0300-2896issn
1579-2129pii
S0300-2896(20)30128-9pub_type
杂志文章abstract::Although bacteria are the main pathogens involved in community-acquired pneumonia, a significant number of community-acquired pneumonia are caused by viruses, either directly or as part of a co-infection. The clinical picture of these different pneumonias can be very similar, but viral infection is more common in the ...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,评审
doi:10.1016/j.arbres.2015.02.015
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:In a split-night study, the first part consists of standard polysomnography (PSG) for the diagnosis of obstructive sleep apnea syndrome while the second part is used to establish a suitable level of continuous positive airway pressure. The aim of our study was to compare the sleep and respirato...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/s1579-2129(08)60002-6
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abstract::In the last few years, considerable interest has been aroused in the treatment of chronic obstructive pulmonary disease (COPD) and the dearth of therapeutic options has been replaced by a far more proactive treatment approach, reflected in the development of the various guidelines and recommendations of the scientific...
journal_title:Archivos de bronconeumologia
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abstract:OBJECTIVE:To analyze the factors that determine the risk of morbidity and mortality associated with lung resection in patients with bronchogenic carcinoma. PATIENTS AND METHODS:Prospective multicenter study conducted between October 1, 1993 and September 30, 1997 in the 19 hospitals that make up the Bronchogenic Carci...
journal_title:Archivos de bronconeumologia
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abstract::Infection of the larynx by Candida is rare and usually accompanies lung or disseminated candidiasis. The incidence of isolated laryngeal candidiasis (ILC) is low, although it may be underestimated. We describe 2 patients with ILC confirmed during autopsy: a 45-years-old male with pulmonary fibrosis and a 4-years-old g...
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journal_title:Archivos de bronconeumologia
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doi:10.1016/j.arbres.2015.01.014
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abstract::Despite the administration of appropriate treatment, a high number of patients with asthma remain uncontrolled. This suggests the need for alternative treatments that are effective, safe and selective for the established asthma phenotypes, especially in patients with uncontrolled severe asthma. The most promising opti...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,评审
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
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journal_title:Archivos de bronconeumologia
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doi:
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journal_title:Archivos de bronconeumologia
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pub_type: 杂志文章,评审
doi:
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,评审
doi:
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/s0300-2896(15)30613-x
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journal_title:Archivos de bronconeumologia
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doi:
更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:Archivos de bronconeumologia
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,多中心研究
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更新日期:1999-10-01 00:00:00
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,评审
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,评审
doi:
更新日期:1994-10-01 00:00:00
abstract::We assessed the clinicopathological features of solitary fibrous tumors of the pleura in a case series comprising 30 patients (20 women, 66.6%) with a mean age of 58.39 years. Forty-five percent of the cases were asymptomatic. In 70% of the cases the tumors arose in the visceral pleura. Twenty percent presented multip...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,评审
doi:10.1016/s1579-2129(06)60124-9
更新日期:2006-02-01 00:00:00
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pub_type: 杂志文章
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abstract::This study aimed to determine the attitudes toward smoking and the characteristics of smoking patterns in young men of military age. Individuals performing their military service were surveyed using a self-administered, anonymous, personal and voluntary questionnaire. Questions were included on smoking habits, social ...
journal_title:Archivos de bronconeumologia
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更新日期:1998-12-01 00:00:00
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
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