Abstract：
:Despite the administration of appropriate treatment, a high number of patients with asthma remain uncontrolled. This suggests the need for alternative treatments that are effective, safe and selective for the established asthma phenotypes, especially in patients with uncontrolled severe asthma. The most promising options among the new asthma treatments in development are biological therapies, particularly those monoclonal antibodies directed at selective targets. It should be noted that the different drugs, and especially the new biologics, act on very specific pathogenic pathways. Therefore, determination of the individual profile of predominant pathophysiological alterations of each patient will be increasingly important for prescribing the most appropriate treatment in each case. The treatment of severe allergic asthma with anti-IgE monoclonal antibody (omalizumab) has been shown to be effective in a large number of patients, and new anti-IgE antibodies with improved pharmacodynamic properties are being investigated. Among developing therapies, biologics designed to block certain pro-inflammatory cytokines, such as IL-5 (mepolizumab) and IL-13 (lebrikizumab), have a greater chance of being used in the clinic. Perhaps blocking more than one cytokine pathway (such as IL-4 and IL-13 with dulipumab) might confer increased efficacy of treatment, along with acceptable safety. Stratification of asthma based on the predominant pathogenic mechanisms of each patient (phenoendotypes) is slowly, but probably irreversibly, emerging as a tailored medical approach to asthma, and is becoming a key factor in the development of drugs for this complex respiratory syndrome.
journal_name
Arch Bronconeumoljournal_title
Archivos de bronconeumologiaauthors
Quirce S,Bobolea I,Domínguez-Ortega J,Barranco Pdoi
10.1016/j.arbres.2014.02.002subject
Has Abstractpub_date
2014-08-01 00:00:00pages
355-61issue
8eissn
0300-2896issn
1579-2129pii
S0300-2896(14)00075-1journal_volume
50pub_type
杂志文章,评审abstract：OBJECTIVE:To study the validity of quantitative cultures of tracheal aspirate (TA) in comparison with the plugged telescoping catheter (PTC) for the diagnosis of mechanical ventilator-associated pneumonia. METHOD:Prospective multicenter study enrolling patients undergoing mechanical ventilation for longer than 72 hour...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,多中心研究
doi：10.1016/s0300-2896(03)75414-3
更新日期：2003-09-01 00:00:00
abstract：OBJECTIVE:The bronchial challenge test is commonly used to diagnose asthma but it is a tedious, time-consuming procedure. Although in recent years, several shortened methods have been proposed, it has been shown that they can give rise to exaggerated bronchoconstriction. The aims of the present study were a) to determi...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:Results supporting the use and the effectiveness of positive expiratory, pressure devices in chronic obstructive pulmonary disease (COPD) patients are still controversial, We have tested the hypothesis that adding TPEP or IPPB to standard pharmacological therapy may provide additional clinical benefit over, ...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.arbres.2013.07.019
更新日期：2014-01-01 00:00:00
abstract：:Our objective was to study agreement between the compression ultrasound images taken in our respiratory medicine department and the duplex ultrasound images obtained by radiologists at our hospital for patients admitted to our ward with suspected diagnoses of venous thromboembolism.Seventy-eight consecutive patients a...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(02)75185-5
更新日期：2002-04-01 00:00:00
abstract：UNLABELLED:The diaphragm seems to undergo adaptive structural change in chronic obstructive pulmonary disease. The possibility of obtaining muscle specimens is limited, however, particularly when respiratory function is severely affected. OBJECTIVE:To assess the viability of a new technique for obtaining diaphragm mus...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(15)30228-3
更新日期：2000-01-01 00:00:00
abstract：INTRODUCTION:Few studies have examined the 24-hour symptom profile in patients with chronic obstructive pulmonary disease (COPD). The main objective of this study was to determine daily variations in the symptoms of patients with stable COPD in Spain, compared with other European countries. METHODS:Observational study...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,多中心研究
doi：10.1016/j.arbres.2015.11.010
更新日期：2016-06-01 00:00:00
abstract：:This study aimed to determine the attitudes toward smoking and the characteristics of smoking patterns in young men of military age. Individuals performing their military service were surveyed using a self-administered, anonymous, personal and voluntary questionnaire. Questions were included on smoking habits, social ...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：OBJECTIVE:Localized fibrous tumors of the pleura are rare. We report 7 cases and review the literature in order to define the range of clinical characteristics of these tumors, treatment options, and prognosis. METHODS:A retrospective review of 7 cases treated between 1997 and 2003, focusing on clinical presentation, ...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s1579-2129(06)60311-x
更新日期：2004-07-01 00:00:00
abstract：INTRODUCTION:Pulse transit time (PTT) is the time that a pulse wave takes to travel between two different arterial points, and may be useful in estimating blood pressure. This noninvasive technique, which does not add any cost to the procedure, offers the advantage of avoiding 'arousals' during sleep measurement as occ...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2013.12.001
更新日期：2014-07-01 00:00:00
abstract：:A review has been made of original articles on invasive pneumology techniques, interstitial diseases and lung transplantation, published in the Archivos de Bronconeumología during the year 2008. We have selected the publication by Martínez-Olondrins et al on the mediastinal staging of bronchogenic carcinoma by
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：10.1016/S0300-2896(09)70271-6
更新日期：2009-01-01 00:00:00
abstract：INTRODUCTION:NECPAL is a tool for identification of patients with advanced chronic disease in need of palliative care. The main objective of the study is to know the prevalence of patients with palliative needs in an acute respiratory ward in a Spanish tertiary hospital using NECPAL. A second objective of the study is ...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2020.08.009
更新日期：2020-09-25 00:00:00
abstract：:Amyloidosis is a systemic disease caused by abnormal deposition of amyloid material that is detected with Congo red staining and is difficult to diagnose. Involvement of the tracheobronchial tree is rare and is a challenge for pulmonologists because of the wide differential diagnosis of this disease. We present two ca...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2012.08.002
更新日期：2013-05-01 00:00:00
abstract：:It has been suggested that human papillomavirus (HPV) could participate in the development of non-small-cell lung cancer (NSCLC). A higher HPV infection rate has been reported in the NSCLC samples from Asian non-smoker patients, with adenocarcinomas or responders to EGFR tyrosine kinase inhibitors (EGFR-TKI). We explo...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2012.04.003
更新日期：2013-02-01 00:00:00
abstract：:In view of the presentations in the First National Forum of Trainee Pneumologists, the present article focuses on infectious pleural effusions and on the study of possible markers of malignant disease in asbestos-exposed individuals. The yield of the distinct techniques for the diagnosis of tuberculous pleural effusio...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/S0300-2896(09)72854-6
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:To study the results of surgical treatment of pulmonary metastases in our department. PATIENTS AND METHODS:We retrospectively studied 44 patients undergoing surgery between 1986 and 1999 for complete resection of pulmonary metastases. Primary tumors had been eradicated, no metastasis to other organs was evid...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：:Sixty patients diagnosed as having chronic respiratory diseases were surveyed in order to establish how many knew the name of their disease, the medications they were taking, the name of the medical specialty dedicated to treating their condition and the nature of spirometry. Only 23 patients (38%) knew the name of th...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(15)31111-x
更新日期：1994-03-01 00:00:00
abstract：INTRODUCTION:Persistent air leak is frustrating for both patients and physicians, above all leaks with a high risk of surgery. Insertion of endobronchial valves could be an alternative to surgery. The aim of this study is to describe our experience in these valves and analyse their efficacy in a series of patients with...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2014.04.007
更新日期：2015-01-01 00:00:00
abstract：:Proliferating cell nuclear antigen (PCNA) is a 36 kD nuclear protein involved in DNA replication that is believed to provide an indication of proliferation in some neoplasms. This study analyzes PCNA expression in 24 cases of primary non-small cell lung cancer using monoclonal PC-10 antibodies in paraffin embedded mat...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(15)30798-5
更新日期：1996-03-01 00:00:00
abstract：INTRODUCTION AND OBJECTIVES:To determine the causes of death in patients operated on for stage IB non-small cell lung cancer (NSCLC) and to assess the impact on survival of the number of lymph nodes removed. PATIENTS AND METHOD:We studied 300 patients operated on for stage IB NSCLC. Only palpable or visible lymph node...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2008.05.003
更新日期：2009-02-01 00:00:00
abstract：:Several commonly prescribed drugs can cause acute non-cardiogenic pulmonary edema. A cause-effect relationship is usually difficult to establish because symptoms are not specific. We report a case of pulmonary edema induced by a common diuretic, hydrochlorothiazide. This complication can occur after a first dose of th...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(03)75329-0
更新日期：2003-02-01 00:00:00
abstract：:During the natural history of patients with chronic obstructive pulmonary disease (COPD), an increase in symptom severity can occur, called exacerbated COPD (ECOPD), sometimes requiring hospital admission. Although there is ongoing debate on the definition of ECOPD--leading to a lack of homogeneity in the numerous stu...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：10.1016/S0300-2896(10)70061-2
更新日期：2010-01-01 00:00:00
abstract：:Our aim was to describe our experience with outpatients requiring pleural biopsy. The first 100 patients with pleural exudate from whom at least one pleural biopsy specimen was taken on an outpatient basis at our hospital since January 1993. Clinical and radiological signs were recorded for all patients. We also analy...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(15)30566-4
更新日期：1997-09-01 00:00:00
abstract：OBJECTIVE:To validate a cardiorespiratory polygraphy system (BITMED NGP 140) by comparing it to conventional polysomnography in the diagnosis of sleep apnea-hypopnea syndrome. PATIENTS AND METHODS:Polysomnography and cardio-respiratory polygraphy were performed simultaneously on 103 consecutive patients referred becau...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s1579-2129(06)60400-x
更新日期：2005-02-01 00:00:00
abstract：:Omalizumab is a monoclonal antibody that interrupts allergic reaction--irrespective of the nature of the allergen--by blocking free immunoglobulin E (IgE). The IgE is thus prevented from attaching to cell receptors and setting in motion an allergic cascade of inflammatory mediators. Other interesting biological effect...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：10.1016/s1579-2129(06)60453-9
更新日期：2006-05-01 00:00:00
abstract：INTRODUCTION:There is no specific health-related quality of life (HRQL) questionnaire that has been validated in Spanish for its use in patients with sleep apnea-hypopnea syndrome (SAHS). The objective of the present study was to validate the Spanish version of the Quebec Sleep Questionnaire (QSQ). PATIENTS AND METHOD...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2011.10.011
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:The non-adherence to tuberculosis treatment is associated with increased infection, antibiotic resistance, increased costs and death. Our objective was to identify factors associated with lack of completion of conventional treatment for tuberculosis in Peru. PATIENTS AND METHODS:An unmatched case-control st...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2011.12.008
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Proper reference values for lung function testing are essential for achieving adequate interpretations. The LMS procedure (lambda, mu, sigma) permits continuous analyses of entire populations avoiding gaps in the transition between childhood and adulthood. It also allows more precise calculations of average ...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2019.12.033
更新日期：2020-02-29 00:00:00
abstract：OBJECTIVE:The aim of this study was to assess changes in the acid-base equilibrium of pleural fluid during the first 2 hours after thoracentesis and to determine whether, as with arterial blood, it is important to keep the fluid on ice. PATIENTS AND METHODS:A prospective, descriptive, comparative study was performed i...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s1579-2129(06)60295-4
更新日期：2005-11-01 00:00:00
abstract：OBJECTIVE:To analyze the factors that determine the risk of morbidity and mortality associated with lung resection in patients with bronchogenic carcinoma. PATIENTS AND METHODS:Prospective multicenter study conducted between October 1, 1993 and September 30, 1997 in the 19 hospitals that make up the Bronchogenic Carci...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s1579-2129(07)60038-x
更新日期：2007-03-01 00:00:00
abstract：:In non-small cell lung cancer, the EGFR gene mutations identify a patient sub-population with different clinical characteristics and treatment responses to those that do not have these mutations. There are mutations that derive in increased sensitive to EGFR targeted therapy, as well as mutations that result in resist...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2010.06.013
更新日期：2011-02-01 00:00:00
