Human papillomavirus in non-small-cell lung cancer: the impact of EGFR mutations and the response to erlotinib.

Abstract:

:It has been suggested that human papillomavirus (HPV) could participate in the development of non-small-cell lung cancer (NSCLC). A higher HPV infection rate has been reported in the NSCLC samples from Asian non-smoker patients, with adenocarcinomas or responders to EGFR tyrosine kinase inhibitors (EGFR-TKI). We explored a potential relationship between EGFR mutation, response to EGFR-TKI and HPV infection in Western NSCLC patients. We retrospectively analyzed 40 NSCLC samples and the impact of age, gender, histology, tobacco habit and sample type. HPV infection rate was 2.5% and it was not statistically modified by any analyzed variable, although the limited sample size did not provide definitive conclusions. The rate of HPV infection in NSCLC should be studied in patients with EGFR mutations or a tendency towards presenting them.

journal_name

Arch Bronconeumol

authors

Márquez-Medina D,Gasol-Cudós A,Taberner-Bonastre MT,Samamé Pérez-Vargas JC,Salud-Salvia A,Llombart-Cussac A

doi

10.1016/j.arbres.2012.04.003

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

79-81

issue

2

eissn

0300-2896

issn

1579-2129

pii

S0300-2896(12)00117-2

journal_volume

49

pub_type

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