Tuberculosis-HIV Co-Infection: Progress and Challenges After Two Decades of Global Antiretroviral Treatment Roll-Out.

Abstract:

:Despite wide antiretroviral scale-up during the past two decades resulting in declining new infections and mortality globally, HIV-associated tuberculosis remains as a major public health concern. Tuberculosis is the leading HIV-associated opportunistic infection and the main cause of death globally and, particularly, in resource-limited settings. Several challenges exist regarding diagnosis, global implementation of latent tuberculosis treatment, management of active tuberculosis, delivery of optimal patient-centered TB and HIV prevention and care in high burden countries. In this article we review the advances on pathogenesis, diagnosis, and treatment after nearly two decades of global roll-out of antiretroviral therapy and discuss the current challenges for the global control of tuberculosis-HIV co-infection.

journal_name

Arch Bronconeumol

authors

Letang E,Ellis J,Naidoo K,Casas EC,Sánchez P,Hassan-Moosa R,Cresswell F,Miró JM,García-Basteiro AL

doi

10.1016/j.arbres.2019.11.015

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

446-454

issue

7

eissn

0300-2896

issn

1579-2129

pii

S0300-2896(19)30589-7

journal_volume

56

pub_type

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