[Clinical relevance of distal airway involvement in asthma].

Abstract:

:Asthma continues to be a global health problem, despite advances in diagnostic techniques and treatment. The inflammatory nature of asthma is currently indisputable, as is the involvement of the entire respiratory tree, both the proximal and most distal airways, which has been demonstrated in multiple studies. The development of the therapeutic arsenal, with more potent drugs and improved inhalation devices, has allowed a certain control to be maintained over the inflammatory process, although the inability to reach the most distal points of the airways has posed a stumbling block that seems difficult to overcome. However, the available information on the real role of distal airway involvement in asthma remains very scarce. Physiopathological evidence shows that, in addition to the large airways, the small or distal airways (those with a diameter of less than 2 mm) substantially contribute to the severity of asthma. Several studies have shown that the inflammatory process seems to be more intense in this area. This finding has been related to nocturnal asthma and an increase in glucocorticoid receptor-beta-expressing cells, associated with corticosteroid-resistant asthma and fatal asthma. Equally, small airway involvement seems to be a highly important factor in asthma in the pediatric age group.

journal_name

Arch Bronconeumol

authors

Torrego Fernández A,Muñoz Cano RM

doi

10.1016/S0300-2896(11)70016-3

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

17-9

eissn

0300-2896

issn

1579-2129

pii

S0300-2896(11)70016-3

journal_volume

47 Suppl 2

pub_type

杂志文章,评审
  • Comparison of intermittent positive pressure breathing and temporary positive expiratory pressure in patients with severe chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Results supporting the use and the effectiveness of positive expiratory, pressure devices in chronic obstructive pulmonary disease (COPD) patients are still controversial, We have tested the hypothesis that adding TPEP or IPPB to standard pharmacological therapy may provide additional clinical benefit over, ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.arbres.2013.07.019

    authors: Nicolini A,Mollar E,Grecchi B,Landucci N

    更新日期:2014-01-01 00:00:00

  • Overall Survival Analysis and Characterization of an EGFR Mutated Non-Small Cell Lung Cancer (NSCLC) Population.

    abstract:BACKGROUND:Patients with activating somatic mutations in the Epidermal Growth Factor Receptor (EGFR) have better clinical outcomes when treated with Tyrosine Kinase Inhibitors (TKI) over chemotherapy. However, the impact of the use of TKIs on overall survival outside clinical trials is not well established. OBJECTIVE:...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/j.arbres.2017.07.012

    authors: Aguiar F,Fernandes G,Queiroga H,Machado JC,Cirnes L,Souto Moura C,Hespanhol V

    更新日期:2018-01-01 00:00:00

  • [Usefulness of chest sonography in a respiratory medicine unit].

    abstract::Chest ultrasound, a diagnostic technique used mainly by radiologists, is useful for managing pleural effusion. Sonography and computed tomography (CT) are complementary, although the former is more accessible to clinicians because it is safe and easy to use and because results are available quickly. We evaluated the u...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/s0300-2896(03)75376-9

    authors: Hidalgo Ramírez M,Cases Viedma E,Sanchis Aldás JL

    更新日期:2003-06-01 00:00:00

  • [Description of a sample of patients with chronic obstructive pulmonary disease treated at hospital-supervised respiratory clinics at primary care centers].

    abstract:OBJECTIVE:To study the general characteristics, health perception and limitations of patients with chronic obstructive pulmonary disease (COPD) treated at respiratory clinics at primary care centers staffed by pulmonologists from our hospital service. METHOD:The study was carried out at 5 primary care centers that enr...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/s0300-2896(03)75437-4

    authors: Esteban C,Moraza J,Aburto M,Quintana JM,Capelastegui A

    更新日期:2003-11-01 00:00:00

  • Success in Optional Vena Cava Filter Retrieval. An Analysis of 246 Patients.

    abstract:OBJECTIVE:This study assessed vena cava filter (VCF) retrieval rates and factors associated with retrieval failure in a single center cohort. METHODS:We conducted an observational retrospective cohort study. The primary endpoint was the percentage of patients whose VCF was retrieved. We performed logistic regression t...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/j.arbres.2018.02.008

    authors: de Gregorio MA,Guirola JA,Serrano C,Figueredo A,Kuo WT,Quezada CA,Jimenez D

    更新日期:2018-03-19 00:00:00

  • [European Asthma Study. Identifying and treating young adults with epidemiological criteria for asthma in five areas of Spain. Spanish Group of the European Asthma Study].

    abstract:BACKGROUND AND OBJECTIVES:Asthma's great impact on public health stems from its chronicity and to high prevalence among all age groups and both sexes. To estimate the appropriateness of treatment and management of asthma in Spain during the period of 1991 and 1992, we analyzed data from the European Community Respirato...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/s0300-2896(15)30259-3

    authors: Martínez-Moratalla J,Almar E,Sunyer J,Ramos J,Pereira A,Payo F,Antó JM

    更新日期:1999-05-01 00:00:00

  • [Effectiveness and tolerance of antituberculosis treatment regimens without isoniazid and rifampicin: analysis of 85 cases].

    abstract:OBJECTIVE:To determine if isoniazid- and/or rifampicin-free antituberculosis treatment regimens are safe and effective and to identify any factors that might require changes in the regimens. PATIENTS AND METHODS:We carried out a retrospective study of patients treated with isoniazid- and/or rifampicin-free regimens be...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:

    authors: Tost JR,Vidal R,Maldonado J,Caylà JA

    更新日期:2008-09-01 00:00:00

  • Internal consistency and validity of the Spanish version of the quality of life questionnaire specific for obstructive sleep apnea: sleep apnea quality of life index.

    abstract:INTRODUCTION:The objective of the present study was to validate the Spanish version of the SAQLI, which is a health-related quality of life (HRQL) questionnaire specific for sleep apnea-hypopnea syndrome (SAHS), and to assess its sensitivity to change. MATERIAL AND METHODS:A multicenter study performed in a group of p...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.arbres.2012.05.004

    authors: Catalán P,Martínez A,Herrejón A,Martínez-García MÁ,Soler-Cataluña JJ,Román-Sánchez P,Pinel J,Blanquer R

    更新日期:2012-12-01 00:00:00

  • [Comparison of the Asthma Control Test (ACT) with lung function, levels of exhaled nitric oxide and control according to the Global Initiative for Asthma (GINA)].

    abstract:INTRODUCTION:The current goal of asthma treatment is to achieve and maintain control. This study aimed to explore the relationship between the ACT (Asthma Control Test) questionnaire and the levels of control according to GINA (Global Initiative for Asthma) to establish the cut-off points for the ACT and evaluate its r...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.arbres.2010.04.003

    authors: Alvarez-Gutiérrez FJ,Medina-Gallardo JF,Pérez-Navarro P,Martín-Villasclaras JJ,Martin Etchegoren B,Romero-Romero B,Praena-Fernández JM

    更新日期:2010-07-01 00:00:00

  • Reliability of an analysis method for measuring diaphragm excursion by means of direct visualization with videofluoroscopy.

    abstract:OBJECTIVE:The purpose of this study was to verify the reproducibility between two different observers of an analysis method for diaphragmatic displacement measurements using direct visualization with videofluoroscopy. PATIENTS AND METHODS:29 mouth breathing children aged 5 to 12 years from both genders were analyzed. ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/j.arbres.2010.12.011

    authors: Yi LC,Nascimento OA,Jardim JR

    更新日期:2011-06-01 00:00:00

  • [Changes in the acid-base equilibrium of pleural fluid during the first 2 hours after thoracentesis].

    abstract:OBJECTIVE:The aim of this study was to assess changes in the acid-base equilibrium of pleural fluid during the first 2 hours after thoracentesis and to determine whether, as with arterial blood, it is important to keep the fluid on ice. PATIENTS AND METHODS:A prospective, descriptive, comparative study was performed i...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/s1579-2129(06)60295-4

    authors: Haro-Estarriol M,Baldó-Padró X,Lora-Díez M,Rubio-Garay M,Rubio-Goday M,Sebastián-Quetglás F

    更新日期:2005-11-01 00:00:00

  • A population-based cohort study on chronic obstructive pulmonary disease in Latin America: methods and preliminary results. The PLATINO Study Phase II.

    abstract:BACKGROUND:The PLATINO baseline study, conducted from 2003-2005 in five Latin American cities (São Paulo, Mexico City, Montevideo, Santiago, Caracas), showed a high prevalence of chronic obstructive pulmonary disease (COPD). METHODS/DESIGN:A follow-up study was conducted in three out of the five centers (Montevideo, S...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.arbres.2013.07.014

    authors: Menezes AM,Muiño A,López-Varela MV,Valdivia G,Lisboa C,Jardim JR,Montes de Oca M,Tálamo C,Wehrmeister FC,Perez-Padilla R,Equipo del estudio Platino.

    更新日期:2014-01-01 00:00:00

  • Results of a Diagnostic Procedure Based on Multiplex Technology on Dried Blood Spots and Buccal Swabs for Subjects With Suspected Alpha1 Antitrypsin Deficiency.

    abstract:INTRODUCTION:The objective of this analysis was the evaluation of a new national circuit used for diagnosing alpha1 antitrypsin deficiency (AATD) based on multiplex technology using online registration and mail posted samples from dried blood spots (DBS) and buccal swabs. METHODS:This is an observational, ongoing stud...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/j.arbres.2020.04.014

    authors: Lopez-Campos JL,Casas-Maldonado F,Torres-Duran M,Medina-Gonzálvez A,Rodriguez-Fidalgo ML,Carrascosa I,Calle M,Osaba L,Rapun N,Drobnic E,Miravitlles M

    更新日期:2021-01-01 00:00:00

  • [Evaluation of replacement therapy in emphysema caused by alpha 1-antitrypsin deficiency].

    abstract::Assessment of alpha 1-antitrypsin replacement therapy (AAT) for emphysema. Patient characteristics were analyzed along with the possible side effects of the treatment and its efficacy in maintaining appropriate AAT blood levels. Lung function changes were also studied. The treatment protocol began with 4 weekly intrav...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/s0300-2896(15)30997-2

    authors: Miravitlles M,Vidal R,Torrella M,Bofill JM,Cotrina M,de Gracia J

    更新日期:1994-12-01 00:00:00

  • [Acute respiratory failure as the presentation of amyotrophic lateral sclerosis. Apropos a case].

    abstract::We report the case of a 61-year-old man with amyotrophic lateral sclerosis presenting with respiratory failure requiring long-term mechanical ventilation. Diagnostic difficulties are discussed along with the circumstances that give rise to suspicion of neuromuscular disease in a context of respiratory failure of unkno...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审

    doi:10.1016/s0300-2896(15)30324-0

    authors: Hernández Borge J,García González L,Martín Arroyo Caballero JA,Ruiz Avalos A

    更新日期:1999-01-01 00:00:00

  • [Vascular endothelial growth factor in benign and malignant pleural effusions].

    abstract:OBJECTIVE:Vascular endothelial growth factor (VEGF) is a potent inducer of capillary permeability and its role as a crucial mediator in pleural fluid formation has been established. This study was conducted to assess the usefulness of VEGF for diagnosing malignant and non-malignant pleural effusions of various causes. ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/s1579-2129(06)60244-9

    authors: Kaya A,Poyraz B,Celik G,Ciledag A,Gulbay BE,Savas H,Savas I

    更新日期:2005-07-01 00:00:00

  • [The primary ciliary dyskinesia syndrome. A frequent pathology].

    abstract::The prevalence of primary ciliary dyskinesia syndrome (PCDS) in Western countries is of 1/40,000 but is 13% in patients with bronchiectasis. The aim of this study was to determine the prevalence of PCDS in patients with bronchiectasis and sinusitis, including whether or not these patients present specific clinical sig...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/s0300-2896(15)31145-5

    authors: Barranco MJ,Armengot M,Cardá C,Císcar MA,Peris R,Ramón M,Juan G

    更新日期:1994-01-01 00:00:00

  • [Impact of anemia on COPD].

    abstract::The frequency of anemia may be higher than expected in patients with chronic obstructive pulmonary disease (COPD). Some studies have detected a prevalence of 33%, contrasting with the common idea that associates COPD with secondary polyglobulia. Among the risk factors associated with the development of anemia in these...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/S0300-2896(09)72864-9

    authors: de Miguel Díez Jde M,Martín MJ,Bailón MM,Alvarez-Sala JL

    更新日期:2009-01-01 00:00:00

  • Mortality Predictors In Complicated Patients After Anatomical Lung Resection.

    abstract:INTRODUCTION:Failure to rescue (FTR), defined as the mortality rate among patients suffering from postoperative complications, is considered an indicator of the quality of surgical care. The aim of this study was to investigate the risk factors associated with FTR after anatomical lung resections. METHOD:Patients unde...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/j.arbres.2020.04.015

    authors: Gómez Hernández MAT,Novoa Valentín N,Fuentes Gago M,Aranda Alcaide JL,Varela Simó G,Jiménez López MF

    更新日期:2020-05-31 00:00:00

  • [Sleep apnea-hypopnea syndrome in the elderly].

    abstract::The population pyramid is changing due to the increasing longevity of the population, making it a priority to have better knowledge of those diseases that have an increasingly major impact in advanced age. Sleep apnea-hypopnea syndrome (SAHS) affects 15-20% of individuals over 65 years. However, despite this high prev...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审

    doi:10.1016/j.arbres.2010.05.003

    authors: Martínez-García MA,Durán-Cantolla J,Montserrat JM

    更新日期:2010-09-01 00:00:00

  • [Acute lipoid pneumonia caused by accidental aspiration of vaseline used in nasogastric intubation].

    abstract::Exogenous lipoid pneumonia is a rare disease which is often underdiagnosed. Exogenous lipoid pneumonia has traditionally been considered a chronic process secondary to continued aspiration or inhalation of fatty substances. In its acute form exogenous lipoid pneumonia sometimes coincides with accidental massive aspira...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审

    doi:10.1016/s0300-2896(15)30129-0

    authors: Bernabeu Mora R,Méndez Martínez P,Abellán Martínez MC,Polo García LA,Lorenzo Cruz M,Sánchez Gascón F

    更新日期:2000-09-01 00:00:00

  • [Prognostic factors associated with resectable pulmonary metastases from colorectal cancer].

    abstract:OBJECTIVE:To analyze prognostic factors associated with survival in a group of patients who underwent resection of pulmonary metastases from colorectal cancer. PATIENTS AND METHODS:A retrospective review was performed for 55 consecutive patients who had undergone resection of pulmonary metastases from colorectal adeno...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审

    doi:

    authors: Muñoz Llarena A,Carrera Revilla S,Gil-Negrete Laborda A,Pac Ferrer J,Barceló Galíndez R,López Vivanco G

    更新日期:2007-06-01 00:00:00

  • [Clinicopathological features of solitary fibrous tumors of the pleura: a case series and literature review].

    abstract::We assessed the clinicopathological features of solitary fibrous tumors of the pleura in a case series comprising 30 patients (20 women, 66.6%) with a mean age of 58.39 years. Forty-five percent of the cases were asymptomatic. In 70% of the cases the tumors arose in the visceral pleura. Twenty percent presented multip...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审

    doi:10.1016/s1579-2129(06)60124-9

    authors: Sánchez-Mora N,Cebollero-Presmanes M,Monroy V,Carretero-Albiñana L,Herranz-Aladro M,Alvarez-Fernández E

    更新日期:2006-02-01 00:00:00

  • Official Statement of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) on Electronic Cigarettes and IQOS®.

    abstract::The use of novel tobacco products, particularly the electronic cigarette (EC) and partial tobacco combustion devices (HnB systems: Heat not Burn), has increased exponentially, particularly among adolescents and young people. The health authorities and scientific societies have shown concern about issues surrounding sa...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审

    doi:10.1016/j.arbres.2019.04.023

    authors: Signes-Costa J,de Granda-Orive JI,Ramos Pinedo Á,Camarasa Escrig A,de Higes Martínez E,Rábade Castedo C,Cabrera César E,Jiménez-Ruiz CA

    更新日期:2019-11-01 00:00:00

  • [Smoking in young military men: attitudes and characteristics].

    abstract::This study aimed to determine the attitudes toward smoking and the characteristics of smoking patterns in young men of military age. Individuals performing their military service were surveyed using a self-administered, anonymous, personal and voluntary questionnaire. Questions were included on smoking habits, social ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:

    authors: de Granda Orive JI,Peña Miguel T,González Quijada S,Escobar Sacristán J,Gutiérrez Jiménez T,Herrera de la Rosa A

    更新日期:1998-12-01 00:00:00

  • Differences in clinical features of two immigrant populations with tuberculosis.

    abstract::A study was performed to assess differences in the clinical presentation of tuberculosis between two groups of immigrants. Ninety-four patients seen in the emergency room for newly diagnosed tuberculosis between 2006 and 2012 were included. Forty-nine patients were from Asian countries and 45 from Latin America. Mean ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/j.arbres.2014.08.004

    authors: Supervía A,Pallàs O,Piccari L,Herrera Fernández S,Domínguez Álvarez M,Cirera I,del Baño F

    更新日期:2015-06-01 00:00:00

  • Comparing Spirometric Reference Values From Childhood to Old Age Estimated by LMS and Linear Regression Models.

    abstract:BACKGROUND:Proper reference values for lung function testing are essential for achieving adequate interpretations. The LMS procedure (lambda, mu, sigma) permits continuous analyses of entire populations avoiding gaps in the transition between childhood and adulthood. It also allows more precise calculations of average ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/j.arbres.2019.12.033

    authors: Martínez-Briseño D,Gochicoa-Rangel L,Torre-Bouscoulet L,Cid-Juárez S,Fernández-Plata R,Martínez-Valdeavellano L,Chapela-Lara S,Del Río-Hidalgo R,Pérez-Padilla R

    更新日期:2020-02-29 00:00:00

  • [Perfusion of donor tissue improves the preservation of graft in heterotopic tracheal transplantation].

    abstract::To assess the effect on tracheal graft preservation of perfusion of donor tissue with a Collins solution before extraction and immunosuppression of the recipient. An experimental study was performed in 36 albino rabbits with revascularized heterotopic cervical reconstruction of the trachea with omentum. The animals we...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/s0300-2896(15)30515-9

    authors: Jiménez MF,Gómez-Alonso A,Varela G,Ludeña MD,García-Criado J

    更新日期:1997-12-01 00:00:00

  • [Validation of a respiratory polygraphy system in the diagnosis of sleep apnea syndrome].

    abstract:OBJECTIVE:To validate a cardiorespiratory polygraphy system (BITMED NGP 140) by comparing it to conventional polysomnography in the diagnosis of sleep apnea-hypopnea syndrome. PATIENTS AND METHODS:Polysomnography and cardio-respiratory polygraphy were performed simultaneously on 103 consecutive patients referred becau...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/s1579-2129(06)60400-x

    authors: Candela A,Hernández L,Asensio S,Sánchez-Payá J,Vila J,Benito N,Romero S

    更新日期:2005-02-01 00:00:00

  • [Acute respiratory distress syndrome caused by pulmonary nocardiosis in a patient with systemic lupus erythematosus].

    abstract::Nocardia is a gram-positive bacillus that infects mainly immunodepressed patients. Its association with lupus erythematosus has been described only occasionally and we have found no reports in the literature of an association between lupus and acute respiratory distress syndrome due to pulmonary nocardiosis. We presen...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章

    doi:10.1016/s1579-2129(06)60223-1

    authors: Ferreres Franco J,Blanquer Olivas J,Dosdá Muñoz R,Carbonell Monleón N,Moreno Clari E,Pérez Sancho E

    更新日期:2005-05-01 00:00:00