Immune memory response induced in vitro by recombinant hepatitis B surface antigen challenge 13-18 years after primary vaccination.

Abstract:

:The question of whether booster doses are required to maintain long-term protection against hepatitis B virus (HBV) after primary vaccination remains to be determined. Thus, the aim of this study was to evaluate the immune memory responses to hepatitis B surface antigen (HBsAg) challenge in vaccinated individuals through an in vitro-specific stimulation assay. Peripheral blood mononuclear cells (4 × 10(6)  cells/ml) were stimulated with 50 ng/ml of recombinant HBsAg. In vitro anamnestic antibody responses, as shown by detection of high avidity antibody in culture supernatants, were found 13-18 years after primary vaccination and were not correlated with serum antibodies (r = -0.177; P = 0.377). In addition, the findings from this study indicate that immune memory against hepatitis B was well preserved in 40.0% and 60.0% of vaccinees with anti-HBs levels less than 10 IU/L or lacking serum antibodies altogether, respectively. In conclusion, the data suggest the presence of immunological memory in vaccinated individuals, including those who showed anti-HBs <10 IU/L or undetectable antibody.

journal_name

J Med Virol

authors

do Livramento A,Schultz J,Batista KZ,Treitinger A,de Cordova CM,Spada C

doi

10.1002/jmv.24012

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

1700-4

issue

10

eissn

0146-6615

issn

1096-9071

journal_volume

86

pub_type

杂志文章
  • Favorable efficacy of glecaprevir plus pibrentasvir as salvage therapy for HCV failures to prior direct-acting antivirals regimens.

    abstract::In real-world settings, not much information is probably available on the treatment efficacy of the combination of glecaprevir and pibrentasvir (G/P) as a salvage therapy in failures of prior direct-acting antiviral (DAA) regimens. Especially, the evolution of NS5A resistance-associated variants (RAVs) and treatment e...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25278

    authors: Akuta N,Sezaki H,Suzuki F,Fujiyama S,Kawamura Y,Hosaka T,Kobayashi M,Kobayashi M,Saitoh S,Suzuki Y,Arase Y,Ikeda K,Kumada H

    更新日期:2019-01-01 00:00:00

  • Frequency and genotype of human parvovirus B19 among Iranian patients infected with HIV.

    abstract::The human parvovirus B19 (B19) usually causes a subclinical infection in immunocompetent individuals. Whereas immunocompromised individuals such as patients infected with HIV are at risk of persistent anemia due to B19 infection. Only few studies have been carried out on distribution and molecular epidemiology of B19 ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24169

    authors: Azadmanesh K,Mohraz M,Kazemimanesh M,Aghakhani A,Foroughi M,Banifazl M,Eslamifar A,Ramezani A

    更新日期:2015-07-01 00:00:00

  • Laboratory and epidemiologic assessment of a recent influenza B outbreak.

    abstract::A viral surveillance system in Nashville detected an outbreak of influenza B that occurred between January and March 1986. Paired sera from 32 individuals with culture-documented influenza B illness were tested using three serologic assays. Enzyme-linked immunosorbent assay (ELISA) using purified hemagglutinin-neurami...

    journal_title:Journal of medical virology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jmv.1890250313

    authors: King JC Jr,Haugh CJ,Dupont WD,Thompson JM,Wright PF,Edwards KM

    更新日期:1988-07-01 00:00:00

  • Genotyping and characterization of the geographical distribution of tick-borne encephalitis virus variants with a set of molecular probes.

    abstract::A panel of deoxyoligonucleotide probes for studying the genetic variability and genotyping of Tick-borne encephalitis virus (TBEV) strains by molecular hybridization of nucleic acids (MHNA) was created. This panel allows to estimate the genetic structure of individual TBEV strains, as the targets for probes are both v...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21765

    authors: Demina TV,Dzhioev YP,Verkhozina MM,Kozlova IV,Tkachev SE,Plyusnin A,Doroshchenko EK,Lisak OV,Zlobin VI

    更新日期:2010-05-01 00:00:00

  • Risk factors and clinical characteristics of patients with nosocomial influenza A infection.

    abstract::Influenza is a public health burden, responsible for more than half a million deaths worldwide each year and explosive outbreaks in-hospital care units. At present, little is known about clinical characteristics and outcomes with nosocomial influenza infection. To assess clinical characteristics and outcome between no...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25652

    authors: Naudion P,Lepiller Q,Bouiller K

    更新日期:2020-08-01 00:00:00

  • Changing distribution of norovirus genotypes and genetic analysis of recombinant GIIb among infants and children with diarrhea in Japan.

    abstract::A total of 402 fecal specimens collected during July 2003-June 2004 from infants and children with acute gastroenteritis, encompassing five localities (Maizuru, Tokyo, Sapporo, Saga, and Osaka) of Japan, were tested for the presence of norovirus by RT-PCR. It was found that 58 (14.4%) fecal specimens were positive for...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20649

    authors: Phan TG,Kuroiwa T,Kaneshi K,Ueda Y,Nakaya S,Nishimura S,Yamamoto A,Sugita K,Nishimura T,Yagyu F,Okitsu S,Müller WE,Maneekarn N,Ushijima H

    更新日期:2006-07-01 00:00:00

  • Identification of H-2K(b)-restricted T-cell epitopes within the nucleocapsid protein of Hantaan virus and establishment of cytotoxic T-cell clones.

    abstract::Although neutralizing antibodies against Hantaan virus (HTV) can protect hosts from viral infection, T-cell responses to HTV are also important in host defense against HTV. However, much less is known about cytotoxic T lymphocyte (CTL) responses to HTV. To identify CTL epitopes in the HTV nucleocapsid protein (NP), we...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Park JM,Cho SY,Hwang YK,Um SH,Kim WJ,Cheong HS,Byun SM

    更新日期:2000-02-01 00:00:00

  • Specific IgG and IgA antibodies to herpes simplex virus (HSV)-induced surface antigen in patients with HSV infections and in healthy adults.

    abstract::Herpes simplex virus (HSV)-specific IgG and IgA antibody response in patients with HSV infection and in healthy adults was studied by the immunoperoxidase antibody-membrane antigen (IPAMA) technique. In all HSV infections in which specific IgM antibodies were detected by enzyme-linked immunosorbent assay (ELISA), a si...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890140303

    authors: Hadar T,Sarov I

    更新日期:1984-01-01 00:00:00

  • Detection and typing of human papillomavirus in biopsy and cytological specimens by polymerase chain reaction and restriction enzyme analysis: a method suitable for semiautomation.

    abstract::Screening for high-risk human papillomavirus (HPV) types allows the detection of women at a high risk of cervical squamous carcinomas, thereby defining a subset of patients targeted for more intensive screening and follow-up. Thirty-four cervical biopsy specimens and isolated cells from cervical smears of normal women...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9071(199602)48:2<161::AID-JMV8>

    authors: Adams V,Moll C,Schmid M,Rodrigues C,Moos R,Briner J

    更新日期:1996-02-01 00:00:00

  • Genetic relatedness of Cuban HAV wild-type isolates.

    abstract::Knowledge of the nucleotide sequence in the region of the putative VP1/2A junction of the Hepatitis A virus (HAV) genome has enabled differentiation of HAV strains and their classification into seven genotypes, in some of which sub-genotypes A and B can be defined. A 168 base segment encompassing the putative VP1/2A j...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1023

    authors: Diaz BI,Sariol CA,Normann A,Rodríguez L,Flehmig B

    更新日期:2001-06-01 00:00:00

  • Comparison between patients with norovirus-related gastroenteritis and asymptomatic carriers with respect to distribution of antibody-complexed viral particles and intestinal flora.

    abstract::Asymptomatic carriers have a major influence on the spreading of norovirus infections. The objective of this study was to examine the characteristics of patients and asymptomatic carriers affected by norovirus-related community gastroenteritis outbreaks. No significant difference between the two groups was observed in...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25079

    authors: Mori K,Konishi N,Suzuki Y,Harada S,Maeda M,Akase S,Obata H,Monma C,Nagano M,Kimoto K,Oda M,Somura Y,Hirai A,Shinkai T,Noda M,Sadamasu K

    更新日期:2018-12-01 00:00:00

  • Virus-like particles in the liver of a patient with fulminant hepatitis and antibody to hepatitis E virus.

    abstract::In earlier studies, hepatitis E virus (HEV) particles were detected in the stools of patients with enterically transmitted non-A, non-B (ENANB) hepatitis, and HEV was etiologically associated with this disease. Such particles have not been observed in the liver, however. We describe the pathological findings in the li...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890310310

    authors: Asher LV,Innis BL,Shrestha MP,Ticehurst J,Baze WB

    更新日期:1990-07-01 00:00:00

  • UV-inactivated measles virus stimulates human and mice naive lymphocytes to proliferate in vitro.

    abstract::Ultra violet (UV) light-inactivated measles virus was used for the lymphocyte proliferation assay, where it caused consistently adult human peripheral blood monolymphocytes (PBML) proliferation which was not dependent on the measles virus complement fixation titre in the donor's sera. When the cord blood lymphocytes f...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890460209

    authors: Tu R

    更新日期:1995-06-01 00:00:00

  • An outbreak of gastroenteritis associated with calicivirus in an infant home.

    abstract::In October 1977 an outbreak of acute infectious diarrhea occurred in an infant home in the city of Sapporo, Japan. Of 34 residents aged two to 20 months, 26 (77%) suffered from diarrhea. In ten of these patients the diarrhea was accompanied by vomiting. Electron microscopic examinations revealed typical calicivirus pa...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890040402

    authors: Chiba S,Sakuma Y,Kogasaka R,Akihara M,Horino K,Nakao T,Fukui S

    更新日期:1979-01-01 00:00:00

  • Floating density of hepatitis C virus particles and response to interferon treatment.

    abstract::Hepatitis C virus (HCV) particles can be classified into two major fractions according to their floating density in serum. However, the genomic heterogeneity of each fraction and the relationship between this viral characteristic and interferon (IFN) response in patients with chronic hepatitis are not known. In this s...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Sakai A,Kaneko S,Matsushita E,Kobayashi K

    更新日期:1998-05-01 00:00:00

  • Significance of detectable HCV RNA below the limit of quantification in patients treated with DAAs using standard and ultrasensitive protocols.

    abstract::Predictive factors of HCV relapse after treatment with DAAs are poorly understood. In this study, we aimed to assess whether the residual viral load positivity observed during or at the end of treatment (EOT) has an impact on viral outcome. Blood samples were collected from 337 patients with genotypes (GT) 1a, 1b, 2, ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25084

    authors: Visco-Comandini U,Lapa D,Lionetti R,Taibi C,Loiacono L,Montalbano M,Capobianchi MR,D'Offizi G,Garbuglia AR

    更新日期:2018-07-01 00:00:00

  • Relative frequency of human rotavirus VP4 (P) genotypes recovered over a ten-year period from South African children with diarrhea.

    abstract::The relative frequency and distribution of the VP4 (P) genotypes of 227 human rotavirus field strains were investigated in South Africa. The stool samples were collected between 1984-1993 from infants and young children with diarrhea at Ga-Rankuwa Hospital, Pretoria, South Africa. The RNA was extracted from stools, he...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890470102

    authors: Mphahlele MJ,Steele AD

    更新日期:1995-09-01 00:00:00

  • Longitudinal use of phenotypic resistance testing to HIV-1 protease inhibitors in patients developing HAART failure.

    abstract::An "in-house" recombinant virus protease inhibitor susceptibility assay was carried out (median of 3 per patient) retrospectively in 26 patients failing HIV protease inhibitor based therapy at regular intervals to the initiation of the first protease inhibitor. Patients were treated with either indinavir (N = 6), rito...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10076

    authors: Servais J,Plesséria JM,Lambert C,Fontaine E,Robert I,Arendt V,Staub T,Schneider F,Hemmer R,Schmit JC

    更新日期:2002-07-01 00:00:00

  • Hepatitis C virus genotype 4d in Southern Italy: reconstruction of its origin and spread by a phylodynamic analysis.

    abstract::Hepatitis C Virus (HCV) genotype 4 predominates in Middle East and Central Africa countries. Recently, it has become also prevalent in Southern European countries where it is thought to have been introduced through immigration and the movement of intravenous drug users. In Italy, the prevalence of genotype 4 is partic...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23384

    authors: Ciccozzi M,Equestre M,Costantino A,Marascio N,Quirino A,Lo Presti A,Cella E,Bruni R,Liberto MC,Focà A,Pisani G,Zehender G,Ciccaglione AR

    更新日期:2012-10-01 00:00:00

  • Tula and Puumala hantavirus NSs ORFs are functional and the products inhibit activation of the interferon-beta promoter.

    abstract::The S RNA genome segment of hantaviruses carried by Arvicolinae and Sigmodontinae rodents encodes the nucleocapsid (N) protein and has an overlapping (+1) open reading frame (ORF) for a putative nonstructural protein (NSs). The aim of this study was to determine whether the ORF is functional. A protein corresponding t...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20948

    authors: Jääskeläinen KM,Kaukinen P,Minskaya ES,Plyusnina A,Vapalahti O,Elliott RM,Weber F,Vaheri A,Plyusnin A

    更新日期:2007-10-01 00:00:00

  • Immunity and the burden of herpes zoster.

    abstract::The burden of herpes zoster may be related to patients' immunity, although this has not been studied extensively. This hypothesis was tested in a matched case-control study of patients with herpes zoster who sought treatment at one of seven university hospitals in Korea from January 1, 2007, to December 31, 2010. Pati...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23830

    authors: Choi WS,Kwon SS,Lee J,Choi SM,Lee JS,Eom JS,Sohn JW,Choeng HJ

    更新日期:2014-03-01 00:00:00

  • Longitudinal analysis of frequency and reactivity of Epstein-Barr virus-specific T lymphocytes and their association with intermittent viral reactivation.

    abstract::Persistent Epstein-Barr virus (EBV) infection is controlled tightly by virus-specific T cells. EBV infection is reactivated intermittently over time, even in apparently healthy carriers. Changes in frequency and reactivity of memory T cells, particularly of CD8(+) origin, have not been assessed in this context. It is ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22258

    authors: Vogl BA,Fagin U,Nerbas L,Schlenke P,Lamprecht P,Jabs WJ

    更新日期:2012-01-01 00:00:00

  • Dynamic study of HBsAg and HBeAg in saliva samples from patients with hepatitis B infection: diagnostic and epidemiological significance.

    abstract::Analysis of 505 cases history of patients among men with viral hepatitis demonstrates that HBV infected patients represent 68.9% of the total and that a non-parenteral rate of transmission is the most likely means of hepatitis B infection. Saliva and serum testing for the presence of specific HBV markers (HBsAg, HBeAg...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/1096-9071(200008)61:4<433::aid-jmv4>3.0.co

    authors: Zhevachevsky NG,Nomokonova NY,Beklemishev AB,Belov GF

    更新日期:2000-08-01 00:00:00

  • Genetic analysis of HAV strains isolated from patients with acute hepatitis in Korea, 2005-2006.

    abstract::Hepatitis A virus (HAV) is a causative agent of acute viral hepatitis, which represents a significant public health problem. HAV is usually transmitted by oral-fecal route and prevalent not only in developing countries but also in developed countries worldwide. To characterize the HAV wild type strains circulating in ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21127

    authors: Yun H,Kim S,Lee H,Byun KS,Kwon SY,Yim HJ,Lim YS,Jeong SH,Jee Y

    更新日期:2008-05-01 00:00:00

  • Interferon-alpha therapy for chronic hepatitis B: early response related to pre-treatment changes in viral replication.

    abstract::Chronic hepatitis B patients with low pre-treatment HBeAg (and HBV-DNA) levels are more likely to respond to interferon-alpha therapy. In retrospect, this low level of HBeAg may have been reached just before the start of therapy. Pre-treatment changes in HBeAg levels were studied in 121 patients undergoing interferon-...

    journal_title:Journal of medical virology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Heijtink RA,Janssen HL,Hop WC,Osterhaus AD,Schalm SW

    更新日期:2001-03-01 00:00:00

  • HIV excretion patterns and specific antibody responses in body fluids.

    abstract::HIV excretion patterns and specific antibody responses were evaluated in blood, semen, female genital secretions, saliva, and crevicular fluid. Samples were examined for infectious virus, viral antigens, viral nucleic acid, HIV specific IgG, IgA, anti-nef, and anti-p24. Viral load in peripheral blood appeared to incre...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890310409

    authors: O'Shea S,Cordery M,Barrett WY,Richman DD,Bradbeer C,Banatvala JE

    更新日期:1990-08-01 00:00:00

  • Prognostic impact of platelet distribution width in patients with Crimean-Congo hemorrhagic fever.

    abstract::Platelet distribution width (PDW) is a readily available blood test involving calculations performed by automated blood analyzers. Crimean-Congo hemorrhagic fever (CCHF) may exhibit a severe profile with fatal hemorrhaging or else present with a mild clinical process. The purpose of our study was to investigate the im...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24547

    authors: Yilmaz H,Yilmaz G,Menteşe A,Kostakoğlu U,Karahan SC,Köksal İ

    更新日期:2016-11-01 00:00:00

  • Human papillomavirus genotype detection and viral load in paired genital and urine samples from both females and males.

    abstract::The ability to detect type-specific high risk HPV (HR-HPV) infections in samples from females and males is important for monitoring the epidemiology of HPV and the impact of vaccination. Type-specific detection concordance between paired urine and genital samples from females (n = 264) undergoing routine colposcopy an...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22167

    authors: Bissett SL,Howell-Jones R,Swift C,De Silva N,Biscornet L,Parry JV,Saunders NA,Nathan M,Soldan K,Szarewski A,Cuzick J,Beddows S

    更新日期:2011-10-01 00:00:00

  • Detection of hepatitis C viraemia in Caucasian patients with hepatocellular carcinoma.

    abstract::Potential risk factors for the development of hepatocellular carcinoma were analysed in 40 Caucasian patients with this malignancy. A higher proportion (14 of 40; 35%) had evidence of hepatitis C virus (HCV) infection than had evidence of either hepatitis B virus (HBV) carriage (17.5%) or alcohol abuse (30%). In all 1...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890380215

    authors: Garson JA,Wicki AN,Ring CJ,Joller H,Zala G,Schmid M,Buehler H

    更新日期:1992-10-01 00:00:00

  • Epidemiology of an outbreak in a maternity unit of infections with an antigenic variant of Echovirus 11.

    abstract::After an 8-day-old child had died with clinical signs of septicemia, 6 other newborns fell ill. Virus was isolated from various sites from all the 6 children (28 isolations). The agent was identified by cross neutralization tests as an antigenic variant of Echovirus 11. The agent could not be isolated from mothers or ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890090202

    authors: Mertens T,Hager H,Eggers HJ

    更新日期:1982-01-01 00:00:00