Abstract:
:Both multiple endocrine neoplasia type 1 (MEN1)-related gastrinomas and gastrointestinal stromal tumors (GISTs) are rare neoplasms, and their association has been rarely reported. We describe an unusual association between a GIST and a MEN1-related gastrinoma. A 44-year-old man had undergone surgical removal of a pancreatic gastrinoma in 2004 and was then administered long-term somatostatin analogs, and diagnosed as having MEN1 syndrome. Following an uneventful follow-up, in April 2009, an upper gastrointestinal tract endoscopy showed esophageal narrowing, with evidence of a 2-cm solid mass on endoscopic ultrasonography. Histology revealed a tumor composed of elongated cells with plump cytoplasm arranged in a storiform pattern. The immunophenotype of the lesion was CD117 and Platelet Derived Growth Factor (PDGF) positive, whereas alpha-1 muscle actin and S-100 protein were negative. Due to morphological and immunohistochemical results, a final diagnosis of esophageal GIST was made. The association between GISTs and MEN1 could be casual, although a single case of the coexistence of a GIST and a MEN1-related gastrinoma has already been reported. A role of the MEN1 gene in the pathogenesis of GISTs could be hypothesized.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Massironi S,Rossi RE,Ferrero S,Cavalcoli F,Spampatti MP,Conte D,Corbetta S,Peracchi Mdoi
10.4103/0973-1482.136685subject
Has Abstractpub_date
2014-04-01 00:00:00pages
443-5issue
2eissn
0973-1482issn
1998-4138pii
JCanResTher_2014_10_2_443_136685journal_volume
10pub_type
信件,评审abstract:Objective:Undesired neutron contamination imposed to patients during treatment is among the main factors increasing the risk of secondary cancer in radiotherapy. This additional undesirable dose is due to neutron contamination production in high-energy accelerators. In this study, neutron contamination is investigated ...
journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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更新日期:2012-10-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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更新日期:2020-07-01 00:00:00
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更新日期:2019-07-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_325_17
更新日期:2020-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 信件,评审
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更新日期:2015-07-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
abstract:Aim of Study:Prostate cancer (PCa) is one of the most common cancers among men and has become a significant health problem in developing and developed countries. Prostate-specific antigen (PSA) is a useful marker for screening and monitoring the patients. In this study, the author aimed to detect the prevalence of PCa ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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更新日期:2019-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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更新日期:2019-07-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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更新日期:2018-12-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,meta分析
doi:10.4103/0973-1482.176422
更新日期:2018-09-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 临床试验,杂志文章
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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更新日期:2015-08-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,评审
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更新日期:2009-09-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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更新日期:2019-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 信件
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更新日期:2015-07-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,评审
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更新日期:2014-11-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00