Clear cell hepatocellular carcinoma: Back to the basics for diagnosis.

Abstract:

:Hepatocellular carcinoma (HCC) is a common cancer world-wide with a higher incidence in Asia. Clear cell variant of HCC (CCHCC) has a frequency ranging from 0.4% to 37%. The presence of 90-100% clear cells is rare. In the present case, a 35-year-old female patient presented with fever and a large abdominal mass in the right hypochondrium. Histology of the tumor revealed >95% clear cells and after taking multiple sections from different areas of tumor only few scattered cells with eosinophilic cytoplasm were found. Immunohistochemistry with Hep Par 1, Glypican 3 and polyclonal carcinoembryonic antigen were negative as were all other markers for metastatic clear cell tumors. Histological diagnosis was based on routine H and E sections showing a histological pattern of architecture with thickened trabeculae. We describe a rare case of CCHCC with >95% clear cells and no immunoreactivity in tumor cells in a non-cirrhotic liver.

journal_name

J Cancer Res Ther

authors

Sakhuja P,Mishra PK,Rajesh R,Sharma AK,Gondal R,Singh M

doi

10.4103/0973-1482.136041

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

656

issue

3

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2015_11_3_656_136041

journal_volume

11

pub_type

信件
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