Lower serum levels of bilirubin in the newly diagnosed lung cancer patients: A case-control study in China.


PURPOSE:A few prospective studies demonstrated that bilirubin levels were inversely associated with the risk of lung cancer. However, the retrospective study about the relationship between bilirubin levels and lung cancer in China was not available. So, we want to know whether there has a difference in serum bilirubin concentrations between normal people and lung cancer patients. MATERIALS AND METHODS:Using a case-control study, we investigated the bilirubin levels in 317 patients with lung cancer and 317 age-, sex-matched controls from Zhejiang Cancer Hospital. Furthermore, we analyzed the associations between serum bilirubin expressions and baseline clinical features of lung cancer patients using a Wilcoxon rank sum test. RESULTS:Bilirubin levels, including total bilirubin, direct bilirubin, and indirect bilirubin, were significantly lower in human lung cancer serum relative to normal control (P < 0.001), and the older (> 50 years) had higher bilirubin levels compared with the younger (27-50 years) in lung cancer group. Besides, the duration of smoking was negatively related to bilirubin levels, but they did not reach statistical significance except for indirect bilirubin (P = 0.041). However, there was no difference in bilirubin levels between small cell lung cancer (SCLC) and non-SCLC (NSCLC), and we did not find that the bilirubin levels were correlated with sex, drinking status in patients of lung cancer. CONCLUSION:Serum total bilirubin, indirect bilirubin, and direct bilirubin levels of the patients with lung cancer were all significantly lower than those of control group (P < 0.001). Lower levels of bilirubin may be a risk factor for lung cancer, and it could serve as a potential screening biomarker for lung cancer. Large-scale investigations and additional improvements are urgently needed to demonstrate the mechanism and molecular pathway in order to achieve the clinical utility in the future.


J Cancer Res Ther


Song Q,Wang B,Wang S,Zhang YM,Chen WH




Has Abstract


2015-10-01 00:00:00










11 Suppl 2


  • Does hospital-based transitional care reduce the postoperative complication in patients with enterostomy? A meta-analysis.

    abstract:OBJECTIVE:The objective of the study is to investigate whether hospital-based transitional care can reduce the postoperative complication in patients who received enterostomy or not by pooling the published prospective clinical studies. MATERIALS AND METHODS:Prospective clinical studies related to hospital-based trans...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,meta分析


    authors: Chen Y,Jiang J,Wu Y,Yan J,Chen H,Zhu X

    更新日期:2016-10-01 00:00:00

  • Transarterial chemoembolization, ablation, tyrosine kinase inhibitors, and immunotherapy (TATI): A novel treatment for patients with advanced hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Currently, the main effective treatment options for HCC include resection, liver transplantation, various percutaneous modalities (such as transarterial chemoembolization [TACE] and thermal ablation), and tyrosine kinase inhibitors (TKIs). Here...

    journal_title:Journal of cancer research and therapeutics



    authors: Meng M,Li W,Yang X,Huang G,Wei Z,Ni Y,Han X,Wang J,Ye X

    更新日期:2020-01-01 00:00:00

  • Measurement of fast neutron contamination caused by the presence of wedge and block using CR-39 detector.

    abstract:Objective:Undesired neutron contamination imposed to patients during treatment is among the main factors increasing the risk of secondary cancer in radiotherapy. This additional undesirable dose is due to neutron contamination production in high-energy accelerators. In this study, neutron contamination is investigated ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Khajetash B,Bahreyni Toossi MT,Ghorbani M,Jahangiri M,Akbari F

    更新日期:2019-03-01 00:00:00

  • Precision dose measurement of 125I seed in solid water through SPECT/CT detecting.

    abstract:Purpose:The aim of the study is to study the feasibility of gamma-ray-detection-based precision dose measurement of 125I seed brachytherapy in solid water. Materials and Methods:Seven group 125I seeds with different activities were put into a hole in the center of solid water individually. Each group had ten seeds, an...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Zhang H,Liang Y,Qiu G,Wang Z,Dev D,Liu Z,Li H,Yu H,Chen J,Sui A,Wang J,Shi G

    更新日期:2019-01-01 00:00:00

  • Telomere length variation and expression analysis of shelterin complex genes during gallbladder carcinogenesis.

    abstract:BACKGROUND:Telomeres, which are bound with shelterin protein complex, play an important role in maintaining genomic stability and its dysfunction may lead to carcinogenesis. Here, we aimed to analyze whether shelterin complex gene expression and telomere length variation, play any role in gallbladder carcinogenesis. M...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Poojary SS,Mishra G,Singh TD,Gupta S,Shrivastav BR,Tiwari PK

    更新日期:2017-04-01 00:00:00

  • Transnasal endoscopic resection of vascular leiomyomas of the nasal septum.

    abstract:OBJECTIVE:Our experience with endoscopic surgery for vascular leiomyomas of the nasal septum was reviewed. PATIENTS AND METHODS:All patients with vascular leiomyomas of the nasal septum who were treated with endoscopic surgery from May 1995 to June 2007 were reviewed retrospectively. RESULTS:Twelve patients had vascu...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Chen HH,Wang QY,Zhou SH

    更新日期:2016-01-01 00:00:00

  • Rechallenge of camrelizumab in non-small-cell lung cancer patients treated previously with camrelizumab and microwave ablation.

    abstract::Camrelizumab is a programmed death receptor-1 inhibitor originally developed in China for the treatment of refractory lymphoma. It has also been effective in non-small-cell lung cancer patients. However, the rechallenge of camrelizumab was not reported previously. We report the rechallenge of camrelizumab therapy in t...

    journal_title:Journal of cancer research and therapeutics



    authors: Wei Z,Yang X,Ye X

    更新日期:2020-09-01 00:00:00

  • Association between clinical pathology and multiple genes mRNA expression in Chinese patients with NSCLC.

    abstract:OBJECTIVE:The aim of this study was to evaluate whether there was an association between pathology type and ERCC1, BRCA1, RRM1, TUBB3, STMN1, TOP2A and epidermal growth factor receptor (EGFR) messenger ribonucleic acid (mRNA) expression level in Chinese patients with non-small cell lung carcinoma (NSCLC). MATERIALS AN...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Chen G,Jundong GU,Chen J,Liu Y,Song Z

    更新日期:2013-09-01 00:00:00

  • Integral dose to the carotid artery in intensity modulated radiotherapy of carcinoma nasopharynx: extended field IMRT versus split-field IMRT.

    abstract:AIM:To evaluate the integral dose to carotid vessels in extended field intensity modulated radiotherapy (IMRT) (including the lower neck nodes in IMRT field) and split field IMRT (using separate single anterior field to treat lower neck nodes) in cancer nasopharynx. MATERIALS AND METHODS:Dosimetric data from 10 patien...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Bahl A,Basu KS,Sharma DN,Rath GK,Julka PK,Thulkar S

    更新日期:2010-10-01 00:00:00

  • Awareness of cervical cancer, Papanicolau's smear and its utilization among female, final year undergraduates in Durban, South Africa.

    abstract:CONTEXT:Cervical cancer is a preventable disease; it is the primary cancer amongst women in South Africa. AIMS:The objective of this study is to assess the awareness and detection methods of cervical cancer. SETTINGS AND DESIGN:This was a cross-sectional study conducted among 180 full time final year undergraduate fe...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Hoque ME

    更新日期:2013-01-01 00:00:00

  • Cytology of hyalinising trabecular adenoma-like variant of medullary thyroid carcinoma.

    abstract::Medullary thyroid carcinoma is a rare thyroid neoplasm that can be either sporadic or familial. It occurs in adults, presenting as a solitary cold nodule on thyroid scan. Most are solid, firm, and non-encapsulated, and occur in the mid portion or upper half of the thyroid gland, corresponding to areas with greater num...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Santosh KV,Raychaudhuri S,Subramanya H,Naveen Kumar BJ

    更新日期:2011-04-01 00:00:00

  • Systemic lupus erythematous increased lung cancer risk: Evidence from a meta-analysis.

    abstract:AIMS:Several studies suggested that systemic lupus erythematosus (SLE) were associated with the risk of lung cancer. However, other studies did not confirm the result. Therefore, we conducted a meta-analysis to investigate this association. MATERIALS AND METHODS:A systematic literature search was conducted using the P...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,meta分析


    authors: Wu Y,Hou Q

    更新日期:2016-04-01 00:00:00

  • Plasma interleukin 17 in the diagnosis of hepatocellular carcinoma: a retrospective study of 39 cases.

    abstract:OBJECTIVE:The purpose of this retrospective study was to evaluate the diagnosis efficacy of plasma interleukin 17 (IL-17) for hepatocellular carcinoma (HCC). MATERIALS AND METHODS:Thirty-nine patients with confirmed HCC and 41 healthy controls were retrospectively analyzed in this study. The serum level of IL-17 was t...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Liu J,Zhou G,Lu W

    更新日期:2014-12-01 00:00:00

  • Role of Toll-like receptors in microbiota-associated gastrointestinal cancer metastasis.

    abstract::Toll-like receptors (TLRs) serve as specific pattern recognition molecules that bind to microbial components to activate innate immunity and instruct and modulate adaptive immunity in the face of immunological danger. Accumulating evidence supports that TLR signaling pathway responses to luminal microbes participate i...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审


    authors: Lu Q,Ding H,Li W

    更新日期:2013-11-01 00:00:00

  • Primary amyloidosis with high grade transitional cell carcinoma of bladder: a rare case report.

    abstract::Primary amyloidosis of bladder is a rare disease that closely resembles bladder cancer on clinical presentation with painless gross hematuria. Pathologically this is a totally benign non-neoplastic lesion and its association with urothelial carcinoma of the bladder is rare. We herein report a 64-year-old diabetic male...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Gupta P,Hanamshetti S,Kulkarni JN

    更新日期:2012-04-01 00:00:00

  • Complete response of a recurrent-metastatic liposarcoma with dedifferentiated histological features following the administration of trabectedin and review of literature.

    abstract::The present case report defines a rare case of a liposarcoma with bone metastasis resulting in a complete remission (CR) following trabectedin treatment. The patient was referred with abdominal swelling and pain. A retroperitoneal mass was detected and described as dedifferentiated liposarcoma (DDLS). The mass was sur...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件,评审


    authors: Kus T,Aktas G,Kalender ME,Tutar E,Ulker E,Camci C

    更新日期:2015-10-01 00:00:00

  • Which is the most optimal technique to spare hippocampus?-Dosimetric comparisons of SCRT, IMRT, and tomotherapy.

    abstract:AIMS:To evaluate current focal high precision radiotherapy (RT) techniques to spare hippocampi most optimally, in view of mounting clinical evidence to preserve neurocognition. MATERIALS AND METHODS:Computed tomography/magnetic resonance imaging (CT/MRI) datasets of 10 patients with benign/low-grade brain tumors, trea...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Kothavade V,Jamema SV,Gupta T,Pungavkar S,Upasani M,Juvekar S,Jalali R

    更新日期:2015-04-01 00:00:00

  • Colposcopy in oral epithelial dysplasia: seeing the unseen, a pilot study.

    abstract:CONTEXT:The diagnosis of malignant and potentially malignant epithelial lesions of oral mucosa cannot be based solely on clinical findings. The histologic evaluation of a representative biopsy specimen thus becomes necessary. The site for biopsy, however, is always a subjective choice that sometimes raises doubts about...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,收录出版


    authors: Nayyar AS,Khan M,Bafna UD,Ahmed S,Chaluvaiah GH

    更新日期:2014-07-01 00:00:00

  • Brain cancer surgery in the language areas of Mandarin-Cantonese bilinguals.

    abstract:OBJECTIVE:This study aimed to study methods for protecting the language areas during tumor surgery in Mandarin-Cantonese bilinguals (MCBs). MATERIALS AND METHODS:Eleven MCB patients were positioned for awake surgery with the purpose of preserving both of their language proficiencies. All the exposed cortices were elec...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Gao H,Bai HM,Han LX,Li TD,Wang GL,Wang WM

    更新日期:2015-04-01 00:00:00

  • Neoadjuvant imatinib in locally advanced gastrointestinal stromal tumors.

    abstract:AIM:To study the role of neoadjuvant imatinib mesylate in downsizing tumors in patients with locally advanced nonmetastatic gastrointestinal stromal tumors (GISTs), thus improving the possibility of complete resection. MATERIALS AND METHODS:We used neoadjuvant imatinib in six patients with locally advanced GISTs, at a...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 临床试验,杂志文章


    authors: Seshadri RA,Rajendranath R

    更新日期:2009-10-01 00:00:00

  • Multidetector computed tomography evaluation of synchronous lymphoma and other solid malignancies.

    abstract:Objective:The objective of this study is to review the multidetector computed tomography (MDCT) findings of synchronous lymphoma and other solid malignancies. Patients and Methods:This retrospective study included 18 patients confirmed with diagnosis of lymphoma and other solid malignancies. They were 8 women and 10 m...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: El-Badrawy A,Gadelhak B,Helmy EM,Farouk O,Fady T,Refky B,Elzaafarany M,Emarah Z,Taalab MM,Eisa N,El-Etreby SA,Bahgat MH,El-Badrawy MK,Elalfy H,Besheer T,El-Mesery A,Akl MF,Megahed N,Khashaba EO

    更新日期:2020-01-01 00:00:00

  • Morphometric computer-assisted image analysis of epithelial cells in different grades of oral squamous cell carcinoma.

    abstract:Introduction:Oral squamous cell carcinoma (OSCC) accounts 94% of all malignant lesions in the oral cavity. In the assessment of OSCC, nowadays the WHO grading system has been followed widely but due to its subjectivity, investigators applied the sophisticated technique of computer-assisted image analysis in the grading...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Ananjan C,Jyothi M,Laxmidevi BL,Gopinathan PA,Nazir SH,Pradeep L

    更新日期:2018-01-01 00:00:00

  • Multiple subcutaneous metastases as the solitary presenting site of colorectal cancer.

    abstract::Skin metastases, as a presenting symptom of gastrointestinal malignancies, are very rare and signify aggressive disease. They usually occur after a long period of diagnosis and along with other visceral metastases. We present the case of an 18-year-old male with diffuse subcutaneous metastases as a presenting feature ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件


    authors: Nallathambi C,Singh IY,Patton Z

    更新日期:2018-04-01 00:00:00

  • Spritzer: For diagnostic cytopathology.

    abstract:BACKGROUND:Exfoliative cytology is an easy, economical, noninvasive, and feasible method for early detection and screening program of any premalignant or malignant lesion. In case of routine cytological procedure, classical Papanicolaou (PAP) stain is widely used while Romanowsky stains are sparingly used. Leishman-Gie...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Metgud R,Surbhi.,Naik S,Patel S

    更新日期:2017-10-01 00:00:00

  • Radiotherapy for management of skin cancers in fibrodysplasia ossificans progressiva: a case report and review of the literature.

    abstract::Fibrodysplasia ossificans progressiva (FOP) is a rare condition of ectopic calcification leading to increasing disability throughout life, with most patients being wheelchair bound by the age of 30. Ectopic calcification can be triggered by trauma and it is therefore important to minimize biopsies and operative proced...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Frew JA,Kelly CG

    更新日期:2008-01-01 00:00:00

  • Low titer of antibody against Toxoplasma gondii may be related to resistant to cancer.

    abstract:CONTEXT:Toxoplasma gondii is a protozoan parasite with a world-wide distribution. However, the majority of infected cases remain symptomless. There are raising scientific evidences indicating that parasitic infections induce antitumor activity against certain types of cancers. The inhibitory effect of T. gondii on canc...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Seyedeh MS,Nahid S,Nahid M,Shima DP,Morteza Y,Hossein YD

    更新日期:2015-04-01 00:00:00

  • Potent chemopreventive effect of mangiferin on lung carcinogenesis in experimental Swiss albino mice.

    abstract:AIM OF THE STUDY:In the present study the effects of mangiferin were tested against lung cancer-bearing mice in both the pre-initiation and post-initiation periods. MATERIALS AND METHODS:Healthy male Swiss albino mice (6-8 weeks old) were used throughout the study. The animals were treated with mangiferin (100 mg/kg b...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Rajendran P,Rengarajan T,Nishigaki I,Ekambaram G,Sakthisekaran D

    更新日期:2014-10-01 00:00:00

  • A dosimetric comparison between three-dimensional conformal radiation therapy and intensity-modulated radiation therapy in the treatment of posterior fossa boost in medulloblastoma.

    abstract:AIMS:To compare three-dimensional conformal radiation therapy (3DCRT) and intensity-modulated radiation therapy (IMRT) in posterior fossa (PF) boost in children with medulloblastoma (MB); dosimetrically evaluating and comparing both techniques with regard to target coverage and doses to organs at risk. SETTINGS AND DE...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Gupta M,Kant R,Nautiyal V,Bisht J,Raghuvanshi S,Saini M,Kalra BP,Ahmad M

    更新日期:2017-10-01 00:00:00

  • Significance of ovoid separation with various applications of high-dose-rate-intracavitary radiotherapy in carcinoma of uterine cervix: a study from rural centre of Maharashtra, India.

    abstract:AIMS:To analyze the differences in dose distribution, with ovoid separation in various applications, by different radiotherapists in the same patient of carcinoma of the uterine cervix treated by multiple fractions of high-dose-rate (HDR) intracavitary Radio therapy (ICRT). SETTINGS:Pravara Rural Hospital and Rural Me...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,随机对照试验


    authors: Jain VS,Singh KK,Umberkar RB,Sarje MB,Jain SM

    更新日期:2010-04-01 00:00:00

  • Wnt5a/Ca (2+) /calcineurin/nuclear factor of activated T signaling pathway as a potential marker of pediatric melanoma.

    abstract::Melanoma is rare in children, but its incidence appears to be increasing. Melanoma accounts for the highest mortality among all skin cancer types. This disease is characterized by high-grade malignancy, easy metastasis, poor prognosis, and high death rate. Melanoma in children may be biologically different from that i...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审


    authors: Yang Y,Qian Q

    更新日期:2014-11-01 00:00:00