Lower serum levels of bilirubin in the newly diagnosed lung cancer patients: A case-control study in China.


PURPOSE:A few prospective studies demonstrated that bilirubin levels were inversely associated with the risk of lung cancer. However, the retrospective study about the relationship between bilirubin levels and lung cancer in China was not available. So, we want to know whether there has a difference in serum bilirubin concentrations between normal people and lung cancer patients. MATERIALS AND METHODS:Using a case-control study, we investigated the bilirubin levels in 317 patients with lung cancer and 317 age-, sex-matched controls from Zhejiang Cancer Hospital. Furthermore, we analyzed the associations between serum bilirubin expressions and baseline clinical features of lung cancer patients using a Wilcoxon rank sum test. RESULTS:Bilirubin levels, including total bilirubin, direct bilirubin, and indirect bilirubin, were significantly lower in human lung cancer serum relative to normal control (P < 0.001), and the older (> 50 years) had higher bilirubin levels compared with the younger (27-50 years) in lung cancer group. Besides, the duration of smoking was negatively related to bilirubin levels, but they did not reach statistical significance except for indirect bilirubin (P = 0.041). However, there was no difference in bilirubin levels between small cell lung cancer (SCLC) and non-SCLC (NSCLC), and we did not find that the bilirubin levels were correlated with sex, drinking status in patients of lung cancer. CONCLUSION:Serum total bilirubin, indirect bilirubin, and direct bilirubin levels of the patients with lung cancer were all significantly lower than those of control group (P < 0.001). Lower levels of bilirubin may be a risk factor for lung cancer, and it could serve as a potential screening biomarker for lung cancer. Large-scale investigations and additional improvements are urgently needed to demonstrate the mechanism and molecular pathway in order to achieve the clinical utility in the future.


J Cancer Res Ther


Song Q,Wang B,Wang S,Zhang YM,Chen WH




Has Abstract


2015-10-01 00:00:00










11 Suppl 2


  • Orientin mitigates 1, 2-dimethylhydrazine induced lipid peroxidation, antioxidant and biotransforming bacterial enzyme alterations in experimental rats.

    abstract:Background:Colorectal cancer (CRC) is the second most diagnosed cancer often identified during the later stages of carcinogenesis. Orientin, a C-glycoside of luteolin, is well known for its versatile therapeutic action toward oxidative stress-induced cellular response may exert chemoprevention against CRC. Materials a...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Thangaraj K,Natesan K,Settu K,Palani M,Govindarasu M,Subborayan V,Vaiyapuri M

    更新日期:2018-10-01 00:00:00

  • Effect of lenalidomide on the human gastric cancer cell line SGC7901/vincristine Notch signaling.

    abstract:Aim of Study:To examine the function of lenalidomide (LEN) on the human multidrug resistance (MDR)-type gastric cancer line SGC7901/vincristine (VCR) via regulating Notch signaling. Materials and Methods:Quantitative polymerase chain reaction was used for checking the genes of Notch, DNA methyltransferase (DNMT), RBP-...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Ding W,Zeng T,Tao W,Ge W,Deng J,Lei H,Xiao Y,Liao F

    更新日期:2018-01-01 00:00:00

  • The overexpression of MRP4 is related to multidrug resistance in osteosarcoma cells.

    abstract::Doxorubicin (Adriamycin, ADM) is an antimitotic drug used in the treatment of a wide range of malignant tumors, including acute leukemia, lymphoma, osteosarcoma, breast cancer, and lung cancer. Multidrug resistance-associated proteins (MRPs) are members of a superfamily of ATP-binding cassette (ABC) transporters, whic...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: He Z,Hu B,Tang L,Zheng S,Sun Y,Sheng Z,Yao Y,Lin F

    更新日期:2015-01-01 00:00:00

  • Immunological subtypes analysis of Uygur diffuse large B-cell lymphoma in Xinjiang and their prognostic significance.

    abstract:OBJECTIVE:This study aims to explore the application of Choi's typing method in the immunological typing of diffuse large B-cell lymphoma (DLBCL) in Xinjiang Autonomous Region and its prognostic significance. MATERIALS AND METHODS:Seventy-eight cases of DLBCL tumor tissues from Xinjiang were collected to detect the ex...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Jia CD,Liang LP,Yang LL,Yue N,Zhao F,Bai JP

    更新日期:2015-10-01 00:00:00

  • Efficacy of apatinib on multiple advanced-stage nongastric cancers.

    abstract:Background:Apatinib has been approved for the treatment of advanced gastric adenocarcinoma and gastric-esophageal junctional adenocarcinoma, but its efficacy is unknown for other advanced solid tumors. Aims and Objectives:We retrospectively reviewed the use of apatinib for multiple advanced-stage non-gastric cancers. ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Wu X,Wang H,Wu Y,Jin J,Zhan Y,Zhu G,Zhang F,Zhang C,Gan J,Li W

    更新日期:2019-01-01 00:00:00

  • Plasma interleukin 17 in the diagnosis of hepatocellular carcinoma: a retrospective study of 39 cases.

    abstract:OBJECTIVE:The purpose of this retrospective study was to evaluate the diagnosis efficacy of plasma interleukin 17 (IL-17) for hepatocellular carcinoma (HCC). MATERIALS AND METHODS:Thirty-nine patients with confirmed HCC and 41 healthy controls were retrospectively analyzed in this study. The serum level of IL-17 was t...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Liu J,Zhou G,Lu W

    更新日期:2014-12-01 00:00:00

  • Does hospital-based transitional care reduce the postoperative complication in patients with enterostomy? A meta-analysis.

    abstract:OBJECTIVE:The objective of the study is to investigate whether hospital-based transitional care can reduce the postoperative complication in patients who received enterostomy or not by pooling the published prospective clinical studies. MATERIALS AND METHODS:Prospective clinical studies related to hospital-based trans...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,meta分析


    authors: Chen Y,Jiang J,Wu Y,Yan J,Chen H,Zhu X

    更新日期:2016-10-01 00:00:00

  • Intranodal palisaded myofibroblastoma: a case report and an update on etiopathogenesis and differential diagnosis.

    abstract::Intra-nodal palisaded myofibroblastoma (IPM) is a rare benign lymph node mesenchymal tumor. It presents as a slow growing, painless nodular mass confined mostly to the inguinal area. Histologically, it shows palisading spindle cells, hemorrhages, hemosiderin laden macrophages, and amianthoid fibers, almost totally rep...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Sarma NH,Arora KS,Varalaxmi KP

    更新日期:2013-04-01 00:00:00

  • What is the role of florine-18 fluorodeoxyglucose/positron emission tomography/computed tomography imaging in well-differentiated thyroid cancers with negative iodine-131 scan high thyroglobulin and normal anti-thyroglobulin levels.

    abstract:PURPOSE:This retrospective study aims to assess the cut-off value of thyroglobulin (Tg) levels in nux or metastatic well-differentiated thyroid cancers (DTCs) with normal anti-Tg levels using with fluorodeoxyglucose/positron emission tomography/computed tomography (FDG PET/CT). MATERIALS AND METHODS:We reviewed FDG PE...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Döner RK,Sager S,Görtan FA,Topuz ÖV,Akyel R,Vatankulu B,Baran A,Teksoz S,Sönmezoglu K

    更新日期:2016-04-01 00:00:00

  • Human papillomavirus infection and p53 mutation in esophageal squamous cell carcinoma and its impact on treatment outcome.

    abstract:Introduction:Human papillomavirus (HPV) is emerging as a risk factor for esophageal squamous carcinoma. The prognostic value of the HPV status has been investigated. However, the results are much controversial. Aim:This study aims to document the association of HPV infection and mutation of p53 gene in esophageal squa...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Singh T,Shirazi N,Bansal S,Gupta M,Saini S,Ahmad M

    更新日期:2020-12-01 00:00:00

  • Hypercalcemia and treated breast cancers: the diagnostic dilemma.

    abstract::The relationship of hypercalcemia with cancer is well described in the literature. Breast cancer is the commonest malignancy associated with hypercalcemia; the detection of hypercalcemia in these patients usually signifies metastatic disease and is associated with a poor prognosis. However, the treating oncologist sho...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Rao V,Chaukar D,D'Cruz AK

    更新日期:2009-01-01 00:00:00

  • Percutaneous thermal ablation combined with simultaneous transarterial chemoembolization for hepatocellular carcinoma ≤5 cm.

    abstract:Background/Aim:Percutaneous thermal ablation combined with transarterial chemoembolization (TACE) becomes a treatment option for unresectable hepatocellular carcinoma (HCC). This study aims to investigate the safety and feasibility of percutaneous thermal ablation combined with simultaneous TACE for patients with HCC ≤...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Wu M,Gao S,Song H,Zhang Z,Wang J,Liu R,Wang X,Cheng J,Luo J,Liu Q,Chen Y,Yan Z,Liu L

    更新日期:2019-01-01 00:00:00

  • Multiple subcutaneous metastases as the solitary presenting site of colorectal cancer.

    abstract::Skin metastases, as a presenting symptom of gastrointestinal malignancies, are very rare and signify aggressive disease. They usually occur after a long period of diagnosis and along with other visceral metastases. We present the case of an 18-year-old male with diffuse subcutaneous metastases as a presenting feature ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件


    authors: Nallathambi C,Singh IY,Patton Z

    更新日期:2018-04-01 00:00:00

  • The impact of perioperative blood transfusion on survival and recurrence after radical prostatectomy for prostate cancer: A systematic review and meta-analysis.

    abstract:Objective:Conflicting data have been reported regarding the association between perioperative blood transfusion (PBT) and clinical outcomes for prostate cancer patients. We conducted a systematic review and meta-analysis to evaluate the impact of PBT on cancer survival and recurrence for patients who underwent radical ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,meta分析,评审


    authors: Pushan Z,Manbiao C,Sulai L,Jun L,Ruidong Z,Hanshen Y

    更新日期:2018-09-01 00:00:00

  • Signal transducer and activator of transcription 3 downregulation in J774A.1 cell line as a model of M2 macrophages in tumor microenvironment.

    abstract:Aim:Tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis, and immune functions within tumor microenvironments. Tumor progression is frequently associated with a phenotypic switch from M1 to M2 in TAM. Activation of signal transdu...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Seyedi Z,Hashemzadeh MR,Colagar AH,Jaafari MR

    更新日期:2018-07-01 00:00:00

  • Prognostic effect of symptomatic extracranial lesions on survival of recursive partitioning analysis Class III brain metastatic patients treated with stereotactic radiotherapy.

    abstract:OBJECTIVE:To explore the outcome and prognostic factors of recursive partitioning analysis (RPA) Class III brain metastatic patients treated with stereotactic radiotherapy (SRT). MATERIALS AND METHODS:Fifty-six consecutive patients with metastatic brain tumors and Karnofsky performance scale (KPS) scores <70 treated w...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Chen XJ,Xiao JP,Li XP,Jiang XS,Zhang Y

    更新日期:2016-01-01 00:00:00

  • The expression and prognostic significance of Mucin 13 and Mucin 20 in esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Mucin 13 (MUC13) and Mucin 20 (MUC20) are high molecular weight transmembrane O-linked glycoprotein secreted by epithelium and are widely overexpressed in epithelial tumor cells. Previously, it has been reported that MUC13 and MUC20 were prognostic molecular biomarkers of some epithelial tumors, but few has ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Wang H,Shen L,Lin Y,Shi Q,Yang Y,Chen K

    更新日期:2015-08-01 00:00:00

  • Detection of atypical metastases in recurrent adenoid cystic carcinoma of parotid gland.

    abstract::We report a known case of adenoid cystic carcinoma of right parotid gland in a 36-year-old Indian male, diagnosed 5 years ago for which he underwent surgery followed by radiotherapy. Now the patient has presented to the surgical oncologist with a mass near angle of right jaw. Computed tomography (CT) performed elsewhe...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Tewari A,Padma S,Sundaram PS

    更新日期:2013-01-01 00:00:00

  • Ganodermanontriol inhibits expression of special AT rich sequence binding protein 1 gene in human hepatocellular carcinoma.

    abstract:Context:The metastasis of liver cancer is a major cause of clinical treatment failure, restrain, and control the cancer metastasis is the major strategy of the treatment and prevention of the disease. Special AT-rich sequence-binding protein 1 (SATB1) gene was overexpressed in many malignant tumors and considered as a ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Xu C,Guo H,Kong D,Pang D,Ding Y

    更新日期:2018-12-01 00:00:00

  • Role of adjuvant radiotherapy in metaplastic matrix producing breast cancer: a case study with review of literature.

    abstract::A rare and unique variant of breast cancer--metaplastic matrix producing carcinoma, is presented. Surgery has been the mainstay of treatment. The role of adjuvant postoperative radiotherapy, as has been used in this patient, has been reviewed. ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Kumar P,Agarwal T,Krishnani N,Singh S,Datta NR

    更新日期:2006-04-01 00:00:00

  • Intractable nausea in a patient with synchronous pancreatic cancer and a fourth-ventricular ependymoma.

    abstract::Symptoms of nausea and vomiting can present a diagnostic challenge for physicians. In this article, we report a patient who was found to have synchronous presentation of an ependymoma and pancreatic cancer. This case illustrates some of the diagnostic challenges in patients with constitutional symptoms. Furthermore, i...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Chowdhry VK,Carter DA,Shapiro A

    更新日期:2013-10-01 00:00:00

  • Dosimetry study of three-dimensional print template-guided precision 125I seed implantation.

    abstract:OBJECTIVE:This study aimed to compare the dose difference in 125 I seed implantation between three-dimensional (3D) print template-guided operation and traditional implantation. MATERIALS AND METHODS:This study retrospectively analyzed 27 patients who underwent 125I seed implantation from August 2015 to December 2015 ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Hongtao Z,Xuemin D,Huimin Y,Zeyang W,Lijuan Z,Jinxin Z,Zezhou L,Aixia S,Juan W

    更新日期:2016-12-01 00:00:00

  • Massive scapular metastasis as a presenting feature of carcinoma of the lip.

    abstract::Carcinoma of the lip is a slow-growing locally-advanced disease with low metastatic potential. Distant skeletal metastasis is reported very rarely and the vertebral column is the most common site. A 58-year-old male smoker presented with pain and massive swelling of the left scapula for six months. He also noticed a s...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Bandyopadhyay R,Nag D,Bandyopadhyay SK

    更新日期:2010-07-01 00:00:00

  • Ultrasonographic diagnosis of benign masseter muscle hypertrophy: A case report.

    abstract::Masseter hypertrophy is a characteristic condition resulting from an increase in the size of the muscle mass. At times, it produces significant facial asymmetry and is an important finding in the differential diagnosis of similar located entities. A proper diagnosis of this condition would avoid more aggressive and un...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件


    authors: Naphade VV,Kedia SG,Patil P,Khare S

    更新日期:2018-12-01 00:00:00

  • Adding bit of esthetics with science modification of batwing mastopexy for breast conservation in a young patient with giant fibroadenoma breast.

    abstract::A 19-year-old girl presented with a lump in her right breast and with a history of surgery for the similar complaint 3 years back. Ultrasound was suggestive of benign solitary lesion of size 16 cm × 10 cm. Core biopsy was suggestive of phyllodes tumor, and the histopathology report of previous surgery was also suggest...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件


    authors: Kumar HH,Rahman NKF,Ramesh RS,Raghunandan GC

    更新日期:2019-07-01 00:00:00

  • Comparison of beam hardening effect of physical and enhanced dynamic wedges at bladder inhomogeneity using EBT3 film dosimeter.

    abstract:INTRODUCTION:Using physical wedges (PWs) to modify dose distribution and more homogeneous target coverage is a well-established technique. However, there are many problems with PWs known as beam hardening, which made them problematic. This can be overcome by dynamic wedges which do not filter beam. Comparison of physic...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Geraily G,Sharafi N,Shirazi A,Esfehani M,Masoudifar M,Rajab BE

    更新日期:2017-01-01 00:00:00

  • Precision dose measurement of 125I seed in solid water through SPECT/CT detecting.

    abstract:Purpose:The aim of the study is to study the feasibility of gamma-ray-detection-based precision dose measurement of 125I seed brachytherapy in solid water. Materials and Methods:Seven group 125I seeds with different activities were put into a hole in the center of solid water individually. Each group had ten seeds, an...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Zhang H,Liang Y,Qiu G,Wang Z,Dev D,Liu Z,Li H,Yu H,Chen J,Sui A,Wang J,Shi G

    更新日期:2019-01-01 00:00:00

  • Clinical study of transcatheter arterial chemoembolization combined with microwave ablation in the treatment of advanced hepatocellular carcinoma.

    abstract:OBJECTIVE:To evaluate the safety and efficacy of transcatheter arterial chemoembolization (TACE) combined with percutaneous microwave ablation (MWA) in the treatment of advanced hepatocellular carcinoma (HCC). MATERIALS AND METHODS:Three thousand cases of advanced HCC patients were randomly divided into two groups: 15...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章


    authors: Li W,Man W,Guo H,Yang P

    更新日期:2016-12-01 00:00:00

  • A rarely seen mucoepidermoid carcinoma of the left main bronchus.

    abstract::Mucoepidermoid carcinomas (MEC) are rare malignant tumors that originate in the submucosal bronchial glands, and complete resection usually correlates with favorable prognosis. A 54-year-old male patient was diagnosed with high-grade MEC in the left main bronchus via bronchoscopy. After the patient was diagnosed with ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件


    authors: Kuzucuoglu M,Karamustafaoglu YA,Cicin I,Yoruk Y

    更新日期:2014-04-01 00:00:00

  • Survival and failure patterns in atypical and anaplastic meningiomas: A single-center experience of surgery and postoperative radiotherapy.

    abstract:INTRODUCTION:Intracranial meningiomas are the second most common tumor of the CNS. The high-grade tumors are atypical and malignant meningioma comprising 5-7% and 1-3% of all meningiomas. The high-grade meningioma have an aggressive histopathological and clinical behavior. MATERIALS AND METHODS:We retrospectively revi...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 临床试验,杂志文章


    authors: Kumar N,Kumar R,Khosla D,Salunke PS,Gupta SK,Radotra BD

    更新日期:2015-10-01 00:00:00