Abstract:
Background:We assessed the frequency of epigenetic lesions, including lymphoid-specific helicase (LSH), 5-hydroxymethylcytosine (5-hmC) and E2F1, and the possible correlations among molecular findings, phenotype, clinical features, and outcome. Methods:We investigated 181 paraffin-embedded B-cell lymphoma samples using immunohistochemistry and in situ hybridization. Results:The levels of Ki67, LSH, 5-hmC, and E2F1 were all increased in germinal center B-cell lymphomas when compared with those in normal lymph nodes, and LSH was highly expressed in diffuse large B-cell lymphomas (DLBCLs) and Burkitt lymphomas (BLs) that were positive for Epstein-Barr virus (EBV) infection, indicating that LSH is linked to EBV infection in DLBCL and BL. Interestingly, LSH was mainly localized in the germinal centers of lymph nodes whereas 5-hmC staining localized to areas surrounding the germinal centers. Conclusions:These findings indicate a critical role for LSH as a biomarker and therapeutic target in follicular germinal center B-cell lymphoma.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Ouyang C,Deng Z,Zhou J,Fu C,Liu S,Tao Y,Xiao Ddoi
10.4103/jcrt.JCRT_243_18subject
Has Abstractpub_date
2019-01-01 00:00:00pages
350-357issue
2eissn
0973-1482issn
1998-4138pii
JCanResTher_2019_15_2_350_255086journal_volume
15pub_type
杂志文章abstract:AIM:The discipline of radiotherapy (RT) in India is considered a low priority subject. Postgraduate (PG) students rarely choose RT as a career option. The possible reasons could be: 1) limited availability of PG course training centers, 2) limited job prospects, etc. We decided to conduct a survey of undergraduate (UG)...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.63556
更新日期:2010-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,meta分析,评审
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,meta分析
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更新日期:2016-04-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 信件
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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pub_type: 杂志文章
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pub_type: 已发布勘误
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更新日期:2016-07-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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pub_type: 杂志文章,meta分析
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