Chromatin remodeling factor lymphoid-specific helicase links with Epstein-Barr virus associated the follicular germinal center B cell lymphomas.

Abstract:

Background:We assessed the frequency of epigenetic lesions, including lymphoid-specific helicase (LSH), 5-hydroxymethylcytosine (5-hmC) and E2F1, and the possible correlations among molecular findings, phenotype, clinical features, and outcome. Methods:We investigated 181 paraffin-embedded B-cell lymphoma samples using immunohistochemistry and in situ hybridization. Results:The levels of Ki67, LSH, 5-hmC, and E2F1 were all increased in germinal center B-cell lymphomas when compared with those in normal lymph nodes, and LSH was highly expressed in diffuse large B-cell lymphomas (DLBCLs) and Burkitt lymphomas (BLs) that were positive for Epstein-Barr virus (EBV) infection, indicating that LSH is linked to EBV infection in DLBCL and BL. Interestingly, LSH was mainly localized in the germinal centers of lymph nodes whereas 5-hmC staining localized to areas surrounding the germinal centers. Conclusions:These findings indicate a critical role for LSH as a biomarker and therapeutic target in follicular germinal center B-cell lymphoma.

journal_name

J Cancer Res Ther

authors

Ouyang C,Deng Z,Zhou J,Fu C,Liu S,Tao Y,Xiao D

doi

10.4103/jcrt.JCRT_243_18

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

350-357

issue

2

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2019_15_2_350_255086

journal_volume

15

pub_type

杂志文章
  • Survey of undergraduate medical students on their understanding and attitude towards the discipline of radiotherapy.

    abstract:AIM:The discipline of radiotherapy (RT) in India is considered a low priority subject. Postgraduate (PG) students rarely choose RT as a career option. The possible reasons could be: 1) limited availability of PG course training centers, 2) limited job prospects, etc. We decided to conduct a survey of undergraduate (UG)...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.63556

    authors: Sharma DN,Rath GK,Parashar A,Singh P

    更新日期:2010-01-01 00:00:00

  • Awareness of cervical cancer, Papanicolau's smear and its utilization among female, final year undergraduates in Durban, South Africa.

    abstract:CONTEXT:Cervical cancer is a preventable disease; it is the primary cancer amongst women in South Africa. AIMS:The objective of this study is to assess the awareness and detection methods of cervical cancer. SETTINGS AND DESIGN:This was a cross-sectional study conducted among 180 full time final year undergraduate fe...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.110350

    authors: Hoque ME

    更新日期:2013-01-01 00:00:00

  • Off-label use of anti-cancer drugs in India: to be or not to be!

    abstract:BACKGROUND:Administering drugs outside the terms of their official labeling is called off-label use. In the West, oncologists often use drugs off-label, which offers several advantages especially while treating patients with multiple comorbidities or advanced cancer. The practice of off-label prescribing of anticancer ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.80455

    authors: Gota V,Patial P

    更新日期:2011-01-01 00:00:00

  • Impact of subventricular zone irradiation on outcome of patients with glioblastoma.

    abstract:Purpose:Glioblastoma (GBM) is characterized by early relapse and mortality. Treatment resistance could be a characteristic exhibited by pro-genitor neoplastic cells that reside in the subventricular zone (SVZ). This retrospective study was conducted to assess the correlation of SVZ doses and survival in patients with G...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_295_17

    authors: Mathew BS,Kaliyath SB,Krishnan J,Bhasi S

    更新日期:2018-10-01 00:00:00

  • Transcriptome network analysis reveals candidate genes for renal cell carcinoma.

    abstract:CONTEXT:Renal cell carcinoma (RCC) is a kidney cancer that originates in renal parenchyma and it is the most common type of kidney cancer with approximately 80% lethal cases. AIMS:To interpret the mechanism, explore the regulation of TF-target genes and TF-pathway, and identify the potential key genes of renal cell ca...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.95170

    authors: Zhai W,Xu YF,Liu M,Zheng JH

    更新日期:2012-01-01 00:00:00

  • The impact of perioperative blood transfusion on survival and recurrence after radical prostatectomy for prostate cancer: A systematic review and meta-analysis.

    abstract:Objective:Conflicting data have been reported regarding the association between perioperative blood transfusion (PBT) and clinical outcomes for prostate cancer patients. We conducted a systematic review and meta-analysis to evaluate the impact of PBT on cancer survival and recurrence for patients who underwent radical ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,meta分析,评审

    doi:10.4103/0973-1482.193115

    authors: Pushan Z,Manbiao C,Sulai L,Jun L,Ruidong Z,Hanshen Y

    更新日期:2018-09-01 00:00:00

  • Adenocarcinoma located at a Meckel's Diverticulum: A case report and literature review.

    abstract::Tumors arising from Meckel's diverticulum (MD) reported in the literature are mainly carcinoid and gastrointestinal stromal tumors. We herein report a rare case of adenocarcinoma arising from intestinal mucosa in an MD with multiple liver metastases at the onset of symptoms. A 57-year-old female complaining of bloody ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件,评审

    doi:10.4103/jcrt.JCRT_124_17

    authors: Zhao Y,Yang X,Ye Y

    更新日期:2017-01-01 00:00:00

  • Adenoid cystic carcinoma of the parotid gland associated with salivary calculi: An unusual presentation.

    abstract::Adenoid cystic carcinomas (ACC) of the head and neck are relatively rare tumors, consisting of approximately 10-15% of all salivary gland neoplasms. ACC, a slow-growing aggressive malignant tumor of salivary gland commonly seen in the submandibular, sublingual, minor salivary glands is seldom found in the parotid. Cal...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.138001

    authors: Shenoy VS,Kamath MP,Sreedharan S,Suhas SS

    更新日期:2015-07-01 00:00:00

  • Renal cell carcinoma, unclassified with unique features.

    abstract::Renal cell carcinoma, unclassified constitute about 3-4% of all renal carcinomas. It essentially is a tumor where more than morphological variants or subtypes are seen in a single tumor. Usually there is a mixture of 2-3 different types. However, in this particular case there were at least 5 different types of morphol...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.151420

    authors: Chander B,Preet K,Bharti R,Deb P

    更新日期:2015-10-01 00:00:00

  • Orbital alveolar soft-part sarcoma: clinico-pathological profiles, management and outcomes.

    abstract:AIM:To study the clinico-radiological and clinic-pathological features of orbital alveolar soft-part sarcomas (ASPS). MATERIALS AND METHODS:We retrieved 9 cases of orbital ASPS. Histopathological and immunohistochemical features and clinico-radiological findings were evaluated. RESULTS:Age at presentation varied from...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.136570

    authors: Mulay K,Ali MJ,Honavar SG,Reddy VA

    更新日期:2014-04-01 00:00:00

  • Comparative retrospective analysis of locoregional recurrence in unselected breast cancer patients treated with conventional versus hypofractionated radiotherapy at a tertiary cancer center?

    abstract:Background:Role of hypofractionated radiotherapy (HFRT) in early breast cancer is established; comparatively, there are limited data for HFRT in locally advanced breast cancer (LABC). We report the impact of HFRT in unselected breast cancer patients in comparison with historically treated patients with conventional fra...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_389_18

    authors: Yadav R,Lal P,Agarwal S,Misra S,Verma M,Das KJM,Senthil Kumar SK,Kumar A,Mishra SK,Agarwal A,Agarwal G,Mishra A,Chand G,Verma AK,Kumar S

    更新日期:2020-10-01 00:00:00

  • Massive scapular metastasis as a presenting feature of carcinoma of the lip.

    abstract::Carcinoma of the lip is a slow-growing locally-advanced disease with low metastatic potential. Distant skeletal metastasis is reported very rarely and the vertebral column is the most common site. A 58-year-old male smoker presented with pain and massive swelling of the left scapula for six months. He also noticed a s...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.73338

    authors: Bandyopadhyay R,Nag D,Bandyopadhyay SK

    更新日期:2010-07-01 00:00:00

  • Association of toll-like receptors with the risk of oral squamous cell carcinoma.

    abstract:Aim of Study:Association of toll-like receptors (TLRs) with the risk of oral squamous cell carcinoma (OSCC) from the published reports is still conflicting. This study was conducted to evaluate the relationship between TLRs and the risk of OSCC using meta-analysis method. Materials and Methods:The association studies ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,meta分析

    doi:10.4103/0973-1482.163789

    authors: Fang SL,Kong XB,Zhang ZQ

    更新日期:2018-01-01 00:00:00

  • The impact of patient positioning and use of belly board on small bowel toxicity in patients receiving pelvic radiotherapy for gynecological malignancies.

    abstract:AIM:To determine the efficacy of belly board device in patients receiving postoperative radiation for gynecological malignancies in terms of setup error and acute small bowel toxicity. MATERIALS AND METHODS:Patients requiring postoperative radiation for gynecological malignancies were prospectively randomized to eithe...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.179519

    authors: Anjanappa M,Raghavan RK,James FV,Kumar A,Mathews S,Bhaskaran S,Sreedevi SV,Jayaprakash PG

    更新日期:2017-07-01 00:00:00

  • Erratum: Human worth in the era of market forces.

    abstract::[This corrects the article DOI: 10.4103/0973-1482.180080.]. ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 已发布勘误

    doi:10.4103/0973-1482.186738

    authors:

    更新日期:2016-04-01 00:00:00

  • Tumor shrinkage rate as a potential marker for the prediction of long-term outcome in advanced non-small cell lung cancer treated with first-line tyrosine kinase inhibitors.

    abstract:Context:Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR) play an indispensable role in the treatment of non-small cell lung cancer (NSCLC), leading to a survival major breakthrough, but there remains no uniform standard for predicting the efficacy of TKI therapy. Aims:We retrospectiv...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_481_19

    authors: Yu S,Wang X,Wang X,Wu X,Xu R,Wang X,Zhang X,Zhang C,Chen K,Cheng D,Wenfeng L

    更新日期:2019-01-01 00:00:00

  • Lipoblastoma and lipoblastomatosis: A clinicopathological study of six cases.

    abstract::Lipoblastoma and lipoblastomatosis are benign adipocytic tumors seen in children less than 3 years of age. Awareness amongst surgeons of this fast growing lipomatous tumor in young children is important to avoid mutilating surgery and chemotherapy. Histological diagnosis of lipoblastoma is sometimes difficult because ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.176135

    authors: Ghosh P,Das RN,Ghosh R,Chatterjee U,Datta C,Mishra PK

    更新日期:2015-10-01 00:00:00

  • Quadrivalent human papillomavirus recombinant vaccine: the first vaccine for cervical cancers.

    abstract::Gardasil is the first quadrivalent human papillomavirus (HPV)-types 6, 11, 16, 18 recombinant vaccine approved by the FDA on June 8, 2006. It induces genotype-specific virus-neutralizing antibodies and prevents infection with HPV. Various clinical trials demonstrated a reduction in the incidence of vaccine-type-specif...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审

    doi:10.4103/0973-1482.34686

    authors: Sharma R,Sharma CL

    更新日期:2007-04-01 00:00:00

  • Serum paraoxonase and arylesterase can be useful markers to predict neoadjuvant chemotherapy requirement in patients with breast cancer.

    abstract:Aim:The aims of this study are to evaluate the serum levels of paraoxonase (PON) and arylesterase (ARE) in breast cancer (BC) patients; to determine their relationship with chemotherapy requirements in BC; and to find a cut-off value to assess subjects with a higher risk of BC. Subjects and Methods:A total of 40 BC pa...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.235355

    authors: Okuturlar Y,Gunaldi M,Kocoglu H,Hursitoglu M,Gedikbasi A,Acarer D,Harmankaya O,Kumbasar A

    更新日期:2018-06-01 00:00:00

  • CLIC1 overexpression is associated with poor prognosis in pancreatic ductal adenocarcinomas.

    abstract:BACKGROUND:Clinical significance of chloride intracellular channel 1 (CLIC1) in pancreatic ductal adenocarcinomas (PDAC) remains largely unknown. This study was performed to assess the expression of CLIC1 in benign and malignant pancreatic lesions, and to assess its clinicopathological significance. MATERIALS AND METH...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.154057

    authors: Jia N,Dong S,Zhao G,Gao H,Li X,Zhang H

    更新日期:2016-04-01 00:00:00

  • Candidate gene biodosimeters of mice and human exposure to ionizing radiation by quantitative reverse transcription polymerase chain reaction.

    abstract::Understanding of cellular responses to ionizing radiation (IR) is essential for the development of predictive markers useful for assessing human exposure. Biological markers of exposure to IR in human populations are of great interest for assessing normal tissue injury in radiation oncology and for biodosimetry in nuc...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审

    doi:10.4103/0973-1482.160912

    authors: Rezaeejam H,Shirazi A,Valizadeh M,Izadi P

    更新日期:2015-07-01 00:00:00

  • Spritzer: For diagnostic cytopathology.

    abstract:BACKGROUND:Exfoliative cytology is an easy, economical, noninvasive, and feasible method for early detection and screening program of any premalignant or malignant lesion. In case of routine cytological procedure, classical Papanicolaou (PAP) stain is widely used while Romanowsky stains are sparingly used. Leishman-Gie...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.174548

    authors: Metgud R,Surbhi.,Naik S,Patel S

    更新日期:2017-10-01 00:00:00

  • Lambda light chain myeloma presenting as nodular hepatic lesion: a clinical rarity.

    abstract::We report a case of a 63-year-old lady presenting with pain in the right hypochondrium, jaundice, anorexia, and firm tender hepatomegaly with remarkably high serum alkaline phosphatase. Abdominal ultrasonography revealed a hypoechoic solid space-occupying lesion in right lobe of liver which was cytologically diagnosed...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.131409

    authors: Pal S,Chattopadhyay B,Chatterjee A,Bhattacharya B

    更新日期:2014-01-01 00:00:00

  • A modified method by differential adhesion and serum-free culture medium for enrichment of cancer stem cells.

    abstract:Objective:In this study, we showed a modified method for the isolation of cancer stem cells (CSCs) using a combination of differential adhesion method and serum-free culture medium (SFM) method. Materials and Methods:Trypsin-sensitive cells and trypsin-resistant cells were isolated from MB49, EJ, and SK-OV-3 cells usi...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.174533

    authors: Zhu YT,Wang CY,Pang SY,Lei CY,Luo Y,Tan WL

    更新日期:2018-06-01 00:00:00

  • Identification of activated pathways in lung adenocarcinoma based on network strategy.

    abstract:Background:Lung adenocarcinoma has increased incidence over the past years and is the cause for almost 50% of deaths attributable to lung cancer. The objective of this paper is to identify activated pathways associated with lung adenocarcinoma based on gene co-expression network analysis. Materials and Methods:Kyoto E...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.199458

    authors: Yu B,Li T,Chen J,Wang FQ,Fu JH,Liu SM,Wang Y,Zhang X,Yang HT

    更新日期:2020-07-01 00:00:00

  • Laparoscopic partial splenectomy of benign tumors assisted by microwave ablation.

    abstract:Objective:The aim of this study is to investigate the application and the feasibility of microwave ablation in laparoscopic partial splenectomy. Materials and Methods:From January 2018 to June 2019, four patients with benign spleen lesions in our hospital underwent laparoscopic partial splenectomy assisted by microwav...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_816_19

    authors: Li Q,Liu Z,Hu M,Ou M,Liu K,Lin W,Wu F,Cao M

    更新日期:2020-09-01 00:00:00

  • Erratum: Herceptin as a single agent in the treatment of patients with metastatic breast cancer.

    abstract::[This corrects the article DOI: 10.4103/0973-1482.163868.]. ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 已发布勘误

    doi:10.4103/0973-1482.197539

    authors:

    更新日期:2016-07-01 00:00:00

  • Which is the most optimal technique to spare hippocampus?-Dosimetric comparisons of SCRT, IMRT, and tomotherapy.

    abstract:AIMS:To evaluate current focal high precision radiotherapy (RT) techniques to spare hippocampi most optimally, in view of mounting clinical evidence to preserve neurocognition. MATERIALS AND METHODS:Computed tomography/magnetic resonance imaging (CT/MRI) datasets of 10 patients with benign/low-grade brain tumors, trea...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.157310

    authors: Kothavade V,Jamema SV,Gupta T,Pungavkar S,Upasani M,Juvekar S,Jalali R

    更新日期:2015-04-01 00:00:00

  • Apatinib for advanced nonsmall-cell lung cancer: A retrospective case series analysis.

    abstract:Objectives:Apatinib, a tyrosine kinase inhibitor which selectively inhibits vascular endothelial growth factor receptor-2, has been shown to be beneficial to patients with a variety of cancers, including advanced nonsmall-cell lung cancer (NSCLC). Thus, this study was aimed to retrospectively assess the efficacy and sa...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_258_17

    authors: Yang C,Feng W,Wu D

    更新日期:2018-01-01 00:00:00

  • The predictive value of cervical lymph node metastasis through sentinel lymph node biopsy in patients with oral cancer: A meta-analysis.

    abstract:OBJECTIVE:The purpose of this meta-analysis was to evaluate the predictive value of cervical lymph node metastasis through sentinel lymph node biopsy (SLNB) in patients with oral cancer. MATERIALS AND METHODS:Two authors independently searched the databases of PubMed, Cochrane central register of controlled trials, EM...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,meta分析

    doi:10.4103/0973-1482.200751

    authors: Lin R,Yan J,Liu W,Fan T,Tang L

    更新日期:2016-12-01 00:00:00