Pharmacological targeting of the β-amyloid precursor protein intracellular domain.

abstract：:Broadband on-chip optical frequency combs (OFCs) are important for expanding the functionality of photonic integrated circuits. Here, we demonstrate a huge local optical nonlinearity enhancement using graphene. A waveguide is decorated with graphene by precisely manipulating graphene's area and position. Our approach ...

journal_title：Scientific reports

authors： Ishizawa A,Kou R,Goto T,Tsuchizawa T,Matsuda N,Hitachi K,Nishikawa T,Yamada K,Sogawa T,Gotoh H

更新日期：2017-04-12 00:00:00

abstract：:Among the biologically active triterpenes, friedelin has the most-rearranged structure produced by the oxidosqualene cyclases and is the only one containing a cetonic group. In this study, we cloned and functionally characterized friedelin synthase and one cycloartenol synthase from Maytenus ilicifolia (Celastraceae)....

journal_title：Scientific reports

authors： Souza-Moreira TM,Alves TB,Pinheiro KA,Felippe LG,De Lima GM,Watanabe TF,Barbosa CC,Santos VA,Lopes NP,Valentini SR,Guido RV,Furlan M,Zanelli CF

更新日期：2016-11-22 00:00:00

abstract：:In this study, the improved Aesop's fable paradigm-a series of experiments originally used to test whether some animals understand the causality associated with water replacement-was used to explore the cognitive ability of Azure-winged magpies (Cyanopica cyanus). Experimental results on causal cue tasks showed that t...

journal_title：Scientific reports

authors： Zhang Y,Yu C,Chen L,Li Z

更新日期：2021-01-12 00:00:00

abstract：:This paper reports on 3D phase field simulations of IMC growth in Co/Sn and Cu/Sn solder systems. In agreement with experimental micrographs, we obtain uniform growth of the CoSn3 phase in Co/Sn solder joints and a non-uniform wavy morphology for the Cu6Sn5 phase in Cu/Sn solder joints. Furthermore, simulations were p...

journal_title：Scientific reports

authors： Hou L,Moelans N,Derakhshandeh J,De Wolf I,Beyne E

更新日期：2019-10-16 00:00:00

abstract：:Enterovirus 71 (EV71) is a major pathogen of hand, foot, and mouth disease (HFMD). To date, no antiviral drug has been approved to treat EV71 infection. Due to the essential role that EV71 3 C protease (3Cpro) plays in the viral life cycle, it is generally considered as a highly appealing target for antiviral drug dev...

journal_title：Scientific reports

authors： Zhang Y,Ke X,Zheng C,Liu Y,Xie L,Zheng Z,Wang H

更新日期：2017-09-04 00:00:00

abstract：:Spreading rumors on the Internet has become increasingly pervasive due to the proliferation of online social media. This paper investigates how rumors are amplified by a group of users who share similar interests or views, dubbed as an echo chamber. To this end, we identify and analyze 'rumor' echo chambers, each of w...

journal_title：Scientific reports

authors： Choi D,Chun S,Oh H,Han J,Kwon TT

更新日期：2020-01-15 00:00:00

abstract：:We show a coding method of suspension array based on the laser induced breakdown spectroscopy (LIBS), which promotes the barcodes from analog to digital. As the foundation of digital optical barcodes, nanocrystals encoded microspheres are prepared with self-assembly encapsulation method. We confirm that digital multip...

journal_title：Scientific reports

authors： He Q,Liu Y,He Y,Zhu L,Zhang Y,Shen Z

更新日期：2016-11-03 00:00:00

abstract：:Statins are well known to have muscle toxicity problem. Herba Cistanches (HC) is a Chinese herb traditionally used for pain in the loins and knees. Our previous in vitro study suggested that it could protect against statin-induced muscle toxicity. However, its in vivo protective effect has never been investigated. The...

journal_title：Scientific reports

authors： Wat E,Ng CF,Koon CM,Zhang C,Gao S,Tomlinson B,Lau CBS

更新日期：2017-08-24 00:00:00

abstract：:Corticotropin releasing factor (CRF), a peptide hormone involved in the stress response, holds a key position in cardiovascular regulation. Here, we report that the central effect of CRF on cardiovascular activities is mediated by the posterior hypothalamic nucleus (PH), an important structure responsible for stress-i...

journal_title：Scientific reports

authors： Gao HR,Zhuang QX,Li B,Li HZ,Chen ZP,Wang JJ,Zhu JN

更新日期：2016-02-01 00:00:00

abstract：:Fertilisation datasets collected from field experiments (n = 21) in tea-producing areas from 2016 to 2018 were used to build a quantitative evaluation of the fertility of tropical soils (QUEFTS) model to estimate nutrient uptake of tea plants, and to investigate relationships between tea yield and nutrient accumulatio...

journal_title：Scientific reports

authors： Tang S,Liu Y,Zheng N,Li Y,Ma Q,Xiao H,Zhou X,Xu X,Jiang T,He P,Wu L

更新日期：2020-02-04 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Passari AK,Mishra VK,Singh G,Singh P,Kumar B,Gupta VK,Sarma RK,Saikia R,Donovan AO,Singh BP

更新日期：2018-03-12 00:00:00

abstract：:Saccharomyces cerevisiae strains vary in their ability to develop and enhance sensory attributes of alcoholic beverages and are often found growing in mixed strain fermentations; however, quantifying individual strains is challenging due to quantification inaccuracies, low marker longevity, and compromised kinetics. W...

journal_title：Scientific reports

authors： Gustafsson FS,Whiteside MD,Jiranek V,Durall DM

更新日期：2014-11-10 00:00:00

abstract：:El Niño-Southern Oscillation (ENSO), which is one of the main drivers of Earth's inter-annual climate variability, often causes a wide range of climate anomalies, and the advance prediction of ENSO is always an important and challenging scientific issue. Since a unified and complete ENSO theory has yet to be establish...

journal_title：Scientific reports

authors： Yan J,Mu L,Wang L,Ranjan R,Zomaya AY

更新日期：2020-05-15 00:00:00

abstract：:Carcinomas constitute over 80% of all human cancer types with no effective therapy for metastatic disease. Here, we demonstrate, for the first time, the efficacy of therapeutic-ultrasound (TUS) to deliver a human tumor suppressor gene, hSef-b, to prostate tumors in vivo. Sef is downregulated in various human carcinoma...

journal_title：Scientific reports

authors： Mishel S,Shneyer B,Korsensky L,Goldshmidt-Tran O,Haber T,Machluf M,Ron D

更新日期：2017-11-08 00:00:00

abstract：:Orthographic regularity is important for processing Chinese characters. However, the issues how orthographic regularity influences the visual recognition of real Chinese characters and whether common processes related to the potential effect exist between successive (SUCC) and concurrent (CONC) conditions with asynchr...

journal_title：Scientific reports

authors： He W,Fan C,Ren J,Liu T,Zhang M,Luo W

更新日期：2016-03-23 00:00:00

abstract：:The chloride gradient plays an important role in regulating cell volume, membrane potential, pH, secretion, and the reversal potential of inhibitory glycine and GABAA receptors. Measurement of intracellular chloride activity, [Formula: see text], using liquid membrane ion-selective microelectrodes (ISM), however, has ...

journal_title：Scientific reports

authors： DiFranco M,Quinonez M,Dziedzic RM,Spokoyny AM,Cannon SC

更新日期：2019-12-11 00:00:00

abstract：:For a broad class of input-output maps, arguments based on the coding theorem from algorithmic information theory (AIT) predict that simple (low Kolmogorov complexity) outputs are exponentially more likely to occur upon uniform random sampling of inputs than complex outputs are. Here, we derive probability bounds that...

journal_title：Scientific reports

authors： Dingle K,Pérez GV,Louis AA

更新日期：2020-03-10 00:00:00

abstract：:Zika virus (ZIKV) causes significant public health concerns because of its association with congenital malformations, neurological disorders in adults, and, more recently, death. Considering the necessity to mitigate ZIKV-associated diseases, antiviral interventions are an urgent necessity. Sofosbuvir, a drug in clini...

journal_title：Scientific reports

authors： Ferreira AC,Zaverucha-do-Valle C,Reis PA,Barbosa-Lima G,Vieira YR,Mattos M,Silva PP,Sacramento C,de Castro Faria Neto HC,Campanati L,Tanuri A,Brüning K,Bozza FA,Bozza PT,Souza TML

更新日期：2017-08-25 00:00:00

abstract：:Nucleic acid amplification tests have become a common method for diagnosis of STIs due to their improved sensitivity over immunoassays and traditional culture-based methods. Isothermal nucleic acid amplification methods offer significant advantages over polymerase chain reaction (PCR) because they do not require sophi...

journal_title：Scientific reports

authors： Eboigbodin KE,Hoser MJ

更新日期：2016-02-03 00:00:00

abstract：:Regulatory T-cells (Tregs) play a pivotal role in maintaining peripheral tolerance. Increasing Treg numbers/functions has been shown to ameliorate autoimmune diseases. However, common Treg expansion approaches use T-Cell Receptor (TCR)-mediated stimulation which also causes proliferation of effector T-cells (Teff). To...

journal_title：Scientific reports

authors： Kumar P,Alharshawi K,Bhattacharya P,Marinelarena A,Haddad C,Sun Z,Chiba S,Epstein AL,Prabhakar BS

更新日期：2017-01-03 00:00:00

abstract：:L-Asparaginase (L-asparagine aminohydrolase, E.C. 3.5.1.1) has been proven to be competent in treating Acute Lymphoblastic Leukaemia (ALL), which is widely observed in paediatric and adult groups. Currently, clinical L-Asparaginase formulations are derived from bacterial sources such as Escherichia coli and Erwinia ch...

journal_title：Scientific reports

authors： Ashok A,Doriya K,Rao JV,Qureshi A,Tiwari AK,Kumar DS

更新日期：2019-02-05 00:00:00

abstract：:Recent studies on next-generation permanent magnets have focused on filling in the gap between rare-earth magnets and rare-earth-free magnets, taking into account both the cost-effectiveness and magnetic performance of the magnetic materials. As an improved rare-earth-free magnet candidate, here, Ca-substituted M-type...

journal_title：Scientific reports

authors： Lee J,Lee EJ,Hwang TY,Kim J,Choa YH

更新日期：2020-09-28 00:00:00

abstract：:Fine particulate matter 2.5 (PM2.5) induces free radicals and oxidative stress in animals, leading to a range of illnesses. In this study, Ganoderma Microsporum immunomodulatory (GMI) proteins were administered to alleviate PM2.5-induced inflammatory responses in mother rats, and PM2.5-induced inflammatory responses a...

journal_title：Scientific reports

authors： Tseng CY,Yu JY,Chuang YC,Lin CY,Wu CH,Liao CW,Yang FH,Chao MW

更新日期：2019-05-02 00:00:00

abstract：:The study of the preparation phase of large earthquakes is essential to understand the physical processes involved, and potentially useful also to develop a future reliable short-term warning system. Here we analyse electron density and magnetic field data measured by Swarm three-satellite constellation for 4.7 years,...

journal_title：Scientific reports

authors： De Santis A,Marchetti D,Pavón-Carrasco FJ,Cianchini G,Perrone L,Abbattista C,Alfonsi L,Amoruso L,Campuzano SA,Carbone M,Cesaroni C,De Franceschi G,De Santis A,Di Giovambattista R,Ippolito A,Piscini A,Sabbagh D,Soldani M

更新日期：2019-12-30 00:00:00

abstract：:We study theoretically and numerically the kinetics of the coefficient of friction of an elastomer due to abrupt changes of sliding velocity. Numerical simulations reveal the same qualitative behavior which has been observed experimentally on different classes of materials: the coefficient of friction first jumps and ...

journal_title：Scientific reports

authors： Li Q,Dimaki A,Popov M,Psakhie SG,Popov VL

更新日期：2014-07-28 00:00:00

abstract：:One of the greatest enigmas of modern biology is how the geometry of muscular and skeletal structures are created and how their development is controlled during growth and regeneration. Scaling and shaping of vertebrate muscles and skeletal elements has always been enigmatic and required an advanced technical level in...

journal_title：Scientific reports

authors： Tesařová M,Mancini L,Simon A,Adameyko I,Kaucká M,Elewa A,Lanzafame G,Zhang Y,Kalasová D,Szarowská B,Zikmund T,Novotná M,Kaiser J

更新日期：2018-09-20 00:00:00

abstract：:In this study we describe a new methodology to physically probe individual complexes formed between proteins and DNA. By combining nanoscale, high speed physical force measurement with sensitive fluorescence imaging we investigate the complex formed between the prokaryotic DNA repair protein UvrA2 and DNA. This approa...

journal_title：Scientific reports

authors： Simons M,Pollard MR,Hughes CD,Ward AD,Van Houten B,Towrie M,Botchway SW,Parker AW,Kad NM

更新日期：2015-12-22 00:00:00

abstract：:Here we report a high efficiency photocatalyst, i.e., Mn(2+)-doped and N-decorated ZnO nanofibers (NFs) enriched with vacancy defects, fabricated via electrospinning and a subsequent controlled annealing process. This nanocatalyst exhibits excellent visible-light photocatalytic activity and an apparent quantum efficie...

journal_title：Scientific reports

authors： Wang Y,Cheng J,Yu S,Alcocer EJ,Shahid M,Wang Z,Pan W

更新日期：2016-09-07 00:00:00

abstract：:Quaternized polyacrylic polymer has many applications in water treatment because of its ion exchange effects, but its further industrial applications are largely restricted because of its poor mechanical strength. In this work, a magnetic anion exchange resin with a polyacrylic matrix (MAP) was prepared by incorporati...

journal_title：Scientific reports

authors： Zhang G,Li S,Shuang C,Mu Y,Li A,Tan L

更新日期：2020-03-23 00:00:00

abstract：:Modulating the tumor microenvironment to promote an effective immune response is critical in managing any type of tumor. Melanoma is an aggressive skin cancer and the incidence rate is increasing worldwide. Potent protease inhibitors have recently been extensively researched as potential therapeutic agents against var...

journal_title：Scientific reports

authors： Ranasinghe SL,Rivera V,Boyle GM,McManus DP

更新日期：2019-11-07 00:00:00