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Inhibition of acetylcholinesterase modulates NMDA receptor antagonist mediated alterations in the developing brain.

Abstract：

:Exposure to N-methyl-d-aspartate (NMDA) receptor antagonists has been demonstrated to induce neurodegeneration in newborn rats. However, in clinical practice the use of NMDA receptor antagonists as anesthetics and sedatives cannot always be avoided. The present study investigated the effect of the indirect cholinergic agonist physostigmine on neurotrophin expression and the extracellular matrix during NMDA receptor antagonist induced injury to the immature rat brain. The aim was to investigate matrix metalloproteinase (MMP)-2 activity, as well as expression of tissue inhibitor of metalloproteinase (TIMP)-2 and brain-derived neurotrophic factor (BDNF) after co-administration of the non-competitive NMDA receptor antagonist MK801 (dizocilpine) and the acetylcholinesterase (AChE) inhibitor physostigmine. The AChE inhibitor physostigmine ameliorated the MK801-induced reduction of BDNF mRNA and protein levels, reduced MK801-triggered MMP-2 activity and prevented decreased TIMP-2 mRNA expression. Our results indicate that AChE inhibition may prevent newborn rats from MK801-mediated brain damage by enhancing neurotrophin-associated signaling pathways and by modulating the extracellular matrix.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Bendix I,Serdar M,Herz J,von Haefen C,Nasser F,Rohrer B,Endesfelder S,Felderhoff-Mueser U,Spies CD,Sifringer M

doi

10.3390/ijms15033784

subject

Has Abstract

pub_date

2014-03-03 00:00:00

pages

3784-98

issue

3

issn

1422-0067

pii

ijms15033784

journal_volume

15

pub_type

杂志文章

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