Abstract:
:The thymus generates central immune tolerance by producing self-restricted and self-tolerant T-cells as a result of interactions between the developing thymocytes and the stromal microenvironment, mainly formed by the thymic epithelial cells. The thymic epithelium derives from the endoderm of the pharyngeal pouches, embryonic structures that rely on environmental cues from the surrounding mesenchyme for its development. Here, we review the most recent advances in our understanding of the molecular mechanisms involved in early thymic organogenesis at stages preceding the expression of the transcription factor Foxn1, the early marker of thymic epithelial cells identity. Foxn1-independent developmental stages, such as the specification of the pharyngeal endoderm, patterning of the pouches, and thymus fate commitment are discussed, with a special focus on epithelial-mesenchymal interactions.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Figueiredo M,Zilhão R,Neves Hdoi
10.3390/ijms21165765subject
Has Abstractpub_date
2020-08-11 00:00:00issue
16issn
1422-0067pii
ijms21165765journal_volume
21pub_type
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