Determination of serotonin turnover in the rat brain using 6-fluorotryptophan.

abstract：:Both adenosine and interleukin-6 (IL-6) have been implicated in the pathophysiology of, e.g., epileptic seizures, traumatic brain injury, and affective disorders. Stimulation of adenosine A2B receptors on astrocytes in vitro leads to the increased synthesis and secretion of IL-6. We investigated whether or not activat...

journal_title：Journal of neurochemistry

authors： Vazquez JF,Clement HW,Sommer O,Schulz E,van Calker D

更新日期：2008-05-01 00:00:00

abstract：:Pretreatment of striatal membranes with N-ethylmaleimide in the presence of a D1-specific agonist inactivated endogenous guanine nucleotide binding proteins (G proteins), but not D1 dopamine receptors, resulting in a loss of high-affinity agonist binding sites. Such D1 receptors were solubilized, mixed with exogenous ...

journal_title：Journal of neurochemistry

authors： Sidhu A,Sullivan M,Kohout T,Balen P,Fishman PH

更新日期：1991-10-01 00:00:00

abstract：:MAP 1B is a microtubule-associated phosphoprotein that is expressed early in neurons and plays a role in axon growth. MAP 1B has two types of phospho-isoforms, one of which is developmentally down-regulated after neuronal maturation and one of which persists into adulthood. Because phosphorylation regulates MAP 1B bin...

journal_title：Journal of neurochemistry

authors： Johnstone M,Goold RG,Bei D,Fischer I,Gordon-Weeks PR

更新日期：1997-10-01 00:00:00

abstract：:The microtubule-based motor protein kinesin is thought to drive anterograde organelle transport in axons, but nothing is known about how its force-generating activity or organelle-binding properties are regulated. Studies in other motility systems suggest that protein phosphorylation is a reasonable candidate for this...

journal_title：Journal of neurochemistry

authors： Hollenbeck PJ

更新日期：1993-06-01 00:00:00

abstract：:To further analyze the action of copper on brain synaptic mechanisms, the brain dipeptide carnosine (beta-alanyl-L-histidine) was tested in Xenopus laevis oocytes expressing the rat P2X4 or P2X7 receptors. Ten micromolar copper halved the currents evoked by ATP in both receptors; co-application of carnosine plus coppe...

journal_title：Journal of neurochemistry

authors： Coddou C,Villalobos C,González J,Acuña-Castillo C,Loeb B,Huidobro-Toro JP

更新日期：2002-02-01 00:00:00

abstract：:Excess copper exposure is thought to be linked to the development of Alzheimer's disease (AD) neuropathology. However, the mechanism by which copper affects the CNS remains unclear. To investigate the effect of chronic copper exposure on both beta-amyloid and tau pathologies, we treated young triple transgenic (3xTg-A...

journal_title：Journal of neurochemistry

authors： Kitazawa M,Cheng D,Laferla FM

更新日期：2009-03-01 00:00:00

abstract：:Circulating antibody to the bovine white matter proteolipid apoprotein was detected in rabbits 1 month ater a single injection of the water-soluble form of the apoprotein. By double immunodiffusion, the antiserum reacted specifically with the delipidated proteolipid apoprotein and the crude proteolipid fraction contai...

journal_title：Journal of neurochemistry

authors： Macklin WB,Schwarting GA,Lees MB,Cohen SR

更新日期：1981-01-01 00:00:00

abstract：:Cytokines and catecholamines are known to constitute a significant portion of the regulatory neuroimmune networks involved in maintaining homeostasis in the central nervous system (CNS). Although we have already reported an increase in norepinephrine (NE) turnover within the locus coeruleus (LC) at 2 and 4 h after the...

journal_title：Journal of neurochemistry

authors： Kaneko YS,Mori K,Nakashima A,Sawada M,Nagatsu I,Ota A

更新日期：2005-07-01 00:00:00

abstract：:Dopamine neurons have been suggested to use glutamate as a cotransmitter. To identify the basis of such a phenotype, we have examined the expression of the three recently identified vesicular glutamate transporters (VGLUT1-3) in postnatal rat dopamine neurons in culture. We found that the majority of isolated dopamine...

journal_title：Journal of neurochemistry

authors： Dal Bo G,St-Gelais F,Danik M,Williams S,Cotton M,Trudeau LE

更新日期：2004-03-01 00:00:00

abstract：:We have examined some of the characteristics of phorbol ester- and agonist-induced down-regulation of astrocyte receptors coupled to phosphoinositide metabolism. Our results show that preincubation of [3H]inositol-labelled astrocyte cultures with phorbol 12-myristate 13-acetate (PMA) resulted in a time- (t 1/2, 1-2 mi...

journal_title：Journal of neurochemistry

authors： Pearce B,Morrow C,Murphy S

更新日期：1988-03-01 00:00:00

abstract：:Using nuclear reaction 6Li(n, alpha)3H and dielectric detectors, we have studied the distribution of Li in the brain of adult mice, following Li treatment of the animals. Two strains of animals were used in parallel: "quaking" dysmyelinating mutants and normally myelinated controls. The distribution appeared to be sha...

journal_title：Journal of neurochemistry

authors： Heurteaux C,Baumann N,Lachapelle F,Wissocq JC,Thellier M

更新日期：1986-04-01 00:00:00

abstract：:Lysophosphatidic acid receptor (LPA(1)) signaling initiates neuropathic pain through demyelination of the dorsal root (DR). Although LPA is found to cause down-regulation of myelin proteins underlying demyelination, the detailed mechanism remains to be determined. In the present study, we found that a single intrathec...

journal_title：Journal of neurochemistry

authors： Xie W,Uchida H,Nagai J,Ueda M,Chun J,Ueda H

更新日期：2010-05-01 00:00:00

abstract：:Intracranial microdialysis was used to investigate the origin of extracellular gamma-aminobutyric acid (GABA) in the ventral pallidum. Changes in basal GABA levels in response to membrane depolarizers, ion-channel blockers, and receptor agonists were determined. Antagonism of Ca2+ fluxes with high Mg2+ in a Ca(2+)-fre...

journal_title：Journal of neurochemistry

authors： Bourdelais AJ,Kalivas PW

更新日期：1992-06-01 00:00:00

abstract：:The effects of chronic treatment with the specific, mechanism-based, irreversible inhibitors of 4-aminobutyrate aminotransferase (EC 2.6.1.19; GABA transaminase), ethanolamine O-sulphate (EOS), and 4-aminohexenoate [vigabatrin; gamma-vinyl-GABA (GVG)] on the extracellular concentrations of GABA in the hippocampus have...

journal_title：Journal of neurochemistry

authors： Qume M,Whitton PS,Fowler LJ

更新日期：1995-05-01 00:00:00

abstract：:We investigated the effects of 17beta-estradiol, an estrogen, on [(3)H]norepinephrine ([(3)H]NE) secretion in PC12 cells. Pretreatment with 17beta-estradiol reduced 70 mM K(+)-induced [(3)H]NE secretion in a concentration-dependent manner with a half-maximal inhibitory concentration (IC(50)) of 2 +/- 1 microM. The 70 ...

journal_title：Journal of neurochemistry

authors： Kim YJ,Hur EM,Park TJ,Kim KT

更新日期：2000-06-01 00:00:00

abstract：:In the early postnatal period, energy metabolism in the suckling rodent brain relies to a large extent on metabolic pathways alternate to glucose such as the utilization of ketone bodies (KBs). However, how KBs affect neuronal excitability is not known. Using recordings of single NMDA and GABA-activated channels in ne...

journal_title：Journal of neurochemistry

authors： Rheims S,Holmgren CD,Chazal G,Mulder J,Harkany T,Zilberter T,Zilberter Y

更新日期：2009-08-01 00:00:00

abstract：:RGS (regulators of G-protein signaling) proteins comprise a large family that modulates heterotrimeric G-protein signaling. This protein family has a common RGS domain and functions as GTPase-activating proteins for the alpha-subunits of heterotrimeric G-proteins located at the plasma membrane. RGS8 was identified as ...

journal_title：Journal of neurochemistry

authors： Masuho I,Itoh M,Itoh H,Saitoh O

更新日期：2004-01-01 00:00:00

abstract：:By using two structurally unrelated hydrogen sulfide (H2 S) donors 5-(4-methoxyphenyl) -3H-1, 2-dithiole-3-thione (ADT) and sodium hydrosulfide (NaHS), this study investigated if H2 S protected blood-brain barrier (BBB) integrity following middle cerebral artery occlusion (MCAO). ICR mice underwent MCAO and received H...

journal_title：Journal of neurochemistry

authors： Wang Y,Jia J,Ao G,Hu L,Liu H,Xiao Y,Du H,Alkayed NJ,Liu CF,Cheng J

更新日期：2014-06-01 00:00:00

abstract：:A reporter epitope was inserted at 11 positions in a region encompassing proposed transmembrane segments S1 and S2 in the second repeat domain (D2) of the rat skeletal muscle type 1 sodium channel. All mutations produced full-length membrane-associated protein following transfection into cultured cells, although the l...

journal_title：Journal of neurochemistry

authors： Kraner SD,Filatov GN,Sun W,Bannerman P,Lindstrom J,Barchi RL

更新日期：1998-04-01 00:00:00

abstract：:The glial glutamate transporter EAAT2 (excitatory amino acid transporter 2) is the major mediator of glutamate clearance that terminates glutamate-mediated neurotransmission. Loss of EAAT2 and associated glutamate uptake function has been reported in the brains of patients with Alzheimer's disease (AD). We previously ...

journal_title：Journal of neurochemistry

authors： Tian G,Kong Q,Lai L,Ray-Chaudhury A,Lin CL

更新日期：2010-05-01 00:00:00

abstract：:The NMDA receptor/channel has been shown to be inhibited by ethanol in the clinically relevant range 25-100 mM. We studied heteromeric assemblies (NR1b/NR2) of the NMDA receptor, expressed in oocytes, to address three questions regarding this inhibition, and discovered the following: (1) The inhibition was nearly equi...

journal_title：Journal of neurochemistry

authors： Chu B,Anantharam V,Treistman SN

更新日期：1995-07-01 00:00:00

abstract：:A Ca2+- and calmodulin-dependent protein kinase was purified from rat brain cytosol fraction to apparent homogeneity at approximately 800-fold and with a 5% yield. The purified enzyme had a molecular weight of 640,000 as determined by gel filtration analysis on Sephacryl S-300 and a sedimentation coefficient of 15.3 S...

journal_title：Journal of neurochemistry

authors： Fukunaga K,Yamamoto H,Matsui K,Higashi K,Miyamoto E

更新日期：1982-12-01 00:00:00

abstract：:Mouse models of MPTP intoxication have been used extensively to explore the molecular mechanisms of Parkinson's disease. However, these models present some limitations since; (i) Dopaminergic (DA) cell death occurs rapidly in contrast to the presumably slow evolution of the disease process. (ii) Some of the key histol...

journal_title：Journal of neurochemistry

authors： Alvarez-Fischer D,Guerreiro S,Hunot S,Saurini F,Marien M,Sokoloff P,Hirsch EC,Hartmann A,Michel PP

更新日期：2008-11-01 00:00:00

abstract：:In all the species examined thus far, the behavior of microglia during development appears to be highly stereotyped. This reproducibility supports the notion that these cells have a physiological role in development. Microglia are macrophages that migrate from the yolk sac and colonize the central nervous system early...

journal_title：Journal of neurochemistry

authors： Pont-Lezica L,Béchade C,Belarif-Cantaut Y,Pascual O,Bessis A

更新日期：2011-12-01 00:00:00

abstract：:Kindling induces long-term adaptations in neuronal function that lead to a decreased threshold for induction of seizures. In the present study, the influence of amygdala kindling on levels of mRNA for the immediate-early genes (IEGs) c-fos, c-jun, and NGF1-A were examined both before and after an acute electroconvulsi...

journal_title：Journal of neurochemistry

authors： Duman RS,Craig JS,Winston SM,Deutch AY,Hernandez TD

更新日期：1992-11-01 00:00:00

abstract：:The present experiments show that N-[3H]-methylcarbamylcholine ([3H]MCC) binds specifically and with high affinity to rat hippocampus, frontal cortex, and striatum. The highest maximal density of binding sites was apparent in frontal cortex and the lowest in hippocampus. [3H]MCC binding was potently inhibited by nicot...

journal_title：Journal of neurochemistry

authors： Araujo DM,Lapchak PA,Collier B,Quirion R

更新日期：1988-07-01 00:00:00

abstract：:Several analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were synthesized and screened for their capacity to be oxidized by monoamine oxidase (MAO-A or MAO-B) and their capacity to produce nigrostriatal dopaminergic neurotoxicity in mice. All of the compounds were relatively weak substrates for MAO-A but...

journal_title：Journal of neurochemistry

authors： Youngster SK,Sonsalla PK,Heikkila RE

更新日期：1987-03-01 00:00:00

abstract：:Purified rat brain Ca2+/calmodulin-dependent protein kinase II (CaM-kinase II) is stimulated by brain gangliosides to a level of about 30% the activity obtained in the presence of Ca2+/calmodulin (CaM). Of the various gangliosides tested, GT1b was the most potent, giving half-maximal activation at 25 microM. Gangliosi...

journal_title：Journal of neurochemistry

authors： Fukunaga K,Miyamoto E,Soderling TR

更新日期：1990-01-01 00:00:00

abstract：:Cue-induced reinstatement of cocaine seeking after self-administration (SA) and extinction relies on glutamate release in the nucleus accumbens core (NAcore), which activates neuronal nitric oxide synthase interneurons. Nitric oxide (NO) is required for structural plasticity in NAcore medium spiny neurons, as well as ...

journal_title：Journal of neurochemistry

authors： Siemsen BM,McFaddin JA,Haigh K,Brock AG,Nan Leath M,Hooker KN,McGonegal LK,Scofield MD

更新日期：2020-06-01 00:00:00

abstract：:Parkinson's disease is a common neurodegenerative disorder with a mainly sporadic aetiology, although a number of monogenic familiar forms are known. Most of the motor symptoms are due to selective depletion of dopaminergic, neuromelanin-containing neurones of the substantia nigra pars compacta. Neuromelanin is the da...

journal_title：Journal of neurochemistry

authors： Fasano M,Bergamasco B,Lopiano L

更新日期：2006-02-01 00:00:00