当前位置： SCI文献检索 > JOURNAL OF NEUROCHEMISTRY期刊下所有文献 > Amygdala kindling potentiates seizure-stimulated immediate-early gene expression in rat cerebral cortex.

Amygdala kindling potentiates seizure-stimulated immediate-early gene expression in rat cerebral cortex.

Abstract：

:Kindling induces long-term adaptations in neuronal function that lead to a decreased threshold for induction of seizures. In the present study, the influence of amygdala kindling on levels of mRNA for the immediate-early genes (IEGs) c-fos, c-jun, and NGF1-A were examined both before and after an acute electroconvulsive seizure (ECS). Although amygdala kindling did not significantly influence resting levels of c-fos mRNA in cerebral cortex, ECS-stimulated levels of c-fos mRNA (examined 45 min after ECS) were approximately twofold greater in the cerebral cortex of kindled rats relative to sham-treated controls. The influence of kindling on IEG expression was dependent on the time course of kindling, as ECS-stimulated levels of c-fos mRNA were not significantly increased in stage 2 kindled animals. ECS-stimulated levels of c-jun and NGF1-A mRNA were also significantly increased in cerebral cortex of kindled rats relative to sham-treated controls. The influence of kindling on IEG expression was long-lasting because an acute ECS stimulus significantly elevated levels of c-fos and c-jun mRNA in the cerebral cortex of animals that were kindled 5 months previously. In contrast to these effects in cerebral cortex, kindling did not influence ECS-stimulated levels of c-fos mRNA in hippocampus. Finally, immunohistochemical studies revealed lamina-specific changes in the cerebral cortex.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

J Neurochem

journal_title

Journal of neurochemistry

authors

Duman RS,Craig JS,Winston SM,Deutch AY,Hernandez TD

doi

10.1111/j.1471-4159.1992.tb11007.x

keywords:

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

1753-60

issue

5

eissn

0022-3042

issn

1471-4159

journal_volume

59

pub_type

杂志文章

相关文献

JOURNAL OF NEUROCHEMISTRY文献大全
  • Amyloid-beta peptide enhances tumor necrosis factor-alpha-induced iNOS through neutral sphingomyelinase/ceramide pathway in oligodendrocytes.

    abstract：:Although accumulating evidence demonstrates that white matter degeneration contributes to pathology in Alzheimer's disease (AD), the underlying mechanisms are unknown. In order to study the roles of the amyloid-beta peptide in inducing oxidative stress damage in white matter of AD, we investigated the effects of amylo...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2005.03217.x

    authors： Zeng C,Lee JT,Chen H,Chen S,Hsu CY,Xu J

    更新日期：2005-08-01 00:00:00

  • Regulation of mouse delta-opioid receptor gene transcription: involvement of the transcription factors AP-1 and AP-2.

    abstract：:The aim of this study was to examine the effects of the phorbol ester O-tetradecanoylphorbol 13-acetate (TPA) and forskolin on delta-opioid receptor gene transcription. Treatment of NG108-15 cells with TPA (100 nM) for 48 h increased delta-opioid receptor mRNA levels, whereas different concentrations of forskolin indu...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.2000.0741355.x

    authors： Wöltje M,Kraus J,Höllt V

    更新日期：2000-04-01 00:00:00

  • Transcriptional activation of phosphodiesterase 7B1 by dopamine D1 receptor stimulation through the cyclic AMP/cyclic AMP-dependent protein kinase/cyclic AMP-response element binding protein pathway in primary striatal neurons.

    abstract：:Phosphodiesterase (PDE) 7B, a cAMP-specific PDE which is dominantly expressed in striatum, is expected to be involved in dopaminergic signaling in striatal neurons. Here we show, for the first time, the involvement of the dopaminergic signaling pathway in transcriptional activation of rat PDE7B in primary striatal cul...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2004.02354.x

    authors： Sasaki T,Kotera J,Omori K

    更新日期：2004-04-01 00:00:00

  • Regionally selective and age-dependent alterations in benzodiazepine receptor binding in the genetically dystonic hamster.

    abstract：:Previous pharmacological studies have indicated that impairment of GABAergic transmission may be involved in the pathophysiology of dystonia in the mutant dtsz hamster, i.e., a genetic animal model for idiopathic dystonia. In the present experiments, the kinetic constants of [3H]flumazenil binding to the benzodiazepin...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1995.64052153.x

    authors： Pratt GD,Richter A,Möhler H,Löscher W

    更新日期：1995-05-01 00:00:00

  • A possible pathway of phosphoinositide metabolism through EDTA-insensitive phospholipase A1 followed by lysophosphoinositide-specific phospholipase C in rat brain.

    abstract：:Incubation of [2-3H]glycerol-labeled phosphatidylinositol with a crude cytosol fraction of rat brain in the presence of EDTA yielded [3H]lysophosphatidylinositol predominantly without accumulation of labeled monoacylglycerol and diacylglycerol. The pH optimum of this phospholipase A activity was 8.0. The activity for ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1993.tb09829.x

    authors： Ueda H,Kobayashi T,Kishimoto M,Tsutsumi T,Okuyama H

    更新日期：1993-11-01 00:00:00

  • The pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies.

    abstract：:Expansion of CAG trinucleotide repeat within the coding region of several genes results in the production of proteins with expanded polyglutamine (PolyQ) stretch. The expression of these pathogenic proteins leads to PolyQ diseases, such as Huntington's disease or several types of spinocerebellar ataxias. This family o...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章,评审

    doi：10.1111/j.1471-4159.2009.06302.x

    authors： Bauer PO,Nukina N

    更新日期：2009-09-01 00:00:00

  • N-Acetylation of L-aspartate in the nervous system: differential distribution of a specific enzyme.

    abstract：:L-Aspartate N-acetyltransferase, a nervous system enzyme that mediates the synthesis of N-acetyl-L-aspartic acid, has been characterized. In the presence of acetyl-CoA, L-aspartate was acetylated 10-fold more efficiently than L-glutamate, and the acetylation of aspartylglutamate was not detectable. Within the nervous ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1985.tb07240.x

    authors： Truckenmiller ME,Namboodiri MA,Brownstein MJ,Neale JH

    更新日期：1985-11-01 00:00:00

  • Choline acetyltransferase activity and total protein content in selected optic areas of the rat after complete light-deprivation during CNS development.

    abstract：:Choline acetyltransferase (acetyl-CoA: choline O-acetyltransferase, I.U.B. 2.3.1.6) activity and total protein content in visual and extra-visual areas were compared in normal Long-Evans rats and in rats subjected to complete light-deprivation for 21 days from birth. The enzyme activity and the protein content in the ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1968.tb10323.x

    authors： Maletta GJ,Timiras PS

    更新日期：1968-08-01 00:00:00

  • Characterization of bradykinin-induced phosphoinositide turnover in neurohybrid NCB-20 cells.

    abstract：:Phosphoinositide hydrolysis was studied in neurohybrid NCB-20 cells prelabeled with myo-[3H]inositol. Among nearly 20 neurotransmitters and neuromodulators examined, only bradykinin, carbachol, and histamine significantly increased the accumulation of [3H]inositol monophosphate (IP1) in the presence of lithium. The EC...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1988.tb01067.x

    authors： Chuang DM,Dillon-Carter O

    更新日期：1988-08-01 00:00:00

  • To Ub or not to Ub: Regulation of circadian clocks by ubiquitination and deubiquitination.

    abstract：:Circadian clocks are internal timing systems that enable organisms to adjust their behavioral and physiological rhythms to the daily changes of their environment. These clocks generate self-sustained oscillations at the cellular, tissue, and behavioral level. The rhythm-generating mechanism is based on a gene expressi...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.15132

    authors： Srikanta SB,Cermakian N

    更新日期：2020-07-27 00:00:00

  • m1-m5 muscarinic receptor distribution in rat CNS by RT-PCR and HPLC.

    abstract：:Five muscarinic receptor genes (m1-m5) that encode distinct muscarinic receptor subtypes have been cloned. Because of their structural homology and pharmacological similarity, ligand binding probes currently available do not clearly distinguish among the subtypes. To obtain a clear distribution within the CNS of molec...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1994.63030815.x

    authors： Wei J,Walton EA,Milici A,Buccafusco JJ

    更新日期：1994-09-01 00:00:00

  • Chondroitinase ABC has a long-lasting effect on chondroitin sulphate glycosaminoglycan content in the injured rat brain.

    abstract：:Chondroitin sulphate proteoglycans (CSPGs) are axon growth inhibitory molecules present in the glial scar that play a part in regeneration failure after damage to the CNS and which restrict CNS plasticity. Removal of chondroitin sulphate glycosaminoglycan (GAG) chains with chondroitinase-ABC (chABC) in models of CNS i...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2007.05066.x

    authors： Lin R,Kwok JC,Crespo D,Fawcett JW

    更新日期：2008-01-01 00:00:00

  • Thiamine triphosphate and membrane-associated thiamine phosphatases in the electric organ of Electrophorus electricus.

    abstract：:The main electric organ of Electrophorus electricus is particularly rich in thiamine triphosphate, which represents 87% of the total thiamine content in this tissue. The thiamine pyrophosphate concentration, however, is very low in the eel electric organ and skeletal muscle as compared with other eel or rat tissues. F...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1987.tb02891.x

    authors： Bettendorff L,Michel-Cahay C,Grandfils C,De Rycker C,Schoffeniels E

    更新日期：1987-08-01 00:00:00

  • Expression profiling upon Nex1/MATH-2-mediated neuritogenesis in PC12 cells and its implication in regeneration.

    abstract：:The expression of Nex1 peaks during brain development when neurite outgrowth and synaptogenesis are highly active. We previously showed that Nex1 is a critical effector of the nerve growth factor (NGF) pathway and its overexpression results in spontaneous neuritogenesis. Furthermore, the PC12-Nex1 cells exhibit accele...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2004.02814.x

    authors： Uittenbogaard M,Chiaramello A

    更新日期：2004-12-01 00:00:00

  • A dual role for AMP-activated protein kinase (AMPK) during neonatal hypoxic-ischaemic brain injury in mice.

    abstract：:Perinatal hypoxic-ischaemic encephalopathy (HIE) occurs in 1-2 in every 1000 term infants and the devastating consequences range from cerebral palsy, epilepsy and neurological deficit to death. Cellular damage post insult occurs after a delay and is mediated by a secondary neural energy failure. AMP-activated protein ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.13034

    authors： Rousset CI,Leiper FC,Kichev A,Gressens P,Carling D,Hagberg H,Thornton C

    更新日期：2015-04-01 00:00:00

  • Deleting the Arntl clock gene in the granular layer of the mouse cerebellum: impact on the molecular circadian clockwork.

    abstract：:The suprachiasmatic nucleus houses the central circadian clock and is characterized by the timely regulated expression of clock genes. However, neurons of the cerebellar cortex also contain a circadian oscillator with circadian expression of clock genes being controlled by the suprachiasmatic nucleus. It has been sugg...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.14128

    authors： Bering T,Carstensen MB,Rath MF

    更新日期：2017-09-01 00:00:00

  • Changes in brain levels of acidic, basic, and neutral amino acids after consumption of single meals containing various proportions of protein.

    abstract：:Rats fasted overnight were allowed to consume single meals containing 0, 18, or 40% protein or continued to fast; after 2 h, brains and sera were taken and assayed for various amino acids. In general, serum levels of most amino acids were reduced by the 0% protein meal and elevated by the high-protein meal when compar...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1983.tb09045.x

    authors： Glaeser BS,Maher TJ,Wurtman RJ

    更新日期：1983-10-01 00:00:00

  • IL-1 beta induces proMMP-9 expression via c-Src-dependent PDGFR/PI3K/Akt/p300 cascade in rat brain astrocytes.

    abstract：:In a previous study, interleukin-1beta (IL-1beta) has been shown to induce matrix metalloproteinases (MMPs) expression through mitogen-activated protein kinases and nuclear factor-kappaB pathways in rat brain astrocytes. Moreover, transactivation of growth factor receptors and phosphatidylinositol 3-kinase (PI3K)/Akt ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2008.05318.x

    authors： Wu CY,Hsieh HL,Sun CC,Tseng CP,Yang CM

    更新日期：2008-05-01 00:00:00

  • DARPP-32 in the orchestration of responses to positive natural stimuli.

    abstract：:Dopamine- and cAMP-regulated phosphoprotein (Mr 32 kDa, DARPP-32) is an integrator of multiple neuronal signals and plays a crucial role particularly in mediating the dopaminergic component of the systems involved in the evaluation of stimuli and the ensuing elaboration of complex behavioral responses (e.g., responses...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章,评审

    doi：10.1111/jnc.14558

    authors： Scheggi S,De Montis MG,Gambarana C

    更新日期：2018-11-01 00:00:00

  • Cerebral metabolism of 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine in the primate.

    abstract：:The tracers 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine (6-[18F]fluoro-L-DOPA) and L-[14C]DOPA were injected simultaneously into rhesus monkeys, and the time course of their metabolites was measured in the striatum and in the occipital and frontal cortices. In the striatum, 6-[18F]fluoro-L-DOPA was metabolized to 6-[18...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1987.tb05629.x

    authors： Firnau G,Sood S,Chirakal R,Nahmias C,Garnett ES

    更新日期：1987-04-01 00:00:00

  • Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory.

    abstract：:Neurofibrillary tangles (NFTs) consisting of the hyperphosphorylated microtubule-associated protein tau are a defining pathological characteristic of Alzheimer's disease (AD). Hyperphosphorylation of tau is hypothesized to impair the microtubule stabilizing function of tau, leading to the formation of paired helical f...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.2003.02070.x

    authors： Liu SJ,Zhang AH,Li HL,Wang Q,Deng HM,Netzer WJ,Xu H,Wang JZ

    更新日期：2003-12-01 00:00:00

  • Alteration of alpha-tocopherol content in the developing and aging peripheral nervous system: persistence of high correlations with total and specific (n-6) polyunsaturated fatty acids.

    abstract：:In contrast to brain, the sciatic nerve concentration of vitamin E in rats increased rapidly during the postnatal period (approximately fivefold between days 1 and 8), then decreased dramatically (about twofold between days 8 and 30), and further decreased slowly between days 30 and 60 and remained constant up to 2 ye...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1990.tb04917.x

    authors： Clément M,Bourre JM

    更新日期：1990-06-01 00:00:00

  • Analysis of three Ptx2 splice variants on transcriptional activity and differential expression pattern in the brain.

    abstract：:Three different transcripts of the homeodomain gene termed pituitary homeobox (Ptx) 2 (Pitx2/Brx/Rieg/Solurshin/Arp) were cloned from different species encoding proteins belonging to the paired-like family of homeodomain proteins. Ptx2a (324 amino acids), Ptx2b (271 amino acids), and Ptx2c (318 amino acids) share the ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.2000.0751818.x

    authors： Smidt MP,Cox JJ,van Schaick HS,Coolen M,Schepers J,van der Kleij AM,Burbach JP

    更新日期：2000-11-01 00:00:00

  • Ras-regulated hypophosphorylation of the retinoblastoma protein mediates neuronal differentiation in PC12 cells.

    abstract：:To investigate the role of the retinoblastoma protein pRB in neuronal differentiation, we have measured the accumulation of hypophosphorylated pRB in PC12 cells stimulated by nerve growth factor (NGF). NGF induced the accumulation of hypophosphorylated pRB within 30 min and the level peaked after 12 h. Viral Kiras, cy...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1996.66062287.x

    authors： Li H,Kawasaki H,Nishida E,Hattori S,Nakamura S

    更新日期：1996-06-01 00:00:00

  • Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide.

    abstract：:The N-type voltage-gated calcium channel (CaV2.2) is a clinically endorsed target in chronic pain treatments. As directly targeting the channel can lead to multiple adverse side effects, targeting modulators of CaV2.2 may prove better. We previously identified ST1-104, a short peptide from the collapsin response media...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.12070

    authors： Ju W,Li Q,Allette YM,Ripsch MS,White FA,Khanna R

    更新日期：2013-03-01 00:00:00

  • Ischemia-induced changes in cerebral mitochondrial free fatty acids, phospholipids, and respiration in the rat.

    abstract：:Changes in the free fatty acid pool size and fatty acyl chain composition of mitochondrial membrane phospholipids and their relation to disruption of mitochondrial function were examined in rat brains after 30 min of cerebral ischemia (Pulsinelli-Brierley model) and 60 min of normoxic reoxygenation. During ischemia, s...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1994.62051921.x

    authors： Sun D,Gilboe DD

    更新日期：1994-05-01 00:00:00

  • Glutamate neurotoxicity in rat cerebellar granule cells: a major role for xanthine oxidase in oxygen radical formation.

    abstract：:To gain insight into the mechanism through which the neurotransmitter glutamate causally participates in several neurological diseases, in vitro cultured cerebellar granule cells were exposed to glutamate and oxygen radical production was investigated. To this aim, a novel procedure was developed to detect oxygen radi...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1997.68052038.x

    authors： Atlante A,Gagliardi S,Minervini GM,Ciotti MT,Marra E,Calissano P

    更新日期：1997-05-01 00:00:00

  • Microtubule dynamics and the neurodegenerative triad of Alzheimer's disease: The hidden connection.

    abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disorder and is, on a histopathological level, characterized by the presence of extracellular amyloid plaques composed of the protein fragment Aβ, and intracellular neurofibrillary tangles, which contain the microtubule-associated protein tau in a hyperphos...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章,评审

    doi：10.1111/jnc.14011

    authors： Brandt R,Bakota L

    更新日期：2017-11-01 00:00:00

  • Flow cytometric analysis of mitochondria from CA1 and CA3 regions of rat hippocampus reveals differences in permeability transition pore activation.

    abstract：:Mitochondria are important in the pathophysiology of several neurodegenerative diseases, and mitochondrial production of reactive oxygen species (ROS), membrane depolarization, permeability changes and release of apoptogenic proteins are involved in these processes. Following brain insults, cell death often occurs in ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.2003.02026.x

    authors： Mattiasson G,Friberg H,Hansson M,Elmér E,Wieloch T

    更新日期：2003-10-01 00:00:00

  • Identification of the cationic amino acid transporter (System y+) of the rat blood-brain barrier.

    abstract：:Cationic amino acids are transported from blood into brain by a saturable carrier at the blood-brain barrier (BBB). The transport properties of this carrier were examined in the rat using an in situ brain perfusion technique. Influx into brain via this system was found to be sodium independent and followed Michaelis-M...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1993.tb13428.x

    authors： Stoll J,Wadhwani KC,Smith QR

    更新日期：1993-05-01 00:00:00