Flow cytometric analysis of mitochondria from CA1 and CA3 regions of rat hippocampus reveals differences in permeability transition pore activation.

abstract：:In vivo microdialysis in C57BL/6J (B6) mouse was used to test the hypothesis that activating adenosine A(2A) receptors in the pontine reticular formation (PRF) increases acetylcholine (ACh) release and rapid eye movement (REM) sleep. Eight concentrations of the adenosine A(2A) receptor agonist 2-p-(2-carboxyethyl)phen...

journal_title：Journal of neurochemistry

authors： Coleman CG,Baghdoyan HA,Lydic R

更新日期：2006-03-01 00:00:00

abstract：:The murine neuroblastoma N1E-115 cell line possesses a high density of angiotensin II (AngII) receptors that can be solubilized with the zwitterionic detergent 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate. These solubilized binding sites exhibited high affinity for CGP-42112A and not Losartan, indicating ...

journal_title：Journal of neurochemistry

authors： Siemens IR,Reagan LP,Yee DK,Fluharty SJ

更新日期：1994-06-01 00:00:00

abstract：:Rats fasted overnight were allowed to consume single meals containing 0, 18, or 40% protein or continued to fast; after 2 h, brains and sera were taken and assayed for various amino acids. In general, serum levels of most amino acids were reduced by the 0% protein meal and elevated by the high-protein meal when compar...

journal_title：Journal of neurochemistry

authors： Glaeser BS,Maher TJ,Wurtman RJ

更新日期：1983-10-01 00:00:00

abstract：:The release of endogenous dopamine from the axon terminal field in the nucleus accumbens and from the A10 dopamine cell bodies of conscious rats was measured using intracranial dialysis. Release of dopamine from both areas was calcium-dependent and markedly inhibited by the presence of the D2 agonist, quinpirole, in t...

journal_title：Journal of neurochemistry

authors： Kalivas PW,Duffy P

更新日期：1991-03-01 00:00:00

abstract：:Vinpocetine is a neuroprotective drug that exerts beneficial effects on neurological symptoms and cerebrovascular disease. 3-nitropropionic acid (3-NPA) is a toxin that irreversibly inhibits succinate dehydrogenase, the mitochondrial enzyme that acts in the electron transport chain at complex II. In previous studies i...

journal_title：Journal of neurochemistry

authors： Herrera-Mundo N,Sitges M

更新日期：2013-01-01 00:00:00

abstract：:After traumatic brain injury, progesterone has important neuroprotective effects in the nervous system. There is better functional outcome and less oedema formation in pseudopregnant rat females (high levels of endogenous progesterone) than in males. In addition to intracellular progesterone receptors, membrane bindin...

journal_title：Journal of neurochemistry

authors： Meffre D,Delespierre B,Gouézou M,Leclerc P,Vinson GP,Schumacher M,Stein DG,Guennoun R

更新日期：2005-06-01 00:00:00

abstract：:The regulatory role of ascorbic acid in norepinephrine biosynthesis was studied using digitonin-permeabilized chromaffin cells. When permeabilized chromaffin cells were incubated with [3H]3,4-dihydroxyphenylethylamine ([3H]dopamine) in calcium-free medium, the amounts of radioactive dopamine and norepinephrine measure...

journal_title：Journal of neurochemistry

authors： Morita K,Levine M,Pollard HB

更新日期：1986-03-01 00:00:00

abstract：:The influence on microtubule assembly in vitro of monoclonal antibodies against microtubule-associated proteins (MAPs) was studied. Light scattering was used for measuring net polymer formation and electron microscopy for determining the influence of antibodies on microtubule morphology. Control experiments showed tha...

journal_title：Journal of neurochemistry

authors： Matus A,Riederer B,Huber G

更新日期：1987-09-01 00:00:00

abstract：:Three conserved serine residues (Ser193, Ser194, and Ser197) in transmembrane spanning region (TM) V of the D2 dopamine receptor have been mutated to alanine, individually and in combination, to explore their role in ligand binding and G protein coupling. The multiple Ser -->Ala mutations had no effect on the binding ...

journal_title：Journal of neurochemistry

authors： Coley C,Woodward R,Johansson AM,Strange PG,Naylor LH

更新日期：2000-01-01 00:00:00

abstract：:Myelination, during both normal development and with respect to disorders of myelination, is commonly studied by morphological and/or biochemical techniques that assay as their end-points the extent of myelination. The rate of myelination is potentially a more useful parameter, but it is difficult and time-consuming t...

journal_title：Journal of neurochemistry

authors： Muse ED,Jurevics H,Toews AD,Matsushima GK,Morell P

更新日期：2001-01-01 00:00:00

abstract：:To differentiate the effect of muscle contractile activity from that of motor nerve on oxidative processes in type I muscle, oxidative processes were studied in muscle after immobilization and after denervation. The two processes led to similar atrophy of muscle weight and of the mean diameter of muscle fibers. Disuse...

journal_title：Journal of neurochemistry

authors： Nemeth PM,Meyer D,Kark RA

更新日期：1980-12-01 00:00:00

abstract：:Although alterations in mitochondrial dynamics are associated with cellular responses to injury, the functional role of these dynamic changes in ischemic neurons is underexplored. One of these dynamic responses to injury includes mitochondrial biogenesis. Various sublethal pre-conditioning stimuli that induce an ische...

journal_title：Journal of neurochemistry

authors： Stetler RA,Leak RK,Yin W,Zhang L,Wang S,Gao Y,Chen J

更新日期：2012-11-01 00:00:00

abstract：:A diverse group of neurodegenerative diseases - including progressive supranuclear palsy (PSP), corticobasal degeneration and Alzheimer's disease among others, collectively referred to as tauopathies - are characterized by progressive, age-dependent intracellular formations of misfolded protein aggregates that play ke...

journal_title：Journal of neurochemistry

authors： Pasinetti GM,Ksiezak-Reding H,Santa-Maria I,Wang J,Ho L

更新日期：2010-09-01 00:00:00

abstract：:Intracellular calcium ions regulate the structure and functions of cytoskeletal proteins. On the other hand, recent studies have shown that the cytoskeleton, and actin filaments in particular, can modulate calcium influx through plasma membrane ligand- and voltage-gated channels. We now report that calcium release fro...

journal_title：Journal of neurochemistry

authors： Wang Y,Mattson MP,Furukawa K

更新日期：2002-08-01 00:00:00

abstract：:Previous studies have suggested that protein kinase C is important in the regulation of angiotensin II receptors in neuronal cultures, because the C-kinase agonists, phorbol esters, are able to increase the number of these receptors. In the present study, we have further investigated the role of protein kinase C in an...

journal_title：Journal of neurochemistry

authors： Sumners C,Rueth SM,Myers LM,Kalberg CJ,Crews FT,Raizada MK

更新日期：1988-07-01 00:00:00

abstract：:Ca2+ uptake into the endoplasmic reticulum (ER) is mediated by Ca2+ ATPase isoforms, which are all selectively inhibited by nanomolar concentrations of thapsigargin. Using ATP/Mg2+-dependent 45Ca2+ transport in rat brain microsomes, tissue sections, and permeabilized cells, as well as Ca2+ imaging in living cells we d...

journal_title：Journal of neurochemistry

authors： Watson WD,Facchina SL,Grimaldi M,Verma A

更新日期：2003-10-01 00:00:00

abstract：:In situ phosphorylation of the presynaptic protein kinase C substrate B-50 was investigated in rat hippocampal slices incubated with the convulsant drug 4-aminopyridine (4-AP). Phosphorylation of B-50 was significantly enhanced 1 min after the addition of 4-AP (100 microM). This increase by 4-AP was concentration depe...

journal_title：Journal of neurochemistry

authors： Heemskerk FM,Schrama LH,Gianotti C,Spierenburg H,Versteeg DH,De Graan PN,Gispen WH

更新日期：1990-03-01 00:00:00

abstract：:The rat adrenal hormone corticosterone binds to low and high affinity receptors, discretely localized in brain, including the dentate gyrus. Differential activation of the two receptor types under physiological conditions alters gene expression and functional characteristics of hippocampal neurones. In the present stu...

journal_title：Journal of neurochemistry

authors： Qin Y,Karst H,Joëls M

更新日期：2004-04-01 00:00:00

abstract：:The ability of catecholestrogens to induce cytosolic progestin binding sites in the hypothalamus, pituitary gland, and uterus of ovariectomised-adrenalectomised rats was demonstrated by the increase in high-affinity [3H]promegestone binding sites (KD 1.39, 0.50, and 0.54 nM, respectively) following a single subcutaneo...

journal_title：Journal of neurochemistry

authors： Kirchhoff J,Reinhardt W,Grünke W,Ghraf R,Ball P,Knuppen R

更新日期：1983-02-01 00:00:00

abstract：:The adenylate cyclase activity of rat hippocampal plasma membranes can be stimulated by vasoactive intestinal polypeptide (VIP). Low concentrations (10(-9) to 19(-7) M) of 5'-guanylyl-imido diphosphate (GppNHp) evoke a transient inhibition of the enzyme, which is followed by stimulation with increasing GppNHp concentr...

journal_title：Journal of neurochemistry

authors： Girardot JM,Kempf J,Cooper DM

更新日期：1983-09-01 00:00:00

abstract：:Young rats (21 days old) made nutritionally iron deficient, by feeding them a semisynthetic diet containing skimmed milk for 5 weeks, had significantly lowered hemoglobin levels (5.2 +/- 4 g/100 ml). The nonheme iron content in caudate nucleus was decreased by 47%. The behavioral response of iron-deficient rats to apo...

journal_title：Journal of neurochemistry

authors： Youdim MB,Sills MA,Heydorn WE,Creed GJ,Jacobowitz DM

更新日期：1986-09-01 00:00:00

abstract：:This Editorial highlights a study by Xia and coworkers in the current issue of the Journal of Neurochemistry, in which the authors reveal a possible mechanistic link between DISC1 (disrupted-in-schizophrenia-1), a genetic risk factor for schizophrenia, and N-methyl-d-aspartate receptor (NMDAR) that is also linked with...

journal_title：Journal of neurochemistry

authors： Wu S,Barger SW

更新日期：2016-08-01 00:00:00

abstract：:Glucocorticoids (GCs), the adrenal steroids secreted during stress, can compromise the ability of hippocampal neurons to survive numerous necrotic insults. We have previously observed that GCs worsen the deleterious effects of gp120, the glycoprotein of the acquired immune deficiency syndrome virus, which can indirect...

journal_title：Journal of neurochemistry

authors： Yusim A,Franklin L,Brooke S,Ajilore O,Sapolsky R

更新日期：2000-03-01 00:00:00

abstract：:The activity-dependent fusion, retrieval and recycling of synaptic vesicles is essential for the maintenance of neurotransmission. Until relatively recently it was believed that most mutations in genes that were essential for this process would be incompatible with life, because of this fundamental role. However, an e...

journal_title：Journal of neurochemistry

authors： Bonnycastle K,Davenport EC,Cousin MA

更新日期：2020-05-07 00:00:00

abstract：:GABA(A) receptors are the major inhibitory neurotransmitter receptors in the brain. Some of them are targets of benzodiazepines that are widely used in clinical practice for their sedative/hypnotic, anxiolytic, muscle relaxant and anticonvulsant effects. In order to rationally separate these different drug actions, we...

journal_title：Journal of neurochemistry

authors： Tan KR,Baur R,Charon S,Goeldner M,Sigel E

更新日期：2009-12-01 00:00:00

abstract：:Metallothionein (MT) protein and mRNA levels were monitored following exposure of rat neonatal primary astrocyte cultures to methylmercury (MeHg). MT-I and MT-II mRNAs were probed on northern blots with an [alpha-32P]dCTP-labeled synthetic cDNA probe specific for rat MT mRNA. MT-I and MT-II mRNAs were detected in untr...

journal_title：Journal of neurochemistry

authors： Rising L,Vitarella D,Kimelberg HK,Aschner M

更新日期：1995-10-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) is a potent biomediator that can act as either an intracellular or an intercellular messenger. In the nervous system it exerts a wide range of actions, and specific membrane receptors for it have been identified in various regions. However, the physiological origin of extracellular S1P in...

journal_title：Journal of neurochemistry

authors： Anelli V,Bassi R,Tettamanti G,Viani P,Riboni L

更新日期：2005-03-01 00:00:00

abstract：:There is growing evidence that activation of either protein kinases or protein phosphatases determines the type of plasticity observed after different patterns of hippocampal stimulation. Because activation of the extracellular signal-regulated kinase (ERK) has been shown to be necessary for long-term potentiation, we...

journal_title：Journal of neurochemistry

authors： Norman ED,Thiels E,Barrionuevo G,Klann E

更新日期：2000-01-01 00:00:00

abstract：:Hippocampal neurons are affected by chronic stress and have a high density of cytoplasmic mineralocorticoid and glucocorticoid receptors (MR and GR). Detailed studies on the genomic effects of the stress hormone corticosterone at physiologically relevant concentrations on different steps in synaptic transmission are l...

journal_title：Journal of neurochemistry

authors： Chatterjee S,Sikdar SK

更新日期：2014-02-01 00:00:00

abstract：:Docosahexaenoic acid (DHA), an n-3 fatty acid, is rapidly deposited during the period of rapid brain development. The influence of n-3 fatty acid deficiency on learning performance in adult rats over two generations was investigated. Rats were fed either an n-3 fatty acid-adequate (n-3 Adq) or -deficient (n-3 Def) die...

journal_title：Journal of neurochemistry

authors： Moriguchi T,Greiner RS,Salem N Jr

更新日期：2000-12-01 00:00:00