Role of calmodulin in the effect of guanyl nucleotides on rat hippocampal adenylate cyclase: involvement of adenosine and opiates.

abstract：:The autoradiographic method with L-[35S]methionine was used to determine the effects of an n-3 fatty acid deficiency on brain protein synthesis. Brain protein synthesis was significantly increased (from 50 to 150%) in 45 of the 52 brain structures studied in n-3 fatty acid-deficient rats as compared with control anima...

journal_title：Journal of neurochemistry

authors： Giaume M,Gay N,Baubet V,Gharib A,Durand G,Bobillier P,Sarda N

更新日期：1994-11-01 00:00:00

abstract：:Mouse models of MPTP intoxication have been used extensively to explore the molecular mechanisms of Parkinson's disease. However, these models present some limitations since; (i) Dopaminergic (DA) cell death occurs rapidly in contrast to the presumably slow evolution of the disease process. (ii) Some of the key histol...

journal_title：Journal of neurochemistry

authors： Alvarez-Fischer D,Guerreiro S,Hunot S,Saurini F,Marien M,Sokoloff P,Hirsch EC,Hartmann A,Michel PP

更新日期：2008-11-01 00:00:00

abstract：:Quinolinic acid (QUIN), an excitotoxic compound present in the mammalian CNS and periphery, has been hypothetically linked to human neurodegenerative disorders such as Huntington's disease and epilepsy. Quinolinic acid phosphoribosyltransferase (QPRT), the catabolic enzyme of QUIN, is found in the CNS and peripheral o...

journal_title：Journal of neurochemistry

authors： Foster AC,Schwarcz R

更新日期：1985-07-01 00:00:00

abstract：:The present study aims to investigate the role of extracellular glutamate and NMDA receptor stimulation in the neuronal death induced by a transient exposure to H2O2 of cultured neurons originating from mouse cerebral cortex. Most of the neuronal loss following a transient exposure to H2O2 of cortical neurons results ...

journal_title：Journal of neurochemistry

authors： Mailly F,Marin P,Israël M,Glowinski J,Prémont J

更新日期：1999-09-01 00:00:00

abstract：:We investigated changes in the extracellular levels of acetylcholine (ACh) following local application of serotonergic agents to the dorsal hippocampus of freely moving rats by means of perfusion using a microdialysis technique. Perfusion of serotonin (5-HT; 10 microM, for 30 min at a rate of 3 microliters/min), disso...

journal_title：Journal of neurochemistry

authors： Izumi J,Washizuka M,Miura N,Hiraga Y,Ikeda Y

更新日期：1994-05-01 00:00:00

abstract：:We have studied neurotoxicity induced by pharmacological concentrations of 3-hydroxykynurenine (3-HK), an endogenous toxin implicated in certain neurodegenerative diseases, in cerebellar granule cells, PC12 pheochromocytoma cells, and GT1-7 hypothalamic neurosecretory cells. In all three cell types, the toxicity was i...

journal_title：Journal of neurochemistry

authors： Wei H,Leeds P,Chen RW,Wei W,Leng Y,Bredesen DE,Chuang DM

更新日期：2000-07-01 00:00:00

abstract：:Rat cerebellar granule cells differentiated in culture were fed [1-(3)H]sphingosine, allowing the metabolic radiolabelling of all cell sphingolipids and phosphatidylethanolamine. A detergent-insoluble sphingolipid-enriched membrane fraction, containing about 60% of cell sphingolipids, but only trace amounts of phospha...

journal_title：Journal of neurochemistry

authors： Prinetti A,Prioni S,Chigorno V,Karagogeos D,Tettamanti G,Sonnino S

更新日期：2001-09-01 00:00:00

abstract：:Expression of the Ca(2+)-dependent phospholipids binding protein annexin A2 (ANX2) in the brain is thought to be largely associated with brain pathological conditions such as tumor, inflammation, and neurodegeneration. The recent findings that ANX2 heterotetramer is involved in learning and neuronal activities necessi...

journal_title：Journal of neurochemistry

authors： Zhao WQ,Lu B

更新日期：2007-03-01 00:00:00

abstract：:The NMDA receptor has recently been found to be phosphorylated on tyrosine. To assess the possible connection between tyrosine phosphorylation of the NMDA receptor and signaling pathways in the postsynaptic cell, we have investigated the relationship between tyrosine phosphorylation and the binding of NMDA receptor su...

journal_title：Journal of neurochemistry

authors： Gurd JW,Bissoon N

更新日期：1997-08-01 00:00:00

abstract：:Saturable and specific binding sites for 5-[3H]hydroxytryptamine (5-HT, serotonin) characterized by a KD of 3.5-4.5 nM were detected in the chick embryo brain and were shown to develop linearly as a function of age, weight, and protein content. Saturation and displacement studies using unlabeled 5-HT as the displacing...

journal_title：Journal of neurochemistry

authors： Soblosky JS,Jeng I

更新日期：1985-02-01 00:00:00

abstract：:Peptide extracts of rat brain powerfully inhibited the cyclic AMP phosphodiesterase activity of rat brain homogenate. Similar extracts of ox brain showed comparable although less potent activity. Preliminary investigation of the physicochemical properties of brain extracts indicated that the rat brain extract containe...

journal_title：Journal of neurochemistry

authors： Collier HO,Butt NM,Saeed SA

更新日期：1982-01-01 00:00:00

abstract：:As an initial step to study the function of the gene encoding the human neuropeptide FF (NPFF), we cloned a 4.7-kb sequence from the promoter region. Primer extension and 5'-rapid amplification of cDNA ends revealed multiple transcription initiation sites. Northern blot analysis of the mRNA expression revealed a speci...

journal_title：Journal of neurochemistry

authors： Nystedt JM,Brandt AM,Mandelin J,Vilim FS,Ziff EB,Panula P

更新日期：2002-09-01 00:00:00

abstract：:Early malnutrition is a risk factor for depression and schizophrenia. Since the offspring of malnourished dams exhibit increased brain levels of serotonin (5-HT), a tryptophan-derived neurotransmitter involved in the pathophysiology of these mental disorders, it is believed that the deleterious effects of early malnut...

journal_title：Journal of neurochemistry

authors： Honório de Melo Martimiano P,de Sa Braga Oliveira A,Ferchaud-Roucher V,Croyal M,Aguesse A,Grit I,Ouguerram K,Lopes de Souza S,Kaeffer B,Bolaños-Jiménez F

更新日期：2017-01-01 00:00:00

abstract：:Increased cerebrovascular permeability is an important factor for the development of cerebral edema. To investigate the effect of hypoxia on the transport of blood-borne proteins to the brain, we used a cell culture model of the blood-brain barrier (BBB) consisting of a coculture of brain capillary endothelial cells a...

journal_title：Journal of neurochemistry

authors： Plateel M,Teissier E,Cecchelli R

更新日期：1997-02-01 00:00:00

abstract：:Prolonged hypoxia exerts profound effects on cell function, and has been associated with increased production of amyloid beta peptides (A beta Ps) of Alzheimer's disease. Here, we have investigated the effects of chronic hypoxia (2.5% O2, 24 h) on capacitative Ca2+ entry (CCE) in primary cultures of rat type-I cortica...

journal_title：Journal of neurochemistry

authors： Smith IF,Plant LD,Boyle JP,Skinner RA,Pearson HA,Peers C

更新日期：2003-06-01 00:00:00

abstract：:Hypothalamic norepinephrine (NE) release regulates arterial pressure by altering sympathetic nervous system activity. Because angiotensin (Ang) (1-7) decreases hypothalamic NE release and this effect may be correlated with a diminished NE synthesis, we hypothesize that Ang-(1-7) down-regulates tyrosine hydroxylase (TH...

journal_title：Journal of neurochemistry

authors： Lopez Verrilli MA,Pirola CJ,Pascual MM,Dominici FP,Turyn D,Gironacci MM

更新日期：2009-04-01 00:00:00

abstract：:The myelin transcription factor 1 (Myt1) gene family is comprised of three zinc finger genes [Myt1, Myt1L (Myt1-Like) and NZF3] of the structurally unique CCHHC class that are expressed predominantly in the developing CNS. To understand the mechanism by which this family regulates neural differentiation, we searched f...

journal_title：Journal of neurochemistry

authors： Romm E,Nielsen JA,Kim JG,Hudson LD

更新日期：2005-06-01 00:00:00

abstract：:A wealth of evidence supports the view that conformational change of the prion protein, PrPC, into a pathogenic isoform, PrPSc, is the hallmark of sporadic, infectious, and inherited forms of prion disease. Although the central role played by PrPSc in the pathogenesis of prion disease is appreciated, the cellular mech...

journal_title：Journal of neurochemistry

authors： Deleault NR,Dolph PJ,Feany MB,Cook ME,Nishina K,Harris DA,Supattapone S

更新日期：2003-06-01 00:00:00

abstract：:Ion channels are classically understood to regulate the flux of ions across the plasma membrane in response to a variety of environmental and intracellular cues. Ion channels serve a number of functions in intracellular membranes as well. These channels may be temporarily localized to intracellular membranes as a func...

journal_title：Journal of neurochemistry

authors： Dong XP,Wang X,Xu H

更新日期：2010-04-01 00:00:00

abstract：:Sequence data from key fragments of the P2 protein established the order of cyanogen bromide (CNBr) peptides in the structure of the protein and the primary structure for approximately one-half of the molecule. Data were obtained from the three tryptic peptides of blocked NH2-terminal CNBr peptide (CN3), the large CNB...

journal_title：Journal of neurochemistry

authors： Weise MJ,Hsieh DL,Levit S,Brostoff SW

更新日期：1980-08-01 00:00:00

abstract：:Studies suggest that activation of phosphoinositide 3-kinase-Akt may protect against neuronal cell death in Alzheimer's disease (AD). Here, however, we provide evidence of increased Akt activation, and hyperphosphorylation of critical Akt substrates in AD brain, which link to AD pathogenesis, suggesting that treatment...

journal_title：Journal of neurochemistry

authors： Griffin RJ,Moloney A,Kelliher M,Johnston JA,Ravid R,Dockery P,O'Connor R,O'Neill C

更新日期：2005-04-01 00:00:00

abstract：:Multiple molecular defects trigger cell death in amyotrophic lateral sclerosis (ALS). Among these, altered transcriptional activity may perturb many cellular functions, leading to a cascade of secondary pathological effects. We showed that pharmacological treatment, using the histone deacetylase inhibitor sodium pheny...

journal_title：Journal of neurochemistry

authors： Ryu H,Smith K,Camelo SI,Carreras I,Lee J,Iglesias AH,Dangond F,Cormier KA,Cudkowicz ME,Brown RH Jr,Ferrante RJ

更新日期：2005-06-01 00:00:00

abstract：:Nitric oxide (NO) has a number of physiological and pathophysiological effects in the nervous system. One target of NO is the mitochondrion, where it inhibits respiration and ATP synthesis, which may contribute to NO-mediated neuronal injury. Our recent studies suggested that impaired mitochondrial function impairs mi...

journal_title：Journal of neurochemistry

authors： Rintoul GL,Bennett VJ,Papaconstandinou NA,Reynolds IJ

更新日期：2006-05-01 00:00:00

abstract：:The mediatophore is a presynaptic membrane protein that has been shown to translocate acetylcholine (ACh) under calcium stimulation when reconstituted into artificial membranes. The mediatophore subunit, a 15-kDa proteolipid, presents a very high sequence homology with the N,N'-dicyclohexylcarbodiimide (DCCD)-binding ...

journal_title：Journal of neurochemistry

authors： Sbia M,Diebler MF,Morel N,Israël M

更新日期：1992-10-01 00:00:00

abstract：:Previous work in this laboratory has shown that adrenal medullary transplants into the spinal cord subarachnoid space can reduce pain sensitivity. This analgesia most likely results from the release of neuroactive substances, particularly catecholamines and opioid peptides, from the transplanted cells into the CSF of ...

journal_title：Journal of neurochemistry

authors： Sagen J,Kemmler JE,Wang H

更新日期：1991-02-01 00:00:00

abstract：:Cue-induced reinstatement of cocaine seeking after self-administration (SA) and extinction relies on glutamate release in the nucleus accumbens core (NAcore), which activates neuronal nitric oxide synthase interneurons. Nitric oxide (NO) is required for structural plasticity in NAcore medium spiny neurons, as well as ...

journal_title：Journal of neurochemistry

authors： Siemsen BM,McFaddin JA,Haigh K,Brock AG,Nan Leath M,Hooker KN,McGonegal LK,Scofield MD

更新日期：2020-06-01 00:00:00

abstract：:The presence of insulin receptors was investigated in human Y-79 retinoblastoma cells grown in suspension culture. The binding of [125I] insulin to these cells was time, temperature, and pH dependent, was competed for by insulin and proinsulin but not other peptides, and was inhibited by antibodies against the insulin...

journal_title：Journal of neurochemistry

authors： Saviolakis GA,Kyritsis AP,Chader GJ

更新日期：1986-07-01 00:00:00

abstract：:We studied the formation of early endosomes in differentiating oligodendrocytes and type-2 astrocytes, which are derived from common precursor cells in rat neonates, using fluorescent analogues of lactosylceramide (LacCer) and sulfatide labeled with 4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene++ +-3-pentano...

journal_title：Journal of neurochemistry

authors： Watanabe R,Asakura K,Rodriguez M,Pagano RE

更新日期：1999-10-01 00:00:00

abstract：:Five muscarinic receptor genes (m1-m5) that encode distinct muscarinic receptor subtypes have been cloned. Because of their structural homology and pharmacological similarity, ligand binding probes currently available do not clearly distinguish among the subtypes. To obtain a clear distribution within the CNS of molec...

journal_title：Journal of neurochemistry

authors： Wei J,Walton EA,Milici A,Buccafusco JJ

更新日期：1994-09-01 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) is accumulated in lipoproteins, especially high-density lipoprotein (HDL), in plasma. However, it remains uncharacterized how extracellular S1P is produced in the CNS. The treatment of rat astrocytes with retinoic acid and dibutyryl cAMP, which induce apolipoprotein E (apoE) synthesis and...

journal_title：Journal of neurochemistry

authors： Sato K,Malchinkhuu E,Horiuchi Y,Mogi C,Tomura H,Tosaka M,Yoshimoto Y,Kuwabara A,Okajima F

更新日期：2007-12-01 00:00:00