Abstract：
:The myelin transcription factor 1 (Myt1) gene family is comprised of three zinc finger genes [Myt1, Myt1L (Myt1-Like) and NZF3] of the structurally unique CCHHC class that are expressed predominantly in the developing CNS. To understand the mechanism by which this family regulates neural differentiation, we searched for interaction partners. In both yeast and a mammalian two-hybrid system, Myt1 and Myt1L interacted with Sin3B, a protein that mediates transcriptional repression by binding to histone deacetylases (HDACs). Myt1-Sin3B complexes were co-immunoprecipitated from transfected mammalian cells and included HDAC1 and HDAC2. Myt1 and Myt1L could partner with all three Sin3B isoforms, the long form (Sin3B(LF)) that includes the HDAC-binding domain, and the two short forms (Sin3B(SF293) and Sin3B(SF302)) that lack this domain and may consequently antagonize Sin3B(LF)/HDAC-mediated co-repression. Myt1 or Myt1L interactions with the HDAC-binding form of Sin3B conferred repression on a heterologous promoter. Oligodendrocytes were shown to express transcripts encoding each of the Sin3B isoforms. We present a model in which the Myt1 family of zinc finger proteins, when bound to a neural promoter, can recruit Sin3B. Depending on the relative availability of Sin3B isoforms, the Myt1 gene family may favor the silencing of genes during neural development.
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
Romm E,Nielsen JA,Kim JG,Hudson LDdoi
10.1111/j.1471-4159.2005.03131.xkeywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
1444-53issue
6eissn
0022-3042issn
1471-4159pii
JNC3131journal_volume
93pub_type
杂志文章abstract：:Genomic and cDNA clones encoding the rat D1 receptor were isolated and sequenced. Comparison of the D1 receptor cDNA and genomic sequences revealed that the rat D1 receptor gene is organized into two exons separated by a small intron in the 5' untranslated region of its mRNA. The transcription start site is located 86...
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doi：10.1111/j.1471-4159.1983.tb12658.x
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journal_title：Journal of neurochemistry
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doi：10.1111/j.1471-4159.1989.tb01873.x
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pub_type： 杂志文章
doi：10.1111/j.1471-4159.1991.tb02113.x
更新日期：1991-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2002-08-01 00:00:00
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doi：10.1111/j.1471-4159.2010.07059.x
更新日期：2010-12-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/j.1471-4159.1989.tb09157.x
更新日期：1989-02-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/jnc.12499
更新日期：2014-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2010-06-01 00:00:00
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更新日期：2018-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1046/j.1471-4159.2000.0742146.x
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journal_title：Journal of neurochemistry
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更新日期：1987-02-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
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更新日期：2009-08-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/j.1471-4159.1984.tb02802.x
更新日期：1984-05-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/j.1471-4159.1983.tb08148.x
更新日期：1983-06-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
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更新日期：2010-05-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/jnc.13433
更新日期：2016-02-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/j.1471-4159.1981.tb02389.x
更新日期：1981-01-01 00:00:00
abstract：:Adrenomedullary chromaffin cells represent an excellent model to study the molecular events linked to exocytosis, because they use the same type of SNAREs for vesicle docking and fusion as neurons. In these cells, both in the intact tissue and in isolated cells in culture, syntaxin-1 and SNAP-25 are present in the pla...
journal_title：Journal of neurochemistry
pub_type： 杂志文章,评审
doi：10.1111/j.1471-4159.2010.06872.x
更新日期：2010-09-01 00:00:00
