1,8- and 1,4-cineole enhance spontaneous excitatory transmission by activating different types of transient receptor potential channels in the rat spinal substantia gelatinosa.

abstract：:Alzheimer's disease (AD) is characterized by amyloid-beta peptide (Abeta) deposition in the brain. Abeta is produced by sequential cleavage of amyloid precursor protein (APP) by beta-secretase (BACE1: beta-site APP-cleaving enzyme 1) and gamma-secretase. Previously, we demonstrated that BACE1 also cleaves beta-galacto...

journal_title：Journal of neurochemistry

authors： Nakagawa K,Kitazume S,Oka R,Maruyama K,Saido TC,Sato Y,Endo T,Hashimoto Y

更新日期：2006-02-01 00:00:00

abstract：:Neural stem cells (NSCs) are self-renewing multipotent cells that undergo symmetric and asymmetric cell division during development of the nervous system. The behavior of NSCs is tightly regulated by intrinsic processes such as transcriptional and post-transcriptional control, as well as the stem cell niche factors th...

journal_title：Journal of neurochemistry

authors： Gan HT,Tham M,Hariharan S,Ramasamy S,Yu YH,Ahmed S

更新日期：2011-05-01 00:00:00

abstract：:We examined the axonal transport of actin and its monomer binding proteins, actin depolymerizing factor, cofilin, and profilin, in the chicken sciatic nerve following injection of [35S]methionine into the lumbar spinal cord. At intervals up to 20 days after injection, nerves were cut into 1-cm segments and separated i...

journal_title：Journal of neurochemistry

authors： Mills RG,Minamide LS,Yuan A,Bamburg JR,Bray JJ

更新日期：1996-09-01 00:00:00

abstract：:Ischemic postconditioning is increasingly being investigated as a therapeutic approach for cerebral ischemia. However, the majority of studies are focused on the acute protection of neurons per se. Whether and how postconditioning affects multiple cells in the recovering neurovascular unit remains to be fully elucidat...

journal_title：Journal of neurochemistry

authors： Esposito E,Hayakawa K,Ahn BJ,Chan SJ,Xing C,Liang AC,Kim KW,Arai K,Lo EH

更新日期：2018-07-01 00:00:00

abstract：:HNK-1 antibody reactive sulfoglucuronyl carbohydrate (SGC) and SSEA-1 antibody reactive Lewis X (Lex) epitope are expressed on several glycolipids, glycoproteins, and proteoglycans of the nervous system and have been implicated in cell-cell recognition, neurite outgrowth, and/or neuronal migration during development. ...

journal_title：Journal of neurochemistry

authors： Chou DK,Henion TR,Jungalwala FB

更新日期：2003-08-01 00:00:00

abstract：:Noradrenaline (NA) release and its modulation via presynaptic opioid receptors were studied in rabbit hippocampal slices, which were preincubated with [3H]NA, continuously superfused in the presence of 30 microM cocaine and stimulated electrically. The evoked release of [3H]NA was strongly reduced by the preferential ...

journal_title：Journal of neurochemistry

authors： Jackisch R,Geppert M,Illes P

更新日期：1986-06-01 00:00:00

abstract：:Molecular mechanisms underlying tauopathy remain undetermined. In the current study, single cell gene expression profiling was coupled with custom-designed cDNA array analysis to evaluate tau expression and other cytoskeletal elements within individual neuronal populations in patients with no cognitive impairment (NCI...

journal_title：Journal of neurochemistry

authors： Ginsberg SD,Che S,Counts SE,Mufson EJ

更新日期：2006-03-01 00:00:00

abstract：:The protein B-50 is dephosphorylated in rat cortical synaptic plasma membranes (SPM) by protein phosphatase type 1 and 2A (PP-1 and PP-2A)-like activities. The present studies further demonstrate that B-50 is dephosphorylated not only by a spontaneously active PP-1-like enzyme, but also by a latent form after pretreat...

journal_title：Journal of neurochemistry

authors： Han YF,Wang W,Schlender KK,Ganjeizadeh M,Dokas LA

更新日期：1992-07-01 00:00:00

abstract：:Aggregate-prone mutant proteins, such as α-synuclein and huntingtin, play a prominent role in the pathogenesis of various neurodegenerative disorders; thus, it has been hypothesized that reducing the aggregate-prone proteins may be a beneficial therapeutic strategy for these neurodegenerative disorders. Here, we ident...

journal_title：Journal of neurochemistry

authors： Shen W,Henry AG,Paumier KL,Li L,Mou K,Dunlop J,Berger Z,Hirst WD

更新日期：2014-06-01 00:00:00

abstract：:A combination of posttranslational modifications contributes to the high heterogeneity of brain tubulin in mammals. In this report, the structures of the detyrosinated carboxy-terminal peptides of alpha-tubulin from newborn and adult mouse brain were compared. The heterogeneity of these carboxy-terminal peptides was o...

journal_title：Journal of neurochemistry

authors： Redeker V,Rusconi F,Mary J,Promé D,Rossier J

更新日期：1996-11-01 00:00:00

abstract：:The extension of microglial processes toward injured sites in the brain is triggered by the stimulation of the purinergic receptor P2Y(12) by extracellular ATP. We recently showed that P2Y(12) stimulation by ATP induces microglial process extension in collagen gels. In the present study, we found that a P2Y(12) agonis...

journal_title：Journal of neurochemistry

authors： Ohsawa K,Sanagi T,Nakamura Y,Suzuki E,Inoue K,Kohsaka S

更新日期：2012-04-01 00:00:00

abstract：:The export of glutamine from astrocytes, and the uptake of glutamine by neurons, are integral steps in the glutamate-glutamine cycle, a major pathway for the replenishment of neuronal glutamate. We review here the functional and molecular identification of the transporters that mediate this transfer. The emerging pict...

journal_title：Journal of neurochemistry

authors： Bröer S,Brookes N

更新日期：2001-05-01 00:00:00

abstract：:The potential anxiolytic effects of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor subgroup 2 (mGluR₂) were investigated using a self-referencing recording technique with enzyme-based microelectrode arrays (MEAs) that reliably measures tonic and phasic changes in extracellular gluta...

journal_title：Journal of neurochemistry

authors： Hascup ER,Hascup KN,Pomerleau F,Huettl P,Hajos-Korcsok E,Kehr J,Gerhardt GA

更新日期：2012-08-01 00:00:00

abstract：:The lipid composition of the brain, including myelin, was studied in detail in two cases with a variant form of metachromatic leukodystrophy (multiple sulphatase deficiency type). In the white matter, the sulphatide concentration was 3-4 times higher than the normal level in both cases. There was a significant accumul...

journal_title：Journal of neurochemistry

authors： Eto Y,Meier C,Herschkowitz NN

更新日期：1976-11-01 00:00:00

abstract：:Tryptic digestion of tyrosine hydroxylase (TH) isolated from rat adrenal glands labeled with 32Pi produced five phosphopeptides. Based on the correspondence of these phosphopeptides with those identified in TH from rat pheochromocytoma cells, four phosphorylation sites (Ser8, Ser19, Ser31, and Ser40) were inferred. Fi...

journal_title：Journal of neurochemistry

authors： Haycock JW,Wakade AR

更新日期：1992-01-01 00:00:00

abstract：:The motor signs of Parkinson's disease have been partly attributed to an overinhibition of the external globus pallidus (GP) that results from hyperactivity of striatopallidal GABA/enkephalinergic neurons. The goals of this study were to measure basal levels of extracellular fluid GABA in the GP of normal cats, 1-meth...

journal_title：Journal of neurochemistry

authors： Schroeder JA,Schneider JS

更新日期：2002-08-01 00:00:00

abstract：:Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, catalyzes the conversion of tyrosine to DOPA, Cyclic AMP-dependent protein phosphorylation conditions alter tyrosine hydroxylase activity in rat striatal homogenates. In agreement with other laboratories, we find that short-term pre-incubati...

journal_title：Journal of neurochemistry

authors： Vrana KE,Allhiser CL,Roskoski R Jr

更新日期：1981-01-01 00:00:00

abstract：:RGS (regulators of G-protein signaling) proteins comprise a large family that modulates heterotrimeric G-protein signaling. This protein family has a common RGS domain and functions as GTPase-activating proteins for the alpha-subunits of heterotrimeric G-proteins located at the plasma membrane. RGS8 was identified as ...

journal_title：Journal of neurochemistry

authors： Masuho I,Itoh M,Itoh H,Saitoh O

更新日期：2004-01-01 00:00:00

abstract：:Much has been learned in recent years about the genetics of familial Parkinson's disease. However, far less is known about those malfunctioning genes which contribute to the emergence and/or progression of the vast majority of cases, the 'sporadic Parkinson's disease', which is the focus of our current review. Drastic...

journal_title：Journal of neurochemistry

authors： Benmoyal-Segal L,Soreq H

更新日期：2006-06-01 00:00:00

abstract：:Monoclonal antibodies were raised against the synaptosomal plasma membranes (SPMs) purified from the electric organ of the Torpedo. One antibody that reacts preferentially with SPMs rather than with other membrane fractions isolated from this tissue was previously found to inhibit hydrophilic and amphiphilic choline-O...

journal_title：Journal of neurochemistry

authors： Eder-Colli L,Briand PA,Pellegrinelli N,Dunant Y

更新日期：1989-11-01 00:00:00

abstract：:There is much evidence to suggest that G protein coupled receptors exist as oligomers but the relevance to their function is unclear. We have, therefore, examined the binding of the radiolabelled agonist [(3)H]NPA to membranes of CHO cells expressing the D(2) dopamine receptor in dissociation rate experiments. When [(...

journal_title：Journal of neurochemistry

authors： Kara E,Lin H,Strange PG

更新日期：2010-03-01 00:00:00

abstract：:Astrocytes can either exacerbate or ameliorate secondary degeneration at sites of injury in the CNS but the contextual basis for eliciting these opposing phenotypes is poorly understood. In this study, we demonstrate that the two major cytokines produced by Th1 and Th2 cells, interferon-gamma (IFN-gamma), and interleu...

journal_title：Journal of neurochemistry

authors： Garg SK,Kipnis J,Banerjee R

更新日期：2009-03-01 00:00:00

abstract：:Sequence data from key fragments of the P2 protein established the order of cyanogen bromide (CNBr) peptides in the structure of the protein and the primary structure for approximately one-half of the molecule. Data were obtained from the three tryptic peptides of blocked NH2-terminal CNBr peptide (CN3), the large CNB...

journal_title：Journal of neurochemistry

authors： Weise MJ,Hsieh DL,Levit S,Brostoff SW

更新日期：1980-08-01 00:00:00

abstract：:In rat mesencephalic cell cultures, L-glutamate at concentrations ranging from 100 microM to 1 mM stimulated release of [3H]dopamine that was attenuated by the non-N-methyl-D-aspartate (non-NMDA) receptor antagonist 6,7-dinitroquinoxalinedione, but not by the selective NMDA receptor antagonists (+)-5-methyl-10,11-dihy...

journal_title：Journal of neurochemistry

authors： Mount H,Quirion R,Chaudieu I,Boksa P

更新日期：1990-07-01 00:00:00

abstract：:Rats fasted overnight were allowed to consume single meals containing 0, 18, or 40% protein or continued to fast; after 2 h, brains and sera were taken and assayed for various amino acids. In general, serum levels of most amino acids were reduced by the 0% protein meal and elevated by the high-protein meal when compar...

journal_title：Journal of neurochemistry

authors： Glaeser BS,Maher TJ,Wurtman RJ

更新日期：1983-10-01 00:00:00

abstract：:The P2X7 receptor/channel responds to extracellular ATP and is associated with neuronal death and neuroinflammation in spinal cord injury and amyotrophic lateral sclerosis. Whether activation of P2X7 directly causes motor neuron death is unknown. We found that cultured motor neurons isolated from embryonic rat spinal ...

journal_title：Journal of neurochemistry

authors： Gandelman M,Levy M,Cassina P,Barbeito L,Beckman JS

更新日期：2013-08-01 00:00:00

abstract：:An oligodendroglial specific property, glucocorticoid regulation of glycerol-3-phosphate dehydrogenase (GPDH) levels, was inhibited in C6 rat glioma cells when 4 beta-phorbol 12-myristate 13-acetate (PMA) was added to the cultures. PMA inhibited GPDH induction in both logarithmic- and stationary-phase cells. These eve...

journal_title：Journal of neurochemistry

authors： Bressler JP,Weingarten D,Kornblith PL

更新日期：1985-10-01 00:00:00

abstract：:Parkinson's disease (PD) is caused by neuronal cell death. Although a precursor of dopamine and inhibitors of dopamine degradation have been used for PD therapy, cell death progresses during treatment. DJ-1, a causative gene product of a familial form of PD, PARK7, plays roles in transcriptional regulation and anti-ox...

journal_title：Journal of neurochemistry

authors： Miyazaki S,Yanagida T,Nunome K,Ishikawa S,Inden M,Kitamura Y,Nakagawa S,Taira T,Hirota K,Niwa M,Iguchi-Ariga SM,Ariga H

更新日期：2008-06-01 00:00:00

abstract：:The binding of L-2-[3H]amino-4-phosphonobutyrate ([3H]L-AP4) was examined in brain sections of wild-type mice and mice lacking the mGluR4 subtype of metabotropic glutamate receptors (mGluRs). Very high relative densities of [3H]L-AP4 binding were observed in the molecular layer of the cerebellar cortex, the nucleus ba...

journal_title：Journal of neurochemistry

authors： Thomsen C,Hampson DR

更新日期：1999-02-01 00:00:00

abstract：:Kainate receptors (KARs) modulate synaptic transmission at both pre-synaptic and post-synaptic sites. The overlap in the distribution of KA-2 and GluR6/7 subunits in several brain regions suggests the co-assembly of these subunits in native KARs. The molecular mechanisms that control the assembly and surface expressio...

journal_title：Journal of neurochemistry

authors： Gallyas F Jr,Ball SM,Molnar E

更新日期：2003-09-01 00:00:00