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Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.

Abstract：

:Molecular mechanisms underlying tauopathy remain undetermined. In the current study, single cell gene expression profiling was coupled with custom-designed cDNA array analysis to evaluate tau expression and other cytoskeletal elements within individual neuronal populations in patients with no cognitive impairment (NCI), mild cognitive impairment (MCI), and Alzheimer's disease (AD). Results revealed a shift in the ratio of three-repeat tau (3Rtau) to four-repeat tau (4Rtau) mRNAs within individual human cholinergic basal forebrain (CBF) neurons within nucleus basalis (NB) and CA1 hippocampal neurons during the progression of AD, but not during normal aging. A shift in 3Rtau to 4Rtau may precipitate a cascade of events in the selective vulnerability of neurons, ultimately leading to frank neurofibrillary tangle (NFT) formation in tauopathies including AD.

journal_name

J Neurochem

journal_title

Journal of neurochemistry

authors

Ginsberg SD,Che S,Counts SE,Mufson EJ

doi

10.1111/j.1471-4159.2005.03641.x

keywords:

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

1401-8

issue

5

eissn

0022-3042

issn

1471-4159

pii

JNC3641

journal_volume

96

pub_type

杂志文章

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