当前位置： SCI文献检索 > JOURNAL OF NEUROCHEMISTRY期刊下所有文献 > Identification of ApoE as an autocrine/paracrine factor that stimulates neural stem cell survival via MAPK/ERK signaling pathway.

Identification of ApoE as an autocrine/paracrine factor that stimulates neural stem cell survival via MAPK/ERK signaling pathway.

Abstract：

:Neural stem cells (NSCs) are self-renewing multipotent cells that undergo symmetric and asymmetric cell division during development of the nervous system. The behavior of NSCs is tightly regulated by intrinsic processes such as transcriptional and post-transcriptional control, as well as the stem cell niche factors that activate ligand-receptor-mediated signaling pathways. However, the role of these niche factors that regulate NSC behavior is not clearly understood. We identified chondroitin sulfate proteoglycan, apolipoprotein E (ApoE) and cystatin C as factors derived from the mouse neurosphere conditioned medium. Here, we show that ApoE is an autocrine/paracrine factor that regulates NSC survival. Stimulation of NSC survival is mediated by ApoE receptor interaction and the downstream extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway. In addition, ApoE also enhanced neurosphere formation of mouse embryonic stem cell-derived NSCs. Finally, in vitro differentiation studies with ApoE knock-out NSCs suggest a role for ApoE in oligodendrogenesis.

journal_name

J Neurochem

journal_title

Journal of neurochemistry

authors

Gan HT,Tham M,Hariharan S,Ramasamy S,Yu YH,Ahmed S

doi

10.1111/j.1471-4159.2011.07227.x

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

565-78

issue

3

eissn

0022-3042

issn

1471-4159

journal_volume

117

pub_type

杂志文章

相关文献

JOURNAL OF NEUROCHEMISTRY文献大全
  • Adrenal medullary transplants increase spinal cord cerebrospinal fluid catecholamine levels and reduce pain sensitivity.

    abstract：:Previous work in this laboratory has shown that adrenal medullary transplants into the spinal cord subarachnoid space can reduce pain sensitivity. This analgesia most likely results from the release of neuroactive substances, particularly catecholamines and opioid peptides, from the transplanted cells into the CSF of ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1991.tb08195.x

    authors： Sagen J,Kemmler JE,Wang H

    更新日期：1991-02-01 00:00:00

  • Glutathione depletion resulting in selective mitochondrial complex I inhibition in dopaminergic cells is via an NO-mediated pathway not involving peroxynitrite: implications for Parkinson's disease.

    abstract：:An early biochemical change in the Parkinsonian substantia nigra (SN) is reduction in total glutathione (GSH + GSSG) levels in affected dopaminergic neurons prior to depletion in mitochondrial complex I activity, dopamine loss, and cell death. We have demonstrated using dopaminergic PC12 cell lines genetically enginee...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2004.02929.x

    authors： Hsu M,Srinivas B,Kumar J,Subramanian R,Andersen J

    更新日期：2005-03-01 00:00:00

  • Activation of cholecystokinin neurons in the dorsal pallium of the telencephalon is indispensable for the acquisition of chick imprinting behavior.

    abstract：:Chick imprinting behavior is a good model for the study of learning and memory. Imprinting object is recognized and processed in the visual wulst, and the memory is stored in the intermediate medial mesopallium in the dorsal pallium of the telencephalon. We identified chicken cholecystokinin (CCK)-expressing cells loc...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2007.04733.x

    authors： Maekawa F,Nakamori T,Uchimura M,Fujiwara K,Yada T,Tsukahara S,Kanamatsu T,Tanaka K,Ohki-Hamazaki H

    更新日期：2007-09-01 00:00:00

  • Novel endogenous 1,2,3,4-tetrahydroisoquinoline derivatives: uptake by dopamine transporter and activity to induce parkinsonism.

    abstract：:We designed as candidate metabolites and synthesized two 1-benzyl-1,2,3,4-tetrahydroisoquinoline derivatives containing a dopamine moiety: 1-(3',4'-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline (3',4'DHBnTIQ) and 1-benzyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (6,7DHBnTIQ). Both were detected in mouse brain as...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1998.70020745.x

    authors： Kawai H,Makino Y,Hirobe M,Ohta S

    更新日期：1998-02-01 00:00:00

  • Extracellular glutamate is increased in thalamus during thiamine deficiency-induced lesions and is blocked by MK-801.

    abstract：:The current study measured extracellular fluid (ECF) levels of excitatory amino acids before and during the onset of thiamine deficiency-induced pathologic lesions. Male Sprague-Dawley rats were treated with daily pyrithiamine (0.25 mg/kg i.p.) and a thiamine-deficient diet (PTD). Microdialysates were simultaneously c...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1993.tb07457.x

    authors： Langlais PJ,Zhang SX

    更新日期：1993-12-01 00:00:00

  • Fate of jimpy-type oligodendrocytes in jimpy heterozygote.

    abstract：:In the jimpy mutant mouse, as well as in many other animals with mutations in the myelin proteolipid protein (PLP) gene, oligodendrocytes degenerate before their maturation. To analyze whether this degeneration is caused by the loss of function of PLP gene products related to oligodendrocyte maturation/survival acting...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1994.62051887.x

    authors： Kagawa T,Nakao J,Yamada M,Shimizu K,Hayakawa T,Mikoshiba K,Ikenaka K

    更新日期：1994-05-01 00:00:00

  • Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1.

    abstract：:The FE65 adaptor protein family was identified in two-hybrid screens as proteins that bind the cytoplasmic domain of the amyloid precursor protein (APP). Studies have shown that FE65 binding to APP modulates APP processing. Increased levels of alpha-secretase derived secreted APP (APPsalpha) and beta-amyloid (Abeta) w...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.2002.01009.x

    authors： Guénette SY,Chang Y,Hyman BT,Tanzi RE,Rebeck GW

    更新日期：2002-08-01 00:00:00

  • L-3,4-dihydroxyphenylalanine-induced dopamine release in the striatum of intact and 6-hydroxydopamine-treated rats: differential effects of monoamine oxidase A and B inhibitors.

    abstract：:Administration of L-DOPA (50 mg/kg) elicits a significant increase in extracellular dopamine in striata of rats treated with the catecholaminergic neurotoxin 6-hydroxydopamine but not in striata of intact rats. To assess the role of dopaminergic nerve terminals in determining the effects of exogenous L-DOPA on extrace...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1994.63010108.x

    authors： Wachtel SR,Abercrombie ED

    更新日期：1994-07-01 00:00:00

  • Social isolation stress and chronic glutathione deficiency have a common effect on the glutamine-to-glutamate ratio and myo-inositol concentration in the mouse frontal cortex.

    abstract：:Environmental stress can interact with genetic predisposition to increase the risk of developing psychopathology. In this work, we tested the hypothesis that social isolation stress interacts with impaired glutathione synthesis and have cumulative effects on the neurochemical profile of the frontal cortex. A mouse mod...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.14116

    authors： Corcoba A,Gruetter R,Do KQ,Duarte JMN

    更新日期：2017-09-01 00:00:00

  • Ganglioside GM1 does not initiate, but enhances neurite regeneration of nerve growth factor-dependent sensory neurones.

    abstract：:An enzyme-linked immunoadsorbent assay (ELISA) for neurofilament protein was utilised to quantify the effect of exogenous ganglioside on neurite regeneration in cultures of dorsal root ganglion neurones. In contrast to nerve growth factor (NGF), ganglioside GM1 (100 micrograms/ml) failed to support neuronal survival a...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1985.tb08752.x

    authors： Doherty P,Dickson JG,Flanigan TP,Walsh FS

    更新日期：1985-04-01 00:00:00

  • Axon targeting of the alpha 7 nicotinic receptor in developing hippocampal neurons by Gprin1 regulates growth.

    abstract：:Cholinergic signaling plays an important role in regulating the growth and regeneration of axons in the nervous system. The α7 nicotinic receptor (α7) can drive synaptic development and plasticity in the hippocampus. Here, we show that activation of α7 significantly reduces axon growth in hippocampal neurons by coupli...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.12641

    authors： Nordman JC,Phillips WS,Kodama N,Clark SG,Del Negro CA,Kabbani N

    更新日期：2014-05-01 00:00:00

  • Inability of [125I]Sar1, Ile8-angiotensin II to move between the blood and cerebrospinal fluid compartments.

    abstract：:The angiotensin II competitive antagonist [125I]-Sar1, Ile8-angiotensin II was not transported from the vascular space to the cerebroventricular space in either intact or nephrectomized rats. In addition [125I]Sar1, Ile8-angiotensin II lacked the capacity to move in the opposite direction over a 20-min collection peri...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1988.tb02946.x

    authors： Harding JW,Sullivan MJ,Hanesworth JM,Cushing LL,Wright JW

    更新日期：1988-02-01 00:00:00

  • A novel diagnostic method to detect truncated neurofibromin in neurofibromatosis 1.

    abstract：:Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic condition caused by dominant loss-of-function mutations of the tumor suppressor gene NF1 that encodes neurofibromin, a negative regulator of RAS activity. Mutation analysis of NF1 located at 17q11.2 has been hampered by the large size of the gene, the hig...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.13396

    authors： Esposito T,Piluso G,Saracino D,Uccello R,Schettino C,Dato C,Capaldo G,Giugliano T,Varriale B,Paolisso G,Di Iorio G,Melone MA

    更新日期：2015-12-01 00:00:00

  • Drug testing complementary metal-oxide-semiconductor chip reveals drug modulation of transmitter release for potential therapeutic applications.

    abstract：:Neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, and Huntington's disease, are considered incurable and significantly reduce the quality of life of the patients. A variety of drugs that modulate neurotransmitter levels have been used for the treatment of the neurodegenerative diseases but ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.14815

    authors： Huang M,Rathore SS,Lindau M

    更新日期：2019-10-01 00:00:00

  • Phosphodiesterase isoform-specific expression induced by traumatic brain injury.

    abstract：:Traumatic brain injury (TBI) results in significant inflammation which contributes to the evolving pathology. Previously, we have demonstrated that cyclic AMP (cAMP), a molecule involved in inflammation, is down-regulated after TBI. To determine the mechanism by which cAMP is down-regulated after TBI, we determined wh...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.12049

    authors： Oliva AA Jr,Kang Y,Furones C,Alonso OF,Bruno O,Dietrich WD,Atkins CM

    更新日期：2012-12-01 00:00:00

  • Hyaluronidase inhibition accelerates functional recovery from stroke in the mouse brain.

    abstract：:Perineuronal nets (PNNs) are presumed to limit plasticity in adult animals. Ischaemic stroke results in the massive breakdown of PNNs resulting in rejuvenating states of neuronal plasticity, but the mechanisms of this phenomenon are largely unknown. As hyaluronic acid (HA) is the structural backbone of PNNs, we hypoth...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.15279

    authors： Katarzyna Greda A,Nowicka D

    更新日期：2020-12-20 00:00:00

  • The role of exercise in mitigating subcortical ischemic vascular cognitive impairment.

    abstract：:Subcortical ischemic vascular cognitive impairment (SIVCI) is the most preventable form of cognitive dysfunction. There is converging evidence from animal and human studies that indicate vascular injury as the primary cause of SIVCI. Currently, there are no curative pharmaceutical treatments for vascular dementia; how...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章,评审

    doi：10.1111/jnc.14153

    authors： Dao E,Hsiung GR,Liu-Ambrose T

    更新日期：2018-03-01 00:00:00

  • Glycogen synthase kinase 3β in the basolateral amygdala is critical for the reconsolidation of cocaine reward memory.

    abstract：:Exposure to cocaine-associated conditioned stimuli elicits craving and increases the probability of cocaine relapse in cocaine users even after extended periods of abstinence. Recent evidence indicates that cocaine seeking can be inhibited by disrupting the reconsolidation of the cocaine cue memories and that basolate...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2011.07277.x

    authors： Wu P,Xue YX,Ding ZB,Xue LF,Xu CM,Lu L

    更新日期：2011-07-01 00:00:00

  • Down-regulation of Bcl-2 and Bcl-xL expression with bispecific antisense treatment in glioblastoma cell lines induce cell death.

    abstract：:The functions of the antiapoptotic proteins Bcl-2 and Bcl-xL were examined in glioblastoma cells. Expression of both Bcl-2 and Bcl-xL were found to be elevated in protein lysates from seven early passage cell lines derived from human glioblastoma tumors compared with non-neoplastic glial cells. Down-regulation of both...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.2003.01522.x

    authors： Jiang Z,Zheng X,Rich KM

    更新日期：2003-01-01 00:00:00

  • Intra- and interchain disulfide bond generation in S100b protein.

    abstract：:Disulfide-bridged S100b protein formation, aircatalyzed and induced by thiol/disulfide exchange, was studied under various ionic conditions. As native, physiological disulfide-bridged proteins are obtained easily from their reduced counterparts under appropriate redox conditions, this work was performed to determine w...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1990.tb03111.x

    authors： Mely Y,Gérard D

    更新日期：1990-10-01 00:00:00

  • Increased AP-1 DNA binding activity in PC12 cells treated with lead.

    abstract：:The possibility that the mechanism of lead neurotoxicity may be at the level of transcription was investigated in PC12 cells. In electrophoretic mobility gel shift assays Pb2+ was found to increase activator protein-1 complex (AP-1) DNA binding activity in PC12 cells; the increase was time- and concentration-dependent...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1999.0730187.x

    authors： Chakraborti T,Kim KA,Goldstein GG,Bressler JP

    更新日期：1999-07-01 00:00:00

  • Solubilization of an adenosine uptake site in brain.

    abstract：:Procedures are described for the solubilization of adenosine uptake sites in guinea pig and rat brain tissue. Using [3H]nitrobenzylthioinosine [( 3H]NBI) the solubilized site is characterized both kinetically and pharmacologically. The binding is dependent on protein concentration and is saturable, reversible, specifi...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1985.tb04028.x

    authors： Verma A,Houston M,Marangos PJ

    更新日期：1985-08-01 00:00:00

  • Role of extracellular adenosine in ethanol-induced desensitization of cyclic AMP production.

    abstract：:The decrease in receptor-stimulated cyclic AMP production after chronic ethanol exposure was suggested previously to be secondary to an ethanol-induced increase in extracellular adenosine. The present study was undertaken to ascertain whether a similar mechanism was responsible for the ethanol-induced desensitization ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1993.tb03249.x

    authors： Rabin RA,Fiorella D,Van Wylen DG

    更新日期：1993-03-01 00:00:00

  • In vivo assessment of riluzole as a potential therapeutic drug for spinocerebellar ataxia type 3.

    abstract：:Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominantly inherited neurodegenerative disorder for which no curative therapy is available. The cause of this disease is the expansion of a CAG repeat in the so-called ATXN3 gene leading to an expanded polyglutamine stretch in the ataxin-3 protein. Although the func...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.13606

    authors： Schmidt J,Schmidt T,Golla M,Lehmann L,Weber JJ,Hübener-Schmid J,Riess O

    更新日期：2016-07-01 00:00:00

  • The picrotoxinin binding site and its relationship to the GABA receptor complex.

    abstract：:The binding characteristics of [3H] alpha-dihydropicrotoxinin to the picrotoxinin binding site were investigated in membrane preparations of adult rat forebrain and living cultures of rat cerebral cortex. The binding of [3H]alpha-dihydropicrotoxinin to rat forebrain was decreased by lysing, treating with Triton X-100,...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1985.tb12888.x

    authors： White WF,Snodgrass SR,Dichter MA

    更新日期：1985-03-01 00:00:00

  • Autophosphorylation of calmodulin-kinase II in synaptic junctions modulates endogenous kinase activity.

    abstract：:Previous studies have purified from brain a Ca2+/calmodulin-dependent protein kinase II (designated CaM-kinase II) that phosphorylates synapsin I, a synaptic vesicle-associated phosphoprotein. CaM-kinase II is composed of a major Mr 50K polypeptide and a minor Mr 60K polypeptide; both bind calmodulin and are phosphory...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1984.tb06084.x

    authors： Shields SM,Vernon PJ,Kelly PT

    更新日期：1984-12-01 00:00:00

  • The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?

    abstract：:EAAC1/EAAT3 is a transporter of glutamate (Glu) present at the post-synaptic neuronal element, in opposition to the two other main transporters, GLAST/EAAT1 and GLT1/EAAT2, expressed at the excitatory amino acid (EAA) synapse by surrounding astrocytes. Although, in the adult, EAAC1/EAAT3 exhibits a rather low expressi...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章,评审

    doi：10.1111/j.1471-4159.2006.03978.x

    authors： Nieoullon A,Canolle B,Masmejean F,Guillet B,Pisano P,Lortet S

    更新日期：2006-08-01 00:00:00

  • How is alpha-synuclein cleared from the cell?

    abstract：:The levels and conformers of alpha-synuclein are critical in the pathogenesis of Parkinson's Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation and secretion have been identified as regulators of alpha-synuclein at different stages of its intracellular trafficking and transcellular pr...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章,评审

    doi：10.1111/jnc.14704

    authors： Stefanis L,Emmanouilidou E,Pantazopoulou M,Kirik D,Vekrellis K,Tofaris GK

    更新日期：2019-09-01 00:00:00

  • Lipid metabolism during early stages of Wallerian degeneration in the rat sciatic nerve.

    abstract：:We examined changes in biosynthetic capacity of sciatic nerve during the early stages of Wallerian degeneration, utilizing a model that permits exclusion of nonresident cells from degenerating nerve. Sciatic nerve segments were placed in either 5-microns pore (allowing infiltration of nonresident cells) or 0.22-micron...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1989.tb01851.x

    authors： White FV,Toews AD,Goodrum JF,Novicki DL,Bouldin TW,Morell P

    更新日期：1989-04-01 00:00:00

  • Seasonal decrease in thermogenesis and increase in vasoconstriction explain seasonal response to N6 -cyclohexyladenosine-induced hibernation in the Arctic ground squirrel (Urocitellus parryii).

    abstract：:Hibernation is a seasonal phenomenon characterized by a drop in metabolic rate and body temperature. Adenosine A1 receptor agonists promote hibernation in different mammalian species, and the understanding of the mechanism inducing hibernation will inform clinical strategies to manipulate metabolic demand that are fun...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.14814

    authors： Frare C,Jenkins ME,McClure KM,Drew KL

    更新日期：2019-11-01 00:00:00