Abstract：
:In the jimpy mutant mouse, as well as in many other animals with mutations in the myelin proteolipid protein (PLP) gene, oligodendrocytes degenerate before their maturation. To analyze whether this degeneration is caused by the loss of function of PLP gene products related to oligodendrocyte maturation/survival acting extrinsically, expression of the PLP gene was investigated in the jimpy heterozygote, in which one-half of the cells are jimpy type and the other half are wild type due to random X-chromosome inactivation. We first showed that jimpy PLP gene expression is normally regulated at the early stages of development in brains of jimpy hemizygotes and heterozygotes, at least to day 2 after birth. However, the great increase in the level of PLP gene transcripts observed in wild-type mouse brain is suppressed in jimpy mouse brain. This increase was also suppressed in the jimpy heterozygote, and by 2 months after birth, very few jimpy-type PLP gene transcripts were detected in heterozygotes. These results indicate that jimpy-type oligodendrocytes cannot survive or are still in the immature stage in the brain of jimpy heterozygotes. Thus, degeneration of jimpy oligodendrocytes is not caused merely by the lack of trophic factors.
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
Kagawa T,Nakao J,Yamada M,Shimizu K,Hayakawa T,Mikoshiba K,Ikenaka Kdoi
10.1046/j.1471-4159.1994.62051887.xsubject
Has Abstractpub_date
1994-05-01 00:00:00pages
1887-93issue
5eissn
0022-3042issn
1471-4159journal_volume
62pub_type
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更新日期：1999-05-01 00:00:00
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doi：10.1111/j.1471-4159.1982.tb08650.x
更新日期：1982-02-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/j.1471-4159.1985.tb05551.x
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pub_type： 杂志文章
doi：10.1111/j.1471-4159.1982.tb08669.x
更新日期：1982-02-01 00:00:00
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journal_title：Journal of neurochemistry
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更新日期：1992-03-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/j.1471-4159.1985.tb05458.x
更新日期：1985-02-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
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更新日期：2015-05-01 00:00:00
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