Effects of free fatty acids on synaptosomal amino acid uptake systems.

Abstract:

:The Na+-dependent synaptosomal uptakes of proline, aspartic acid, glutamic acid, and gamma-aminobutyric acid were strong inhibited by monounsaturated fatty acids. With oleic acid, half-maximal inhibition was observed at about 15 microM. The Na+-independent uptakes of leucine, phenylalanine, histidine, and valine were less sensitive to inhibition by the unsaturated fatty acids. In contrast, the uptakes of all of these amino acids were unaffected by saturated fatty acids. The inhibition of proline uptake (and that of the other Na+-dependent amino acids) by oleic acid was overcome by the addition of serum albumin and the data presented further indicate that the previously reported stimulation of proline uptake by albumin could be related to its fatty acid binding properties.

journal_name

J Neurochem

authors

Rhoads DE,Kaplan MA,Peterson NA,Raghupathy E

doi

10.1111/j.1471-4159.1982.tb07898.x

subject

Has Abstract

pub_date

1982-05-01 00:00:00

pages

1255-60

issue

5

eissn

0022-3042

issn

1471-4159

journal_volume

38

pub_type

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