SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development.

abstract：:Some data on the concentration range of response and the concentration for half-response (EC50) of gamma-aminobutyric acid (GABA) for the GABAA receptor are reviewed and compared. An analysis of the 36Cl- flux assay demonstrates that both the EC50 and the slope of a Hill plot depend on the ion influx or efflux assay t...

journal_title：Journal of neurochemistry

authors： Kardos J,Cash DJ

更新日期：1990-10-01 00:00:00

abstract：:Because of the relative impermeability of the blood-brain barrier (BBB), many drugs are unable to reach the CNS in therapeutically relevant concentration. One method to deliver drugs to the CNS is the osmotic opening of the BBB using mannitol. Hyperosmotic mannitol induces a strong phosphorylation on tyrosine residues...

journal_title：Journal of neurochemistry

authors： Wilhelm I,Nagyoszi P,Farkas AE,Couraud PO,Romero IA,Weksler B,Fazakas C,Dung NT,Bottka S,Bauer H,Bauer HC,Krizbai IA

更新日期：2008-10-01 00:00:00

abstract：:The effect of docosahexaenoic acid (DHA) on neuronal survival was studied in cultured cells isolated from newborn rat retina. In vivo, the content of DHA in the retina increased nearly fourfold from days 2 to 12 after birth, whereas in retinal cells in culture it remained constant. Unlike amacrine cells, the photorece...

journal_title：Journal of neurochemistry

authors： Rotstein NP,Aveldaño MI,Barrantes FJ,Politi LE

更新日期：1996-05-01 00:00:00

abstract：:GABA(A) receptors are the major inhibitory neurotransmitter receptors in the brain. Some of them are targets of benzodiazepines that are widely used in clinical practice for their sedative/hypnotic, anxiolytic, muscle relaxant and anticonvulsant effects. In order to rationally separate these different drug actions, we...

journal_title：Journal of neurochemistry

authors： Tan KR,Baur R,Charon S,Goeldner M,Sigel E

更新日期：2009-12-01 00:00:00

abstract：:In the epididymal portion of rat vas deferens, facilitation of noradrenaline release mediated by adenosine A2A receptors, but not that mediated by beta2-adrenoceptors or by direct activation of adenylyl cyclase, was attenuated by blockade of alpha2-adrenoceptors and abolished by simultaneous blockade of alpha2-adrenoc...

journal_title：Journal of neurochemistry

authors： Queiroz G,Talaia C,Gonçalves J

更新日期：2003-05-01 00:00:00

abstract：:A simple radioenzymatic method for the determination of DOPA is described. The method is based on the conversion of DOPA to 3-O-[methyl-3H]DOPA by catechol-O-methyltransferase in the presence of S-adenosyl-[methyl-3H]methionine and purification of the labelled product by Sephadex G10 and Dowex 50 W x 4 ion exchange re...

journal_title：Journal of neurochemistry

authors： Argiolas A,Gessa GL

更新日期：1981-01-01 00:00:00

abstract：:The dose-dependent effects of two putative gamma-aminobutyric acid (GABA)-ergic agonists, muscimol and 4,5,6,7-tetrahydroisoxazolo(4,5-e)-pyridin-3-ol (THIP), upon local cerebral glucose utilisation in 60 discrete regions of the CNS have been examined in conscious rats using the [14C]2-deoxyglucose quantitative autora...

journal_title：Journal of neurochemistry

authors： Kelly PA,McCulloch J

更新日期：1982-09-01 00:00:00

abstract：:Glial uptake of neurotransmitter glutamate (GLU) from the extracellular fluid was studied in vivo in rat brain by (13)C NMR and microdialysis combined with gas-chromatography/mass-spectrometry. Brain GLU C5 was (13)C enriched by intravenous [2,5-(13)C]glucose infusion, followed by [(12)C]glucose infusion to chase (13)...

journal_title：Journal of neurochemistry

authors： Kanamori K,Ross BD,Kondrat RW

更新日期：2002-11-01 00:00:00

abstract：:L-glutamate (Glu) is the predominant excitatory neurotransmitter in the mammalian central nervous system. It plays major roles in normal neurophysiology and many brain disorders by binding to membrane-bound Glu receptors. To overcome the spatial and temporal limitations encountered in previous in vivo extracellular Gl...

journal_title：Journal of neurochemistry

authors： Day BK,Pomerleau F,Burmeister JJ,Huettl P,Gerhardt GA

更新日期：2006-03-01 00:00:00

abstract：:Changes in the activity of Na+,K+-ATPase and in the water, Na+, and K+ levels in the parietal cortex, hippocampus, and thalamus were investigated in rats 1, 3, 6, and 24 h following systemic kainic acid injection. An increase in Na+,K+-ATPase activity was observed in all three regions 3 h after the treatment, with a s...

journal_title：Journal of neurochemistry

authors： Sztriha L,Joó F,Dux L,Böti Z

更新日期：1987-07-01 00:00:00

abstract：:Choline acetyltransferase (ChAT), the enzyme synthesizing acetylcholine, is known to be activated by brain derived neurotrophic factor (BDNF). We found that the specific removal of the carbohydrate polysialic acid (PSA) significantly increased BDNF-induced ChAT-activity in embryonic septal neurons. Using a p75 neurotr...

journal_title：Journal of neurochemistry

authors： Burgess A,Aubert I

更新日期：2006-11-01 00:00:00

abstract：:Parkinson's disease is a debilitating neurodegenerative disease characterized by loss of midbrain dopaminergic neurons. These neurons are particularly sensitive to the neurotoxin 1-methyl-4-phenylpyridinium (MPP+), the active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which causes parkinsonian ...

journal_title：Journal of neurochemistry

authors： Chu CT,Zhu JH,Cao G,Signore A,Wang S,Chen J

更新日期：2005-09-01 00:00:00

abstract：:The ability of cholinergic vesicles to incorporate acetylcholine (ACh) was studied using highly purified synaptic vesicles from Torpedo electric organ. Depleted vesicles were capable of rapidly taking up exogenous ACh. Evidence that this represented true incorporation was that labelled ACh comigrated with vesicular AT...

journal_title：Journal of neurochemistry

authors： Diebler MF,Morot-Gaudry Y

更新日期：1981-08-01 00:00:00

abstract：:The subcellular distribution of the ectoenzyme, 5'-nucleotidase, in cerebral cortex and cerebellum of the rat was studied both biochemically and cytochemically. The fractions were characterized biochemically by marker enzymes. The localization of 5'-nucleotidase activity was also investigated cytochemically in the mye...

journal_title：Journal of neurochemistry

authors： Heymann D,Reddington M,Kreutzberg GW

更新日期：1984-10-01 00:00:00

abstract：:Guanidino compounds in CSF of 57 human subjects were determined fluorometrically after reaction with phenanthrenequinone in alkali solution, using HPLC. Creatinine (65.2 +/- 13.4 nmol/ml), arginine (24.7 +/- 6.4 nmol/ml), and homoarginine (0.7 +/- 0.3 nmol/ml) were found in all subjects. Trace amounts of guanidinosucc...

journal_title：Journal of neurochemistry

authors： Mori A,Watanabe Y,Fujimoto N

更新日期：1982-02-01 00:00:00

abstract：:The neuronal protein B-50 may be involved in diverse functions including neural development, axonal regeneration, neural plasticity, and synaptic transmission. The rat B-50 sequence contains 226 amino acids which include 14 Ser and 14 Thr residues, all putative sites for phosphorylation by calcium/phospholipid-depende...

journal_title：Journal of neurochemistry

authors： Coggins PJ,Zwiers H

更新日期：1989-12-01 00:00:00

abstract：:Tachykinins play an important role in peripheral inflammatory diseases and disorders of the CNS. Most members of the tachykinin family are generated by alternative post-transcriptional splicing of the prepro-tachykinin (PPT) A gene. Here, we examined the simultaneous expression of PPT-A splice variants in individual n...

journal_title：Journal of neurochemistry

authors： Springer J,McGregor GP,Fink L,Fischer A

更新日期：2003-05-01 00:00:00

abstract：:We investigated the receptor mechanisms by which vasoactive intestinal polypeptide (VIP) and related peptides exert their effects on tyrosine hydroxylase (TH) gene expression. VIP, secretin, and peptide histidine isoleucine (PHI) each produced increases in TH gene expression, as measured by increases in TH mRNA levels...

journal_title：Journal of neurochemistry

authors： Wessels-Reiker M,Basiboina R,Howlett AC,Strong R

更新日期：1993-03-01 00:00:00

abstract：:1-[2-(4-Aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (PAPP) inhibits [3H]5-hydroxytryptamine (5-HT, serotonin) binding to 5-HT1A and 5-HT1B sites in rat brain with apparent equilibrium dissociation constants (KD) of 2.9 and 328 nM, respectively. [3H]PAPP was synthesized, its binding to central serotonin re...

journal_title：Journal of neurochemistry

authors： Ransom RW,Asarch KB,Shih JC

更新日期：1986-01-01 00:00:00

abstract：:The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain. Rats were treated intraperitoneally, with gabapentin (30, 100 and 300 mg/kg), lamotrigine (2, 10 and 50 mg/kg) or riluzole (6 and 12 mg/kg) prior to, and eve...

journal_title：Journal of neurochemistry

authors： Coderre TJ,Kumar N,Lefebvre CD,Yu JS

更新日期：2007-03-01 00:00:00

abstract：:Myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP) have been implicated in membrane-cytoskeletal events underlying cell adhesion, migration, secretion, and phagocytosis. In BV-2 microglial cells, lipopolysaccharide (LPS) elicited a dose-dependent increase in mRNA of both MRP (sixfo...

journal_title：Journal of neurochemistry

authors： Sunohara JR,Ridgway ND,Cook HW,Byers DM

更新日期：2001-08-01 00:00:00

abstract：:Prospective studies in humans and experimental investigations in animals have correlated elevated perinatal blood lead levels with enduring behavioural and cognitive perturbations. Although deficits in neuroplastic events necessary for long-term memory consolidation have been observed during the postnatal period, ther...

journal_title：Journal of neurochemistry

authors： Murphy KJ,Regan CM

更新日期：1999-05-01 00:00:00

abstract：:As the leading genetic cause for infantile death, Spinal Muscular Atrophy (SMA) has been extensively studied since its first description in the early 1890s. Though today much is known about the cause of the disease, a cure or effective treatment is not currently available. Recently the short chain fatty acid valproic ...

journal_title：Journal of neurochemistry

authors： Lunke S,El-Osta A

更新日期：2009-06-01 00:00:00

abstract：:Developmental profiles were determined for the activities of eight enzymes involved in fatty acid beta-oxidation in rat brain. The enzymes studied were the palmitoyl-CoA, octanoyl-CoA, butyryl-CoA, glutaryl-CoA, and 3-hydroxyacyl-CoA dehydrogenases, the enoyl-CoA hydratase (crotonase), and the C4- and C10-thiolases. W...

journal_title：Journal of neurochemistry

authors： Reichmann H,Maltese WA,DeVivo DC

更新日期：1988-08-01 00:00:00

abstract：:Cannabinoid receptors and the endocannabinoids anandamide and 2-arachidonoylglycerol have been suggested to regulate food intake in several animal phyla. Orthologs of the mammalian cannabinoid CB(1) and CB(2) receptors have been identified in fish. We investigated the presence of this endocannabinoid system in the bra...

journal_title：Journal of neurochemistry

authors： Valenti M,Cottone E,Martinez R,De Pedro N,Rubio M,Viveros MP,Franzoni MF,Delgado MJ,Di Marzo V

更新日期：2005-11-01 00:00:00

abstract：:The protein kinase v-akt murine thymoma viral oncogene homolog (AKT) gene family comprises three human homologs that phosphorylate and inactivate glycogen synthase kinase 3beta (GSK3beta). Studies have reported the genetic association of AKT1 with schizophrenia. Additionally, decreased AKT1 protein expression and the ...

journal_title：Journal of neurochemistry

authors： Ide M,Ohnishi T,Murayama M,Matsumoto I,Yamada K,Iwayama Y,Dedova I,Toyota T,Asada T,Takashima A,Yoshikawa T

更新日期：2006-10-01 00:00:00

abstract：:Nerve growth factor (NGF) plays a key role in the differentiation of neurons. In this study, we established three NGF-induced neurite-positive (NIN+) subclones that showed high responsiveness to NGF-induced neurite outgrowth and three NGF-induced neurite-negative (NIN-) subclones that abolished NGF-induced neurite out...

journal_title：Journal of neurochemistry

authors： Oe T,Sasayama T,Nagashima T,Muramoto M,Yamazaki T,Morikawa N,Okitsu O,Nishimura S,Aoki T,Katayama Y,Kita Y

更新日期：2005-09-01 00:00:00

abstract：:Calcium-activated neutral proteases (calpains) are regulated by specific endogenous protein inhibitors, the calpastatins, which are widely distributed in mammalian tissues. Calpastatins from different species or in various tissues from the same species exhibit considerable size heterogeneity on sodium dodecyl sulfate ...

journal_title：Journal of neurochemistry

authors： Mohan PS,Nixon RA

更新日期：1995-02-01 00:00:00

abstract：:Activation of microglia, the resident macrophages of the brain, around the amyloid plaques is a key hallmark of Alzheimer's disease (AD). Recent evidence in mouse models indicates that microglia are required for the neurodegenerative process of AD. Amyloid-β (Aβ) peptides, the core components of the amyloid plaques, c...

journal_title：Journal of neurochemistry

authors： Capiralla H,Vingtdeux V,Zhao H,Sankowski R,Al-Abed Y,Davies P,Marambaud P

更新日期：2012-02-01 00:00:00

abstract：:Both acidosis and oxidative stress contribute to ischemic brain injury. The present study examines interactions between acidosis and oxidative stress in murine cortical cultures. Acidosis (pH 6.2) was found to potentiate markedly neuronal death induced by H2O2 exposure. To determine if this effect was mediated by decr...

journal_title：Journal of neurochemistry

authors： Ying W,Han SK,Miller JW,Swanson RA

更新日期：1999-10-01 00:00:00