Transmembrane 36Cl- flux measurements and desensitization of the gamma-aminobutyric acidA receptor.

abstract：:5-Hydroxytryptamine2 (5-HT2) receptor antagonists have been shown to interfere with the stimulation of striatal dopamine synthesis and release produced by the amphetamine analogue 3,4-methylenedioxymethamphetamine (MDMA). To localize the receptors responsible for the attenuation of MDMA-induced release, 5-HT2 receptor...

journal_title：Journal of neurochemistry

authors： Schmidt CJ,Sullivan CK,Fadayel GM

更新日期：1994-04-01 00:00:00

abstract：:The alkylating agent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) is a peptide-coupling agent that is being used to inactivate irreversibly alpha 2-adrenoceptors and other receptors. The aim of the present study was to assess the in vitro and in vivo effects of EEDQ on the newly discovered brain I2-imidazolin...

journal_title：Journal of neurochemistry

authors： Miralles A,Ribas C,Olmos G,García-Sevilla JA

更新日期：1993-11-01 00:00:00

abstract：:Microglial activation by blood-borne factors following blood-brain barrier damage may play a significant role in subsequent neuropathogenesis of several neurodegenerative diseases. Exposure of primary cultured rat brain microglia to pure, fatty acid- and lipid-deficient rat serum albumin or fraction V, (fatty acid and...

journal_title：Journal of neurochemistry

authors： Hooper C,Pinteaux-Jones F,Fry VA,Sevastou IG,Baker D,Heales SJ,Pocock JM

更新日期：2009-05-01 00:00:00

abstract：:Accumulations of the neuropeptides substance P (SP), somatostatin (ST), and vasoactive intestinal polypeptide (VIP) proximal to a crush in the cervical vagus nerve of the rat have been measured using sensitive radioimmunoassays. Each of the peptides was rapidly transport towards the peripheral terminals of vagal affer...

journal_title：Journal of neurochemistry

authors： Gilbert RF,Emson PC,Fahrenkrug J,Lee CM,Penman E,Wass J

更新日期：1980-01-01 00:00:00

abstract：:Most neurodegenerative disorders (NDDs) are characterized by cognitive impairment and other neurological defects. The definite cause of and pathways underlying the progression of these NDDs are not well-defined. Several mechanisms have been proposed to contribute to the development of NDDs. These mechanisms may procee...

journal_title：Journal of neurochemistry

authors： Basavarajappa BS,Shivakumar M,Joshi V,Subbanna S

更新日期：2017-09-01 00:00:00

abstract：:The subcellular localization of organelles, mRNAs and proteins is particularly challenging in neurons. Owing to their extended morphology, with axons in humans exceeding a meter in length, in addition to which they are not renewed but persist for the entire lifespan, it is no surprise that neurons are highly vulnerabl...

journal_title：Journal of neurochemistry

authors： Götz J,Ittner LM,Kins S

更新日期：2006-08-01 00:00:00

abstract：:Epidermal growth factor (EGF) is a member of a structurally related family containing heparin-binding EGF-like growth factor (HB-EGF) and transforming growth factor alpha (TGFalpha) that exerts neurotrophic activity on midbrain dopaminergic neurons. To examine neurotrophic abnormality in Parkinson's disease (PD), we m...

journal_title：Journal of neurochemistry

authors： Iwakura Y,Piao YS,Mizuno M,Takei N,Kakita A,Takahashi H,Nawa H

更新日期：2005-05-01 00:00:00

abstract：:The present study aimed to examine the proteins involved in the methamphetamine (MA)-induced nigrostriatal dopaminergic toxicity. Infusion of anisomycin into striatum and substantia nigra both abolished the MA-induced striatal dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) depletions, indicating a critical role ...

journal_title：Journal of neurochemistry

authors： Liao PC,Kuo YM,Hsu HC,Cherng CG,Yu L

更新日期：2005-10-01 00:00:00

abstract：:Postmortem changes in catecholamines, indoleamines, and their metabolites in rat brain regions following decapitation were determined by LCEC. In the three regions studied neurotransmitter levels declined after decapitation, whereas the metabolite levels increased. Microwave irradiation at 10 kW rapidly inactivated br...

journal_title：Journal of neurochemistry

authors： Ikarashi Y,Sasahara T,Maruyama Y

更新日期：1985-09-01 00:00:00

abstract：:In the sympatho-adrenal system, angiotensin II (Ang II) acts as a key neuromodulatory component. At sympathetic nerve terminals, Ang II influences sympathetic transmission by enhancing norepinephrine (NE) synthesis, facilitating NE release and inhibiting NE uptake. Previously, it was demonstrated that tyrosine hydroxy...

journal_title：Journal of neurochemistry

authors： Aschrafi A,Berndt A,Kowalak JA,Gale JR,Gioio AE,Kaplan BB

更新日期：2019-09-01 00:00:00

abstract：:The effects of muscarinic agonists and depolarizing agents on inositol phospholipid hydrolysis in the rabbit vagus nerve were assessed by the measurement of [3H]inositol monophosphate production in nerves that had been preincubated with [3H]inositol. After 1 h of drug action, carbachol, oxotremorine, and arecoline inc...

journal_title：Journal of neurochemistry

authors： Sierro CD,Vitus J,Dunant Y

更新日期：1992-08-01 00:00:00

abstract：:The zebrafish, long recognized as a model organism for the analysis of basic developmental processes, is now also emerging as an alternative animal model for human diseases. This review will first provide an overview of the particular characteristics of zebrafish in general and their dopaminergic nervous system in par...

journal_title：Journal of neurochemistry

authors： Flinn L,Bretaud S,Lo C,Ingham PW,Bandmann O

更新日期：2008-09-01 00:00:00

abstract：:Presynaptic modulation of synaptic transmission is the primary function of central nicotinic acetylcholine receptors (nAChRs) in developing and adult brain. nAChR activation regulates release of various neurotransmitters, including norepinephrine (NA). Given evidence that NA may serve a critical functional role in cer...

journal_title：Journal of neurochemistry

authors： O'Leary KT,Leslie FM

更新日期：2003-03-01 00:00:00

abstract：:We have analyzed brain coated vesicles and synaptic plasma membrane for the presence of the plasma membrane proteolipid protein. Coated vesicles were isolated from calf brain gray matter with a final purification on Sephacryl S-1000 and reisolated twice by chromatography to ensure homogeneity. Fractions were analyzed ...

journal_title：Journal of neurochemistry

authors： Sapirstein VS,Nolan C,Stern R,Ciocci M,Masur SK

更新日期：1988-09-01 00:00:00

abstract：:The serotonin 5-HT3 receptor, a ligand-gated ion channel, has previously been shown to be present on a subpopulation of brain nerve terminals, where, on activation, the 5-HT3 receptors induce Ca2+ influx. Whereas postsynaptic 5-HT3 receptors induce depolarization, being permeant to Na+ and K+, the basis of presynaptic...

journal_title：Journal of neurochemistry

authors： Rondé P,Nichols RA

更新日期：1998-03-01 00:00:00

abstract：:A neutral, mannose-rich, concanavalin A (Con A)-binding glycopeptide fraction was obtained by proteolytic digestion of defatted beef brain tissue. Hydrazinolysis followed by gel filtration of the reaction products provided three oligosaccharides. A portion of each oligosaccharide was treated by exhaustive digestion wi...

journal_title：Journal of neurochemistry

authors： Somawardhana CW,Brunngraber EG

更新日期：1983-08-01 00:00:00

abstract：:Modulation of acetylcholine (ACh) release from superfused hippocampal slices was examined when the release of ACh was stimulated by exposure of slices to elevated K+ concentration. Evoked release was not sensitive to inhibition by 0.1 microM tetrodotoxin, but it could be inhibited in a dose-dependent manner by a musca...

journal_title：Journal of neurochemistry

authors： Benishin CG

更新日期：1990-12-01 00:00:00

abstract：:Astrocytes have important roles in control of extracellular environment, de novo synthesis of neurotransmitters, and regulation of neurotransmission and blood flow. All of these functions require energy, suggesting that astrocytic metabolism should rise and fall with changes in neuronal activity and that brain imaging...

journal_title：Journal of neurochemistry

authors： Dienel GA,Schmidt KC,Cruz NF

更新日期：2007-11-01 00:00:00

abstract：:Hyperglycemia is known to induce microvascular complications, thereby altering blood-brain barrier (BBB) permeability. This study investigated the role of matrix metalloproteinases (MMPs) and their endogenous inhibitors in increased BBB permeability and evaluated the protective effect of S-nitrosoglutathione (GSNO) in...

journal_title：Journal of neurochemistry

authors： Aggarwal A,Khera A,Singh I,Sandhir R

更新日期：2015-03-01 00:00:00

abstract：:A reversed-phase HPLC system was used to concentrate and separate components of substance P-like immunoreactivity (SP-LI) from human CSF. When CSF was injected and fractions collected, no SP-LI could be detected by radioimmunoassay (RIA) at the retention time of SP or SP-sulfoxide. Instead, SP-LI was detected in later...

journal_title：Journal of neurochemistry

authors： Toresson G,Brodin E,Wahlström A,Bertilsson L

更新日期：1988-06-01 00:00:00

abstract：:Parkinson's disease is a common neurodegenerative disorder with a mainly sporadic aetiology, although a number of monogenic familiar forms are known. Most of the motor symptoms are due to selective depletion of dopaminergic, neuromelanin-containing neurones of the substantia nigra pars compacta. Neuromelanin is the da...

journal_title：Journal of neurochemistry

authors： Fasano M,Bergamasco B,Lopiano L

更新日期：2006-02-01 00:00:00

abstract：:Tau pathologically aggregates in Alzheimer's disease, and evidence suggests that reducing tau expression may be safe and beneficial for the prevention or treatment of this disease. We sought to examine the role of the 3'-untranslated region (3'-UTR) of human tau mRNA in regulating tau expression. Tau expresses two 3'-...

journal_title：Journal of neurochemistry

authors： Dickson JR,Kruse C,Montagna DR,Finsen B,Wolfe MS

更新日期：2013-12-01 00:00:00

abstract：:The effect of thyroid hormones (THs) on the expression of actin gene during fetal human brain development and the period of sensitivity to the hormones have been investigated. Developmental profile of actin in the cytoskeletal (CSK) and noncytoskeletal (non-CSK) fractions in the fetal cerebra showed a pronounced rise ...

journal_title：Journal of neurochemistry

authors： Pal U,Biswas SC,Sarkar PK

更新日期：1997-09-01 00:00:00

abstract：:After traumatic brain injury, progesterone has important neuroprotective effects in the nervous system. There is better functional outcome and less oedema formation in pseudopregnant rat females (high levels of endogenous progesterone) than in males. In addition to intracellular progesterone receptors, membrane bindin...

journal_title：Journal of neurochemistry

authors： Meffre D,Delespierre B,Gouézou M,Leclerc P,Vinson GP,Schumacher M,Stein DG,Guennoun R

更新日期：2005-06-01 00:00:00

abstract：:The effect of glucose concentration on the in vitro release of histamine (HA) was examined, using two different preparations of the mouse hypothalamus. The HA and tele-methylhistamine released from whole blocks of the hypothalamus into the medium linearly increased during 2-h incubation in normal Krebs-Ringer bicarbon...

journal_title：Journal of neurochemistry

authors： Nishibori M,Oishi R,Itoh Y,Saeki K

更新日期：1986-12-01 00:00:00

abstract：:A new protein kinase modulated by S-100 (tentatively referred to as protein kinase X) was partially purified from pig brain extracts. The activity of protein kinase X, which was independent of Ca2+, was demonstrated when protamine (free base), but not protamine sulfate and other proteins (including histone), was used ...

journal_title：Journal of neurochemistry

authors： Qi DF,Turner RS,Kuo JF

更新日期：1984-02-01 00:00:00

abstract：:The mu-opioid receptor agonists have a preferential effect on nociception in adults but their analgesic effect is less selective in neonates. Here we presented our finding that the mu-opioid receptor agonists had no effect on high voltage-activated Ca(2+) channels (HVACCs) in adult dorsal root ganglion (DRG) neurons t...

journal_title：Journal of neurochemistry

authors： Wu ZZ,Cai YQ,Pan HL

更新日期：2009-05-01 00:00:00

abstract：:Lactoferrin (Lf) is an iron-binding protein involved in host defense against infection and severe inflammation, which accumulates in the brain during neurodegenerative disorders. Prior to determining Lf function in pathological brain tissues, we investigated its transport through the blood-brain barrier (BBB) in infla...

journal_title：Journal of neurochemistry

authors： Fillebeen C,Dehouck B,Benaïssa M,Dhennin-Duthille I,Cecchelli R,Pierce A

更新日期：1999-12-01 00:00:00

abstract：:Alzheimer's disease (AD) belongs to one of the most multifactorial, complex and heterogeneous morbidity-leading disorders. Despite the extensive research in the field, AD pathogenesis is still at some extend obscure. Mechanisms linking AD with certain comorbidities, namely diabetes mellitus, obesity and dyslipidemia, ...

journal_title：Journal of neurochemistry

authors： Nday CM,Eleftheriadou D,Jackson G

更新日期：2018-02-01 00:00:00

abstract：:Pilocarpine-induced seizures are mediated by the M(1) subtype of muscarinic acetylcholine receptor (mAChR), but little is known about the signaling mechanisms linking the receptor to seizures. The extracellular signal-regulated kinase (ERK) signaling cascade is activated by M(1) mAChR and is elevated during status epi...

journal_title：Journal of neurochemistry

authors： Berkeley JL,Decker MJ,Levey AI

更新日期：2002-07-01 00:00:00