Endocannabinoid system in neurodegenerative disorders.

abstract：:Lumbar punctures were performed on four occasions over a 5-day period (8:30 a.m. on days 1, 3, and 5; 2:30 p.m. on day 2) on 10 normal volunteers (five of each sex; mean age, 27.7 years) to assess, with repeated sampling, the day-to-day variation of selected CSF parameters. Two subjects abstained from the lumbar punct...

journal_title：Journal of neurochemistry

authors： Ben Menachem E,Persson L,Schechter PJ,Haegele KD,Huebert N,Hardenberg J

更新日期：1989-02-01 00:00:00

abstract：:Neuroimage analysis in alcoholic corpus callosum (CC) suggests that microstructural abnormalities are higher in the genu followed by the body and the splenium. Molecular mechanisms underlying these dysmorphologys are still unclear. Protein expression was performed using the CC body samples [(nine controls, seven uncom...

journal_title：Journal of neurochemistry

authors： Kashem MA,Etages HD,Kopitar-Jerala N,McGregor IS,Matsumoto I

更新日期：2009-07-01 00:00:00

abstract：:Peroxynitrite, the product of the radical-radical reaction between nitric oxide and superoxide anion, is a potent oxidant involved in tissue damage in neurodegenerative disorders. We investigated the modifications induced by peroxynitrite in tyrosine residues of proteins from synaptosomes. Peroxynitrite treatment (> o...

journal_title：Journal of neurochemistry

authors： Di Stasi AM,Mallozzi C,Macchia G,Petrucci TC,Minetti M

更新日期：1999-08-01 00:00:00

abstract：:The capacity of D1 and D2 agonists and antagonists to regulate the in vivo release and metabolism of dopamine (DA) in mesolimbic and nigrostriatal DA neurons of the mouse was determined using gas chromatographic and mass fragmentographic (GC-MF) analysis. DA release was inferred from levels of 3-methoxytyramine (3-MT)...

journal_title：Journal of neurochemistry

authors： Boyar WC,Altar CA

更新日期：1987-03-01 00:00:00

abstract：:We have identified and cataloged 54 genes that exhibit predominant expression in the striatum. Our hypothesis is that such mRNA molecules are likely to encode proteins that are preferentially associated with particular physiological processes intrinsic to striatal neurons, and therefore might contribute to the regiona...

journal_title：Journal of neurochemistry

authors： Desplats PA,Kass KE,Gilmartin T,Stanwood GD,Woodward EL,Head SR,Sutcliffe JG,Thomas EA

更新日期：2006-02-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) has central functions in development, tissue maintenance, and repair and has been implicated in major diseases. We discovered that TGF-beta1 contains several amphipathic helices and hydrophobic domains similar to apolipoprotein E (apoE), a protein involved in lipoprotein me...

journal_title：Journal of neurochemistry

authors： Tesseur I,Zhang H,Brecht W,Corn J,Gong JS,Yanagisawa K,Michikawa M,Weisgraber K,Huang Y,Wyss-Coray T

更新日期：2009-08-01 00:00:00

abstract：:[3H]Cocaine dissociates from its binding sites in the mouse cerebral cortex with a half-time of 25 s. The dissociation kinetics in the striatum is consonant with the presence of two populations of sites with dissociation half times of 2 s and 27 s, comprising 88% and 12%, respectively, of the total binding sites. On t...

journal_title：Journal of neurochemistry

authors： Reith ME,Sershen H,Lajtha A

更新日期：1986-01-01 00:00:00

abstract：:The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain. Rats were treated intraperitoneally, with gabapentin (30, 100 and 300 mg/kg), lamotrigine (2, 10 and 50 mg/kg) or riluzole (6 and 12 mg/kg) prior to, and eve...

journal_title：Journal of neurochemistry

authors： Coderre TJ,Kumar N,Lefebvre CD,Yu JS

更新日期：2007-03-01 00:00:00

abstract：:Evidence that glucagon-like peptide-1 (GLP-1) (7-36) amide functions as a novel neuropeptide prompted us to study the gene expression of its receptor in rat brain. Northern blot analysis showed transcripts of similar size in RINm5F cells, hypothalamus, and brain-stem. First-strand cDNA was prepared by using RNA from h...

journal_title：Journal of neurochemistry

authors： Alvarez E,Roncero I,Chowen JA,Thorens B,Blázquez E

更新日期：1996-03-01 00:00:00

abstract：:Gamma-Aminobutyric acid (GABA) was taken up by a MgATP-dependent mechanism into synaptic vesicles isolated by hypoosmotic shock and density gradient centrifugation. The properties of the vesicular uptake differed clearly from those of synaptosomal and glial uptake, both with respect to Na+, Mg2+, and ATP dependence an...

journal_title：Journal of neurochemistry

authors： Fykse EM,Fonnum F

更新日期：1988-04-01 00:00:00

abstract：:The effectiveness of intranasal drug administration to stimulate central neuronal systems is well known from drug addiction and has also been considered as an alternative pharmacokinetic approach to treat brain disorders such as Parkinson's disease. In the present study, the possible neurochemical effects of intranasa...

journal_title：Journal of neurochemistry

authors： De Souza Silva MA,Mattern C,Häcker R,Nogueira PJ,Huston JP,Schwarting RK

更新日期：1997-01-01 00:00:00

abstract：:Diabetic retinopathy (DR) is one of the common complications associated with diabetes mellitus and the leading cause of blindness worldwide. Recent research has demonstrated that DR is not only a microvascular disease but may be a result of neurodegenerative processes. Moreover, glucose-induced neuron and glial cell d...

journal_title：Journal of neurochemistry

authors： Zorrilla-Zubilete MA,Yeste A,Quintana FJ,Toiber D,Mostoslavsky R,Silberman DM

更新日期：2018-01-01 00:00:00

abstract：:The dopamine transporter is a plasma membrane protein that controls extracellular concentrations of the neurotransmitter dopamine. The physiological importance of the DAT provides the impetus for studies aimed at understanding the molecular mechanisms underlying regulation of the DAT gene. In this study, we identified...

journal_title：Journal of neurochemistry

authors： Wang J,Bannon MJ

更新日期：2005-04-01 00:00:00

abstract：:The development of the specific binding sites for L-[3H]glutamic acid (KD = 370 nM) and for [3H]kainic acid (KD = 39 nM) was studied in the rat cerebellum. Specific binding at both sites remains low during the first week after birth but increases markedly during the second and third weeks after birth, when glutamaterg...

journal_title：Journal of neurochemistry

authors： Slevin JT,Coyle JT

更新日期：1981-08-01 00:00:00

abstract：:Neurofilament proteins (Nf) are a biomarker of disease progression in amyotrophic lateral sclerosis (ALS). This study investigated whether there are major differences in expression from in vivo measurements of neurofilament isoforms, from the light chain, NfL (68 kDa), compared with larger proteins, the medium chain (...

journal_title：Journal of neurochemistry

authors： Zucchi E,Lu CH,Cho Y,Chang R,Adiutori R,Zubiri I,Ceroni M,Cereda C,Pansarasa O,Greensmith L,Malaspina A,Petzold A

更新日期：2018-09-01 00:00:00

abstract：:The cDNA for Tyr-Loc, a G protein-coupled receptor that clearly shows homology to a number of mammalian and fruit fly receptors for biogenic amines, was cloned from the nervous system of Locusta migratoria. Functional expression of the cloned cDNA was obtained in cultured insect cells, i.e., in Spodoptera SF9 cells us...

journal_title：Journal of neurochemistry

authors： Vanden Broeck J,Vulsteke V,Huybrechts R,De Loof A

更新日期：1995-06-01 00:00:00

abstract：:We sought to investigate whether dexamethasone produces a coordinated, time-dependent effect on all enzymes in the catecholamine biosynthetic pathway in PC12 cells. The levels of mRNAs of tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC), and dopamine beta-hydroxylase (DBH) were examined at 0, 6, 1...

journal_title：Journal of neurochemistry

authors： Kim KT,Park DH,Joh TH

更新日期：1993-03-01 00:00:00

abstract：:Neuropeptide Y (NPY) is an important regulator of energy balance in mammals through its orexigenic, antithermogenic, and insulin secretagogue actions. We investigated the regulation of endogenous NPY release from rat hypothalamic slices by NPY receptor ligands and calcium channel antagonists. High-potassium stimulatio...

journal_title：Journal of neurochemistry

authors： King PJ,Widdowson PS,Doods HN,Williams G

更新日期：1999-08-01 00:00:00

abstract：:Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is responsible for the production of PGD(2), the main PG in the CNS. PGD(2) is an endogenous sleep inducer, and it is involved in the control of odor and pain responses and body temperature. In addition, PGD synthase transports lipophilic molecules in the subarachn...

journal_title：Journal of neurochemistry

authors： García-Fernández LF,Iñiguez MA,Eguchi N,Fresno M,Urade Y,Muñoz A

更新日期：2000-08-01 00:00:00

abstract：:Glutamate or a related excitatory amino acid is thought to be the major excitatory neurotransmitter of hippocampal afferents, intrinsic neurons, and efferents. We have used an autoradiographic technique to investigate the status of excitatory amino acid receptors in the hippocampal formation of patients dying with dem...

journal_title：Journal of neurochemistry

authors： Greenamyre JT,Penney JB,D'Amato CJ,Young AB

更新日期：1987-02-01 00:00:00

abstract：:We have investigated the transport characteristics of dehydroepiandrosterone sulfate (DHEAS), a neuroactive steroid, at the blood-brain barrier (BBB) in a series of functional in vivo and in vitro studies. The apparent BBB efflux rate constant of [(3)H]DHEAS evaluated by the brain efflux index method was 2.68 x 10(-2)...

journal_title：Journal of neurochemistry

authors： Asaba H,Hosoya K,Takanaga H,Ohtsuki S,Tamura E,Takizawa T,Terasaki T

更新日期：2000-11-01 00:00:00

abstract：:Administration of L-DOPA is commonly used to treat Parkinson's disease, yet controversy continues as to whether the dopamine arising from it aggravates neuronal loss. Several authors have reported cytotoxic effects of L-DOPA and dopamine on cultured cells, but others have not. In this report using the rat pheochromocy...

journal_title：Journal of neurochemistry

authors： Clement MV,Long LH,Ramalingam J,Halliwell B

更新日期：2002-05-01 00:00:00

abstract：:Phospholipids are asymmetrically distributed across the mammalian plasma membrane, with phosphatidylserine (PS) and phosphatidylethanolamine concentrated in the cytoplasmic leaflet of the membrane bilayer and phosphatidylcholine in the exoplasmic leaflet. This asymmetric distribution is dependent on a group of P4 ATPa...

journal_title：Journal of neurochemistry

authors： Yang Y,Liu W,Sun K,Jiang L,Zhu X

更新日期：2019-02-01 00:00:00

abstract：:The distributions of glutamate decarboxylase (EC 4.1.1.15), gamma-aminobutyric acid transaminase (EC 2.6.1.19), and succinate semialdehyde dehydrogenase (EC 1.2.1.24) were determined in monkey retina. The decarboxylase was almost restricted to the inner plexiform layer. The transaminase was also highest in this layer,...

journal_title：Journal of neurochemistry

authors： Pusateri ME,Carter JG,Berger SJ,Lowry OH

更新日期：1984-05-01 00:00:00

abstract：:The activation of the inflammatory/immunological response system is suggested to be related to the pathophysiology of schizophrenia. Aripiprazole is a novel atypical antipsychotic, which is a high-affinity dopamine D(2) receptor partial agonist. Atypical antipsychotics, all of which have dopamine D(2) receptor antagon...

journal_title：Journal of neurochemistry

authors： Kato T,Mizoguchi Y,Monji A,Horikawa H,Suzuki SO,Seki Y,Iwaki T,Hashioka S,Kanba S

更新日期：2008-07-01 00:00:00

abstract：:Monoamine action in the dorsal striatum and nucleus accumbens plays essential roles in striatal physiology. Although research often focuses on dopamine and its receptors, norepinephrine (NE) and adrenergic receptors are also crucial in regulating striatal function. While noradrenergic neurotransmission has been identi...

journal_title：Journal of neurochemistry

authors： Meitzen J,Luoma JI,Stern CM,Mermelstein PG

更新日期：2011-03-01 00:00:00

abstract：:Myelin P2 protein is a small (14,800 Da) protein found in peripheral and central nervous system myelin. To investigate the regulation of expression of this myelin protein, a mouse genomic library was screened with a rabbit P2 cDNA (pSN2.2-2), and a single positive phage clone containing a 20-kb insert was obtained. Th...

journal_title：Journal of neurochemistry

authors： Narayanan V,Kaestner KH,Tennekoon GI

更新日期：1991-07-01 00:00:00

abstract：:Head injury was induced in rats by a weight drop device, falling over the left hemisphere. The rats were killed at 15 min, 4 h, and 24 h after injury. Cortical slices were taken from the injured zone, from the corresponding region of the contralateral hemisphere, and from the frontal lobe of both hemispheres. These co...

journal_title：Journal of neurochemistry

authors： Shohami E,Shapira Y,Yadid G,Reisfeld N,Yedgar S

更新日期：1989-11-01 00:00:00

abstract：:A clone of murine neuroblastoma (N1E-115) was shown to have functional receptors for the nonapeptide bradykinin. These receptors mediated a large, rapid (about 1 min to peak) and calcium-dependent increase in cyclic GMP. The median effective concentration (EC50) averaged 1.4 nM. In addition, this event was inhibited b...

journal_title：Journal of neurochemistry

authors： Snider RM,Richelson E

更新日期：1984-12-01 00:00:00

abstract：:The rat adrenal hormone corticosterone binds to low and high affinity receptors, discretely localized in brain, including the dentate gyrus. Differential activation of the two receptor types under physiological conditions alters gene expression and functional characteristics of hippocampal neurones. In the present stu...

journal_title：Journal of neurochemistry

authors： Qin Y,Karst H,Joëls M

更新日期：2004-04-01 00:00:00