Uptake of gamma-aminobutyric acid by a synaptic vesicle fraction isolated from rat brain.

abstract：:F2-isoprostanes (F2-IsoPs) are well-established sensitive and specific markers of oxidative stress in vivo. Isofurans (IsoFs) are also products of lipid peroxidation, but in contrast to F2-IsoPs, their formation is favored when oxygen tension is increased in vitro or in vivo. Mitochondrial dysfunction in Parkinson's d...

journal_title：Journal of neurochemistry

authors： Fessel JP,Hulette C,Powell S,Roberts LJ 2nd,Zhang J

更新日期：2003-05-01 00:00:00

abstract：:The molecular forms of angiotensin converting enzyme (ACE; EC 3.4.15.1) in preparations of pig brain cortical microvessels and striatal synaptosomal membranes have been identified by immunoelectrophoretic blot analysis. The cortical microvessels contained only the endothelial form of the enzyme, Mr 180,000, which comi...

journal_title：Journal of neurochemistry

authors： Williams TA,Hooper NM,Turner AJ

更新日期：1991-07-01 00:00:00

abstract：:The primary structure of the second transmembrane (M2) segment of resistant to dieldrin (RDL), an ionotropic γ-aminobutyric acid receptor (GABAR) subunit, and the structure-function relationships in RDL are well conserved among insect species. An amino acid substitution at the 2' position in the M2 segment (Ala to Ser...

journal_title：Journal of neurochemistry

authors： Kobayashi T,Hiragaki S,Suzuki T,Ochiai N,Canlas LJ,Tufail M,Hayashi N,Mohamed AAM,Dekeyser MA,Matsuda K,Takeda M

更新日期：2020-12-01 00:00:00

abstract：:Taurine is the abundant sulfur-containing beta-amino acid in brain where it exerts a neuroprotective effect. Although it is known that the blood-brain barrier (BBB) mediates taurine transport, the regulation of taurine transport have not been clarified yet. A conditionally immortalized rat brain capillary endothelial ...

journal_title：Journal of neurochemistry

authors： Kang YS,Ohtsuki S,Takanaga H,Tomi M,Hosoya K,Terasaki T

更新日期：2002-12-01 00:00:00

abstract：:Tamoxifen has been found to be neuroprotective in both transient and permanent experimental ischemic stroke. However, it remains unknown whether this agent shows a similar beneficial effect after spinal cord injury (SCI), and what are its underlying mechanisms. In this study, we investigated the efficacy of tamoxifen ...

journal_title：Journal of neurochemistry

authors： Tian DS,Liu JL,Xie MJ,Zhan Y,Qu WS,Yu ZY,Tang ZP,Pan DJ,Wang W

更新日期：2009-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative pathology characterized by aggregates of amyloid-β (Aβ) and phosphorylated tau protein, synaptic dysfunction, and spatial memory impairment. The Wnt signaling pathway has several key functions in the adult brain and has been associated with AD, mainly as a neuroprotectiv...

journal_title：Journal of neurochemistry

authors： Tapia-Rojas C,Inestrosa NC

更新日期：2018-02-01 00:00:00

abstract：:Galactosyltransferase activities were examined in the cerebellum, cerebral cortex, and brain stem of reeler and wild-type mice. Galactosyltransferase assays were optimal for all required substrates, linear with incubation time, and proportional to protein concentration. In brain areas affected by the reeler mutation (...

journal_title：Journal of neurochemistry

authors： Shur BD

更新日期：1982-07-01 00:00:00

abstract：:Levels of multidrug efflux transporter P-glycoprotein (P-gp) on endothelial cells lining brain blood vessels are important for limiting access of many compounds to the brain. In vivo studies have indicated that ischaemia-reperfusion that generates reactive oxygen species also increases P-gp levels in brain endothelial...

journal_title：Journal of neurochemistry

authors： Robertson SJ,Kania KD,Hladky SB,Barrand MA

更新日期：2009-10-01 00:00:00

abstract：:To further analyze the action of copper on brain synaptic mechanisms, the brain dipeptide carnosine (beta-alanyl-L-histidine) was tested in Xenopus laevis oocytes expressing the rat P2X4 or P2X7 receptors. Ten micromolar copper halved the currents evoked by ATP in both receptors; co-application of carnosine plus coppe...

journal_title：Journal of neurochemistry

authors： Coddou C,Villalobos C,González J,Acuña-Castillo C,Loeb B,Huidobro-Toro JP

更新日期：2002-02-01 00:00:00

abstract：:The parenteral administration of L-phenylalanine or p-tyrosine increases the mouse striatal concentration of p-tyramine, an effect that is enhanced by monoamine oxidase inhibition and reduced by an L-aromatic aminoacid decarboxylase inhibitor. Striatal m-tyramine was increased following administration of L-phenylalani...

journal_title：Journal of neurochemistry

authors： Juorio AV,Boulton AA

更新日期：1982-09-01 00:00:00

abstract：:Deposit of beta-amyloid protein (A beta) in Alzheimer's disease brain may contribute to the associated neurodegeneration. We have studied the neurotoxicity of A beta in primary cultures of murine cortical neurons, with the aim of identifying pharmacologic ways of attenuating the injury. Exposure of cultures to A beta ...

journal_title：Journal of neurochemistry

authors： Weiss JH,Pike CJ,Cotman CW

更新日期：1994-01-01 00:00:00

abstract：:Iron, a transition metal and essential nutrient, is a typical pro-oxidant forming free radicals, lipid peroxides and causing cell damage when added at high (> or = 50 microM) concentrations to oligodendroglia-like OLN-93 cells that have been enriched for 3 days with 10 microM docosahexaenoic acid (DHA, 22 : 6 n-3). At...

journal_title：Journal of neurochemistry

authors： Brand A,Schonfeld E,Isharel I,Yavin E

更新日期：2008-05-01 00:00:00

abstract：:Protein aggregation into amyloid fibrils is a key feature of a multitude of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Prion disease. To detect amyloid fibrils, fluorophores with high sensitivity and better efficiency coupled with the low toxicity are in high demand even to date. In this pursuit,...

journal_title：Journal of neurochemistry

authors： Pravin N,Kumar R,Tripathi S,Kumar P,Mohite GM,Navalkar A,Panigrahi R,Singh N,Gadhe LG,Manchanda S,Shimozawa M,Nilsson P,Johansson J,Kumar A,Maji SK,Shanmugam M

更新日期：2020-08-04 00:00:00

abstract：:Hydrogen sulfide (H(2)S), a gasotransmitter, induces neuronal differentiation characterized by neuritogenesis and functional up-regulation of high voltage-activated Ca(2+) channels, via activation of T-type Ca(2+) channels in NG108-15 cells. We thus analyzed signaling mechanisms for the H(2)S-evoked neuronal different...

journal_title：Journal of neurochemistry

authors： Tarui T,Fukami K,Nagasawa K,Yoshida S,Sekiguchi F,Kawabata A

更新日期：2010-07-01 00:00:00

abstract：:To study potential biochemical correlates of dopamine (DA) and serotonin receptor supersensitivity, rats were lesioned at 3 days after birth with 6-hydroxydopamine (6-OHDA; 67 micrograms in each lateral ventricle; desipramine pretreatment, 20 mg/kg i.p., 1 h) and then sensitized with the DA D1 agonist, SKF 38393 HCl (...

journal_title：Journal of neurochemistry

authors： Gong L,Kostrzewa RM,Li C

更新日期：1994-10-01 00:00:00

abstract：:A rapid and simple chromatographic procedure using HPLC with electrochemical detection is described for simultaneous determination of the substrates from precursor amino acids to metabolites related to synthesis and metabolism of three monoamine neurotransmitters--norepinephrine (NE), dopamine (DA), and 5-hydroxytrypt...

journal_title：Journal of neurochemistry

authors： Murai S,Saito H,Masuda Y,Itoh T

更新日期：1988-02-01 00:00:00

abstract：:Accumulation of misfolded proteins and alterations in the ubiquitin-proteasome pathway are associated with various neurodegenerative conditions of the CNS and PNS. Aggregates containing ubiquitin and peripheral myelin protein 22 (PMP22) have been observed in the Trembler J mouse model of Charcot-Marie-Tooth disease ty...

journal_title：Journal of neurochemistry

authors： Fortun J,Li J,Go J,Fenstermaker A,Fletcher BS,Notterpek L

更新日期：2005-03-01 00:00:00

abstract：:[3H]Cocaine dissociates from its binding sites in the mouse cerebral cortex with a half-time of 25 s. The dissociation kinetics in the striatum is consonant with the presence of two populations of sites with dissociation half times of 2 s and 27 s, comprising 88% and 12%, respectively, of the total binding sites. On t...

journal_title：Journal of neurochemistry

authors： Reith ME,Sershen H,Lajtha A

更新日期：1986-01-01 00:00:00

abstract：:Hyperphosphorylated tau, the major component of the paired helical filaments of Alzheimer's disease, was found to accumulate in the brains of mice in which the calcineurin A alpha gene was disrupted [calcineurin A alpha knockout (CNA alpha -/-)]. The hyperphosphorylation involved several sites on tau, especially the S...

journal_title：Journal of neurochemistry

authors： Kayyali US,Zhang W,Yee AG,Seidman JG,Potter H

更新日期：1997-04-01 00:00:00

abstract：:L-DOPA-induced dyskinesia (LID) is among the motor complications that arise in Parkinson's disease (PD) patients after a prolonged treatment with L-DOPA. To this day, transcriptome analysis has been performed in a rat model of LID [Neurobiol. Dis., 17 (2004), 219] but information regarding the proteome is still lackin...

journal_title：Journal of neurochemistry

authors： Valastro B,Dekundy A,Krogh M,Lundblad M,James P,Danysz W,Quack G,Cenci MA

更新日期：2007-08-01 00:00:00

abstract：:Dysregulated metabolism and consequent extracellular accumulation of amyloid-β (Aβ) peptides in the brain underlie the pathogenesis of Alzheimer's disease. Extracellular Aβ in the brain parenchyma is mainly secreted from the pre-synaptic terminals of neuronal cells in a synaptic activity-dependent manner. The p24 fami...

journal_title：Journal of neurochemistry

authors： Liu L,Fujino K,Nishimura M

更新日期：2015-05-01 00:00:00

abstract：:The hippocampus is a distinct brain structure that is crucial in memory storage and retrieval. To identify comprehensively proteins of hippocampal plasma membrane (PM) and detect the neuronal-specific PM proteins, we performed a proteomic analysis of rat hippocampus PM using the following three technical strategies. F...

journal_title：Journal of neurochemistry

authors： Chen P,Li X,Sun Y,Liu Z,Cao R,He Q,Wang M,Xiong J,Xie J,Wang X,Liang S

更新日期：2006-08-01 00:00:00

abstract：:beta-nerve growth factor (NGF) was modified by biotinylation via carboxyl group substitution (C-bio-NGF) using biotin hydrazide and the coupling reagent 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide, under reaction conditions that yielded an average of 3 biotin additions per NGF subunit. NGF was also biotinylated thr...

journal_title：Journal of neurochemistry

authors： Rosenberg MB,Hawrot E,Breakefield XO

更新日期：1986-02-01 00:00:00

abstract：:Repeated intermittent treatment with amphetamine (AMPH) induces both neurite outgrowth and enhanced AMPH-stimulated dopamine (DA) release in PC12 cells. We investigated the role of protein kinases in the induction of these AMPH-mediated events by using inhibitors of protein kinase C (PKC), mitogen activated protein ki...

journal_title：Journal of neurochemistry

authors： Park YH,Kantor L,Guptaroy B,Zhang M,Wang KK,Gnegy ME

更新日期：2003-12-01 00:00:00

abstract：:Effects of concanavalin A on transmitter release were investigated in primary cultures of chick sympathetic neurons. The lectin reduced electrically evoked [3H]noradrenaline release by up to 30% with half-maximal inhibition at 0.16 microM. Concanavalin A also reduced the release triggered by extracellular Ca2+ in neur...

journal_title：Journal of neurochemistry

authors： Boehm S,Huck S

更新日期：1998-12-01 00:00:00

abstract：:Synaptic scaffolding molecule (S-SCAM) is a synaptic protein, which harbors five or six PSD-95/Discs large/ZO-1 (PDZ), a guanylate kinase and two WW domains. It interacts with NMDA receptor subunits, neuroligin and beta-catenin, and is involved in the accumulation of neuroligin at excitatory synapses. In this study, w...

journal_title：Journal of neurochemistry

authors： Sumita K,Sato Y,Iida J,Kawata A,Hamano M,Hirabayashi S,Ohno K,Peles E,Hata Y

更新日期：2007-01-01 00:00:00

abstract：:The metabolism of L-tryptophan to the neuroactive kynurenine pathway metabolites, L-kynurenine, kynurenate and quinolinate, and the effects of two inhibitors of quinolinate synthesis (6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate) were investigated by mass spectrometric assays in cultured cells and in vivo. Ce...

journal_title：Journal of neurochemistry

authors： Naritsin DB,Saito K,Markey SP,Chen CY,Heyes MP

更新日期：1995-11-01 00:00:00

abstract：:A Ca2+- and calmodulin-dependent protein kinase was purified from rat brain cytosol fraction to apparent homogeneity at approximately 800-fold and with a 5% yield. The purified enzyme had a molecular weight of 640,000 as determined by gel filtration analysis on Sephacryl S-300 and a sedimentation coefficient of 15.3 S...

journal_title：Journal of neurochemistry

authors： Fukunaga K,Yamamoto H,Matsui K,Higashi K,Miyamoto E

更新日期：1982-12-01 00:00:00

abstract：:We have previously reported that the intrinsic ability of motor axons to sprout can vary considerably from nerve to nerve with an inverse correlation to axonal length. In this study we asked whether this variation might be associated with differences in one axonal component, neurofilaments, near the site of outgrowth....

journal_title：Journal of neurochemistry

authors： Pestronk A,Watson DF,Yuan CM

更新日期：1990-03-01 00:00:00

abstract：:It is well established that ischemia-induced release of glutamate and the subsequent activation of post-synaptic glutamate receptors are important processes involved in the development of ischemic neuronal damage. Moderate intraischemic hypothermia attenuates glutamate release and confers protection from ischemic dama...

journal_title：Journal of neurochemistry

authors： Busto R,Globus MY,Neary JT,Ginsberg MD

更新日期：1994-09-01 00:00:00