Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease.

abstract：:Gliomas are the most common primary malignant brain tumor in adults, but current treatment for glioblastoma multiforme (GBM) is insufficient. Even though glucose is the primary energetic substrate of glioma cells, they are capable of using fatty acids to generate energy. Fatty acid oxidation (FAO) in mitochondria requ...

journal_title：Journal of neurochemistry

authors： Juraszek B,Czarnecka-Herok J,Nałęcz KA

更新日期：2020-07-12 00:00:00

abstract：:Tau, a microtubule-associated protein, is encoded by a single gene, whose expression is primarily neuronal. In this work, we defined an 80-bp region of the tau promoter that confers tau protein with neuronal expression. This fragment works in conjunction with an endogenous initiation region to activate neuronal precur...

journal_title：Journal of neurochemistry

authors： Heicklen-Klein A,Ginzburg I

更新日期：2000-10-01 00:00:00

abstract：:Peptidyl-glycine alpha-amidation enzyme activity has been measured in 36 nuclei or areas in the rat CNS and pituitary using D-Tyr-Phe-Gly as the substrate. The distribution of this enzyme is highly uneven, with highest activity levels (greater than 30 pmol/mg of protein/h) in hypothalamic nuclei, substantia grisea cen...

journal_title：Journal of neurochemistry

authors： Meng F,Tsou K

更新日期：1988-05-01 00:00:00

abstract：:The protein kinase v-akt murine thymoma viral oncogene homolog (AKT) gene family comprises three human homologs that phosphorylate and inactivate glycogen synthase kinase 3beta (GSK3beta). Studies have reported the genetic association of AKT1 with schizophrenia. Additionally, decreased AKT1 protein expression and the ...

journal_title：Journal of neurochemistry

authors： Ide M,Ohnishi T,Murayama M,Matsumoto I,Yamada K,Iwayama Y,Dedova I,Toyota T,Asada T,Takashima A,Yoshikawa T

更新日期：2006-10-01 00:00:00

abstract：:One of the most striking features of neurons in the mature peripheral nervous system is their ability to survive and to regenerate their axons following axonal injury. To perform a comprehensive survey of the molecular mechanisms that underlie peripheral nerve regeneration, we analyzed a cDNA library derived from the ...

journal_title：Journal of neurochemistry

authors： Kubo T,Yamashita T,Yamaguchi A,Hosokawa K,Tohyama M

更新日期：2002-09-01 00:00:00

abstract：:The formation and refinement of synaptic connections are key steps of neural development to establish elaborate brain networks. To investigate the functional role of protein tyrosine phosphatase (PTP) σ, we employed an olfactory sensory neuron (OSN)-specific gene manipulation system in combination with in vivo imaging...

journal_title：Journal of neurochemistry

authors： Chen X,Yoshida T,Sagara H,Mikami Y,Mishina M

更新日期：2011-11-01 00:00:00

abstract：:Cultures of myelinated SJL/J fetal mouse spinal cord were incubated with serum and lymphoid cells from syngeneic animals with experimental allergic encephalomyelitis (EAE) induced by syngeneic spinal cord homogenate (SSCH) in complete Freund's adjuvant or others injected with complete Freund's adjuvant alone. After 24...

journal_title：Journal of neurochemistry

authors： Roth GA,Bornstein MB,Röyttä M,Lyman WD,Raine CS

更新日期：1985-02-01 00:00:00

abstract：:Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, catalyzes the conversion of tyrosine to DOPA, Cyclic AMP-dependent protein phosphorylation conditions alter tyrosine hydroxylase activity in rat striatal homogenates. In agreement with other laboratories, we find that short-term pre-incubati...

journal_title：Journal of neurochemistry

authors： Vrana KE,Allhiser CL,Roskoski R Jr

更新日期：1981-01-01 00:00:00

abstract：:Vesicular sequestration is important in the regulation of cytoplasmic concentrations of monoamines such as dopamine. Moreover, recent evidence suggests that increases in cytoplasmic dopamine levels, perhaps attributable to changes in vesicular monoamine transporter function, contribute to methamphetamine-induced dopam...

journal_title：Journal of neurochemistry

authors： Brown JM,Hanson GR,Fleckenstein AE

更新日期：2000-05-01 00:00:00

abstract：:Aspartic acid (Asp) undergoes l-isomer-selective efflux transport across the blood-brain barrier (BBB). This transport system appears to play an important role in regulating l- and d-Asp levels in the brain. The purpose of this study was to identify the responsible transporters and elucidate the mechanism for l-isomer...

journal_title：Journal of neurochemistry

authors： Tetsuka K,Takanaga H,Ohtsuki S,Hosoya K,Terasaki T

更新日期：2003-11-01 00:00:00

abstract：:The X11-like (X11L) protein was originally isolated as a protein bound to the cytoplasmic domain of the beta-amyloid precursor protein (APP), which is associated with Alzheimer's disease. In mammals, X11L is believed to play an important role in the regulation of APP metabolism. Here we isolated and characterized the ...

journal_title：Journal of neurochemistry

authors： Hase M,Yagi Y,Taru H,Tomita S,Sumioka A,Hori K,Miyamoto K,Sasamura T,Nakamura M,Matsuno K,Suzuki T

更新日期：2002-06-01 00:00:00

abstract：:The glial glutamate transporter EAAT2 (excitatory amino acid transporter 2) is the major mediator of glutamate clearance that terminates glutamate-mediated neurotransmission. Loss of EAAT2 and associated glutamate uptake function has been reported in the brains of patients with Alzheimer's disease (AD). We previously ...

journal_title：Journal of neurochemistry

authors： Tian G,Kong Q,Lai L,Ray-Chaudhury A,Lin CL

更新日期：2010-05-01 00:00:00

abstract：:2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitous environmental pollutant that could induce significant toxic effects in the human nervous system. However, the underlying molecular mechanism has not been entirely elucidated. Reactive astrogliosis has implicated in various neurological diseases via the product...

journal_title：Journal of neurochemistry

authors： Zhang Y,Nie X,Tao T,Qian W,Jiang S,Jiang J,Li A,Guo A,Xu G,Wu Q

更新日期：2014-06-01 00:00:00

abstract：:Read the highlighted article 'Defective synthesis and release of astrocytic thrombospondin-1 mediates the neuronal TDP-43 proteinopathy, resulting in defects in neuronal integrity associated with chronic traumatic encephalopathy: in vitro studies' on page 645. ...

journal_title：Journal of neurochemistry

authors： Jaber SM,Polster BM

更新日期：2017-02-01 00:00:00

abstract：:A wealth of evidence supports the view that conformational change of the prion protein, PrPC, into a pathogenic isoform, PrPSc, is the hallmark of sporadic, infectious, and inherited forms of prion disease. Although the central role played by PrPSc in the pathogenesis of prion disease is appreciated, the cellular mech...

journal_title：Journal of neurochemistry

authors： Deleault NR,Dolph PJ,Feany MB,Cook ME,Nishina K,Harris DA,Supattapone S

更新日期：2003-06-01 00:00:00

abstract：:Dopamine and norepinephrine are involved in regulation of melatonin synthesis in the pineal gland. In bovine pineal gland, D1- and D2-dopaminergic and alpha 1-adrenergic receptors have been characterized pharmacologically in several laboratories, while beta 1-adrenergic receptors have been studied using physiological ...

journal_title：Journal of neurochemistry

authors： Simonneaux V,Happe HK,Ebadi M,Murrin LC

更新日期：1991-11-01 00:00:00

abstract：:Ischemic stroke is a neurovascular disease treatable by thrombolytic therapy, but the therapy has to be initiated within 3 h of the incident. This therapeutic limitation stems from the secondary injury which results mainly from oxidative stress and inflammation. A potent antioxidant/anti-inflammatory agent, caffeic ac...

journal_title：Journal of neurochemistry

authors： Khan M,Elango C,Ansari MA,Singh I,Singh AK

更新日期：2007-07-01 00:00:00

abstract：:The levels of hexokinase, as well as those of the cytoplasmic glycolytic enzyme lactate dehydrogenase and the mitochondrial tricarboxylic acid cycle enzymes fumarase and citrate synthase, have been determined in whole rat brain and in neuronal, astrocytic, and oligodendroglial fractions isolated from rat brain. Compar...

journal_title：Journal of neurochemistry

authors： Snyder CD,Wilson JE

更新日期：1983-04-01 00:00:00

abstract：:Deposit of beta-amyloid protein (A beta) in Alzheimer's disease brain may contribute to the associated neurodegeneration. We have studied the neurotoxicity of A beta in primary cultures of murine cortical neurons, with the aim of identifying pharmacologic ways of attenuating the injury. Exposure of cultures to A beta ...

journal_title：Journal of neurochemistry

authors： Weiss JH,Pike CJ,Cotman CW

更新日期：1994-01-01 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) is known to cause a destruction of the dopaminergic nigrostriatal pathway in certain animal species including mice. MPTP and some structurally related analogs were tested in vitro for their capacity to inhibit the uptake of [3H]3,4-dihydroxyphenylethylamine-([3H]DA),...

journal_title：Journal of neurochemistry

authors： Heikkila RE,Youngster SK,Manzino L,Cabbat FS,Duvoisin RC

更新日期：1985-01-01 00:00:00

abstract：:The phosphorylation of microtubule-associated protein 2 (MAP2) by four different kinases was studied in vitro to determine whether MAP2 is phosphorylated in its tubulin binding region or in the microtubule projection portion. Fragments corresponding to both regions of MAP2 were produced not only by chymotrypsin or try...

journal_title：Journal of neurochemistry

authors： Hernández MA,Wandosell F,Avila J

更新日期：1987-01-01 00:00:00

abstract：:The Kölliker-Fuse nucleus (KF) is a functionally distinct component of the parabrachial complex, located in the dorsolateral pons of mammals. The KF has a major role in respiration and upper airway control. A comprehensive understanding of the KF and its contributions to respiratory function and dysfunction requires a...

journal_title：Journal of neurochemistry

authors： Varga AG,Maletz SN,Bateman JT,Reid BT,Levitt ES

更新日期：2021-01-01 00:00:00

abstract：:Ammonia is responsible for cerebral edema associated with acute liver failure, but the role of the vasogenic mechanism has been a matter of dispute. Here, we tested the hypothesis that ammonia induces changes in blood-brain barrier (BBB) permeability by a mechanism coupled to oxidative/nitrosative stress (ONS) evoked ...

journal_title：Journal of neurochemistry

authors： Skowrońska M,Zielińska M,Wójcik-Stanaszek L,Ruszkiewicz J,Milatovic D,Aschner M,Albrecht J

更新日期：2012-04-01 00:00:00

abstract：:'Metabolism' refers to the vast collection of chemical processes that occur within a living organism. Within this broad designation, one can identify metabolism events that relate specifically to energy homeostasis, whether they occur at the subcellular, cellular, organ, or whole organism level. This review operationa...

journal_title：Journal of neurochemistry

authors： Swerdlow RH

更新日期：2016-10-01 00:00:00

abstract：:Hyperexcitability of the hippocampus is a commonly observed phenomenon in the years preceding a diagnosis of Alzheimer's disease (AD). Our previous work suggests a dysregulation in glutamate neurotransmission may mediate this hyperexcitability, and glutamate dysregulation correlates with cognitive deficits in the rTg(...

journal_title：Journal of neurochemistry

authors： Hunsberger HC,Weitzner DS,Rudy CC,Hickman JE,Libell EM,Speer RR,Gerhardt GA,Reed MN

更新日期：2015-10-01 00:00:00

abstract：:In this article, we demonstrate that an increase in intracellular Ca2+ concentration may represent a specific common step(s) in the mechanism(s) of action of glutamate (Glu) and depolarizing agents on formation of inositol phosphates (IPs) in 8-day-old rat forebrain synaptoneurosomes. In fact, A23187, a Ca2+ ionophore...

journal_title：Journal of neurochemistry

authors： Guiramand J,Vignes M,Récasens M

更新日期：1991-11-01 00:00:00

abstract：:Purified rat brain Ca2+/calmodulin-dependent protein kinase II (CaM-kinase II) is stimulated by brain gangliosides to a level of about 30% the activity obtained in the presence of Ca2+/calmodulin (CaM). Of the various gangliosides tested, GT1b was the most potent, giving half-maximal activation at 25 microM. Gangliosi...

journal_title：Journal of neurochemistry

authors： Fukunaga K,Miyamoto E,Soderling TR

更新日期：1990-01-01 00:00:00

abstract：:Head injury was induced in rats by a weight drop device, falling over the left hemisphere. The rats were killed at 15 min, 4 h, and 24 h after injury. Cortical slices were taken from the injured zone, from the corresponding region of the contralateral hemisphere, and from the frontal lobe of both hemispheres. These co...

journal_title：Journal of neurochemistry

authors： Shohami E,Shapira Y,Yadid G,Reisfeld N,Yedgar S

更新日期：1989-11-01 00:00:00

abstract：:This study was undertaken to explore the metabolic fate of acetyl-L-carnitine in rat brain. To measure the flux of carbon atoms into anabolic processes occurring at regional levels, we have injected [1-(14)C]acetyl-L-carnitine into the lateral brain ventricle of conscious rats. After injection of [1-(14)C]acetyl-L-car...

journal_title：Journal of neurochemistry

authors： Ricciolini R,Scalibastri M,Kelleher JK,Carminati P,Calvani M,Arduini A

更新日期：1998-12-01 00:00:00

abstract：:Perlecan is a specific proteoglycan that binds to amyloid precursor protein and beta-amyloid peptide, is present within amyloid deposits, and has been implicated in plaque formation. Because plaque formation is associated with local inflammation, we hypothesized that the mechanisms involved in brain inflammatory respo...

journal_title：Journal of neurochemistry

authors： García de Yébenes E,Ho A,Damani T,Fillit H,Blum M

更新日期：1999-08-01 00:00:00