Metabolism of L-tryptophan to kynurenate and quinolinate in the central nervous system: effects of 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.

abstract：:Null mutations in progranulin (GRN) are associated with frontotemporal lobar degeneration characterized by intraneuronal accumulation of TAR DNA-binding protein-43 (TDP-43). However, the mechanism by which GRN deficiency leads to neurodegeneration remains largely unknown. In primary cortical neurons derived from Grn k...

journal_title：Journal of neurochemistry

authors： Kleinberger G,Wils H,Ponsaerts P,Joris G,Timmermans JP,Van Broeckhoven C,Kumar-Singh S

更新日期：2010-11-01 00:00:00

abstract：:Agonist activation of the delta-opioid receptor leads to internalization via G betagamma recruitment of G protein coupled receptor kinase-2, which phosphorylates the receptor at several sites, including Ser363, allowing beta-arrestin binding and localization to clathrin coated pits. Using human embryonic kidney cells ...

journal_title：Journal of neurochemistry

authors： Bradbury FA,Zelnik JC,Traynor JR

更新日期：2009-06-01 00:00:00

abstract：:β-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the transmembrane aspartyl protease that catalyzes the first cleavage step in the proteolysis of the APP to the amyloid β-protein (Aβ), a process involved in the pathogenesis of Alzheimer disease. BACE1 pre-mRNA undergoes complex alternative splicing,...

journal_title：Journal of neurochemistry

authors： Fisette JF,Montagna DR,Mihailescu MR,Wolfe MS

更新日期：2012-06-01 00:00:00

abstract：:The subcellular distribution of the ectoenzyme, 5'-nucleotidase, in cerebral cortex and cerebellum of the rat was studied both biochemically and cytochemically. The fractions were characterized biochemically by marker enzymes. The localization of 5'-nucleotidase activity was also investigated cytochemically in the mye...

journal_title：Journal of neurochemistry

authors： Heymann D,Reddington M,Kreutzberg GW

更新日期：1984-10-01 00:00:00

abstract：:The content, synthesis and transport of D-aspartate (D-Asp) in the CNS of Aplysia californica is investigated using capillary electrophoresis (CE) with both laser-induced fluorescence and radionuclide detection. Millimolar concentrations of D-Asp are found in various regions of the CNS. In the cerebral ganglion, three...

journal_title：Journal of neurochemistry

authors： Miao H,Rubakhin SS,Scanlan CR,Wang L,Sweedler JV

更新日期：2006-04-01 00:00:00

abstract：:Experimental evidence suggests that magnesium plays a role in the pathophysiological sequelae of brain injury. The present study examined the variation of blood ionized and total magnesium, as well as potassium, sodium, and ionized calcium, after experimental fluid percussion brain injury in rats. Blood ionized magnes...

journal_title：Journal of neurochemistry

authors： Bareyre FM,Saatman KE,Helfaer MA,Sinson G,Weisser JD,Brown AL,McIntosh TK

更新日期：1999-07-01 00:00:00

abstract：:Focal brain ischemia leads to a slow type of neuronal death in the penumbra that starts several hours after ischemia and continues to mature for days. During this maturation period, blood flow, cellular ATP and ionic homeostasis are gradually recovered in the penumbral region. In striking contrast, protein synthesis i...

journal_title：Journal of neurochemistry

authors： Zhang F,Liu CL,Hu BR

更新日期：2006-07-01 00:00:00

abstract：:We examined the effects of chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid (3-NP) in doses ranging from 12 to 16 mg/kg/day for 30 days on striatal cytoarchitecture in rats. Administration of 3-NP at a dose of 16 mg/kg/day resulted in large lesions with a central necrotic core that was ...

journal_title：Journal of neurochemistry

authors： Wüllner U,Young AB,Penney JB,Beal MF

更新日期：1994-11-01 00:00:00

abstract：:P25alpha/tubulin polymerization promoting protein (TPPP) is a brain specific phosphoprotein that displays microtubule bundling activity. In the mature brain, p25alpha/TPPP distributes to oligodendrocytes and choroid plexus epithelium. We mapped the spatial and temporal distribution of p25alpha/TPPP in the developing r...

journal_title：Journal of neurochemistry

authors： Skjoerringe T,Lundvig DM,Jensen PH,Moos T

更新日期：2006-10-01 00:00:00

abstract：:The presynaptic terminals of skate (Raja montagui) electric organ were tested for their sensitivity to calcium channel antagonists. Acetylcholine (ACh) release and the elevation of intraterminal Ca2+ concentrations triggered by K+ depolarisation were studied. ACh release was measured as 3H efflux from slices of organ ...

journal_title：Journal of neurochemistry

authors： Richardson CM,Dowdall MJ,Green AC,Bowman D

更新日期：1995-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by amyloid-beta peptide (Abeta) deposition in the brain. Abeta is produced by sequential cleavage of amyloid precursor protein (APP) by beta-secretase (BACE1: beta-site APP-cleaving enzyme 1) and gamma-secretase. Previously, we demonstrated that BACE1 also cleaves beta-galacto...

journal_title：Journal of neurochemistry

authors： Nakagawa K,Kitazume S,Oka R,Maruyama K,Saido TC,Sato Y,Endo T,Hashimoto Y

更新日期：2006-02-01 00:00:00

abstract：:A rapid loss of protein kinase C (PKC) activity is a prognostic feature of the lethal damage inflicted on neurons by cerebral ischemia in vivo and by hypoxic and excitotoxic insults in vitro. However, it is not known if this inactivation of PKC is incidental or is an essential part of the neurodegenerative process dri...

journal_title：Journal of neurochemistry

authors： Durkin JP,Tremblay R,Chakravarthy B,Mealing G,Morley P,Small D,Song D

更新日期：1997-04-01 00:00:00

abstract：:In vivo microdialysis was used to determine whether the 3,4-methylenedioxymethamphetamine (MDMA)-induced release of serotonin (5-HT) in vivo involves a carrier-mediated process and to investigate further the state-dependent interaction between 5-HT and dopamine. MDMA produced a dose-dependent increase in the extracell...

journal_title：Journal of neurochemistry

authors： Gudelsky GA,Nash JF

更新日期：1996-01-01 00:00:00

abstract：:The uptake of glutamate and other acidic amino acids into barnacle single muscle fibres has been characterized. The uptake of glutamate consists of two components, one Na-independent and one Na-dependent. The Na-dependent uptake is saturable (half-maximal at 250 microM external glutamate) and is inhibited by a variety...

journal_title：Journal of neurochemistry

authors： Revest PA,Baker PF

更新日期：1988-01-01 00:00:00

abstract：:Administration of kainate or pentylenetetrazole increased c-fos, c-jun, junB, and junD mRNA levels in rat brain in a dose-dependent manner. Kainate increased these mRNA levels predominantly in the hippocampus, and pentylenetetrazole was more effective in the cortex. Adrenalectomy (3 days) was used to eliminate endogen...

journal_title：Journal of neurochemistry

authors： Li X,Song L,Kolasa K,Jope RS

更新日期：1992-06-01 00:00:00

abstract：:Recombinant baculoviral vectors efficiently transduce several types of cells in the brain. To characterize host responses to virus challenge, thus verifying the suitability of using baculovirus for the development of gene therapy strategies in the central nervous system, we used cDNA microarray technology to examine i...

journal_title：Journal of neurochemistry

authors： Boulaire J,Zhao Y,Wang S

更新日期：2009-06-01 00:00:00

abstract：:The tracers 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine (6-[18F]fluoro-L-DOPA) and L-[14C]DOPA were injected simultaneously into rhesus monkeys, and the time course of their metabolites was measured in the striatum and in the occipital and frontal cortices. In the striatum, 6-[18F]fluoro-L-DOPA was metabolized to 6-[18...

journal_title：Journal of neurochemistry

authors： Firnau G,Sood S,Chirakal R,Nahmias C,Garnett ES

更新日期：1987-04-01 00:00:00

abstract：:An adrenomedullary protease capable of generating Met5-enkephalin from endogenous precursor(s) has been purified 1,000-fold using affinity chromatography in combination with gel filtration. This trypsin-like enzyme has an apparent molecular weight of 20,000 daltons by gel filtration. The reactivity of the enzyme towar...

journal_title：Journal of neurochemistry

authors： Lindberg I,Yang HY,Costa E

更新日期：1984-05-01 00:00:00

abstract：:Glucocorticoids (GCs), the adrenal steroids secreted during stress, can compromise the ability of hippocampal neurons to survive numerous necrotic insults. We have previously observed that GCs worsen the deleterious effects of gp120, the glycoprotein of the acquired immune deficiency syndrome virus, which can indirect...

journal_title：Journal of neurochemistry

authors： Yusim A,Franklin L,Brooke S,Ajilore O,Sapolsky R

更新日期：2000-03-01 00:00:00

abstract：:It has been suggested that disturbances during neurodevelopment may play a crucial role in the etiology of schizophrenia (SZ). This premise is supported by brain imaging, epidemiological, and pathological studies as well as the discovery of susceptibility genes for SZ that appear to be implicated in development of the...

journal_title：Journal of neurochemistry

authors： Cascella NG,Takaki M,Lin S,Sawa A

更新日期：2007-08-01 00:00:00

abstract：:Amyloid-β peptide (Aβ) concentration in CSF is potentially a diagnostic and therapeutic target for Alzheimer's disease (AD). The purpose of this study was to clarify the elimination mechanism of human Aβ(1-40) [hAβ (1-40)] from CSF. After intracerebroventricular (ICV) administration, [(125) I]hAβ(1-40) was eliminated ...

journal_title：Journal of neurochemistry

authors： Fujiyoshi M,Tachikawa M,Ohtsuki S,Ito S,Uchida Y,Akanuma S,Kamiie J,Hashimoto T,Hosoya K,Iwatsubo T,Terasaki T

更新日期：2011-08-01 00:00:00

abstract：:[3H]Ouabain binding was studied in sections of rabbit somatosensory cortex by quantitative autoradiography and in rabbit brain microsomal membranes using a conventional filtration assay. KD values of 8-12 nM for specific high-affinity binding of [3H]ouabain were found by both methods. High-affinity binding was not uni...

journal_title：Journal of neurochemistry

authors： Antonelli MC,Baskin DG,Garland M,Stahl WL

更新日期：1989-01-01 00:00:00

abstract：:There is ample evidence that both acid (ASMase) and neutral (NSMase) sphingomyelinases play a role in cell death so inhibitors of either enzyme could have significant value as protectors against neurodegeneration. We used a fluorogenic sphingomyelinase substrate, 6-hexadecanoylamino-4-methylumbelliferyl-phosphorylchol...

journal_title：Journal of neurochemistry

authors： Testai FD,Landek MA,Goswami R,Ahmed M,Dawson G

更新日期：2004-05-01 00:00:00

abstract：:Neuron-astrocyte interactions are critical for signalling, energy metabolism, extracellular ion and glutamate homeostasis, volume regulation and neuroprotection in the CNS. Glutamate uptake by astrocytes may prevent excitotoxic glutamate elevation and determine neuronal survival. However, an excess of glutamate can ca...

journal_title：Journal of neurochemistry

authors： Szydlowska K,Zawadzka M,Kaminska B

更新日期：2006-11-01 00:00:00

abstract：:At present, treatment for Parkinson's disease (PD) is only symptomatic; therefore, it is important to identify new targets tackling the molecular causes of the disease. We previously found that lymphoblasts from sporadic PD patients display increased activity of the cyclin D3/CDK6/pRb pathway and higher proliferation ...

journal_title：Journal of neurochemistry

authors： Alquézar C,Barrio E,Esteras N,de la Encarnación A,Bartolomé F,Molina JA,Martín-Requero Á

更新日期：2015-06-01 00:00:00

abstract：:Neuromelanin (NM) is a compound which highly accumulates mainly in catecholamine neurons of the substantia nigra (SN), and is contained in organelles (NM-containing organelles) with lipid bodies and proteins. These neurons selectively degenerate in Parkinson's disease and NM can play either a protective or toxic role....

journal_title：Journal of neurochemistry

authors： Biesemeier A,Eibl O,Eswara S,Audinot JN,Wirtz T,Pezzoli G,Zucca FA,Zecca L,Schraermeyer U

更新日期：2016-07-01 00:00:00

abstract：:The pH dependency of the binding of ligands to adenosine A2a receptors in rat striatal membranes was examined. For those agonists sensitive to adenosine deaminase a solubilised membrane preparation was used. A two- to fourfold increase in affinity was observed for CGS-21680, 5'-N-ethylcarboxamidoadenosine, adenosine, ...

journal_title：Journal of neurochemistry

authors： Askalan R,Richardson PJ

更新日期：1994-10-01 00:00:00

abstract：:Neurofibrillary tangles, one of the major pathological hallmarks of Alzheimer-diseased brains, consist primarily of aggregated paired helical filaments (PHFs) of hyperphosphorylated tau protein. Tau from normal brain and especially from foetal brain is also phosphorylated on some of the sites phosphorylated in PHFs, m...

journal_title：Journal of neurochemistry

authors： Reynolds CH,Nebreda AR,Gibb GM,Utton MA,Anderton BH

更新日期：1997-07-01 00:00:00

abstract：:Phosphoinositide hydrolysis was studied in neurohybrid NCB-20 cells prelabeled with myo-[3H]inositol. Among nearly 20 neurotransmitters and neuromodulators examined, only bradykinin, carbachol, and histamine significantly increased the accumulation of [3H]inositol monophosphate (IP1) in the presence of lithium. The EC...

journal_title：Journal of neurochemistry

authors： Chuang DM,Dillon-Carter O

更新日期：1988-08-01 00:00:00

abstract：:To investigate regulation of D2 receptor (D2R) gene expression by protein kinases, we evaluated effects of constitutively active MAPK kinase kinase (MEKK), Ca2+/calmodulin-dependent protein kinase (CaMK) II, CaMKIV and cyclic AMP-dependent protein kinase (PKA) on D2R promoter activity using luciferase reporter gene as...

journal_title：Journal of neurochemistry

authors： Takeuchi Y,Miyamoto E,Fukunaga K

更新日期：2002-11-01 00:00:00