P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain.

abstract：:Research on stem cells has developed as one of the most promising areas of neurobiology. In the beginning of the 1990s, neurogenesis in the adult brain was indisputably accepted, eliciting great research efforts. Neural stem cells in the adult mammalian brain are located in the 'neurogenic' areas of the subventricular...

journal_title：Journal of neurochemistry

authors： Bellenchi GC,Volpicelli F,Piscopo V,Perrone-Capano C,di Porzio U

更新日期：2013-01-01 00:00:00

abstract：:5-Hydroxytryptamine2 (5-HT2) receptor antagonists have been shown to interfere with the stimulation of striatal dopamine synthesis and release produced by the amphetamine analogue 3,4-methylenedioxymethamphetamine (MDMA). To localize the receptors responsible for the attenuation of MDMA-induced release, 5-HT2 receptor...

journal_title：Journal of neurochemistry

authors： Schmidt CJ,Sullivan CK,Fadayel GM

更新日期：1994-04-01 00:00:00

abstract：:Spinocerebellar ataxia type-3, also known as Machado-Joseph Disease, is one of many inherited neurodegenerative disorders caused by polyglutamine-encoding CAG repeat expansions in otherwise unrelated disease genes. Polyglutamine disorders are characterized by disease protein misfolding and aggregation; often within th...

journal_title：Journal of neurochemistry

authors： Berke SJ,Schmied FA,Brunt ER,Ellerby LM,Paulson HL

更新日期：2004-05-01 00:00:00

abstract：:N alpha-Acyl amino acid releasing enzyme (NAARE), an enzyme cleaving acetylMet-Ala at the Met-Ala bond was purified from rat brain cytosol to apparent homogeneity by salt precipitation, gel filtration, and several steps of ion exchange. Levels of NAARE exceeded acylase measured with acetylmethionine in all brain regio...

journal_title：Journal of neurochemistry

authors： Marks N,Lo ES,Stern F,Danho W

更新日期：1983-07-01 00:00:00

abstract：:In cerebellum, 13 different GABA(A) receptor subunits are expressed. The number of different receptor subtypes formed in this tissue, their subunit composition and their quantitative importance so far has not been determined. In the present study, immunodepletion by immunoaffinity chromatography, as well as immunoprec...

journal_title：Journal of neurochemistry

authors： Pöltl A,Hauer B,Fuchs K,Tretter V,Sieghart W

更新日期：2003-12-01 00:00:00

abstract：:It has been suggested that disturbances during neurodevelopment may play a crucial role in the etiology of schizophrenia (SZ). This premise is supported by brain imaging, epidemiological, and pathological studies as well as the discovery of susceptibility genes for SZ that appear to be implicated in development of the...

journal_title：Journal of neurochemistry

authors： Cascella NG,Takaki M,Lin S,Sawa A

更新日期：2007-08-01 00:00:00

abstract：:The effects of ATP and taurine on the kinetics of calcium uptake in rat retinal membrane preparations were determined. ATP increased calcium uptake at low calcium ion concentrations. Addition of ATP plus taurine further increased calcium uptake. Cooperative relationships were observed for calcium uptake in the absence...

journal_title：Journal of neurochemistry

authors： Lombardini JB

更新日期：1983-02-01 00:00:00

abstract：:Enzymes considered to be markers for neurons (angiotensin converting enzyme, thermolysin-like metalloendopeptidase, alanine aminopeptidase, and glutamate-oxaloacetate transaminase), glia (glutamine synthetase, pyruvate carboxylase, and beta-glucuronidase), and endothelial cells (alkaline phosphatase and plasminogen ac...

journal_title：Journal of neurochemistry

authors： Butterworth J

更新日期：1986-08-01 00:00:00

abstract：:The physiological function of the cellular prion protein (PrP(c)) is unclear. PrP(c) associates with lipid rafts, highly glycolipid-rich membrane domains containing a large variety of signaling molecules, e.g., sphingolipids (SL). In this study, we investigated possible connections between PrP(c) and sphingolipid-asso...

journal_title：Journal of neurochemistry

authors： Schmalzbauer R,Eigenbrod S,Winoto-Morbach S,Xiang W,Schütze S,Bertsch U,Kretzschmar HA

更新日期：2008-08-01 00:00:00

abstract：:Previous studies have purified from brain a Ca2+/calmodulin-dependent protein kinase II (designated CaM-kinase II) that phosphorylates synapsin I, a synaptic vesicle-associated phosphoprotein. CaM-kinase II is composed of a major Mr 50K polypeptide and a minor Mr 60K polypeptide; both bind calmodulin and are phosphory...

journal_title：Journal of neurochemistry

authors： Shields SM,Vernon PJ,Kelly PT

更新日期：1984-12-01 00:00:00

abstract：:The nicotinic acetylcholine receptor (AChR) exhibits at least four different conformational states varying in affinity for agonists such as acetylcholine (ACh). Photoaffinity labeling has been previously used to elucidate the topography of the AChR. However, to date, the photosensitive probes used to explore the choli...

journal_title：Journal of neurochemistry

authors： Kotzyba-Hibert F,Kessler P,Zerbib V,Bogen C,Snetkov V,Takeda K,Goeldner M,Hirth C

更新日期：1996-12-01 00:00:00

abstract：:The specific binding of [3H]8-hydroxy-2-(di-n-propylamino)tetralin ([ 3H]8-OH-DPAT) to 5-hydroxytryptamine (5-HT)-related sites was investigated in several regions of the rat brain. Marked differences were observed in the characteristics of binding to membranes from hippocampus, striatum, and cerebral cortex. Hippocam...

journal_title：Journal of neurochemistry

authors： Hall MD,el Mestikawy S,Emerit MB,Pichat L,Hamon M,Gozlan H

更新日期：1985-06-01 00:00:00

abstract：:Abnormalities of alpha-synuclein (alpha-Syn) are mechanistically linked to Parkinson's disease (PD) and other alpha-synucleinopathies. To gain additional insights into the relationships between alpha-Syn expression and cell death, we examined the effects of expressing human alpha-Syn (Hualpha-Syn) variants on the cell...

journal_title：Journal of neurochemistry

authors： Li W,Lee MK

更新日期：2005-06-01 00:00:00

abstract：:A dipeptidyl aminopeptidase was partially purified from a supernatant fraction of bovine adrenal medulla by gel filtration and anion-exchange chromatography. From gel filtration, the apparent molecular weight of the enzyme was 68,100 and its pH optimum was 9.5. Its Km for hydrolysis of the synthetic substrate arginyla...

journal_title：Journal of neurochemistry

authors： Kecorius E,Small DH,Livett BG

更新日期：1988-01-01 00:00:00

abstract：:The specific binding of [N-methyl-3H]flunitrazepam ([3H]FNZP) to a membrane fraction from the supraoesophageal ganglion of the locust (Schistocerca gregaria) has been measured. The ligand binds reversibly with a KD of 47 nM. The binding is Ca2+-dependent, a property not found for the equivalent binding site in vertebr...

journal_title：Journal of neurochemistry

authors： Robinson T,MacAllan D,Lunt G,Battersby M

更新日期：1986-12-01 00:00:00

abstract：:The presynaptic regulation of amino acid release from nerve terminals was investigated using synaptosomes prepared from the rat spinal cord. The basal releases of endogenous glutamate (Glu), aspartate (Asp), and gamma-amino-butyric acid (GABA) were 34.6, 21.5, and 10.0 pmol/min/mg of protein, respectively. Exposure to...

journal_title：Journal of neurochemistry

authors： Kamisaki Y,Hamada T,Maeda K,Ishimura M,Itoh T

更新日期：1993-02-01 00:00:00

abstract：:Schwann cells provide a favorable microenvironment for successful regeneration of the injured peripheral nerve. Even though the roles of extracellular matrix proteins in the Schwann cell physiology have long been studied, the precise function of nidogen, a ubiquitous component of the basal lamina, in Schwann cells is ...

journal_title：Journal of neurochemistry

authors： Lee HK,Seo IA,Park HK,Park YM,Ahn KJ,Yoo YH,Park HT

更新日期：2007-08-01 00:00:00

abstract：:The incorporation of radioactive precursors into gangliosides and other glycolipids, glycoproteins, and total lipids has been studied in rat pheochromocytoma PC12 cells. Starting with the same PC12 cell pool, cultures displaying different degrees of neuritic expression in response to nerve growth factor (NGF) and comb...

journal_title：Journal of neurochemistry

authors： Katoh-Semba R,Skaper SD,Varon S

更新日期：1986-02-01 00:00:00

abstract：:We investigated the role of Ca(2+)-dependent protein kinases in the regulation of astrocytic cell volume. Calmodulin (CaM) antagonists were used to inhibit CaM and thus Ca2+/CaM-dependent protein kinase. The effect of these inhibitors as well as activators and inhibitors of protein kinase C (PKC) on astrocytic volume ...

journal_title：Journal of neurochemistry

authors： Bender AS,Neary JT,Blicharska J,Norenberg LO,Norenberg MD

更新日期：1992-05-01 00:00:00

abstract：:The brain adapts to dynamic environmental conditions by altering its epigenetic state, thereby influencing neuronal transcriptional programs. An example of an epigenetic modification is protein methylation, catalyzed by protein arginine methyltransferases (PRMT). One member, Prmt8, is selectively expressed in the cent...

journal_title：Journal of neurochemistry

authors： Lee PK,Goh WW,Sng JC

更新日期：2017-02-01 00:00:00

abstract：:Docosahexaenoic acid (DHA), an n-3 fatty acid, is rapidly deposited during the period of rapid brain development. The influence of n-3 fatty acid deficiency on learning performance in adult rats over two generations was investigated. Rats were fed either an n-3 fatty acid-adequate (n-3 Adq) or -deficient (n-3 Def) die...

journal_title：Journal of neurochemistry

authors： Moriguchi T,Greiner RS,Salem N Jr

更新日期：2000-12-01 00:00:00

abstract：:NMDA receptors are potentiated by phosphorylation in a subunit- and kinase-specific manner. Both native and recombinant NMDA receptors are inhibited by behaviorally relevant concentrations of ethanol. Whether the phosphorylation state of individual subunits modulates the ethanol sensitivity of these receptors is not k...

journal_title：Journal of neurochemistry

authors： Anders DL,Blevins T,Sutton G,Swope S,Chandler LJ,Woodward JJ

更新日期：1999-04-01 00:00:00

abstract：:Wallerian degeneration in peripheral nerves occurs after a traumatic insult when the distal nerve part degenerates while peripheral macrophages enter the nerve stump and remove the accruing debris by phagozytosis. We used an experimental model to investigate the effect of either the absence or over-expression of alpha...

journal_title：Journal of neurochemistry

authors： Siebert H,Kahle PJ,Kramer ML,Isik T,Schlüter OM,Schulz-Schaeffer WJ,Brück W

更新日期：2010-08-01 00:00:00

abstract：:We assessed the functional expression of the norepinephrine (NE) transporter (NET) in cultured rat cortical astrocytes. Specific [3H]NE uptake increased in a time-dependent manner, and this uptake involves temperature- and Na+-sensitive mechanisms. The Na+-dependent [3H]NE uptake was saturable, and the Km for the proc...

journal_title：Journal of neurochemistry

authors： Inazu M,Takeda H,Matsumiya T

更新日期：2003-01-01 00:00:00

abstract：:Rosiglitazone is a member of the thiazolidinedione family of synthetic peroxisome proliferator-activated receptor (PPAR) agonists. It is a selective ligand of the PPARgamma subtype and functions by regulating the transcription of insulin-responsive genes. A screen of FDA-approved compounds identified rosiglitazone as ...

journal_title：Journal of neurochemistry

authors： Doonan F,Wallace DM,O'Driscoll C,Cotter TG

更新日期：2009-04-01 00:00:00

abstract：:A recent study has linked the butyrylcholinesterase (BChE) K-variant and the apolipoprotein epsilon4 isoform to late-onset Alzheimer's disease. These findings have been controversial and have led us to examine the differences between wild-type and K-variant BChE in enzyme activity, protein stability, and quaternary st...

journal_title：Journal of neurochemistry

authors： Altamirano CV,Bartels CF,Lockridge O

更新日期：2000-02-01 00:00:00

abstract：:Spiroxatrine has been reported to be a 5-HT1A serotonin receptor antagonist. Therefore [3H]spiroxatrine was synthesized and its 5-HT1A receptor binding properties in homogenates of rat hippocampal membranes were characterized with the expectation that it would be the first 5-HT1A antagonist radioligand. [3H]8-Hydroxyd...

journal_title：Journal of neurochemistry

authors： Herrick-Davis K,Titeler M

更新日期：1988-02-01 00:00:00

abstract：:The tyrosine kinase receptors for the neurotrophins (Trk) are a family of transmembrane receptors that regulate the differentiation and survival of different neuronal populations. Neurotrophin binding to Trk leads to the activation of several signalling pathways including a rapid, but moderate, increase in intracellul...

journal_title：Journal of neurochemistry

authors： Llovera M,de Pablo Y,Egea J,Encinas M,Peiró S,Martín-Zanca D,Rocamora N,Comella JX

更新日期：2004-01-01 00:00:00

abstract：:We assessed the effects of cold and isolation stress on arginine vasopressin (AVP) mRNA in the paraventricular (PVN) and supraoptic (SON) nuclei of the hypothalamus. Vasopressin mRNA levels were determined by in situ hybridization histochemistry at the cellular level. In posterior magnocellular neurons of the PVN isol...

journal_title：Journal of neurochemistry

authors： Angulo JA,Ledoux M,McEwen BS

更新日期：1991-06-01 00:00:00

abstract：:Late Infantile Neuronal Ceroid Lipofuscinosis (LINCL) is a rare neurodegenerative disease caused by mutations in the Cln2 gene that leads to deficiency or loss of function of the tripeptidyl peptidase 1 (TPP1) enzyme. TPP1 deficiency is known to cause the accumulation of autofluoroscent lipid-protein pigments in brain...

journal_title：Journal of neurochemistry

authors： Ghosh A,Rangasamy SB,Modi KK,Pahan K

更新日期：2017-05-01 00:00:00