Gemfibrozil, food and drug administration-approved lipid-lowering drug, increases longevity in mouse model of late infantile neuronal ceroid lipofuscinosis.

abstract：:Wallerian degeneration in peripheral nerves occurs after a traumatic insult when the distal nerve part degenerates while peripheral macrophages enter the nerve stump and remove the accruing debris by phagozytosis. We used an experimental model to investigate the effect of either the absence or over-expression of alpha...

journal_title：Journal of neurochemistry

authors： Siebert H,Kahle PJ,Kramer ML,Isik T,Schlüter OM,Schulz-Schaeffer WJ,Brück W

更新日期：2010-08-01 00:00:00

abstract：:There is ample evidence that both acid (ASMase) and neutral (NSMase) sphingomyelinases play a role in cell death so inhibitors of either enzyme could have significant value as protectors against neurodegeneration. We used a fluorogenic sphingomyelinase substrate, 6-hexadecanoylamino-4-methylumbelliferyl-phosphorylchol...

journal_title：Journal of neurochemistry

authors： Testai FD,Landek MA,Goswami R,Ahmed M,Dawson G

更新日期：2004-05-01 00:00:00

abstract：:The neurotoxic metabolite of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenylpyridinium, selectively accumulates in dopaminergic neurons via the dopamine reuptake system. Consequently, nontoxic radiolabeled MPTP analogs may be potentially useful for visualizing catecholaminergic neurons in vivo. ...

journal_title：Journal of neurochemistry

authors： Efange SM,Mash D,Hefti F,Kung HF,Billings J

更新日期：1989-08-01 00:00:00

abstract：:The olfactory bulb is one of the most vulnerable brain regions in age-related proteinopathies. Proteinopathic stress is mitigated by the heat shock protein (Hsp) family of chaperones. Here, we describe age-related decreases in Hsc70 in the olfactory bulb of the female rat and higher levels of Hsp70 and Hsp25 in middle...

journal_title：Journal of neurochemistry

authors： Crum TS,Gleixner AM,Posimo JM,Mason DM,Broeren MT,Heinemann SD,Wipf P,Brodsky JL,Leak RK

更新日期：2015-06-01 00:00:00

abstract：:Chronic exposure to manganese (Mn) can cause manganism, a neurodegenerative disorder similar to Parkinson's disease. The toxicity of Mn includes impairment of astrocytic glutamate transporters. 17beta-Estradiol (E2) has been shown to be neuroprotective in various neurodegenerative diseases including Parkinson's diseas...

journal_title：Journal of neurochemistry

authors： Lee ES,Sidoryk M,Jiang H,Yin Z,Aschner M

更新日期：2009-07-01 00:00:00

abstract：:Single-bilayer vesicles of myelin are desirable for studying myelin development and metabolism. Accordingly, our interest was drawn to a procedure for vesiculating myelin (Steck et al., Biochim, Biophys. Acta 509, 397-408, 1978). We used X-ray diffraction analysis to examine these putative vesicle preparations because...

journal_title：Journal of neurochemistry

authors： Sedzik J,Toews AD,Blaurock AE,Morell P

更新日期：1984-11-01 00:00:00

abstract：:Beta-carbolines have been suggested to be involved in the pathogenesis of Parkinson's disease as a result of their structural similarity to the neurotoxin N -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The chloral-derived beta-carboline derivative 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) caus...

journal_title：Journal of neurochemistry

authors： Riederer F,Luborzewski A,God R,Bringmann G,Scholz J,Feineis D,Moser A

更新日期：2002-05-01 00:00:00

abstract：:A method was developed for direct and continuous detection of secretion of ATP from primary monolayer cultures of bovine adrenal chromaffin cells. ATP, which is costored with catecholamines within adrenal chromaffin cells, was released into the incubation medium, where it reacted with firefly luciferin-luciferase prod...

journal_title：Journal of neurochemistry

authors： White TD,Bourke JE,Livett BG

更新日期：1987-10-01 00:00:00

abstract：:The structure and function of mitochondrial respiratory-chain enzyme proteins were studied postmortem in the substantia nigra of nine patients with Parkinson's disease and nine matched controls. Total protein and mitochondrial mass were similar in the two groups. NADH-ubiquinone reductase (Complex I) and NADH cytochro...

journal_title：Journal of neurochemistry

authors： Schapira AH,Cooper JM,Dexter D,Clark JB,Jenner P,Marsden CD

更新日期：1990-03-01 00:00:00

abstract：:Developmental profiles were determined for the activities of eight enzymes involved in fatty acid beta-oxidation in rat brain. The enzymes studied were the palmitoyl-CoA, octanoyl-CoA, butyryl-CoA, glutaryl-CoA, and 3-hydroxyacyl-CoA dehydrogenases, the enoyl-CoA hydratase (crotonase), and the C4- and C10-thiolases. W...

journal_title：Journal of neurochemistry

authors： Reichmann H,Maltese WA,DeVivo DC

更新日期：1988-08-01 00:00:00

abstract：:In recent years, there has been increasing evidence that serotonergic neurotransmission modulates a wide variety of experimentally induced seizures. Generally, agents that elevate extracellular serotonin (5-HT) levels, such as 5-hydroxytryptophan and serotonin reuptake blockers, inhibit both focal and generalized seiz...

journal_title：Journal of neurochemistry

authors： Bagdy G,Kecskemeti V,Riba P,Jakus R

更新日期：2007-02-01 00:00:00

abstract：:It is well-known that the extracellular concentration of calcium affects neuronal excitability and synaptic transmission. Less is known about the physiological concentration of extracellular calcium in the brain. In electrophysiological brain slice experiments, the artificial cerebrospinal fluid traditionally contains...

journal_title：Journal of neurochemistry

authors： Forsberg M,Seth H,Björefeldt A,Lyckenvik T,Andersson M,Wasling P,Zetterberg H,Hanse E

更新日期：2019-05-01 00:00:00

abstract：:The nature of the opiate modulation of adenylate cyclase following acute and chronic agonist exposure has been investigated in rat spinal cord. Using membranes of both adult rat spinal cord and spinal cord-dorsal root ganglion cocultures, we found that kappa-opiate receptors are negatively coupled to adenylate cyclase...

journal_title：Journal of neurochemistry

authors： Attali B,Saya D,Vogel Z

更新日期：1989-02-01 00:00:00

abstract：:Chronic alcohol exposure induces lasting behavioral changes, tolerance, and dependence. This results, at least partially, from neural adaptations at a cellular level. Previous genome-wide gene expression studies using pooled human brain samples showed that alcohol abuse causes widespread changes in the pattern of gene...

journal_title：Journal of neurochemistry

authors： Liu J,Lewohl JM,Dodd PR,Randall PK,Harris RA,Mayfield RD

更新日期：2004-09-01 00:00:00

abstract：:Two semisynthetic acetyl derivatives of the alkaloid sauroine from Huperzia saururus, monoacetyl sauroine, and diacetyl sauroine (DAS) were obtained and their chemical structures were analyzed by NMR. While monoacetyl sauroine is the typical product of acetylation, DAS is an unexpected derivative related to the keto-e...

journal_title：Journal of neurochemistry

authors： Vallejo M,Loyola S,Contreras D,Ugarte G,Cifuente D,Ortega G,Cabrera JL,Zeise M,Tonn C,Carreño M,Delgado R,Morales B,Agnese M

更新日期：2014-06-01 00:00:00

abstract：:Malignant gliomas are common and aggressive brain tumours associated with significant morbidity and mortality. We showed in this report that substratum adherence and migration by human U87MG glioma cells in culture were significantly attenuated by the extracellular domains of Nogo-A (Nogo-66) and the myelin-associated...

journal_title：Journal of neurochemistry

authors： Liao H,Duka T,Teng FY,Sun L,Bu WY,Ahmed S,Tang BL,Xiao ZC

更新日期：2004-09-01 00:00:00

abstract：:To investigate the role of the retinoblastoma protein pRB in neuronal differentiation, we have measured the accumulation of hypophosphorylated pRB in PC12 cells stimulated by nerve growth factor (NGF). NGF induced the accumulation of hypophosphorylated pRB within 30 min and the level peaked after 12 h. Viral Kiras, cy...

journal_title：Journal of neurochemistry

authors： Li H,Kawasaki H,Nishida E,Hattori S,Nakamura S

更新日期：1996-06-01 00:00:00

abstract：:Post-ischemic inflammation is an essential step in the progression of ischemic stroke. This review focuses on the function of infiltrating immune cells, macrophages, and T cells, in ischemic brain injury. The brain is a sterile organ; however, the activation of Toll-like receptor (TLR) 2 and TLR4 is pivotal in the beg...

journal_title：Journal of neurochemistry

authors： Shichita T,Ago T,Kamouchi M,Kitazono T,Yoshimura A,Ooboshi H

更新日期：2012-11-01 00:00:00

abstract：:Reactive oxygen species (ROS) and oxidative stress have long been linked to cell death of neurons in many neurodegenerative conditions. However, the exact molecular mechanisms triggered by oxidative stress in neurodegeneration are at present unclear. In the current work we have used the human neuroblastoma SH-SY5Y cel...

journal_title：Journal of neurochemistry

authors： Sanvicens N,Gómez-Vicente V,Messeguer A,Cotter TG

更新日期：2006-08-01 00:00:00

abstract：:In this review, we discuss the poorly explored role of calcium/calmodulin-dependent protein kinase II (CaMKII) in memory maintenance, and its influence on memory destabilization. After a brief review on CaMKII and memory destabilization, we present critical pieces of evidence suggesting that CaMKII activity increases ...

journal_title：Journal of neurochemistry

authors： Vigil FA,Giese KP

更新日期：2018-10-01 00:00:00

abstract：:Stimulation of prostaglandin (PG) release in rat astroglial cultures by various substances, including phorbol esters, melittin, or extracellular ATP, has been reported recently. It is shown here that glucocorticoids (GCs) reduced both basal and stimulated PGD2 release. Hydrocortisone, however, did not inhibit ATP-, ca...

journal_title：Journal of neurochemistry

authors： Gebicke-Haerter PJ,Schobert A,Dieter P,Honegger P,Hertting G

更新日期：1991-07-01 00:00:00

abstract：:Kallikrein 6 is a serine protease expressed abundantly in normal adult human and rodent CNS, and therein is regulated by injury. In the case of CNS demyelinating disease, K6 expression in CNS occurs additionally in perivascular and parenchymal inflammatory cells suggesting a role in pathogenesis. Herein we describe tw...

journal_title：Journal of neurochemistry

authors： Christophi GP,Isackson PJ,Blaber S,Blaber M,Rodriguez M,Scarisbrick IA

更新日期：2004-12-01 00:00:00

abstract：:Transcriptional dysregulation is a hallmark of Huntington's disease (HD) and one cause of this dysregulation is enhanced activity of the REST-mSIN3a-mSIN3b-CoREST-HDAC repressor complex, which silences transcription through REST binding to the RE1/NRSE silencer. Normally, huntingtin (HTT) prevents this binding, allowi...

journal_title：Journal of neurochemistry

authors： Conforti P,Zuccato C,Gaudenzi G,Ieraci A,Camnasio S,Buckley NJ,Mutti C,Cotelli F,Contini A,Cattaneo E

更新日期：2013-10-01 00:00:00

abstract：:Early onset familial Alzheimer's disease (FAD) is linked to autosomal dominant mutations in the amyloid precursor protein (APP) and presenilin 1 and 2 (PS1 and PS2) genes. These are critical mediators of total amyloid beta-peptide (Abeta) production, inducing cell death through uncertain mechanisms. Tauroursodeoxychol...

journal_title：Journal of neurochemistry

authors： Ramalho RM,Borralho PM,Castro RE,Solá S,Steer CJ,Rodrigues CM

更新日期：2006-09-01 00:00:00

abstract：:Signaling by muscarinic agonists is thought to result from the activation of cell surface acetylcholine receptors (mAChRs) that transmit extracellular signals to intracellular systems. In N1E-115 neuroblastoma cells, we detected both plasma membrane and intracellular M(1) -mAChRs using both biochemical and pharmacolog...

journal_title：Journal of neurochemistry

authors： Uwada J,Anisuzzaman AS,Nishimune A,Yoshiki H,Muramatsu I

更新日期：2011-09-01 00:00:00

abstract：:Inhibition of the mitochondrial electron transport chain (ETC) ultimately limits ATP production and depletes cellular ATP. However, the individual complexes of the ETC in brain mitochondria need to be inhibited by approximately 50% before causing significant depression of ATP synthesis. Moreover, the ETC is the key si...

journal_title：Journal of neurochemistry

authors： Jacobson J,Duchen MR,Hothersall J,Clark JB,Heales SJ

更新日期：2005-10-01 00:00:00

abstract：:The glutamate receptor 2 (GluR2) subunit determines many of the functional properties of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate subtype of glutamate receptor. The roles of untranslated regions (UTRs) in mRNA stability, transport, or translation are increasingly recognized. The 3' end of the GluR2 tra...

journal_title：Journal of neurochemistry

authors： Irier HA,Shaw R,Lau A,Feng Y,Dingledine R

更新日期：2009-04-01 00:00:00

abstract：:A central role of iron in the pathogenesis of Parkinson's disease (PD), due to its increase in substantia nigra pars compacta dopaminergic neurons and reactive microglia and its capacity to enhance production of toxic reactive oxygen radicals, has been discussed for many years. Recent transcranial ultrasound findings ...

journal_title：Journal of neurochemistry

authors： Berg D,Gerlach M,Youdim MB,Double KL,Zecca L,Riederer P,Becker G

更新日期：2001-10-01 00:00:00

abstract：:The role of the glutamate dehydrogenase reaction as a pathway of glutamate synthesis was studied by incubating synaptosomes with 5 mM 15NH4Cl and then utilizing gas chromatography-mass spectrometry to measure isotopic enrichment in glutamate and aspartate. The rate of formation of [15N]glutamate and [15N]aspartate fro...

journal_title：Journal of neurochemistry

authors： Yudkoff M,Nissim I,Nelson D,Lin ZP,Erecińska M

更新日期：1991-07-01 00:00:00

abstract：:In the present study we have used perfused hippocampal slices to examine the hypothesis that nitric oxide (NO) can evoke the release of adenosine from nervous tissue. ATP stores were labeled by incubation with [3H]adenine. Electrical field stimulation at 5 Hz for 5 min evoked the release of 3H-purines, and this was en...

journal_title：Journal of neurochemistry

authors： Fallahi N,Broad RM,Jin S,Fredholm BB

更新日期：1996-07-01 00:00:00