Mitochondrial complex I deficiency in Parkinson's disease.

abstract：:Benzodiazepines are commonly used as sedatives, sleeping aids, and anti-anxiety drugs. However, chronic treatment with benzodiazepines is known to induce dependence, which is considered related to neuroplastic changes in the mesolimbic system. This study investigated the involvement of K(+) -Cl(-) co-transporter 2 (KC...

journal_title：Journal of neurochemistry

authors： Shibasaki M,Masukawa D,Ishii K,Yamagishi Y,Mori T,Suzuki T

更新日期：2013-06-01 00:00:00

abstract：:Myelin basic protein (MBP) dissociated from brain myelin membranes when they were incubated (37 degrees C; pH 7.4) at physiological ionic strength. Zinc ions inhibited, and calcium promoted, this process. Protease activity in the membrane preparations cleaved the dissociated MBP into both small (less than 4 kilodalton...

journal_title：Journal of neurochemistry

authors： Earl C,Chantry A,Mohammad N,Glynn P

更新日期：1988-09-01 00:00:00

abstract：:The autoradiographic method with L-[35S]methionine was used to determine the effects of an n-3 fatty acid deficiency on brain protein synthesis. Brain protein synthesis was significantly increased (from 50 to 150%) in 45 of the 52 brain structures studied in n-3 fatty acid-deficient rats as compared with control anima...

journal_title：Journal of neurochemistry

authors： Giaume M,Gay N,Baubet V,Gharib A,Durand G,Bobillier P,Sarda N

更新日期：1994-11-01 00:00:00

abstract：:Specific D2 binding in rat striatum was characterized and then the effects of chronic disruption of dopaminergic activity on antagonist and agonist binding to these sites were studied. D2 receptors were defined as those sites capable of binding [3H]spiperone in the presence of cinanserin, a 5-HT2 antagonist, but not i...

journal_title：Journal of neurochemistry

authors： MacKenzie RG,Zigmond MJ

更新日期：1984-11-01 00:00:00

abstract：:We previously reported that annexin V promoted the survival of cultured rat neocortical neurons. In an effort to elucidate the mechanism underlying this neurotrophic activity of annexin V, we have attempted to identify the target or binding proteins of annexin V in neuronal cells. Herein, we screened an embryonic day ...

journal_title：Journal of neurochemistry

authors： Ohsawa K,Imai Y,Ito D,Kohsaka S

更新日期：1996-07-01 00:00:00

abstract：:Seven monoclonal antibodies (MAbs) directed to tetrasialoganglioside (GQ1b) were established, purified GQ1b being used for immunization and hybridoma screening. All of the MAbs reacted strongly with GQ1b, although they also reacted with other gangliosides, with different specificities and reactivities. Some MAbs (1H10...

journal_title：Journal of neurochemistry

authors： Yamamoto H,Tsuji S,Nagai Y

更新日期：1990-02-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) has been reported to enhance dopaminergic neuron survival and differentiation in vitro and in vivo, although those results are still being debated. Glial cell line-derived neurotrophic factor (gdnf) is highly conserved in zebrafish and plays a role in enteric nervous ...

journal_title：Journal of neurochemistry

authors： Wong CED,Hua K,Monis S,Saxena V,Norazit A,Noor SM,Ekker M

更新日期：2020-06-24 00:00:00

abstract：:Levels of multidrug efflux transporter P-glycoprotein (P-gp) on endothelial cells lining brain blood vessels are important for limiting access of many compounds to the brain. In vivo studies have indicated that ischaemia-reperfusion that generates reactive oxygen species also increases P-gp levels in brain endothelial...

journal_title：Journal of neurochemistry

authors： Robertson SJ,Kania KD,Hladky SB,Barrand MA

更新日期：2009-10-01 00:00:00

abstract：:At 1, 2, and 4 weeks after unilateral premotor and motor cortex ablation in rats, a significant and lasting decrease in glutamate levels in the ipsilateral versus contralateral striatum was observed. A significant corresponding fall in aspartate was seen only after 1 week. In contrast, there was a large increase in th...

journal_title：Journal of neurochemistry

authors： Hassler R,Haug P,Nitsch C,Kim JS,Paik K

更新日期：1982-04-01 00:00:00

abstract：:Traumatic brain injury (TBI) results in significant inflammation which contributes to the evolving pathology. Previously, we have demonstrated that cyclic AMP (cAMP), a molecule involved in inflammation, is down-regulated after TBI. To determine the mechanism by which cAMP is down-regulated after TBI, we determined wh...

journal_title：Journal of neurochemistry

authors： Oliva AA Jr,Kang Y,Furones C,Alonso OF,Bruno O,Dietrich WD,Atkins CM

更新日期：2012-12-01 00:00:00

abstract：:Poly A(+) messenger RNA (mRNA) was isolated from the brains of 3-week-old mice and translated in a cell-free system derived from wheat germ. Maximal stimulation of the system by brain mRNA was observed at a relatively low K+ concentration (45 mM) and low mRNA concentration (1-10 microgram/ml). The translational system...

journal_title：Journal of neurochemistry

authors： Matthees J,Campagnoni AT

更新日期：1980-10-01 00:00:00

abstract：:Prostaglandin E2 (PGE2 ) plays crucial roles in managing microglial activation through the prostanoid EP2 receptor, a PGE2 receptor subtype. In this study, we report that PGE2 enhances interferon-γ (IFN-γ)-induced nitric oxide production in microglia. IFN-γ increased the release of nitrite, a metabolite of nitric oxid...

journal_title：Journal of neurochemistry

authors： Nagano T,Nishiyama R,Sanada A,Mutaguchi Y,Ioku A,Umeki H,Kishimoto S,Yamanaka D,Kimura SH,Takemura M

更新日期：2017-02-01 00:00:00

abstract：:Sympathetic denervation of the iris muscle produces increases in both the breakdown of phosphatidylinositol 4,5-bisphosphate (PIP2) and in muscle contraction in response to norepinephrine (NE). To shed more light on the biochemical basis underlying this supersensitivity we investigated: the effects of NE on PIP2 break...

journal_title：Journal of neurochemistry

authors： Akhtar RA,Abdel-Latif AA

更新日期：1986-01-01 00:00:00

abstract：:Excitotoxicity and defects in neuronal energy metabolism have both been implicated in the pathogenesis of neurodegenerative disease. These two mechanisms may be linked through the NMDA receptor, activation of which is dependent on neuronal membrane potential. Because the ability to maintain membrane potential is depen...

journal_title：Journal of neurochemistry

authors： Greene JG,Porter RH,Eller RV,Greenamyre JT

更新日期：1993-09-01 00:00:00

abstract：:We have shown that following heat shock (42.5 degree C for 30 min), mouse-derived C1300 N2A neuroblastoma cells contain increased levels of mRNA coding for the inducible form of heat shock protein 70 and for ubiquitin. Incubation of C1300 cells with iron also induces an elevation in content of mRNAs coding for the sam...

journal_title：Journal of neurochemistry

authors： Uney JB,Anderton BH,Thomas SM

更新日期：1993-02-01 00:00:00

abstract：:35SO4-labeled fast-transported proteins of bullfrog dorsal root ganglion neurons were separated by two-dimensional gel electrophoresis, and their mobilities were compared to similar species labeled with [3H]mannose or [3H]fucose. Fluorography revealed regions of poorly resolved, high molecular weight material, likely ...

journal_title：Journal of neurochemistry

authors： Stone GC,Hammerschlag R,Bobinski JA

更新日期：1983-10-01 00:00:00

abstract：:Therapy of malignant glioma relies on treatment with the O6 -methylating agent temozolomide (TMZ) concomitant with ionizing radiation followed by adjuvant TMZ. For the treatment of recurrences, DNA chloroethylating drugs are also used. The main killing lesion induced by these drugs is O6 -alkylguanine. Since this dama...

journal_title：Journal of neurochemistry

authors： Aasland D,Reich TR,Tomicic MT,Switzeny OJ,Kaina B,Christmann M

更新日期：2018-01-01 00:00:00

abstract：:The molecular forms of angiotensin converting enzyme (ACE; EC 3.4.15.1) in preparations of pig brain cortical microvessels and striatal synaptosomal membranes have been identified by immunoelectrophoretic blot analysis. The cortical microvessels contained only the endothelial form of the enzyme, Mr 180,000, which comi...

journal_title：Journal of neurochemistry

authors： Williams TA,Hooper NM,Turner AJ

更新日期：1991-07-01 00:00:00

abstract：:Stimulation of glutamate binding by the dipeptide L-phenylalanyl-L-glutamate (Phe-Glu) was inhibited by the peptidase inhibitor bestatin, suggesting that the stimulation was caused by glutamate liberated from the dipeptide and not by the dipeptide itself. It further suggests that this form of glutamate binding should ...

journal_title：Journal of neurochemistry

authors： Kessler M,Petersen G,Vu HM,Baudry M,Lynch G

更新日期：1987-04-01 00:00:00

abstract：:We examined the effect of phenylalanine (50-400 microM) on the electrically stimulated release of endogenous 3,4-dihydroxyphenylethylamine (dopamine or DA) from superfused rat striatal slices. In the absence of tyrosine, phenylalanine (25 microM) partially sustained DA release, but less well than an equimolar concentr...

journal_title：Journal of neurochemistry

authors： Milner JD,Irie K,Wurtman RJ

更新日期：1986-11-01 00:00:00

abstract：:Discoidin domain receptor 1 (DDR1) is expressed in myelin oligodendrocytes and co-localizes with myelin basic protein (MBP). Alternative splicing of DDR1 generates five isoforms designated DDR1a-e. The MBP mRNA contains an hnRNP A2 response element (A2RE) sequence that is recognized by heterogeneous nuclear ribonucleo...

journal_title：Journal of neurochemistry

authors： Roig B,Moyano S,Martorell L,Costas J,Vilella E

更新日期：2012-02-01 00:00:00

abstract：:Growth cone response to the bifunctional guidance cue netrin-1 is regulated by the activity of intracellular signaling intermediates such as protein kinase C-alpha (PKCalpha) and adenylyl cyclase. Among the diverse cellular events these enzymes regulate is receptor trafficking. Netrin-1, itself, may govern the activit...

journal_title：Journal of neurochemistry

authors： McKenna WL,Wong-Staal C,Kim GC,Macias H,Hinck L,Bartoe JL

更新日期：2008-02-01 00:00:00

abstract：:The nervous tissue-specific protein B-50 (GAP-43), which has been implicated in the regulation of neurotransmitter release, is a member of a family of atypical calmodulin-binding proteins. To investigate to what extent calmodulin and the interaction between B-50 and calmodulin are involved in the mechanism of Ca(2+)-i...

journal_title：Journal of neurochemistry

authors： Hens JJ,Oestreicher AB,De Wit M,Marquart A,Gispen WH,De Graan PN

更新日期：1996-05-01 00:00:00

abstract：:Nitric oxide (.NO) synthase (NOS) was induced in cultured rat astrocytes by incubation with lipopolysaccharide (LPS) for 18 h and gap junction permeability was assessed by the scrape-loading/Lucifer yellow transfer technique. Induction of NOS was confirmed by determining either the NG-methyl-L-arginine (NMMA)-inhibita...

journal_title：Journal of neurochemistry

authors： Bolaños JP,Medina JM

更新日期：1996-05-01 00:00:00

abstract：:Nitric oxide (NO) has been implicated in both the pathogenesis of and protection from NMDA receptor-mediated neuronal injury. This apparent paradox has been attributed to alternate redox states of nitrogen monoxide, whereby, depending on the redox milieu, nitrogen monoxide can be neuroprotective via nitrosation chemis...

journal_title：Journal of neurochemistry

authors： Vidwans AS,Kim S,Coffin DO,Wink DA,Hewett SJ

更新日期：1999-05-01 00:00:00

abstract：:Increasing evidence suggests that proteasome inhibition plays a causal role in promoting the neurodegeneration and neuron death observed in multiple disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). The ability of severe and acute inhibition of proteasome function to induce neuron death and n...

journal_title：Journal of neurochemistry

authors： Ding Q,Dimayuga E,Martin S,Bruce-Keller AJ,Nukala V,Cuervo AM,Keller JN

更新日期：2003-07-01 00:00:00

abstract：:2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitous environmental pollutant that could induce significant toxic effects in the human nervous system. However, the underlying molecular mechanism has not been entirely elucidated. Reactive astrogliosis has implicated in various neurological diseases via the product...

journal_title：Journal of neurochemistry

authors： Zhang Y,Nie X,Tao T,Qian W,Jiang S,Jiang J,Li A,Guo A,Xu G,Wu Q

更新日期：2014-06-01 00:00:00

abstract：:As a basis for attempts to define the structures of the proteins within myelin, methods have been developed for their extraction and isolation in solutions of non-denaturing detergents. With use of solutions of deoxycholate or Triton X-100, up to 90% of the protein has been extracted from bovine CNS myelin, along with...

journal_title：Journal of neurochemistry

authors： Smith R,Cook J,Dickens PA

更新日期：1984-02-01 00:00:00

abstract：:The amyloid precursor protein (APP) is an ubiquitous receptor-like molecule involved in the pathogenesis of Alzheimer's disease (AD). APP and some of its C-terminal proteolytic fragments (CTFs) have been shown to be phosphorylated and to interact with cytosolic phosphotyrosine binding (PTB) domain containing proteins ...

journal_title：Journal of neurochemistry

authors： Venezia V,Russo C,Repetto E,Salis S,Dolcini V,Genova F,Nizzari M,Mueller U,Schettini G

更新日期：2004-09-01 00:00:00

abstract：:A glutamate binding protein was purified from bovine brain to apparent homogeneity. The procedure used for the purification of this protein involved extraction of a crude synaptic membrane fraction with Na-cholate, followed by solubilization of the binding protein from the membranes by Triton X-100, and, finally, affi...

journal_title：Journal of neurochemistry

authors： Michaelis EK,Chittenden WL,Johnson BE,Galton N,Decedue C

更新日期：1984-02-01 00:00:00