Abstract：
:At 1, 2, and 4 weeks after unilateral premotor and motor cortex ablation in rats, a significant and lasting decrease in glutamate levels in the ipsilateral versus contralateral striatum was observed. A significant corresponding fall in aspartate was seen only after 1 week. In contrast, there was a large increase in the striatal concentrations of lysine, threonine, alanine, and glutamine 1 week after the cortical ablation. This correlates with the extensive glial proliferation in the deafferented ipsilateral striatum. Four weeks after cortical ablation the GABA concentration was significantly increased. There was no decrease in other putative transmitters (dopamine, serotonin, acetylcholine, glycine and taurine), nor was a glutamate decrease observed in the hippocampus or in the hypothalamus, which do not receive direct premotor and motor cortical inputs. Both biochemical and morphological evidence for a minor contralateral cortico-striatal projection was obtained. Correlating with the fall in glutamate, ultrastructural observations indicated the degeneration of two types of striatal synapses, i.e., those of the axo-spinous type III and of the axo-dendritic type VII. Frontal cortex ablation clearly affects, in opposite directions, the metabolism of various striatal amino acids but not that of acetylcholine and the monoamine transmitters. The results strongly support the view that glutamate is the transmitter of the cortico-striatal fibers.
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
Hassler R,Haug P,Nitsch C,Kim JS,Paik Kdoi
10.1111/j.1471-4159.1982.tb05352.xsubject
Has Abstractpub_date
1982-04-01 00:00:00pages
1087-98issue
4eissn
0022-3042issn
1471-4159journal_volume
38pub_type
杂志文章abstract：:This study describes the effect of signalling through muscarinic acetylcholine receptors on two transcription factors implicated in long-term synaptic plasticity and memory formation, EGR1 and the cyclic AMP response element binding protein (CREB). In SK-N-SH neuroblastoma cells, treatment with the cholinergic agonist...
journal_title：Journal of neurochemistry
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doi：10.1111/j.1471-4159.1992.tb11016.x
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pub_type： 杂志文章
doi：10.1111/j.1471-4159.1990.tb01228.x
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doi：10.1046/j.0022-3042.2002.00796.x
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doi：10.1046/j.1471-4159.1998.70041628.x
更新日期：1998-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：1994-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：1995-06-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/j.1471-4159.1989.tb07366.x
更新日期：1989-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1471-4159.2007.04745.x
更新日期：2007-10-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/j.1471-4159.1985.tb05447.x
更新日期：1985-02-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/j.1471-4159.2008.05356.x
更新日期：2008-07-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1111/jnc.14256
更新日期：2018-02-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1046/j.1471-4159.1995.65031124.x
更新日期：1995-09-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1046/j.1471-4159.2002.00791.x
更新日期：2002-04-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/j.1471-4159.1986.tb13052.x
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pub_type： 杂志文章
doi：10.1111/j.1471-4159.1993.tb05845.x
更新日期：1993-01-01 00:00:00
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journal_title：Journal of neurochemistry
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更新日期：1987-03-01 00:00:00
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pub_type： 新闻
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更新日期：2019-06-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/j.1471-4159.1991.tb08252.x
更新日期：1991-09-01 00:00:00
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更新日期：1985-12-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
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更新日期：2005-07-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/j.1471-4159.1991.tb03474.x
更新日期：1991-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-02-01 00:00:00
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journal_title：Journal of neurochemistry
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