Content of quinolinic acid and of other tryptophan metabolites increases in brain regions of rats used as experimental models of hepatic encephalopathy.

abstract：:Each of the known classes of mammalian glycosaminoglycans, with the exception of keratan sulphate, was found in cerebral cortex samples from patients with Alzheimer-type dementia and age-matched controls. These molecules were quantitated, after electrophoresis and staining with Alcian Blue dye, by scanning densitometr...

journal_title：Journal of neurochemistry

authors： Jenkins HG,Bachelard HS

更新日期：1988-11-01 00:00:00

abstract：:msec7-1, a mammalian homologue of yeast sec7p, is known as a GDP/GTP exchange factor (GEF) for the ADP ribosylation factor (ARF) family of small GTPases. Here, we report that msec7-1 overexpression in cultured Aplysia neurons leads to an extensive neuritogenesis in a GEF activity-dependent manner through the modulatio...

journal_title：Journal of neurochemistry

authors： Huh M,Han JH,Lim CS,Lee SH,Kim S,Kim E,Kaang BK

更新日期：2003-04-01 00:00:00

abstract：:Epilepsy is a serious neurological condition exhibiting complex pathology and deserving of more serious attention. More than 30% of people with epilepsy are not responsive to more than 20 anti-epileptic drugs currently available, reflecting an unmet clinical need for novel therapeutic strategies. Not much is known abo...

journal_title：Journal of neurochemistry

authors： Paudel YN,Semple BD,Jones NC,Othman I,Shaikh MF

更新日期：2019-12-01 00:00:00

abstract：:Previous work from our laboratory points to plasma free tryptophan being a useful predictor of brain tryptophan concentration in many circumstances. Other work, in particular various studies on the acute effects of food intake, has emphasized the roles of plasma total tryptophan and of plasma large neutral amino acids...

journal_title：Journal of neurochemistry

authors： Sarna GS,Kantamaneni BD,Curzon G

更新日期：1985-05-01 00:00:00

abstract：:Repeated intermittent treatment with amphetamine (AMPH) induces both neurite outgrowth and enhanced AMPH-stimulated dopamine (DA) release in PC12 cells. We investigated the role of protein kinases in the induction of these AMPH-mediated events by using inhibitors of protein kinase C (PKC), mitogen activated protein ki...

journal_title：Journal of neurochemistry

authors： Park YH,Kantor L,Guptaroy B,Zhang M,Wang KK,Gnegy ME

更新日期：2003-12-01 00:00:00

abstract：:Pumiliotoxins (PTX) A, B, and 251D, members of a new class of indolizidine alkaloids isolated from the skin of poison frogs of the family Dendrobatidae, inhibit Ca2+-ATPase activity in sarcoplasmic reticulum vesicles from frog and rat hind-limb muscles. PTX-B and PTX-A appear to be relatively specific inhibitors of Ca...

journal_title：Journal of neurochemistry

authors： Tamburini R,Albuquerque EX,Daly JW,Kauffman FC

更新日期：1981-09-01 00:00:00

abstract：:Variations occurring in cortical nitric oxide (NO) release were analysed with a voltametric method in rats (i) placed in control conditions, (ii) while being paradoxical sleep deprived (PSD), or (iii) recovering from a PSD. Activities of neuronal (nNOS) and inducible (iNOS) NO-synthases as well as nNOS expression were...

journal_title：Journal of neurochemistry

authors： Clément P,Sarda N,Cespuglio R,Gharib A

更新日期：2004-08-01 00:00:00

abstract：:Rarefaction of the dendritic tree leading to neuronal dysfunction is a hallmark of many neurodegenerative diseases and we have shown previously that heat shock protein B5 (HspB5)/αB-crystallin is able to increase dendritic complexity in vitro. The aim of this study was to investigate if this effect is also present in ...

journal_title：Journal of neurochemistry

authors： Bartelt-Kirbach B,Wiegreffe C,Birk S,Baur T,Moron M,Britsch S,Golenhofen N

更新日期：2020-11-21 00:00:00

abstract：:Previous studies on central 5-hydroxytryptamine1A (5-HT1A) receptors have consistently shown the existence of a GTP-insensitive component of agonist binding, i.e., binding of [3H]8-hydroxy-2-(di-n-propylamino)tetralin ([3H]8-OH-DPAT) that persists in the presence of 0.1 mM GTP or guanylylimidodiphosphate (GppNHp). The...

journal_title：Journal of neurochemistry

authors： Emerit MB,Miquel MC,Gozlan H,Hamon M

更新日期：1991-05-01 00:00:00

abstract：:Spinal muscular atrophy (SMA) is a motor neuron disease caused by loss of function mutations in the Survival Motor Neuron 1 (SMN1) gene and reduced expression of the SMN protein, leading to spinal motor neuron death, muscle weakness and atrophy. Although humans harbour the highly homologous SMN2 gene, its defective sp...

journal_title：Journal of neurochemistry

authors： Pagliarini V,Guerra M,Di Rosa V,Compagnucci C,Sette C

更新日期：2020-04-01 00:00:00

abstract：:α-Synuclein causes Parkinson's disease if mutated or aberrantly produced in neurons. α-Synuclein-lipid interactions are important for the normal function of the protein, but can also contribute to pathogenesis. We previously reported that deletion of the first 10 N-terminal amino acids dramatically reduced lipid bindi...

journal_title：Journal of neurochemistry

authors： Vamvaca K,Lansbury PT Jr,Stefanis L

更新日期：2011-10-01 00:00:00

abstract：:Perilymph, which bathes the sensory cells of the cochlea, was collected from guinea pigs exposed to noise and analyzed via two cation-exchange HPLC procedures with fluorescence detection, resolving 51 and 81 primary-amine compounds, respectively, at a sensitivity limit of 0.1 pmol relative to leucine. During a first p...

journal_title：Journal of neurochemistry

authors： Drescher MJ,Drescher DG,Medina JE

更新日期：1983-08-01 00:00:00

abstract：:In this work, we have studied (a) the contents of gangliosides, glycoproteins, and phospholipids of the vesicle and plasma membrane fractions from brains of anesthetized and control rats and chickens and (b) the labeling of gangliosides and glycoproteins in the retina ganglion cell layer and optic tectum of urethane-a...

journal_title：Journal of neurochemistry

authors： Domowicz MS,Kivatinitz SC,Caputto BL,Caputto R

更新日期：1988-05-01 00:00:00

abstract：:Melatonin is neuroprotective because of its antioxidative action, but it also can modify neuronal vulnerability by altering gene expression. 5-Lipoxygenase (5-LO) gene expression is suppressed by the binding of melatonin to its high-affinity nuclear receptors. Recently, we reported that in rats the melatonin deficienc...

journal_title：Journal of neurochemistry

authors： Uz T,Longone P,Manev H

更新日期：1997-11-01 00:00:00

abstract：:Regional distribution of endogenous gamma-aminobutyric acid (GABA), its synthesizing enzyme, glutamic acid decarboxylase (GAD), and metabolic enzyme, GABA transaminase (GABA-T), were determined in the intestinal tract of guinea pigs and cats and the findings compared with the number of ganglion cells in Auerbach's ple...

journal_title：Journal of neurochemistry

authors： Miki Y,Taniyama K,Tanaka C,Tobe T

更新日期：1983-03-01 00:00:00

abstract：:Acetylcholine and choline release from rat brain synaptosomes have been measured using a chemiluminescent technique under a variety of conditions set up to mimic anoxic insult, including conditions of low pH (6.2) and the presence of lactate plus pyruvate as substrate. Lactate plus pyruvate as substrate consistently g...

journal_title：Journal of neurochemistry

authors： Sanchez-Prieto J,Harvey SA,Clark JB

更新日期：1987-04-01 00:00:00

abstract：:The thermodynamic parameters associated with the interactions of agonists and antagonists with glycine receptors in rat spinal cord membranes were determined. The binding of the antagonist [3H]strychnine and the inhibition of strychnine binding by 11 different glycinergic ligands were examined at temperatures between ...

journal_title：Journal of neurochemistry

authors： Ruiz-Gómez A,García-Calvo M,Vázquez J,Marvizón JC,Valdivieso F,Mayor F Jr

更新日期：1989-06-01 00:00:00

abstract：:Within the cell membrane there exist various microdomains (lipid rafts) in which specific lipids and proteins are assembled and these microdomains are recovered in the detergent-resistant low-density membrane fraction (DRM). Septin is a novel GTP-binding, cytoskeletal protein having various isoforms that assemble into...

journal_title：Journal of neurochemistry

authors： Maimaitiyiming M,Kumanogoh H,Nakamura S,Nagata K,Suzaki T,Maekawa S

更新日期：2008-08-01 00:00:00

abstract：:Release-regulating heterocarriers exist on brain nerve endings. We have investigated in this study the mechanisms involved in the neurotransmitter release evoked by GABA heterocarrier activation. GABA increased the basal release of [3H]acetylcholine and [3H]noradrenaline from rat hippocampal synaptosomes and of [3H]do...

journal_title：Journal of neurochemistry

authors： Fassio A,Bonanno G,Fontana G,Usai C,Marchi M,Raiteri M

更新日期：1996-04-01 00:00:00

abstract：:Rat hippocampal glutamatergic terminals possess NMDA autoreceptors whose activation by low micromolar NMDA elicits glutamate exocytosis in the presence of physiological Mg(2+) (1.2 mM), the release of glutamate being significantly reduced when compared to that in Mg(2+)-free condition. Both glutamate and glycine were ...

journal_title：Journal of neurochemistry

authors： Musante V,Summa M,Cunha RA,Raiteri M,Pittaluga A

更新日期：2011-05-01 00:00:00

abstract：:In the presence of lithium, carbamylcholine chloride (carbachol) and epinephrine increase the accumulation of inositol monophosphate severalfold in hippocampal slices from the rat. The stimulation by carbachol (EC50, 31 microM) is mediated by muscarinic receptors, whereas the effects of epinephrine (EC50, 2 microM) ar...

journal_title：Journal of neurochemistry

authors： Lenox RH,Hendley D,Ellis J

更新日期：1988-02-01 00:00:00

abstract：:PEA-15 has recently been identified as a major phosphoprotein in astrocytes and an endogenous substrate for protein kinase C. This 15-kDa protein exists under three molecular forms, an unphosphorylated form, N, and two phosphorylated forms, Pa and Pb. Antisera were raised against synthetic peptides corresponding to th...

journal_title：Journal of neurochemistry

authors： Danziger N,Yokoyama M,Jay T,Cordier J,Glowinski J,Chneiweiss H

更新日期：1995-03-01 00:00:00

abstract：:Aspartic acid (Asp) undergoes l-isomer-selective efflux transport across the blood-brain barrier (BBB). This transport system appears to play an important role in regulating l- and d-Asp levels in the brain. The purpose of this study was to identify the responsible transporters and elucidate the mechanism for l-isomer...

journal_title：Journal of neurochemistry

authors： Tetsuka K,Takanaga H,Ohtsuki S,Hosoya K,Terasaki T

更新日期：2003-11-01 00:00:00

abstract：:Mutations in Parkin, an E3 ligase, which participates in the ubiquitin-proteasome system (UPS), cause juvenile onset Parkinson's disease (PD). Some mutants aggregate upon over-expression, but the effects of such aggregation on the UPS and neuronal survival have not been characterized. We show in this study that transi...

journal_title：Journal of neurochemistry

authors： Kyratzi E,Pavlaki M,Kontostavlaki D,Rideout HJ,Stefanis L

更新日期：2007-08-01 00:00:00

abstract：:A rat kidney epithelial cell line expressing the rat neurokinin-1 receptor (NK-1 R) was used to investigate the relationship between receptor phosphorylation and desensitization. Substance P (SP) maximally stimulated cellular inositol 1,4,5-trisphosphate (IP3) production 14-fold within 3 s, after which cellular IP3 le...

journal_title：Journal of neurochemistry

authors： Vigna SR

更新日期：1999-11-01 00:00:00

abstract：:The 1-methyl-4-phenylpyridinium species (MPP+) is the four-electron oxidation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and is widely assumed to be the actual neurotoxic species responsible for the MPTP-induced destruction of dopaminergic neurons. MPTP is oxidized by the enzyme monoamine oxidase-B...

journal_title：Journal of neurochemistry

authors： Heikkila RE,Hwang J,Ofori S,Geller HM,Nicklas WJ

更新日期：1990-03-01 00:00:00

abstract：:There is growing evidence that activation of either protein kinases or protein phosphatases determines the type of plasticity observed after different patterns of hippocampal stimulation. Because activation of the extracellular signal-regulated kinase (ERK) has been shown to be necessary for long-term potentiation, we...

journal_title：Journal of neurochemistry

authors： Norman ED,Thiels E,Barrionuevo G,Klann E

更新日期：2000-01-01 00:00:00

abstract：:Tau, a microtubule-associated protein, is encoded by a single gene, whose expression is primarily neuronal. In this work, we defined an 80-bp region of the tau promoter that confers tau protein with neuronal expression. This fragment works in conjunction with an endogenous initiation region to activate neuronal precur...

journal_title：Journal of neurochemistry

authors： Heicklen-Klein A,Ginzburg I

更新日期：2000-10-01 00:00:00

abstract：:The selective metabotropic glutamate receptor agonist trans-1-aminocyclopentane-1,3-dicarboxylic acid (trans-ACPD) stimulates phosphoinositide hydrolysis and elicits several physiological responses in rat hippocampal slices. However, recent studies suggest that the physiological effects of trans-ACPD in the hippocampu...

journal_title：Journal of neurochemistry

authors： Winder DG,Conn PJ

更新日期：1992-07-01 00:00:00

abstract：:Pretreatment of striatal membranes with N-ethylmaleimide in the presence of a D1-specific agonist inactivated endogenous guanine nucleotide binding proteins (G proteins), but not D1 dopamine receptors, resulting in a loss of high-affinity agonist binding sites. Such D1 receptors were solubilized, mixed with exogenous ...

journal_title：Journal of neurochemistry

authors： Sidhu A,Sullivan M,Kohout T,Balen P,Fishman PH

更新日期：1991-10-01 00:00:00