Role of external and internal calcium on heterocarrier-mediated transmitter release.

abstract：:α-Synuclein causes Parkinson's disease if mutated or aberrantly produced in neurons. α-Synuclein-lipid interactions are important for the normal function of the protein, but can also contribute to pathogenesis. We previously reported that deletion of the first 10 N-terminal amino acids dramatically reduced lipid bindi...

journal_title：Journal of neurochemistry

authors： Vamvaca K,Lansbury PT Jr,Stefanis L

更新日期：2011-10-01 00:00:00

abstract：:Levels of multidrug efflux transporter P-glycoprotein (P-gp) on endothelial cells lining brain blood vessels are important for limiting access of many compounds to the brain. In vivo studies have indicated that ischaemia-reperfusion that generates reactive oxygen species also increases P-gp levels in brain endothelial...

journal_title：Journal of neurochemistry

authors： Robertson SJ,Kania KD,Hladky SB,Barrand MA

更新日期：2009-10-01 00:00:00

abstract：:Brain iron homeostasis is increasingly recognized as a potential target for the development of drug therapies for aging-related disorders. Dysregulation of iron metabolism associated with cellular damage and oxidative stress is reported as a common event in several neurodegenerative disorders such as Alzheimer's, Park...

journal_title：Journal of neurochemistry

authors： Belaidi AA,Bush AI

更新日期：2016-10-01 00:00:00

abstract：:Mouse monoclonal B-50 antibodies (Mabs) were screened to select a Mab that may interfere with suggested functions of B-50 (GAP-43), such as involvement in neurotransmitter release. Because the Mab NM2 reacted with peptide fragments of rat B-50 containing the unique protein kinase C (PKC) phosphorylation site at serine...

journal_title：Journal of neurochemistry

authors： Oestreicher AB,Hens JJ,Marquart A,Mercken M,De Graan PN,Zwiers H,Gipsen WH

更新日期：1994-03-01 00:00:00

abstract：:A protein that binds vesamicol has been purified from a soluble fraction of the Torpedo electric organ homogenate that does not contain synaptic vesicles. The purified vesamicol-binding protein (VBP) has a molecular mass of 470 kDa composed of 30- and 24-kDa subunits. Chemical deglycosylation yielded a single, heterog...

journal_title：Journal of neurochemistry

authors： Hicks BW,Rogers GA,Parsons SM

更新日期：1991-08-01 00:00:00

abstract：:Complementary DNAs that encode two forms of the chicken gamma-aminobutyric acid type A (GABAA) receptor beta 2 subunit have been isolated. These polypeptides differ by the presence of (beta 2L) or absence (beta 2S) of 17 amino acids, which contain a possible target for phosphorylation by protein kinase C, in the large...

journal_title：Journal of neurochemistry

authors： Harvey RJ,Chinchetru MA,Darlison MG

更新日期：1994-01-01 00:00:00

abstract：:The adenylate cyclase activity of rat hippocampal plasma membranes can be stimulated by vasoactive intestinal polypeptide (VIP). Low concentrations (10(-9) to 19(-7) M) of 5'-guanylyl-imido diphosphate (GppNHp) evoke a transient inhibition of the enzyme, which is followed by stimulation with increasing GppNHp concentr...

journal_title：Journal of neurochemistry

authors： Girardot JM,Kempf J,Cooper DM

更新日期：1983-09-01 00:00:00

abstract：:The neuronal protein B-50 may be involved in diverse functions including neural development, axonal regeneration, neural plasticity, and synaptic transmission. The rat B-50 sequence contains 226 amino acids which include 14 Ser and 14 Thr residues, all putative sites for phosphorylation by calcium/phospholipid-depende...

journal_title：Journal of neurochemistry

authors： Coggins PJ,Zwiers H

更新日期：1989-12-01 00:00:00

abstract：:RIC-3 enhances the functional expression of certain nicotinic acetylcholine receptors (nAChRs) in vertebrates and invertebrates and increases the availability of functional receptors in cultured cells and Xenopus laevis oocytes. Maximal activity of RIC-3 may be cell-type dependent, so neither mammalian nor invertebrat...

journal_title：Journal of neurochemistry

authors： Bennett HM,Lees K,Harper KM,Jones AK,Sattelle DB,Wonnacott S,Wolstenholme AJ

更新日期：2012-12-01 00:00:00

abstract：:The dopamine transporter is a plasma membrane protein that controls extracellular concentrations of the neurotransmitter dopamine. The physiological importance of the DAT provides the impetus for studies aimed at understanding the molecular mechanisms underlying regulation of the DAT gene. In this study, we identified...

journal_title：Journal of neurochemistry

authors： Wang J,Bannon MJ

更新日期：2005-04-01 00:00:00

abstract：:Cyclic-AMP-binding proteins in membrane and soluble fractions from rat forebrain were compared; membrane fractions included smooth and rough microsomes and a plasma membrane fraction enriched in synaptic membranes. Protein fractions were treated with 8-azido-[32P]cyclic AMP and ultraviolet irradiation to covalently ta...

journal_title：Journal of neurochemistry

authors： Strocchi P,Sapirstein VS,Rubin CS,Gilbert JM

更新日期：1984-08-01 00:00:00

abstract：:Stem cell-based approaches provide hope as a potential therapy for neurodegenerative diseases and stroke. One of the major scientific hurdles for stem cell therapy is the poor survival rate of the newly formed or transplanted neural stem cells. In this study, we found that low-dose treatment with the Heat shock protei...

journal_title：Journal of neurochemistry

authors： Wang G,Krishnamurthy K,Tangpisuthipongsa D

更新日期：2011-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is a typical progressive, chronic neurodegenerative disorder with worldwide prevalence. Its clinical manifestation involves the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs). NFTs occur in brain tissues as a result of both Aβ agglomeration and Tau phosphory...

journal_title：Journal of neurochemistry

authors： Jha NK,Jha SK,Kar R,Nand P,Swati K,Goswami VK

更新日期：2019-07-01 00:00:00

abstract：:Post-traumatic immune suppression renders individuals with spinal cord injury (SCI) susceptible to infection. Normally, proper immune function is regulated by collaboration between the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis and involves the controlled release of glucocorticoids ...

journal_title：Journal of neurochemistry

authors： Lucin KM,Sanders VM,Popovich PG

更新日期：2009-09-01 00:00:00

abstract：:To assess the importance of the cysteine residues Cys347 and Cys351 in the carboxylic tail in the human D1 dopamine receptor, seven mutant receptors were constructed by PCR. The pharmacological and functional properties of the wild-type and mutant receptors were assessed following transient expression in COS-7 cells. ...

journal_title：Journal of neurochemistry

authors： Jensen AA,Pedersen UB,Kiemer A,Din N,Andersen PH

更新日期：1995-09-01 00:00:00

abstract：:Multiple sclerosis (MS) pathology is marked by the massive infiltration of myelin-specific T cells into the CNS. Hallmarks of T helper (Th) cells during active disease are pro-inflammatory Th1/Th17 cells that predominate over immunoregulatory Th2/Treg cells. Neurodegeneration, a major factor in progressive MS, is ofte...

journal_title：Journal of neurochemistry

authors： Trager N,Smith A,Wallace Iv G,Azuma M,Inoue J,Beeson C,Haque A,Banik NL

更新日期：2014-07-01 00:00:00

abstract：:Beta-amyloid peptides play a major role in the pathogenesis of Alzheimer's disease (AD). Therefore, preventing beta-amyloid formation by inhibition of the beta site amyloid precursor protein-cleaving enzyme (BACE) 1 is considered as a potential strategy to treat AD. Cholinergic mechanisms have been shown to control am...

journal_title：Journal of neurochemistry

authors： Zuchner T,Schliebs R,Perez-Polo JR

更新日期：2005-10-01 00:00:00

abstract：:Ependymins are thought to be implicated in fundamental processes involved in plasticity of the goldfish CNS. Gas-phase sequencing of purified ependymins beta and gamma revealed that they share the same N-terminal sequence. Each sequence displays microheterogeneities at several positions. Based on the protein sequences...

journal_title：Journal of neurochemistry

authors： Königstorfer A,Sterrer S,Eckerskorn C,Lottspeich F,Schmidt R,Hoffmann W

更新日期：1989-01-01 00:00:00

abstract：:To study the role of intracellular pH (pHi) in catecholamine secretion and the regulation of pHi in bovine chromaffin cells, the pH-sensitive fluorescent indicator [2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] was used to monitor the on-line changes in pHi. The pHi of chromaffin cells at resting state is approxima...

journal_title：Journal of neurochemistry

authors： Kao LS,Ho MY,Cragoe EJ Jr

更新日期：1991-11-01 00:00:00

abstract：:β-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the transmembrane aspartyl protease that catalyzes the first cleavage step in the proteolysis of the APP to the amyloid β-protein (Aβ), a process involved in the pathogenesis of Alzheimer disease. BACE1 pre-mRNA undergoes complex alternative splicing,...

journal_title：Journal of neurochemistry

authors： Fisette JF,Montagna DR,Mihailescu MR,Wolfe MS

更新日期：2012-06-01 00:00:00

abstract：:Matrix-assisted laser desorption/ionization with time-of-flight mass spectrometry is used to examine the formation of N-pyroglutamate (pGlu) in single, identified neurons from Aplysia. Six pGlu peptides are identified in the R3-14 and the R15 neurons that result from in vivo processing of peptides containing either Gl...

journal_title：Journal of neurochemistry

authors： Garden RW,Moroz TP,Gleeson JM,Floyd PD,Li L,Rubakhin SS,Sweedler JV

更新日期：1999-02-01 00:00:00

abstract：:Microtubule-associated protein (MAP) 1B is a high-molecular-weight cytoskeletal protein that is abundant in developing neuronal processes and appears to be necessary for axonal growth. Various biochemical and immunocytochemical results are reported, indicating that a significant fraction of MAP1B is expressed as an in...

journal_title：Journal of neurochemistry

authors： Tanner SL,Franzen R,Jaffe H,Quarles RH

更新日期：2000-08-01 00:00:00

abstract：:This review examines the involvement of nitrotyrosine as a marker for peroxynitrite-mediated damage in the dopamine neuronal system. We propose that the dopamine neuronal phenotype can influence the cytotoxic signature of peroxynitrite. Dopamine and tetrahydrobiopterin are concentrated in dopamine neurons, and both ar...

journal_title：Journal of neurochemistry

authors： Kuhn DM,Sakowski SA,Sadidi M,Geddes TJ

更新日期：2004-05-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) has protective effects against beta-amyloid (Abeta)-induced neuronal cell death. Because alterations of the somatostatinergic system have been described in Alzheimer's disease, we investigated the effects of the Abeta peptide and the possible protective role of IGF-I on the somatos...

journal_title：Journal of neurochemistry

authors： Aguado-Llera D,Arilla-Ferreiro E,Campos-Barros A,Puebla-Jiménez L,Barrios V

更新日期：2005-02-01 00:00:00

abstract：:The effect of L-phenylalanine on the transport of tyrosine was studied using membrane vesicles from rat brain synaptosomes. Phenylalanine, which is accumulated in phenylketonuria, competitively inhibits tyrosine uptake at concentrations similar to those found in phenylketonuric patients, with a Ki of the same order of...

journal_title：Journal of neurochemistry

authors： Aragón MC,Giménez C,Valdivieso F

更新日期：1982-10-01 00:00:00

abstract：:IMP-GMP 5'-nucleotidase has been purified to homogeneity from total rat brain extracts. This preparation showed a unique band (Mr 54,000 +/- 1,509) in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The enzyme presented the following properties: optimal pH value, 6.5-6.8; relative velocity measured in the p...

journal_title：Journal of neurochemistry

authors： Marques AF,Teixeira NA,Gambaretto C,Sillero A,Sillero MA

更新日期：1998-09-01 00:00:00

abstract：:Mitochondrial respiratory function, assessed from the rate of oxygen uptake by homogenates of rat brain subregions, was examined after 30 min of forebrain ischemia and at recirculation periods of up to 48 h. Ischemia-sensitive regions which develop extensive neuronal loss during the recirculation period (dorsal-latera...

journal_title：Journal of neurochemistry

authors： Sims NR,Pulsinelli WA

更新日期：1987-11-01 00:00:00

abstract：:Platelet-activating factor (PAF) may be a neuromodulator involved in neural cell differentiation, cerebral inflammation, and ischemia. The PAF receptor is a member of the G protein-coupled receptor superfamily. In the present study, we sought to define the specific G protein(s) that mediate PAF-stimulated phosphoinosi...

journal_title：Journal of neurochemistry

authors： Shi LC,Wang HY,Horwitz J,Friedman E

更新日期：1996-10-01 00:00:00

abstract：:The effects of glutamatergic excitotoxins on intracellular Cl- were investigated in the CA1 pyramidal cell layer of the hippocampal slice. Hippocampal slices from rats (14-19 days old) were loaded with 6-methoxy-N-ethylquinolinium chloride (MEQ), a Cl(-)-sensitive fluorescent probe with a fluorescence intensity that c...

journal_title：Journal of neurochemistry

authors： Inglefield JR,Schwartz-Bloom RD

更新日期：1998-10-01 00:00:00

abstract：:In all the species examined thus far, the behavior of microglia during development appears to be highly stereotyped. This reproducibility supports the notion that these cells have a physiological role in development. Microglia are macrophages that migrate from the yolk sac and colonize the central nervous system early...

journal_title：Journal of neurochemistry

authors： Pont-Lezica L,Béchade C,Belarif-Cantaut Y,Pascual O,Bessis A

更新日期：2011-12-01 00:00:00