D1 dopamine receptors can interact with both stimulatory and inhibitory guanine nucleotide binding proteins.

abstract：:Methyl CpG binding protein 2 (MeCP2) binds to methylated DNA and acts as a transcriptional repressor. Mutations of human MECP2 gene lead to Rett syndrome, a severe neural developmental disorder. Here, we report that the MeCP2 protein can be modified by covalent linkage to small ubiquitin-like modifier (SUMO) and SUMOy...

journal_title：Journal of neurochemistry

authors： Cheng J,Huang M,Zhu Y,Xin YJ,Zhao YK,Huang J,Yu JX,Zhou WH,Qiu Z

更新日期：2014-03-01 00:00:00

abstract：:Quinolinic acid is an excitatory, neurotoxic tryptophan metabolite proposed to play a role in the pathogenesis of hepatic encephalopathy. This involvement was investigated in rat and rabbit models of fulminant hepatic failure at different stages of hepatic encephalopathy. Although plasma and brain tryptophan levels we...

journal_title：Journal of neurochemistry

authors： Basile AS,Saito K,Li Y,Heyes MP

更新日期：1995-06-01 00:00:00

abstract：:Although 3,4-dihydroxyphenylethylamine (dopamine, DA) and vasoactive intestinal peptide (VIP) have been reported to stimulate adenylate cyclase activity in the rabbit retina, possible interactions between VIP-sensitive and DA-sensitive adenylate cyclase systems have not been previously investigated. To elucidate the i...

journal_title：Journal of neurochemistry

authors： Pachter JA,Lam DM

更新日期：1986-01-01 00:00:00

abstract：:Capsaicin receptors are expressed in primary sensory neurons and excited by heat and protons. We examined the inflammation-induced changes of the level of VR1 capsaicin receptor mRNA in sensory neurons and the sensitivity of primary afferents to capsaicin. Carrageenan treatment induced axonal transport of VR1 mRNA, bu...

journal_title：Journal of neurochemistry

authors： Tohda C,Sasaki M,Konemura T,Sasamura T,Itoh M,Kuraishi Y

更新日期：2001-03-01 00:00:00

abstract：:Extracellular amino acid levels in the rat piriform cortex, an area highly susceptible to seizure-induced neuropathology, were determined by means of intracranial microdialysis. Seizures were induced by systemic administration of either soman (O-1,2,2-trimethylpropyl methylphosphonofluoridate), a potent inhibitor of a...

journal_title：Journal of neurochemistry

authors： Wade JV,Samson FE,Nelson SR,Pazdernik TL

更新日期：1987-08-01 00:00:00

abstract：:Prostaglandin E1 (PGE1)-mediated transmembrane signal control systems were investigated in intact murine neuroblastoma cells (clone N1E-115). PGE1 increased intracellular levels of total inositol phosphates (IP), cyclic GMP, cyclic AMP, and calcium ([Ca2+]i). PGE1 transiently increased inositol 1,4,5-trisphosphate for...

journal_title：Journal of neurochemistry

authors： Kanba S,Sasakawa N,Nakaki T,Kanba KS,Yagi G,Kato R,Richelson E

更新日期：1991-12-01 00:00:00

abstract：:The metabolism and blood-brain transport of choline (Ch) were investigated in perfused canine brain under control conditions and for 60 min after inhibition of brain cholinesterases by the organophosphorus (OP) compounds soman (pinacolylmethylphosphonofluoridate). Ch and acetylcholine (ACh) in blood and brain samples ...

journal_title：Journal of neurochemistry

authors： Drewes LR,Singh AK

更新日期：1988-03-01 00:00:00

abstract：:Microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated in affected neurons of Alzheimer disease brain. This hyperphosphorylated tau can be dephosphorylated at some of the abnormal phosphorylated sites by purified protein phosphatase-1, 2A, and 2B in vitro. In the present study, we have dev...

journal_title：Journal of neurochemistry

authors： Gong CX,Shaikh S,Wang JZ,Zaidi T,Grundke-Iqbal I,Iqbal K

更新日期：1995-08-01 00:00:00

abstract：:The elongation of arachidoyl-CoA (20:0-CoA) yielded 22:0 and 24:0 concomitantly, whereas the elongation of behenoyl-CoA (22:0-CoA) yielded only a negligible amount of 24:0 in adult swine cerebral microsomes. The dependence on time, pH, and the substrate concentrations were examined for the synthesis of 22:0 and 24:0 f...

journal_title：Journal of neurochemistry

authors： Yoshida S,Takeshita M

更新日期：1986-05-01 00:00:00

abstract：:Transcriptional responses to growth factor and G protein-coupled receptors were compared in PC12 cells using retroviral luciferase reporters. In cells stably expressing alpha(1A)-adrenergic receptors, norepinephrine activated all five reporters [AP1 (activator protein-1), SRE (serum response element), CRE (cyclic AMP ...

journal_title：Journal of neurochemistry

authors： Minneman KP,Lee D,Zhong H,Berts A,Abbott KL,Murphy TJ

更新日期：2000-06-01 00:00:00

abstract：:Several lines of evidence implicate excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis (ALS). Transgenic mice with a superoxide dismutase mutation (G93A) have been utilized as an animal model of familial ALS (FALS). We examined the cortical concentrations of glutamate using in vivo microdialys...

journal_title：Journal of neurochemistry

authors： Andreassen OA,Jenkins BG,Dedeoglu A,Ferrante KL,Bogdanov MB,Kaddurah-Daouk R,Beal MF

更新日期：2001-04-01 00:00:00

abstract：:Hibernation is a seasonal phenomenon characterized by a drop in metabolic rate and body temperature. Adenosine A1 receptor agonists promote hibernation in different mammalian species, and the understanding of the mechanism inducing hibernation will inform clinical strategies to manipulate metabolic demand that are fun...

journal_title：Journal of neurochemistry

authors： Frare C,Jenkins ME,McClure KM,Drew KL

更新日期：2019-11-01 00:00:00

abstract：:Although the causes of psychiatric disorders are not fully understood, it is well established that mental illness originates from the interaction between genetic and environmental factors. In this regard, compelling evidence demonstrates that depression can be the consequence of altered, and often maladaptive, respons...

journal_title：Journal of neurochemistry

authors： Calabrese F,van der Doelen RH,Guidotti G,Racagni G,Kozicz T,Homberg JR,Riva MA

更新日期：2015-01-01 00:00:00

abstract：:Glycine receptor (GlyR) truncations in the intracellular TM3-4 loop, documented in patients suffering from hyperekplexia and in the mouse mutant oscillator, lead to non-functionality of GlyRs. The missing part that contains the TM3-4 loop, TM4 and C-terminal sequences is essential for pentameric receptor arrangements....

journal_title：Journal of neurochemistry

authors： Langlhofer G,Villmann C

更新日期：2017-07-01 00:00:00

abstract：:G protein-coupled receptors are important regulators of cellular signaling processes. Within the large family of rhodopsin-like receptors, those binding to biogenic amines form a discrete subgroup. Activation of biogenic amine receptors leads to transient changes of intracellular Ca²⁺-([Ca²⁺](i)) or 3',5'-cyclic adeno...

journal_title：Journal of neurochemistry

authors： Balfanz S,Jordan N,Langenstück T,Breuer J,Bergmeier V,Baumann A

更新日期：2014-04-01 00:00:00

abstract：:Although accumulating evidence demonstrates that white matter degeneration contributes to pathology in Alzheimer's disease (AD), the underlying mechanisms are unknown. In order to study the roles of the amyloid-beta peptide in inducing oxidative stress damage in white matter of AD, we investigated the effects of amylo...

journal_title：Journal of neurochemistry

authors： Zeng C,Lee JT,Chen H,Chen S,Hsu CY,Xu J

更新日期：2005-08-01 00:00:00

abstract：:PCR was used to isolate identical partial cDNA clones encoding a serotonin 5-HT3 receptor subunit from rat nodose and superior cervical ganglia. The amino acid sequence predicted from these clones, extending from the putative transmembrane domain I to the stop codon, demonstrated a 93% homology with the 5-HT3 receptor...

journal_title：Journal of neurochemistry

authors： Miquel MC,Emerit MB,Gingrich JA,Nosjean A,Hamon M,el Mestikawy S

更新日期：1995-08-01 00:00:00

abstract：:Adenosine A(1) receptors (A(1)Rs) have been characterized in primary cultures of neurons from cerebral cortex. The specific adenosine A(1) antagonist 8-cyclopentyl-1,3-[(3)H]dipropylxanthine bound to both membranes and intact cells. When saturation experiments were performed in membranes, a K(D) value of 0.76 nM and a...

journal_title：Journal of neurochemistry

authors： Ruiz MA,Escriche M,Lluis C,Franco R,Martín M,Andrés A,Ros M

更新日期：2000-08-01 00:00:00

abstract：:Transporters of the solute carrier 6 (SLC6) family mediate the reuptake of neurotransmitters such as dopamine, norepinephrine, serotonin, GABA, and glycine. SLC6 family members are 12 transmembrane helix-spanning proteins that operate using the transmembrane sodium gradient for transport. These transporters assume var...

journal_title：Journal of neurochemistry

authors： Jayaraman K,Das AK,Luethi D,Szöllősi D,Schütz GJ,Reith MEA,Sitte HH,Stockner T

更新日期：2020-08-07 00:00:00

abstract：:Oligodendrocytes are glial cells responsible for the synthesis and maintenance of myelin in the central nervous system (CNS). Oligodendrocytes are vulnerable to damage occurring in a variety of neurological diseases. Understanding oligodendrocyte biology is crucial for the dissemination of de- and remyelination mechan...

journal_title：Journal of neurochemistry

authors： Dumont D,Noben JP,Moreels M,Vanderlocht J,Hellings N,Vandenabeele F,Lambrichts I,Stinissen P,Robben J

更新日期：2007-07-01 00:00:00

abstract：:Calcium-activated neutral proteases (calpains) are regulated by specific endogenous protein inhibitors, the calpastatins, which are widely distributed in mammalian tissues. Calpastatins from different species or in various tissues from the same species exhibit considerable size heterogeneity on sodium dodecyl sulfate ...

journal_title：Journal of neurochemistry

authors： Mohan PS,Nixon RA

更新日期：1995-02-01 00:00:00

abstract：:The F3 molecule is a member of the immunoglobulin superfamily anchored to plasma membranes by a glycosylphosphatidylinositol group. In adult mouse cerebellum, F3 is predominantly expressed on a subset of axons, the parallel fibers, and at their synapses. In vitro studies established that it is a plurifunctional molecu...

journal_title：Journal of neurochemistry

authors： Olive S,Dubois C,Schachner M,Rougon G

更新日期：1995-11-01 00:00:00

abstract：:We investigated the effect of chronically blocking NMDA receptor stimulation to examine changes in GABA(A) receptor expression and pharmacology in cerebellar granule cells at different stages of maturation. We have previously shown that NMDA-selective glutamate receptor stimulation alters GABA(A) receptor pharmacology...

journal_title：Journal of neurochemistry

authors： Wang XH,Zhu WJ,Corsi L,Ikonomovic S,Paljug WR,Vicini S,Grayson DR

更新日期：1998-08-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative movement disorder. The histopathology of Parkinson's disease comprises proteinaceous inclusions known as Lewy bodies, which contains aggregated α-synuclein. Cathepsin D (CD) is a lysosomal protease previously demonstrated to cleave α-synuclein and decrease its toxicity in bot...

journal_title：Journal of neurochemistry

authors： Crabtree D,Dodson M,Ouyang X,Boyer-Guittaut M,Liang Q,Ballestas ME,Fineberg N,Zhang J

更新日期：2014-03-01 00:00:00

abstract：:We evaluated the possible functional expression of metabotropic glutamate receptors (mGluRs) by neural progenitors from embryonic mouse neocortex. Constitutive expression was seen with group I, II, and III mGluRs in undifferentiated cells and neurospheres formed by clustered cells during culture with epidermal growth ...

journal_title：Journal of neurochemistry

authors： Nakamichi N,Yoshida K,Ishioka Y,Makanga JO,Fukui M,Yoneyama M,Kitayama T,Nakamura N,Taniura H,Yoneda Y

更新日期：2008-06-01 00:00:00

abstract：:Sequential 31P and 1H nuclear magnetic resonance spectra were measured for neonatal piglets (n = 7) to determine the relationship between brain intracellular pH (pHi), lactate, and phosphorylated energy metabolites during partial ischemia. Simultaneous determinations of arterial and cerebral venous blood gases, pH, O2...

journal_title：Journal of neurochemistry

authors： Corbett RJ,Laptook AR,Nunnally RL,Hassan A,Jackson J

更新日期：1988-11-01 00:00:00

abstract：:Beta-carbolines have been suggested to be involved in the pathogenesis of Parkinson's disease as a result of their structural similarity to the neurotoxin N -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The chloral-derived beta-carboline derivative 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) caus...

journal_title：Journal of neurochemistry

authors： Riederer F,Luborzewski A,God R,Bringmann G,Scholz J,Feineis D,Moser A

更新日期：2002-05-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is involved in many aspects of neuronal biology and hippocampal physiology. Status epilepticus (SE) is a condition in which prolonged seizures lead to neuronal degeneration. SE-induced in rodents serves as a model of Temporal Lobe Epilepsy with hippocampal sclerosis, the most f...

journal_title：Journal of neurochemistry

authors： Unsain N,Montroull LE,Mascó DH

更新日期：2009-10-01 00:00:00

abstract：:The binding of a series of glycosylated beta-galactosidases to a fraction rich in synaptic membrane of bovine brain was examined. beta-galactosidase modified with p-aminophenyl beta-D-galactopyranoside (beta-D-Gal beta-gal) was found the most effective in binding to synaptic membrane, followed by that modified with be...

journal_title：Journal of neurochemistry

authors： Naoi M,Nagatsu T

更新日期：1986-02-01 00:00:00

abstract：:Dermorphin and its Hyp6 analogue are opiate-like heptapeptides originally discovered in frog skin and characterized by the presence of a D-Ala2 residue in their sequence. They were assayed for their capacity to compete with [3H]Leu-enkephalin for binding to opioid receptors in membranes of neuroblastoma x glioma hybri...

journal_title：Journal of neurochemistry

authors： Glaser T,Hübner K,de Castiglione R,Hamprecht B

更新日期：1981-12-01 00:00:00