Modification of tyrosine hydroxylase activity by chloral derived beta-carbolines in vitro.

abstract：:Optimal neuronal activity requires that supporting cells provide both efficient nutrient delivery and waste disposal. The incomplete processing of engulfed waste by their lysosomes can lead to accumulation of residual material and compromise their support of neurons. As most degradative lysosomal enzymes function best...

journal_title：Journal of neurochemistry

authors： Guha S,Baltazar GC,Tu LA,Liu J,Lim JC,Lu W,Argall A,Boesze-Battaglia K,Laties AM,Mitchell CH

更新日期：2012-08-01 00:00:00

abstract：:GABA(A) receptors are the major inhibitory neurotransmitter receptors in the brain. Some of them are targets of benzodiazepines that are widely used in clinical practice for their sedative/hypnotic, anxiolytic, muscle relaxant and anticonvulsant effects. In order to rationally separate these different drug actions, we...

journal_title：Journal of neurochemistry

authors： Tan KR,Baur R,Charon S,Goeldner M,Sigel E

更新日期：2009-12-01 00:00:00

abstract：:Benzodiazepine receptor binding was measured in cerebellar cortex of 15 patients with dominantly inherited olivopontocerebellar atrophy (OPCA). The majority of these patients had a moderate to marked Purkinje cell loss, as judged by the lowered levels of dentate nucleus gamma-aminobutyric acid (GABA), a marker of Purk...

journal_title：Journal of neurochemistry

authors： Kish SJ,Perry TL,Hornykiewicz O

更新日期：1984-02-01 00:00:00

abstract：:The multifunctional protein high mobility group box 1 (HMGB1) is expressed in hippocampus and cerebellum of adult mouse brain. Our aim was to determine whether HMGB1 affects glutamatergic transmission by monitoring neurotransmitter release from glial (gliosomes) and neuronal (synaptosomes) re-sealed subcellular partic...

journal_title：Journal of neurochemistry

authors： Pedrazzi M,Raiteri L,Bonanno G,Patrone M,Ledda S,Passalacqua M,Milanese M,Melloni E,Raiteri M,Pontremoli S,Sparatore B

更新日期：2006-11-01 00:00:00

abstract：:Impairment of cognitive functions including hippocampus-dependent spatial learning and memory affects nearly half of the aged population. Age-related cognitive decline is associated with synaptic dysfunction that occurs in the absence of neuronal cell loss, suggesting that impaired neuronal signaling and plasticity ma...

journal_title：Journal of neurochemistry

authors： Vanguilder HD,Bixler GV,Sonntag WE,Freeman WM

更新日期：2012-04-01 00:00:00

abstract：:An oligodendroglial specific property, glucocorticoid regulation of glycerol-3-phosphate dehydrogenase (GPDH) levels, was inhibited in C6 rat glioma cells when 4 beta-phorbol 12-myristate 13-acetate (PMA) was added to the cultures. PMA inhibited GPDH induction in both logarithmic- and stationary-phase cells. These eve...

journal_title：Journal of neurochemistry

authors： Bressler JP,Weingarten D,Kornblith PL

更新日期：1985-10-01 00:00:00

abstract：:Studies on glial cultures have demonstrated that fetal bovine serum contains a factor that induces bipotential glial precursors known as oligodendrocyte-type 2 astrocyte (O-2A) progenitors to become type 2 astroglia rather than oligodendroglia. The goal of this research project was to characterize and purify this fact...

journal_title：Journal of neurochemistry

authors： Levison SW,McCarthy KD

更新日期：1991-09-01 00:00:00

abstract：:Neuropeptide S (NPS) is known to produce anxiolytic-like effects and facilitate extinction of conditioned fear. Catecholaminergic neurotransmission in the medial prefrontal cortex (mPFC) has been suggested to be crucially involved in these brain functions. In the current study, we investigated the effect of NPS on the...

journal_title：Journal of neurochemistry

authors： Si W,Aluisio L,Okamura N,Clark SD,Fraser I,Sutton SW,Bonaventure P,Reinscheid RK

更新日期：2010-10-01 00:00:00

abstract：:Tomosyn is a cytoplasmic protein that was shown to bind to Syntaxin1 and SNAP-25 through an R-SNARE domain, forming a complex that is almost identical in structure to the neuronal SNARE complex. Tomosyn inhibits exocytosis in various cell types and these effects were attributed to direct competition between tomosyn's ...

journal_title：Journal of neurochemistry

authors： Yizhar O,Lipstein N,Gladycheva SE,Matti U,Ernst SA,Rettig J,Stuenkel EL,Ashery U

更新日期：2007-10-01 00:00:00

abstract：:The presynaptic terminals of skate (Raja montagui) electric organ were tested for their sensitivity to calcium channel antagonists. Acetylcholine (ACh) release and the elevation of intraterminal Ca2+ concentrations triggered by K+ depolarisation were studied. ACh release was measured as 3H efflux from slices of organ ...

journal_title：Journal of neurochemistry

authors： Richardson CM,Dowdall MJ,Green AC,Bowman D

更新日期：1995-02-01 00:00:00

abstract：:The Coffin-Lowry syndrome, a rare syndromic form of X-linked mental retardation, is caused by loss-of-function mutations in the hRSK2 (RPS6KA3) gene. To further investigate RSK2 (90-kDa ribosomal S6 kinase) implication in cognitive processes, a mrsk2_KO mouse has previously been generated as an animal model of Coffin-...

journal_title：Journal of neurochemistry

authors： Marques Pereira P,Gruss M,Braun K,Foos N,Pannetier S,Hanauer A

更新日期：2008-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis is a neurodegenerative fatal disease. The only drug recognized to increase the survival time is riluzole(RLZ). In animal models, minocycline (MNC) delayed the onset of the disease and increased the survival time (in combination with RLZ). The objective of our work was to study the interac...

journal_title：Journal of neurochemistry

authors： Milane A,Fernandez C,Vautier S,Bensimon G,Meininger V,Farinotti R

更新日期：2007-10-01 00:00:00

abstract：:Axonal growth cone motility requires precise regulation of adhesion to navigate the complex environment of the nervous system and reach its target. Myristoylated alanine-rich C kinase substrate (MARCKS) protein is enriched in the developing brain and plays an important, phosphorylation-dependent role in the modulation...

journal_title：Journal of neurochemistry

authors： Sosa LJ,Malter JS,Hu J,Bustos Plonka F,Oksdath M,Nieto Guil AF,Quiroga S,Pfenninger KH

更新日期：2016-06-01 00:00:00

abstract：:Excitotoxicity mediated via the (S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) subtype of receptor for l-glutamate contributes to various neuropathologies involving acute brain injury and chronic degenerative disorders. In this study, AMPA-induced neuronal injury and staurosporine (STS)-mediated apopt...

journal_title：Journal of neurochemistry

authors： Beart PM,Lim ML,Chen B,Diwakarla S,Mercer LD,Cheung NS,Nagley P

更新日期：2007-12-01 00:00:00

abstract：:We have shown that following heat shock (42.5 degree C for 30 min), mouse-derived C1300 N2A neuroblastoma cells contain increased levels of mRNA coding for the inducible form of heat shock protein 70 and for ubiquitin. Incubation of C1300 cells with iron also induces an elevation in content of mRNAs coding for the sam...

journal_title：Journal of neurochemistry

authors： Uney JB,Anderton BH,Thomas SM

更新日期：1993-02-01 00:00:00

abstract：:1-[2-(4-Aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (PAPP) inhibits [3H]5-hydroxytryptamine (5-HT, serotonin) binding to 5-HT1A and 5-HT1B sites in rat brain with apparent equilibrium dissociation constants (KD) of 2.9 and 328 nM, respectively. [3H]PAPP was synthesized, its binding to central serotonin re...

journal_title：Journal of neurochemistry

authors： Ransom RW,Asarch KB,Shih JC

更新日期：1986-01-01 00:00:00

abstract：:We previously identified a nuclear envelope protein repressor element-1 silencing transcription factor (REST)/neuron-restrictive silencer factor (NRSF)-interacting Lin-11, Isl-1 and Mec-3 (LIM) domain protein (RILP) that we proposed functions in the nuclear translocation of the transcriptional repressor REST/NRSF. In ...

journal_title：Journal of neurochemistry

authors： Shimojo M,Hersh LB

更新日期：2006-02-01 00:00:00

abstract：:We have investigated the molecular mechanisms of neurotrophin-mediated cell survival in HT22 cells, a murine cell line of hippocampal origin, expressing the brain-derived neurotrophic factor (BDNF) receptor TrkB as well as the TrkB.T1 splice variant. Stimulation with BDNF protected HT22-TrkB cells, but not HT22-TrkB.T...

journal_title：Journal of neurochemistry

authors： Rössler OG,Giehl KM,Thiel G

更新日期：2004-03-01 00:00:00

abstract：:Recent studies have suggested important roles for certain proteases and protease inhibitors in the growth and development of the CNS. In the present studies, inhibitors of urokinase or thrombin in cultured neural cells and serum-free medium from the cells were identified by screening for components that formed sodium ...

journal_title：Journal of neurochemistry

authors： Wagner SL,Lau AL,Nguyen A,Mimuro J,Loskutoff DJ,Isackson PJ,Cunningham DD

更新日期：1991-01-01 00:00:00

abstract：:(-)-[3H]Nicotine was found to bind specifically to membranes of human brains obtained at autopsy. The binding was stereospecific, (-)-nicotine being 40 times more potent than (+)-nicotine in displacing labeled (-)-nicotine. Saturation binding studies revealed the presence of two binding sites with dissociation constan...

journal_title：Journal of neurochemistry

authors： Shimohama S,Taniguchi T,Fujiwara M,Kameyama M

更新日期：1985-08-01 00:00:00

abstract：:5-Hydroxytryptamine (5-HT) specifically and reversibly inhibits nicotine-induced currents and catecholamine release in bovine adrenal chromaffin cells in culture. Pharmacological analysis indicates that the inhibition is not mediated by known 5-HT receptor subtypes. The inhibition is noncompetitive over a range of nic...

journal_title：Journal of neurochemistry

authors： Vijayaraghavan S,Schmid HA,Mapp KS

更新日期：1993-07-01 00:00:00

abstract：:Using optical imaging of retinal ganglion cell (RGC) calcium dynamics in living intact retinal wholemount preparations, we tested whether RGCs in an experimental rat glaucoma model were more sensitive to exogenously applied glutamate as a result of deficient glutamate clearance mechanisms. In contrast to post-natal ra...

journal_title：Journal of neurochemistry

authors： Hartwick AT,Zhang X,Chauhan BC,Baldridge WH

更新日期：2005-08-01 00:00:00

abstract：:A previous report has described the presence of t-[35S]-butylbicyclophosphorothionate binding sites and GABA-gated Cl- flux in the human neuroblastoma IMR-32 cell line. We now report the further characterisation of this binding site and, even more important, the identification of the GABAA receptor alpha 3 sub-unit ex...

journal_title：Journal of neurochemistry

authors： Noble PJ,Anderson SM,De Souza RJ,Cross AJ,Stephenson FA

更新日期：1993-08-01 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic condition caused by dominant loss-of-function mutations of the tumor suppressor gene NF1 that encodes neurofibromin, a negative regulator of RAS activity. Mutation analysis of NF1 located at 17q11.2 has been hampered by the large size of the gene, the hig...

journal_title：Journal of neurochemistry

authors： Esposito T,Piluso G,Saracino D,Uccello R,Schettino C,Dato C,Capaldo G,Giugliano T,Varriale B,Paolisso G,Di Iorio G,Melone MA

更新日期：2015-12-01 00:00:00

abstract：:Enkephalin (ENK) has been implicated in nociceptive transmission in the spinal cord while its functional role is not clear because of difficulties in ideally visualizing ENKergic neurons. We thus developed preproenkephalin-green fluorescent protein transgenic mice to better identify ENKergic neurons. Real-time reverse...

journal_title：Journal of neurochemistry

authors： Huang J,Chen J,Wang W,Wang W,Koshimizu Y,Wei YY,Kaneko T,Li YQ,Wu SX

更新日期：2010-06-01 00:00:00

abstract：:The release of endogenous dopamine from the axon terminal field in the nucleus accumbens and from the A10 dopamine cell bodies of conscious rats was measured using intracranial dialysis. Release of dopamine from both areas was calcium-dependent and markedly inhibited by the presence of the D2 agonist, quinpirole, in t...

journal_title：Journal of neurochemistry

authors： Kalivas PW,Duffy P

更新日期：1991-03-01 00:00:00

abstract：:Rats fasted overnight were allowed to consume single meals containing 0, 18, or 40% protein or continued to fast; after 2 h, brains and sera were taken and assayed for various amino acids. In general, serum levels of most amino acids were reduced by the 0% protein meal and elevated by the high-protein meal when compar...

journal_title：Journal of neurochemistry

authors： Glaeser BS,Maher TJ,Wurtman RJ

更新日期：1983-10-01 00:00:00

abstract：:The specific binding of [3H]8-hydroxy-2-(di-n-propylamino)tetralin ([ 3H]8-OH-DPAT) to 5-hydroxytryptamine (5-HT)-related sites was investigated in several regions of the rat brain. Marked differences were observed in the characteristics of binding to membranes from hippocampus, striatum, and cerebral cortex. Hippocam...

journal_title：Journal of neurochemistry

authors： Hall MD,el Mestikawy S,Emerit MB,Pichat L,Hamon M,Gozlan H

更新日期：1985-06-01 00:00:00

abstract：:Dopamine and norepinephrine are involved in regulation of melatonin synthesis in the pineal gland. In bovine pineal gland, D1- and D2-dopaminergic and alpha 1-adrenergic receptors have been characterized pharmacologically in several laboratories, while beta 1-adrenergic receptors have been studied using physiological ...

journal_title：Journal of neurochemistry

authors： Simonneaux V,Happe HK,Ebadi M,Murrin LC

更新日期：1991-11-01 00:00:00

abstract：:The effect of manipulating the activity of central 5-hydroxytryptamine (5-HT) neurones on extracellular 5-HT in ventral hippocampus of the chloral hydrate-anaesthetized rat was studied using the brain perfusion method, microdialysis. Basal levels of 5-HT in the dialysates were close to the detection limits of our assa...

journal_title：Journal of neurochemistry

authors： Sharp T,Bramwell SR,Clark D,Grahame-Smith DG

更新日期：1989-07-01 00:00:00