Identification of the GABAA receptor alpha 3 subunit in the IMR-32 neuroblastoma cell line.

abstract：:This study evaluated the developmental gene and protein expression of proton-coupled oligopeptide transporters (POTs: peptide transporter, PepT1 and PepT2; peptide-histidine transporter, PhT1 and PhT2) in different regions of rodent brain, and the age-dependent uptake of a POT substrate, glycylsarcosine (GlySar), in b...

journal_title：Journal of neurochemistry

authors： Hu Y,Xie Y,Keep RF,Smith DE

更新日期：2014-06-01 00:00:00

abstract：:Rats with unilateral lesions of the locus coeruleus were used to study the role of norepinephrine (NE) signal input in the down-regulation by antidepressants of the noradrenergic cyclic AMP-generating system in the cortex. Chronic administration of both desipramine (blockade of NE reuptake) and iprindole (no blockade ...

journal_title：Journal of neurochemistry

authors： Janowsky A,Steranka LR,Gillespie DD,Sulser F

更新日期：1982-07-01 00:00:00

abstract：:Presynaptic receptors modulating the release of acetylcholine (ACh) were studied in fetal septal neurons cultured in a growth medium to which various drugs were added from day 3 in vitro (DIV 3) to DIV 14. The influence of these drugs on the function of the presynaptic muscarinic (M-) autoreceptor was determined at DI...

journal_title：Journal of neurochemistry

authors： Ehret A,Birthelmer A,Rutz S,Riegert C,Rothmaier AK,Jackisch R

更新日期：2007-08-01 00:00:00

abstract：:Transgenic Huntington's disease (HD) mice, expressing exon 1 of the HD gene with an expanded CAG repeat, are totally resistant to striatal lesion induced by excessive NMDA receptor activation. We now show that striatal lesions induced by the mitochondrial toxin malonate are reduced by 70-80% in transgenic HD mice comp...

journal_title：Journal of neurochemistry

authors： Hansson O,Castilho RF,Korhonen L,Lindholm D,Bates GP,Brundin P

更新日期：2001-08-01 00:00:00

abstract：:Ammonium (NH(4) (+) ) is required to maintain pathways involved in shuttling metabolic precursors between astrocytes and neurones. Under hyperammonaemic conditions, increases in the cellular influx of NH(4) (+) , and accompanying changes in ion concentrations, may contribute to disruptions in metabolism and neurotrans...

journal_title：Journal of neurochemistry

authors： Kelly T,Rose CR

更新日期：2010-12-01 00:00:00

abstract：:2'-Deoxycoformycin (DCF), a potent inhibitor of adenosine deaminase (ADA), is increasingly used as a tool to investigate adenosine metabolism and neuromodulation. To advance further the usefulness of DCF for studies of purines in the CNS, we determined the inhibitory potency of this compound against ADA and adenylate ...

journal_title：Journal of neurochemistry

authors： Padua R,Geiger JD,Dambock S,Nagy JI

更新日期：1990-04-01 00:00:00

abstract：:Modulation of [3H]muscimol binding by picrotoxin, pentobarbitone, and etomidate was investigated in rat cerebellar and cerebral cortical membranes. In cerebellum, at 37 degrees C in the presence of chloride ions (150 mM), picrotoxin and picrotoxinin decreased specific [3H]muscimol binding to 43 +/- 3% of control, with...

journal_title：Journal of neurochemistry

authors： Quast U,Brenner O

更新日期：1983-08-01 00:00:00

abstract：:The effects of long-term treatment with imipramine or mirtazapine, two antidepressant drugs with different mechanisms of action, on the response of cortical dopaminergic neurons to foot-shock stress or to the anxiogenic drug FG7142 were evaluated in freely moving rats. As expected, foot shock induced a marked increase...

journal_title：Journal of neurochemistry

authors： Dazzi L,Spiga F,Pira L,Ladu S,Vacca G,Rivano A,Jentsch JD,Biggio G

更新日期：2001-02-01 00:00:00

abstract：:2,4,5-Trihydroxyphenylalanine (6-OH-DOPA) destroys central and peripheral noradrenergic neurons, while sparing dopaminergic neurons. Previous studies indicate that 6-OH-DOPA toxicity is mediated by the formation of 6-hydroxydopamine. However, levels of 6-hydroxydopamine in brain following peripheral administration of ...

journal_title：Journal of neurochemistry

authors： Evans JM,Cohen G

更新日期：1989-05-01 00:00:00

abstract：:Japanese encephalitis virus (JEV), a single-stranded RNA (ssRNA) virus, is the leading cause of encephalitis in Asia. Microglial activation is one of the key events in JEV-induced neuroinflammation. Although the various microRNAs (miRNAs) has been shown to regulate microglia activation during pathological conditions i...

journal_title：Journal of neurochemistry

authors： Thounaojam MC,Kaushik DK,Kundu K,Basu A

更新日期：2014-04-01 00:00:00

abstract：:Lysophospholipids are generated during the turnover and breakdown of membrane phospholipids. We have identified and partially characterized three enzymes involved in the metabolism of lysophospholipids in human brain, namely, lysophospholipase, lysophospholipid:acyl-CoA acyltransferase (acyltransferase), and lysophosp...

journal_title：Journal of neurochemistry

authors： Ross BM,Kish SJ

更新日期：1994-11-01 00:00:00

abstract：:Apolipoprotein (apo) A-I is the major protein component of high-density lipoproteins (HDLs), which are responsible for reverse cholesterol transport from peripheral tissues to the liver. A low level of plasma HDL is correlated with susceptibility to atherosclerosis and coronary heart disease. Mammalian apo A-I synthes...

journal_title：Journal of neurochemistry

authors： Möckel B,Zinke H,Flach R,Weiss B,Weiler-Güttler H,Gassen HG

更新日期：1994-02-01 00:00:00

abstract：:Administration of kainate or pentylenetetrazole increased c-fos, c-jun, junB, and junD mRNA levels in rat brain in a dose-dependent manner. Kainate increased these mRNA levels predominantly in the hippocampus, and pentylenetetrazole was more effective in the cortex. Adrenalectomy (3 days) was used to eliminate endogen...

journal_title：Journal of neurochemistry

authors： Li X,Song L,Kolasa K,Jope RS

更新日期：1992-06-01 00:00:00

abstract：:P(0), the major protein of PNS myelin, is considered to play a critical role in the compaction and stabilization of myelin lamellae. The protein undergoes extensive posttranslational modifications, including phosphorylation at multiple serine moieties in the cytoplasmic region. Recently, we demonstrated that P(0) is p...

journal_title：Journal of neurochemistry

authors： Iyer S,Bianchi R,Eichberg J

更新日期：2000-07-01 00:00:00

abstract：:The changes of glutathione S-transferase activity were investigated using rat brain astroglioma C6 cells that were synchronized at different phases of the cell cycle. The enzyme showed two significant activity peaks at G2 and G1 phases. Furthermore, when C6 glioma cells were exposed to a culture medium supplemented wi...

journal_title：Journal of neurochemistry

authors： Senjo M,Ishibashi T

更新日期：1988-01-01 00:00:00

abstract：:Activation of integrin receptors in neurons can promote cell survival and synaptic plasticity, but the underlying signal transduction pathway(s) is unknown. We report that integrin signaling prevents apoptosis of embryonic hippocampal neurons by a mechanism involving integrin-linked kinase (ILK) that activates Akt kin...

journal_title：Journal of neurochemistry

authors： Gary DS,Milhavet O,Camandola S,Mattson MP

更新日期：2003-02-01 00:00:00

abstract：:Neural injury due to ischemia and related insults is thought to involve the action of excitatory amino acids at N-methyl-D-aspartate receptors, which results in the influx of extracellular Ca2+ and the generation of nitric oxide. Because ethanol inhibits physiologic responses to excitatory amino acids, we examined its...

journal_title：Journal of neurochemistry

authors： Lustig HS,von Brauchitsch KL,Chan J,Greenberg DA

更新日期：1992-12-01 00:00:00

abstract：:35SO4-labeled fast-transported proteins of bullfrog dorsal root ganglion neurons were separated by two-dimensional gel electrophoresis, and their mobilities were compared to similar species labeled with [3H]mannose or [3H]fucose. Fluorography revealed regions of poorly resolved, high molecular weight material, likely ...

journal_title：Journal of neurochemistry

authors： Stone GC,Hammerschlag R,Bobinski JA

更新日期：1983-10-01 00:00:00

abstract：:Progress has been made in Guillain-Barré syndrome, a post-infectious autoimmune neuropathy, especially on identifying Campylobacter jejuni genes responsible for the development and determinant of clinical features. C. jejuni strains carrying a sialyltransferase gene (cst-II), which is essential for the biosynthesis of...

journal_title：Journal of neurochemistry

authors： Yuki N

更新日期：2007-11-01 00:00:00

abstract：:Recent evidence indicates that tyrosine phosphorylation may play important roles in retinal photoreceptor rod outer segments (ROS). We investigated the tyrosine phosphorylation of endogenous proteins in isolated bovine ROS. Several proteins with apparent molecular masses of 31, 39, 60, 83, 90, 97, 120, 140, and 180 kD...

journal_title：Journal of neurochemistry

authors： Bell MW,Desai N,Guo XX,Ghalayini AJ

更新日期：2000-11-01 00:00:00

abstract：:Saturable and specific binding sites for 5-[3H]hydroxytryptamine (5-HT, serotonin) characterized by a KD of 3.5-4.5 nM were detected in the chick embryo brain and were shown to develop linearly as a function of age, weight, and protein content. Saturation and displacement studies using unlabeled 5-HT as the displacing...

journal_title：Journal of neurochemistry

authors： Soblosky JS,Jeng I

更新日期：1985-02-01 00:00:00

abstract：:In slices of young rat cerebellum, the glutamate analogue kainate induced a large accumulation of cyclic GMP, which was inhibited by non-N-methyl-D-aspartate antagonists. Quisqualate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate evoked only small cyclic GMP responses and inhibited the effect of kainate. Whe...

journal_title：Journal of neurochemistry

authors： Garthwaite J,Southam E,Anderton M

更新日期：1989-12-01 00:00:00

abstract：:beta-Methyleneaspartate, a specific inhibitor of aspartate aminotransferase (EC 2.6.1.1.), was used to investigate the role of the malate-aspartate shuttle in rat brain synaptosomes. Incubation of rat brain cytosol, "free" mitochondria, synaptosol, and synaptic mitochondria, with 2 mM beta-methyleneaspartate resulted ...

journal_title：Journal of neurochemistry

authors： Cheeseman AJ,Clark JB

更新日期：1988-05-01 00:00:00

abstract：:The regional distribution and acylation of intraventricularly injected [14C]cadaverine was studied in the rat brain over a 48-h period. The concentrations of labeled cadaverine and its acyl derivatives, N-monoacetylcadaverine and N-monopropionylcadaverine, were determined in the telencephalon, striatum, hypothalamus, ...

journal_title：Journal of neurochemistry

authors： Salzman SK,Stepita-Klauco M

更新日期：1981-11-01 00:00:00

abstract：:Fragile X syndrome (FXS) is a developmental disorder caused by the loss of Fragile X Mental Retardation 1 (FMR1) gene function because of a CGG repeat expansion (> 200 repeats) in the gene. The molecular mechanism(s) linking loss of FMR1 function to the molecular pathology and cognitive/behavioral disability remain un...

journal_title：Journal of neurochemistry

authors： Wang X,Snape M,Klann E,Stone JG,Singh A,Petersen RB,Castellani RJ,Casadesus G,Smith MA,Zhu X

更新日期：2012-05-01 00:00:00

abstract：:The ability of cells to control the balance between the generation and quenching of reactive oxygen species is important in combating potentially damaging effects of oxidative stress. One mechanism that cells use to maintain redox homeostasis is the antioxidant response pathway. Antioxidant response elements (AREs) ar...

journal_title：Journal of neurochemistry

authors： Cao TT,Ma L,Kandpal G,Warren L,Hess JF,Seabrook GR

更新日期：2005-10-01 00:00:00

abstract：:Although isoelectric focusing has been used to demonstrate the presence of oligoclonal IgG in the CSF, the technique has not allowed detection of oligoclonal IgG in unconcentrated CSF. A new technique is reported, by which unconcentrated CSF is separated by isoelectric focusing, and the IgG bands are then detected by ...

journal_title：Journal of neurochemistry

authors： Lasne Y,Benzerara O,Chazot G,Creyssel R

更新日期：1981-05-01 00:00:00

abstract：:Aspartic acid (Asp) undergoes l-isomer-selective efflux transport across the blood-brain barrier (BBB). This transport system appears to play an important role in regulating l- and d-Asp levels in the brain. The purpose of this study was to identify the responsible transporters and elucidate the mechanism for l-isomer...

journal_title：Journal of neurochemistry

authors： Tetsuka K,Takanaga H,Ohtsuki S,Hosoya K,Terasaki T

更新日期：2003-11-01 00:00:00

abstract：:Primary cortical neurones exposed to an oxidative insult in the form of hydrogen peroxide (H(2)O(2)) for 30 min showed a concentration-dependent increase in oxidative stress followed by a delayed NMDA receptor-dependent cell death measured 24 h later. Extracellular signal-regulated protein kinase (ERK1/2), c-jun N-ter...

journal_title：Journal of neurochemistry

authors： Crossthwaite AJ,Hasan S,Williams RJ

更新日期：2002-01-01 00:00:00

abstract：:The precursors for neurotrophins are proteolytically cleaved to form biologically active mature molecules which activate their receptors p75NTR and trks. A recent study showed that the precursor for nerve growth factor (NGF) can bind to p75NTR with a high affinity and induces apoptosis of neurons in vitro. Mutation in...

journal_title：Journal of neurochemistry

authors： Zhou XF,Song XY,Zhong JH,Barati S,Zhou FH,Johnson SM

更新日期：2004-11-01 00:00:00