Modulation of [3H]muscimol binding in rat cerebellar and cerebral cortical membranes by picrotoxin, pentobarbitone, and etomidate.

abstract：:Frontotemporal lobar degeneration (FTLD) is the second leading cause of dementia in individuals under age 65. In many patients, the predominant pathology includes neuronal cytoplasmic or intranuclear inclusions of ubiquitinated TAR DNA binding protein 43 (FTLD-TDP). Recently, a genome-wide association study identified...

journal_title：Journal of neurochemistry

authors： Nicholson AM,Finch NA,Wojtas A,Baker MC,Perkerson RB 3rd,Castanedes-Casey M,Rousseau L,Benussi L,Binetti G,Ghidoni R,Hsiung GY,Mackenzie IR,Finger E,Boeve BF,Ertekin-Taner N,Graff-Radford NR,Dickson DW,Rademakers R

更新日期：2013-09-01 00:00:00

abstract：:After intraperitoneal injection of rats with 6-fluorotryptophan (6-FT), brain 5-hydroxytryptamine (5-HT) levels decreased exponentially over 1 h. Depletion was dose-dependent and maximum depletion was observed at 200 mg/kg. 6-FT (200 mg/kg) did not significantly alter the content of 5-hydroxyindoleacetic acid. Turnove...

journal_title：Journal of neurochemistry

authors： Miwa S,Fujiwara M,Lee K,Fujiwara M

更新日期：1987-05-01 00:00:00

abstract：:Proteolytic fragmentation of [3H]diisopropylfluorophosphate-labelled catalytic subunits of different molecular forms of acetylcholinesterase demonstrates that all forms extracted from the electric organ from Torpedo marmorata are true acetylcholinesterases. This is supported by immunochemical results showing that the ...

journal_title：Journal of neurochemistry

authors： Stieger S,Brodbeck U,Witzemann V

更新日期：1987-08-01 00:00:00

abstract：:An aminopeptidase with specificity directed toward peptides with acidic N-terminal amino acid residues has been isolated from mouse brain cytosol. Purification by ion-exchange chromatography and gel filtration resulted in an enzyme that hydrolyzed aspartyl-phenylalanine methyl ester at a rate of 13.2 mumols/min/mg pro...

journal_title：Journal of neurochemistry

authors： Kelly JA,Neidle EL,Neidle A

更新日期：1983-06-01 00:00:00

abstract：:Explants of adrenal medullae were cultured in defined media for up to 48 h, during which time the tissue remained histologically intact. Addition of N6-methyladenosine to the medium led to a diminution in the activity of phenylethanolamine N-methyltransferase (EC 2.1.1.28) in the tissue. The enzyme activity was invers...

journal_title：Journal of neurochemistry

authors： Burke WJ,Joh TH

更新日期：1982-07-01 00:00:00

abstract：:Both acidosis and oxidative stress contribute to ischemic brain injury. The present study examines interactions between acidosis and oxidative stress in murine cortical cultures. Acidosis (pH 6.2) was found to potentiate markedly neuronal death induced by H2O2 exposure. To determine if this effect was mediated by decr...

journal_title：Journal of neurochemistry

authors： Ying W,Han SK,Miller JW,Swanson RA

更新日期：1999-10-01 00:00:00

abstract：:Endogenous norepinephrine (NE) release in cerebral cortex slices taken from normal and morphine-tolerant guinea pigs was measured by HPLC. In normal slices, a linear relationship was found between electrically evoked NE release and the log of the frequency of stimulation in the range of 1-20 Hz. The efficiency of the ...

journal_title：Journal of neurochemistry

authors： Tomasini C,Guidorzi R,Bianchi C,Beani L

更新日期：1992-04-01 00:00:00

abstract：:1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ) was detected as a novel endogenous amine in mouse brain and parkinsonian CSF by using the gas chromatography-selected ion-monitoring method. The level of 1BnTIQ was very high in CSF of some parkinsonian patients compared with that of controls with other neurological dis...

journal_title：Journal of neurochemistry

authors： Kotake Y,Tasaki Y,Makino Y,Ohta S,Hirobe M

更新日期：1995-12-01 00:00:00

abstract：:The development of the specific binding sites for L-[3H]glutamic acid (KD = 370 nM) and for [3H]kainic acid (KD = 39 nM) was studied in the rat cerebellum. Specific binding at both sites remains low during the first week after birth but increases markedly during the second and third weeks after birth, when glutamaterg...

journal_title：Journal of neurochemistry

authors： Slevin JT,Coyle JT

更新日期：1981-08-01 00:00:00

abstract：:The suprachiasmatic nucleus houses the central circadian clock and is characterized by the timely regulated expression of clock genes. However, neurons of the cerebellar cortex also contain a circadian oscillator with circadian expression of clock genes being controlled by the suprachiasmatic nucleus. It has been sugg...

journal_title：Journal of neurochemistry

authors： Bering T,Carstensen MB,Rath MF

更新日期：2017-09-01 00:00:00

abstract：:We assessed the functional expression of the norepinephrine (NE) transporter (NET) in cultured rat cortical astrocytes. Specific [3H]NE uptake increased in a time-dependent manner, and this uptake involves temperature- and Na+-sensitive mechanisms. The Na+-dependent [3H]NE uptake was saturable, and the Km for the proc...

journal_title：Journal of neurochemistry

authors： Inazu M,Takeda H,Matsumiya T

更新日期：2003-01-01 00:00:00

abstract：:We investigated the role of mitogen-activated protein kinase (MAPK) pathways in hypoxic neuronal injury using primary cultures from murine cerebral cortex. Hypoxia caused the death of approximately 50% of neurons at 16 h and approximately 65% of neurons at 24 h. This was associated with phospho-activation of the MAPK/...

journal_title：Journal of neurochemistry

authors： Jin K,Mao XO,Zhu Y,Greenberg DA

更新日期：2002-01-01 00:00:00

abstract：:Intraperitoneal injection of the cyclic imine 1-piperideine in mice resulted in measurable quantities of 5-aminopentanoic acid in brain. 5-Aminopentanoic acid is a methylene homologue of gamma-aminobutyric acid (GABA) that is a weak GABA agonist. 5-Aminopentanoic acid formed in the periphery was ruled out as the sourc...

journal_title：Journal of neurochemistry

authors： Callery PS,Geelhaar LA

更新日期：1985-09-01 00:00:00

abstract：:The neuropathological and immune changes induced in the brain by 'binge drinking' have been investigated in a rat model. Evidence of neuro-inflammation was identified in the 'binge drinking' rat model of alcohol abuse after 3 weeks of administration of 2 or 3 g/kg ethanol (EtOH), three times per day for two consecutiv...

journal_title：Journal of neurochemistry

authors： Ward RJ,Colivicchi MA,Allen R,Schol F,Lallemand F,de Witte P,Ballini C,Corte LD,Dexter D

更新日期：2009-12-01 00:00:00

abstract：:Neuronal survival after ischemic injury is determined through the induction of several biological pathways. We examined whether lubeluzole, an agent efficacious in both clinical and experimental models of cerebral ischemia, modulated the signal transduction mechanisms of nitric oxide (NO), a downstream mediator of ano...

journal_title：Journal of neurochemistry

authors： Maiese K,TenBroeke M,Kue I

更新日期：1997-02-01 00:00:00

abstract：:Amyotrophic lateral sclerosis is a neurodegenerative fatal disease. The only drug recognized to increase the survival time is riluzole(RLZ). In animal models, minocycline (MNC) delayed the onset of the disease and increased the survival time (in combination with RLZ). The objective of our work was to study the interac...

journal_title：Journal of neurochemistry

authors： Milane A,Fernandez C,Vautier S,Bensimon G,Meininger V,Farinotti R

更新日期：2007-10-01 00:00:00

abstract：:The extracellular matrix (ECM) is important for both structural integrity and functions of the brain. Matrix metalloproteinases (MMPs) play major roles in ECM-remodeling under both physiological and pathological conditions. Reversion-inducing cysteine-rich protein with Kazal motifs (Reck) is a membrane-anchored MMP-re...

journal_title：Journal of neurochemistry

authors： Wang H,Imamura Y,Ishibashi R,Chandana EP,Yamamoto M,Noda M

更新日期：2010-10-01 00:00:00

abstract：:This study examined the respective influences of cannabinoid type-1 (CB1) receptors expressed either in forebrain GABAergic neurons, in cortical glutamatergic neurons, or in astrocytes on the turnover rates of the endocannabinoids N-arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), and the non-cannabin...

journal_title：Journal of neurochemistry

authors： Belluomo I,Matias I,Pernègre C,Marsicano G,Chaouloff F

更新日期：2015-04-01 00:00:00

abstract：:Studies on glial cultures have demonstrated that fetal bovine serum contains a factor that induces bipotential glial precursors known as oligodendrocyte-type 2 astrocyte (O-2A) progenitors to become type 2 astroglia rather than oligodendroglia. The goal of this research project was to characterize and purify this fact...

journal_title：Journal of neurochemistry

authors： Levison SW,McCarthy KD

更新日期：1991-09-01 00:00:00

abstract：:We have identified and cataloged 54 genes that exhibit predominant expression in the striatum. Our hypothesis is that such mRNA molecules are likely to encode proteins that are preferentially associated with particular physiological processes intrinsic to striatal neurons, and therefore might contribute to the regiona...

journal_title：Journal of neurochemistry

authors： Desplats PA,Kass KE,Gilmartin T,Stanwood GD,Woodward EL,Head SR,Sutcliffe JG,Thomas EA

更新日期：2006-02-01 00:00:00

abstract：:Pro-thyrotropin-releasing hormone (proTRH) is the precursor to thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2), the hypothalamic releasing factor that stimulates synthesis and release of thyrotropin from the pituitary gland. Five copies of the TRH progenitor sequence (Gln-His-Pro-Gly) and seven cryptic peptides ...

journal_title：Journal of neurochemistry

authors： Nillni EA,Friedman TC,Todd RB,Birch NP,Loh YP,Jackson IM

更新日期：1995-12-01 00:00:00

abstract：:Parkinson's disease is a common neurodegenerative disorder with a mainly sporadic aetiology, although a number of monogenic familiar forms are known. Most of the motor symptoms are due to selective depletion of dopaminergic, neuromelanin-containing neurones of the substantia nigra pars compacta. Neuromelanin is the da...

journal_title：Journal of neurochemistry

authors： Fasano M,Bergamasco B,Lopiano L

更新日期：2006-02-01 00:00:00

abstract：:At the time of terminal differentiation, mammalian cortical neurons undergo a dramatic change in the structural organization of their chromatin: the nucleosomal repeat length shortens from approximately 200 base pairs in fetuses to a value of 165 base pairs after birth. These events occur several days after the end of...

journal_title：Journal of neurochemistry

authors： Cestelli A,Di Liegro I,Castiglia D,Gristina R,Ferraro D,Salemi G,Savettieri G

更新日期：1987-04-01 00:00:00

abstract：:The main objective of these studies was to determine whether the acute administration of choline to rats provides supplemental precursor that can be used to support acetylcholine synthesis when the demand for choline is increased by increasing neurotransmitter release. For these experiments, hippocampal and striatal s...

journal_title：Journal of neurochemistry

authors： Wecker L,Cawley G,Rothermel S

更新日期：1989-02-01 00:00:00

abstract：:Within the cell membrane there exist various microdomains (lipid rafts) in which specific lipids and proteins are assembled and these microdomains are recovered in the detergent-resistant low-density membrane fraction (DRM). Septin is a novel GTP-binding, cytoskeletal protein having various isoforms that assemble into...

journal_title：Journal of neurochemistry

authors： Maimaitiyiming M,Kumanogoh H,Nakamura S,Nagata K,Suzaki T,Maekawa S

更新日期：2008-08-01 00:00:00

abstract：:Activation of extracellular signal-regulated protein kinase 1/2 (ERK1/2) are implicated in the pathophysiology of spinal cord injury (SCI). However, the specific functions of individual ERK isoforms in neurodegeneration are largely unknown. We investigated the hypothesis that ERK2 activation may contribute to patholog...

journal_title：Journal of neurochemistry

authors： Yu CG,Yezierski RP,Joshi A,Raza K,Li Y,Geddes JW

更新日期：2010-04-01 00:00:00

abstract：:The content of the tryptophan metabolites quinolinic acid (QUIN), 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) was measured in various brain areas of rats bearing a portocaval anastomosis (PCA) for 4 weeks, using mass fragmentography or HPLC. In these animals, the content of the excitotoxic comp...

journal_title：Journal of neurochemistry

authors： Moroni F,Lombardi G,Carlà V,Pellegrini D,Carassale GL,Cortesini C

更新日期：1986-03-01 00:00:00

abstract：:Although accumulating evidence demonstrates that white matter degeneration contributes to pathology in Alzheimer's disease (AD), the underlying mechanisms are unknown. In order to study the roles of the amyloid-beta peptide in inducing oxidative stress damage in white matter of AD, we investigated the effects of amylo...

journal_title：Journal of neurochemistry

authors： Zeng C,Lee JT,Chen H,Chen S,Hsu CY,Xu J

更新日期：2005-08-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are a large family of proteases involved in many cell-matrix and cell-cell signalling processes through activation, inactivation or release of extracellular matrix (ECM) and non-ECM molecules, such as growth factors and receptors. Uncontrolled MMP activities underlie the pathophysiolog...

journal_title：Journal of neurochemistry

authors： Van Hove I,Lemmens K,Van de Velde S,Verslegers M,Moons L

更新日期：2012-10-01 00:00:00

abstract：:Extraction of rat brain membrane-associated protein kinase C with high specific activity was obtained by applying benzyl alcohol (a membrane fluidizer), EDTA, and high hydrostatic pressures. Approximately 50% of total brain-associated activity was extracted from membranes. The pressure-extracted activity had an eightf...

journal_title：Journal of neurochemistry

authors： Lester DS

更新日期：1989-06-01 00:00:00