1-Piperideine as an in vivo precursor of the gamma-aminobutyric acid homologue 5-aminopentanoic acid.

abstract：:Glycine receptor (GlyR) truncations in the intracellular TM3-4 loop, documented in patients suffering from hyperekplexia and in the mouse mutant oscillator, lead to non-functionality of GlyRs. The missing part that contains the TM3-4 loop, TM4 and C-terminal sequences is essential for pentameric receptor arrangements....

journal_title：Journal of neurochemistry

authors： Langlhofer G,Villmann C

更新日期：2017-07-01 00:00:00

abstract：:The technique of intracerebral dialysis in combination with a sensitive and specific radioenzymatic method was used for recovery and quantification of endogenous extracellular acetylcholine from the striata of freely moving rats. A thin dialysis tube was inserted transversally through the caudate nuclei, and the tube ...

journal_title：Journal of neurochemistry

authors： Consolo S,Wu CF,Fiorentini F,Ladinsky H,Vezzani A

更新日期：1987-05-01 00:00:00

abstract：:β-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the transmembrane aspartyl protease that catalyzes the first cleavage step in the proteolysis of the APP to the amyloid β-protein (Aβ), a process involved in the pathogenesis of Alzheimer disease. BACE1 pre-mRNA undergoes complex alternative splicing,...

journal_title：Journal of neurochemistry

authors： Fisette JF,Montagna DR,Mihailescu MR,Wolfe MS

更新日期：2012-06-01 00:00:00

abstract：:The subcellular distribution of peptide histidine isoleucine amide (PHI)-27-like peptides (PLP) was investigated in rat cerebral cortex and whole rat brain in comparison with the distribution of vasoactive intestinal peptide (VIP). The highest content of PLP was found in the crude mitochondrial fraction (P2) and was a...

journal_title：Journal of neurochemistry

authors： Korchak DM,Gysling K,Beinfeld MC

更新日期：1985-01-01 00:00:00

abstract：:Muscarinic and nicotinic cholinergic receptors and choline acetyltransferase activity were studied in postmortem brain tissue from patients with histopathologically confirmed Parkinson's disease and matched control subjects. Using washed membrane homogenates from the frontal cortex, hippocampus, caudate nucleus, and p...

journal_title：Journal of neurochemistry

authors： Lange KW,Wells FR,Jenner P,Marsden CD

更新日期：1993-01-01 00:00:00

abstract：:In a previous study, interleukin-1beta (IL-1beta) has been shown to induce matrix metalloproteinases (MMPs) expression through mitogen-activated protein kinases and nuclear factor-kappaB pathways in rat brain astrocytes. Moreover, transactivation of growth factor receptors and phosphatidylinositol 3-kinase (PI3K)/Akt ...

journal_title：Journal of neurochemistry

authors： Wu CY,Hsieh HL,Sun CC,Tseng CP,Yang CM

更新日期：2008-05-01 00:00:00

abstract：:Neuroimage analysis in alcoholic corpus callosum (CC) suggests that microstructural abnormalities are higher in the genu followed by the body and the splenium. Molecular mechanisms underlying these dysmorphologys are still unclear. Protein expression was performed using the CC body samples [(nine controls, seven uncom...

journal_title：Journal of neurochemistry

authors： Kashem MA,Etages HD,Kopitar-Jerala N,McGregor IS,Matsumoto I

更新日期：2009-07-01 00:00:00

abstract：:Presynaptic nicotinic acetylcholine receptors on striatal nerve terminals modulate the release of dopamine. We have compared the effects of a number of nicotinic agonists and antagonists on a perfused synaptosome preparation preloaded with [3H]dopamine. (-)-Nicotine, acetylcholine, and the nicotinic agonists cytisine ...

journal_title：Journal of neurochemistry

authors： Rapier C,Lunt GG,Wonnacott S

更新日期：1990-03-01 00:00:00

abstract：:The effects of the protein kinase inhibitor H-7 on early and delayed responses to nerve growth factor (NGF) were investigated in PC12 cells. H-7 reduced the NGF-induced expression of c-Fos in a dose-dependent manner without affecting the time course of c-Fos appearance. Conversely, H-7 potentiated delayed NGF effects,...

journal_title：Journal of neurochemistry

authors： Kahle P,Mangold M,Kuwahara T,Schubenel R,Hertel C

更新日期：1994-02-01 00:00:00

abstract：:To evaluate the ability of ependymal, microglial and oligodendroglial cells to degrade leucine, the presence of 3-methylcrotonyl-CoA carboxylase (MCC) was investigated in cultures of these cells. MCC is a biotin-containing heterodimeric enzyme that is specific for the irreversible part of the leucine catabolic pathway...

journal_title：Journal of neurochemistry

authors： Murín R,Verleysdonk S,Rapp M,Hamprecht B

更新日期：2006-06-01 00:00:00

abstract：:This study focused on the molecular and pharmacological characterization of muscarinic acetylcholine receptors expressed by progenitors and differentiated oligodendrocytes. We also analyzed the role of muscarinic receptors in regulating downstream signal transduction pathways and the functional significance of recepto...

journal_title：Journal of neurochemistry

authors： Ragheb F,Molina-Holgado E,Cui QL,Khorchid A,Liu HN,Larocca JN,Almazan G

更新日期：2001-06-01 00:00:00

abstract：:The Review "The malleable brain: plasticity of neural circuits and behavior - A review from students to students" has been written by a group of students following the International Society for Neurochemistry and Journal of Neurochemistry Flagship School. Comprehensively written by students for students, it provides b...

journal_title：Journal of neurochemistry

authors： Schulz JB,Hausmann L

更新日期：2017-09-01 00:00:00

abstract：:Primary cortical neurones exposed to an oxidative insult in the form of hydrogen peroxide (H(2)O(2)) for 30 min showed a concentration-dependent increase in oxidative stress followed by a delayed NMDA receptor-dependent cell death measured 24 h later. Extracellular signal-regulated protein kinase (ERK1/2), c-jun N-ter...

journal_title：Journal of neurochemistry

authors： Crossthwaite AJ,Hasan S,Williams RJ

更新日期：2002-01-01 00:00:00

abstract：:The sites of interaction of quinacrine with synaptic membranes were labeled with quinacrine mustard. Quinacrine mustard had an inhibitory effect on depolarization-induced calcium uptake by synaptosomes similar to that of quinacrine. The inhibition of depolarization-induced calcium uptake by quinacrine was reduced by 7...

journal_title：Journal of neurochemistry

authors： Ohta A,Baba A,Iwata H

更新日期：1985-08-01 00:00:00

abstract：:The mammalian telencephalon, which comprises the cerebral cortex, olfactory bulb, hippocampus, basal ganglia, and amygdala, is the most complex and intricate region of the CNS. It is the seat of all higher brain functions including the storage and retrieval of memories, the integration and processing of sensory and mo...

journal_title：Journal of neurochemistry

authors： Corbin JG,Gaiano N,Juliano SL,Poluch S,Stancik E,Haydar TF

更新日期：2008-09-01 00:00:00

abstract：:Substrate-induced endocytic trafficking of dopamine transporter (DAT) has been observed, but little is known about the regulation of DAT oligomerization by substrate. The present study investigates the effect on substrates on DAT oligomerization and explores a potential link with the presence of DAT at the cell surfac...

journal_title：Journal of neurochemistry

authors： Chen N,Reith ME

更新日期：2008-05-01 00:00:00

abstract：:Extracellular levels of norepinephrine (NE) and glutamate (Glu) in the ventral bed nucleus of the stria terminalis (vBNST) of saline- and chronic morphine-treated rats, with or without withdrawal, were studied by means of the in vivo microdialysis technique in anesthetized rats. In addition, the tissue concentration o...

journal_title：Journal of neurochemistry

authors： Fuentealba JA,Forray MI,Gysling K

更新日期：2000-08-01 00:00:00

abstract：:A study was made of the actions of the excitant neurotoxin, kainic acid, on the uptake and the release of D-[2,3-3H]aspartate (D-ASP) in slices of guinea pig cerebral neocortex and striatum. The slices took up D-ASP, reaching concentrations of the amino acid in the tissue which were 14-23 times that in the medium. Sub...

journal_title：Journal of neurochemistry

authors： Potashner SJ,Gerard D

更新日期：1983-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder in which oxidative stress has been implicated as an important event in the progression of the pathology. In particular, it has been shown that protein modification by reactive oxygen species (ROS) occurs to a greater extent in AD than in control brain, suggestin...

journal_title：Journal of neurochemistry

authors： Castegna A,Aksenov M,Thongboonkerd V,Klein JB,Pierce WM,Booze R,Markesbery WR,Butterfield DA

更新日期：2002-09-01 00:00:00

abstract：:Neural injury due to ischemia and related insults is thought to involve the action of excitatory amino acids at N-methyl-D-aspartate receptors, which results in the influx of extracellular Ca2+ and the generation of nitric oxide. Because ethanol inhibits physiologic responses to excitatory amino acids, we examined its...

journal_title：Journal of neurochemistry

authors： Lustig HS,von Brauchitsch KL,Chan J,Greenberg DA

更新日期：1992-12-01 00:00:00

abstract：:Studies performed over the past several years have provided evidence that phosphorylation of proteins is important in the regulation of neurotransmitter release. In this study, it is shown that rabphilin-3A is present in cerebellar granule cells as a phosphoprotein, by using 32P-labeling of cerebellar granule cells, i...

journal_title：Journal of neurochemistry

authors： Fykse EM

更新日期：1998-10-01 00:00:00

abstract：:Temporal carbohydrate expression patterns at cell surfaces are thought to be of crucial regulatory significance during developmental processes. Hitherto, however, data on individual membrane proteins undergoing development-associated changes in glycosylation are sparsely. Here, we show that the two natriuretic peptide...

journal_title：Journal of neurochemistry

authors： Müller D,Hildebrand M,Lübberstedt J,Kuhn M,Middendorff R

更新日期：2010-11-01 00:00:00

abstract：:Glycogen synthase kinase 3 (GSK3) plays important roles in Wnt and insulin signaling, cell fate determination, and Alzheimer-like tau phosphorylation. We discovered an isoform of tau protein kinase I (TPKI)/GSK3beta with a 13 amino acid insert in the catalytic domain owing to alternative splicing. The alternative tran...

journal_title：Journal of neurochemistry

authors： Mukai F,Ishiguro K,Sano Y,Fujita SC

更新日期：2002-06-01 00:00:00

abstract：:Cricket (Acheta domesticus) terminal abdominal ganglia (TG) contain high concentrations (approximately 2 pmol/mg protein) of muscarinic and nicotinic cholinergic binding sites, based on the capacity of TG to bind specifically the labelled ligands L-[3H]quinuclidinyl benzilate ([3H]QNB) and [125I]alpha-bungarotoxin ([1...

journal_title：Journal of neurochemistry

authors： Meyer MR,Reddy GR

更新日期：1985-10-01 00:00:00

abstract：:Marked accumulation of arachidonic acid (AA) and intracellular Ca2+ and Na+ overloads are seen during brain ischemia. In this study, we show that, in neurons, AA induces cytosolic Na+ ([Na+](cyt)) and Ca2+ ([Ca2+](cyt)) overload via a non-selective cation conductance (NSCC), resulting in mitochondrial [Na+](m) and [Ca...

journal_title：Journal of neurochemistry

authors： Fang KM,Chang WL,Wang SM,Su MJ,Wu ML

更新日期：2008-03-01 00:00:00

abstract：:In this study, we show specific intracellular responses evoked by the stimulation of astrocytes with the P1,P5-di(adenosine-5')pentaphosphate, Ap5A. The stimulation of astrocytes with micromolar concentrations of the dinucleotide elicited rapid increases in intracellular calcium concentration ([Ca2+]i), showing an EC5...

journal_title：Journal of neurochemistry

authors： Jiménez AI,Castro E,Delicado EG,Miras-Portugal MT

更新日期：2002-10-01 00:00:00

abstract：:Major membrane lipids were quantified in frontal (Brodmann area 9) and temporal (Brodmann areas 21 and 22) cortices, caudate nucleus, hippocampus, and frontal white matter of 12 cases with Alzheimer's disease (AD) type I (early onset), 21 cases with AD type II (late onset), and 20 age-matched controls. The concentrati...

journal_title：Journal of neurochemistry

authors： Svennerholm L,Gottfries CG

更新日期：1994-03-01 00:00:00

abstract：:The regulation of glial and neuronal Na+-dependent glutamate/aspartate transporters is of interest because abnormal glutamate transport may be responsible for certain neurological diseases. Because expression of the Wnt-1 protooncogene results in induction of the glial-type glutamate transporter GLAST in PC12 neuron-l...

journal_title：Journal of neurochemistry

authors： Palos TP,Zheng S,Howard BD

更新日期：1999-09-01 00:00:00

abstract：:A protein has been purified from human brain that appears to be the human equivalent of bovine 14-3-3 protein. On polyacrylamide gel electrophoresis the protein migrates as a faster major component, termed 14-3-3-2 protein, and a slower minor component, termed 14-3-3-1 protein, which consists of approximately 12% of t...

journal_title：Journal of neurochemistry

authors： Boston PF,Jackson P,Kynoch PA,Thompson RJ

更新日期：1982-05-01 00:00:00

abstract：:Autism is a behaviorally defined neurodevelopmental disorder and among its symptoms are disturbances in face and emotional processing. Emerging evidence demonstrates abnormalities in the GABAergic (gamma-aminobutyric acid) system in autism, which likely contributes to these deficits. GABA(B) receptors play an importan...

journal_title：Journal of neurochemistry

authors： Oblak AL,Gibbs TT,Blatt GJ

更新日期：2010-09-01 00:00:00