Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism.

abstract：:The effect of depolarizing concentrations of potassium (56 mM) on the release of [3H]taurine was examined in two types of cultured neurons from mouse brain: cerebral cortex neurons, which are largely GABAergic, and cerebellar neurons, which after treatment with kainate consist almost entirely of glutamatergic granule ...

journal_title：Journal of neurochemistry

authors： Schousboe A,Pasantes-Morales H

更新日期：1989-10-01 00:00:00

abstract：:Nordihydroguaiaretic acid (NDGA; a lipoxygenase inhibitor), LY-270766 (an inhibitor of 5-lipoxygenase), and the diacylglycerol lipase inhibitor RG 80267 completely eliminated potassium-evoked release of [3H]-noradrenaline ([3H]NA) from the human neuroblastoma clone SH-SY5Y with IC50 values of 10, 15, and 30 microM, re...

journal_title：Journal of neurochemistry

authors： Vaughan PF,Murphy MG,Ball SG

更新日期：1993-04-01 00:00:00

abstract：:Suicide and depression are associated with an increased density of alpha2-adrenoceptors (radioligand receptor binding) in specific regions of the human brain. The function of these inhibitory receptors involves various regulatory proteins (Gi coupling proteins and G protein-coupled receptor kinases, GRKs), which work ...

journal_title：Journal of neurochemistry

authors： García-Sevilla JA,Escribá PV,Ozaita A,La Harpe R,Walzer C,Eytan A,Guimón J

更新日期：1999-01-01 00:00:00

abstract：:The molecular basis of neuroendocrine-specific expression of chromogranin B gene (Chgb) has remained elusive. Utilizing wild-type and mutant Chgb promoter/luciferase reporter constructs, this study established a crucial role for the cAMP response element (CRE) box at -102/-95 bp in endocrine [rat pheochromocytoma (chr...

journal_title：Journal of neurochemistry

authors： Mahapatra NR,Mahata M,Ghosh S,Gayen JR,O'Connor DT,Mahata SK

更新日期：2006-10-01 00:00:00

abstract：:To further analyze the action of copper on brain synaptic mechanisms, the brain dipeptide carnosine (beta-alanyl-L-histidine) was tested in Xenopus laevis oocytes expressing the rat P2X4 or P2X7 receptors. Ten micromolar copper halved the currents evoked by ATP in both receptors; co-application of carnosine plus coppe...

journal_title：Journal of neurochemistry

authors： Coddou C,Villalobos C,González J,Acuña-Castillo C,Loeb B,Huidobro-Toro JP

更新日期：2002-02-01 00:00:00

abstract：:Methods are described for the determination of sheep spinal cord tissue fluid content and norepinephrine, serotonin, and dopamine concentrations after experimental injury. The amount of tissue fluid varied in different regions of sheep spinal cord following injury. Norepinephrine and serotonin wet weight concentration...

journal_title：Journal of neurochemistry

authors： Hinwood BG,Yeo JD,Kidman AD

更新日期：1980-10-01 00:00:00

abstract：:To gain insight into the mechanism through which the neurotransmitter glutamate causally participates in several neurological diseases, in vitro cultured cerebellar granule cells were exposed to glutamate and oxygen radical production was investigated. To this aim, a novel procedure was developed to detect oxygen radi...

journal_title：Journal of neurochemistry

authors： Atlante A,Gagliardi S,Minervini GM,Ciotti MT,Marra E,Calissano P

更新日期：1997-05-01 00:00:00

abstract：:Parkinson disease (PD) is a prevalent neurodegenerative disease, in which the formation of misfolded and aggregated α-synuclein is a key neuropathological hallmark. Recent studies reveal that extracellular vesicles such as exosomes present a potential mechanism for propagation of pathological α-synuclein throughout th...

journal_title：Journal of neurochemistry

authors： Pinnell JR,Cui M,Tieu K

更新日期：2020-12-29 00:00:00

abstract：:Prolonged hypoxia exerts profound effects on cell function, and has been associated with increased production of amyloid beta peptides (A beta Ps) of Alzheimer's disease. Here, we have investigated the effects of chronic hypoxia (2.5% O2, 24 h) on capacitative Ca2+ entry (CCE) in primary cultures of rat type-I cortica...

journal_title：Journal of neurochemistry

authors： Smith IF,Plant LD,Boyle JP,Skinner RA,Pearson HA,Peers C

更新日期：2003-06-01 00:00:00

abstract：:Neural stem/progenitor cells (NSPCs) are multipotent cells within the embryonic and adult brain that give rise to both neuronal and glial cell lineages. Maintenance of NSPC multipotency is promoted by low oxygen tension, although the metabolic underpinnings of this trait have not been described. In this study, we inve...

journal_title：Journal of neurochemistry

authors： Candelario KM,Shuttleworth CW,Cunningham LA

更新日期：2013-05-01 00:00:00

abstract：:A vesicular glutamate transporter (VGLUT) is responsible for the accumulation of l-glutamate in synaptic vesicles in glutamatergic neurons. Two isoforms, VGLUT1 and VGLUT2, have been identified, which are complementarily expressed in these neurons. Mammalian pinealocytes, endocrine cells for melatonin, are also glutam...

journal_title：Journal of neurochemistry

authors： Morimoto R,Hayashi M,Yatsushiro S,Otsuka M,Yamamoto A,Moriyama Y

更新日期：2003-01-01 00:00:00

abstract：:Voltage-dependent calcium channels from ileal smooth muscle can be affinity-labeled with a [3H]dihydropyridine isothiocyanate radioligand. We examined the binding of this agent to brain membranes, to compare the properties of calcium channel drug binding sites in brain with those previously described in ileum. In brai...

journal_title：Journal of neurochemistry

authors： Greenberg DA,Cooper EC,Carpenter CL

更新日期：1985-01-01 00:00:00

abstract：:Specific binding of [3H]granisetron was examined to serotonin 5-HT3 receptors in synaptosomal membranes of rat cerebral cortex between 1 and 37 degrees C. Displacing potencies were determined for 5-HT3 antagonists (granisetron, ondansetron, tropisetron, and d-tubocurarine) and agonists (5-hydroxytryptamine, 2-methyl-5...

journal_title：Journal of neurochemistry

authors： Maksay G

更新日期：1996-07-01 00:00:00

abstract：:Huntington's disease (HD) is a neurodegenerative condition characterized by pathology in the brain and peripheral tissues. Hyperactivity of the innate immune system, due in part to NFκB pathway dysregulation, is an early and active component of HD. Evidence suggests targeting immune disruption may slow disease progres...

journal_title：Journal of neurochemistry

authors： Dobson L,Träger U,Farmer R,Hayardeny L,Loupe P,Hayden MR,Tabrizi SJ

更新日期：2016-06-01 00:00:00

abstract：:In contrast to typical neuroleptic drugs, which have high affinities for dopamine D2 receptors, clozapine binds to multiple neurotransmitter receptors. The mechanisms responsible for its superior clinical efficacy over typical neuroleptics remain unknown. Using an automated genomics approach, total gene expression ana...

journal_title：Journal of neurochemistry

authors： Thomas EA,Danielson PE,Nelson PA,Pribyl TM,Hilbush BS,Hasel KW,Sutcliffe JG

更新日期：2001-02-01 00:00:00

abstract：:Administration of L-DOPA (50 mg/kg) elicits a significant increase in extracellular dopamine in striata of rats treated with the catecholaminergic neurotoxin 6-hydroxydopamine but not in striata of intact rats. To assess the role of dopaminergic nerve terminals in determining the effects of exogenous L-DOPA on extrace...

journal_title：Journal of neurochemistry

authors： Wachtel SR,Abercrombie ED

更新日期：1994-07-01 00:00:00

abstract：:Dopamine is an important neurotransmitter implicated in the regulation of mood, motivation and movement. We have reviewed here recent data suggesting that dopamine, in addition to being a neurotransmitter, also plays a role in the regulation of endogenous neurogenesis in the adult mammalian brain. In addition, we appr...

journal_title：Journal of neurochemistry

authors： Borta A,Höglinger GU

更新日期：2007-02-01 00:00:00

abstract：:According to the amyloid hypothesis, accumulation of amyloid beta-peptide (A beta) in the brain is the primary pathogenic event in Alzheimer's disease (AD). Recent evidence indicates that A beta within the intravascular space is linked to A beta deposited in the brain suggesting that transport of A beta between the br...

journal_title：Journal of neurochemistry

authors： Zlokovic BV

更新日期：2004-05-01 00:00:00

abstract：:cDNAs encoding four isoforms of the human NMDA receptor (NMDAR) NMDAR2C (hNR2C-1, -2, -3, and -4) have been isolated and characterized. The overall identity of the deduced amino acid sequences of human and rat NR2C-1 is 89.0%. The sequences of the rat and human carboxyl termini (Gly925-Val1,236) are encoded by differe...

journal_title：Journal of neurochemistry

authors： Daggett LP,Johnson EC,Varney MA,Lin FF,Hess SD,Deal CR,Jachec C,Lu CC,Kerner JA,Landwehrmeyer GB,Standaert DG,Young AB,Harpold MM,Veliçelebi G

更新日期：1998-11-01 00:00:00

abstract：:We have previously reported that the intrinsic ability of motor axons to sprout can vary considerably from nerve to nerve with an inverse correlation to axonal length. In this study we asked whether this variation might be associated with differences in one axonal component, neurofilaments, near the site of outgrowth....

journal_title：Journal of neurochemistry

authors： Pestronk A,Watson DF,Yuan CM

更新日期：1990-03-01 00:00:00

abstract：:The inhibitors of apoptosis (IAPs) are emerging as key proteins in the control of cell death. In this study, we evaluated the expression and subcellular distribution of the antiapoptotic protein X-linked IAP (XIAP), and its interactions with the XIAP-associated factor 1 (XAF1) in neonatal rat brain following hypoxia-i...

journal_title：Journal of neurochemistry

authors： Russell JC,Whiting H,Szuflita N,Hossain MA

更新日期：2008-08-01 00:00:00

abstract：:Purified rat brain Ca2+/calmodulin-dependent protein kinase II (CaM-kinase II) is stimulated by brain gangliosides to a level of about 30% the activity obtained in the presence of Ca2+/calmodulin (CaM). Of the various gangliosides tested, GT1b was the most potent, giving half-maximal activation at 25 microM. Gangliosi...

journal_title：Journal of neurochemistry

authors： Fukunaga K,Miyamoto E,Soderling TR

更新日期：1990-01-01 00:00:00

abstract：:The formation and refinement of synaptic connections are key steps of neural development to establish elaborate brain networks. To investigate the functional role of protein tyrosine phosphatase (PTP) σ, we employed an olfactory sensory neuron (OSN)-specific gene manipulation system in combination with in vivo imaging...

journal_title：Journal of neurochemistry

authors： Chen X,Yoshida T,Sagara H,Mikami Y,Mishina M

更新日期：2011-11-01 00:00:00

abstract：:The distributions of glutamate decarboxylase (EC 4.1.1.15), gamma-aminobutyric acid transaminase (EC 2.6.1.19), and succinate semialdehyde dehydrogenase (EC 1.2.1.24) were determined in monkey retina. The decarboxylase was almost restricted to the inner plexiform layer. The transaminase was also highest in this layer,...

journal_title：Journal of neurochemistry

authors： Pusateri ME,Carter JG,Berger SJ,Lowry OH

更新日期：1984-05-01 00:00:00

abstract：:Benzodiazepine receptor binding was measured in cerebellar cortex of 15 patients with dominantly inherited olivopontocerebellar atrophy (OPCA). The majority of these patients had a moderate to marked Purkinje cell loss, as judged by the lowered levels of dentate nucleus gamma-aminobutyric acid (GABA), a marker of Purk...

journal_title：Journal of neurochemistry

authors： Kish SJ,Perry TL,Hornykiewicz O

更新日期：1984-02-01 00:00:00

abstract：:Action mechanism of lipopolysaccharide (LPS), interleukin-1β (IL-1β), and lysophosphatidic acid (LPA) to regulate motility, an important process of astrogliosis, was investigated in rat astrocytes. While LPA exerted no significant effect on the cell migration, the prior treatment of the cells with LPS or IL-1β resulte...

journal_title：Journal of neurochemistry

authors： Sato K,Horiuchi Y,Jin Y,Malchinkhuu E,Komachi M,Kondo T,Okajima F

更新日期：2011-04-01 00:00:00

abstract：:Topiramate (TPM) is a structurally novel broad-spectrum anticonvulsant known to modulate the activity of several ligand- and voltage-gated ion channels in neurons. These include an inhibitory effect on the AMPA and kainate subtypes of glutamate receptors, mixed modulatory effects (usually positive) on some types of GA...

journal_title：Journal of neurochemistry

authors： Angehagen M,Ben-Menachem E,Shank R,Rönnbäck L,Hansson E

更新日期：2004-01-01 00:00:00

abstract：:Using the highly sensitive HPLC-fluorophotometry technique, anterograde and retrograde axonal transport of carboxypeptidase H (CPH), a putative prohormone processing enzyme that removes a basic amino acid from the C-terminus of a precursor peptide, was measured 12-72 h after double ligations of rat sciatic nerves. CPH...

journal_title：Journal of neurochemistry

authors： Yajima R,Chikuma T,Kato T

更新日期：1994-09-01 00:00:00

abstract：:Increased awareness for a role of oxidative stress in the pathogenesis of Alzheimer's disease has highlighted the issue of whether oxidative damage is a fundamental step in the pathogenesis or instead results from disease-associated pathology. In vitro experiments support both possibilities: Oxidative stress increases...

journal_title：Journal of neurochemistry

authors： Smith MA,Hirai K,Hsiao K,Pappolla MA,Harris PL,Siedlak SL,Tabaton M,Perry G

更新日期：1998-05-01 00:00:00

abstract：:Melanocortin-4 receptors (MC4 R) are unique among G-protein-coupled receptors (GPCRs) as they have endogenous ligands that can exhibit inverse agonistic properties in the case of elevated basal activity. It is known that the constitutive activity of GPCRs strongly affects the ligand-dependent physiological responses, ...

journal_title：Journal of neurochemistry

authors： Link R,Veiksina S,Tahk MJ,Laasfeld T,Paiste P,Kopanchuk S,Rinken A

更新日期：2020-05-01 00:00:00