Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3beta.

abstract：:Protein aggregation into amyloid fibrils is a key feature of a multitude of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Prion disease. To detect amyloid fibrils, fluorophores with high sensitivity and better efficiency coupled with the low toxicity are in high demand even to date. In this pursuit,...

journal_title：Journal of neurochemistry

authors： Pravin N,Kumar R,Tripathi S,Kumar P,Mohite GM,Navalkar A,Panigrahi R,Singh N,Gadhe LG,Manchanda S,Shimozawa M,Nilsson P,Johansson J,Kumar A,Maji SK,Shanmugam M

更新日期：2020-08-04 00:00:00

abstract：:The weaver mutant mouse has a genetically determined defect in the nigrostriatal dopaminergic system. The present study was undertaken to test the hypothesis that in the weaver mutant mouse, striatal nerve terminals undergo compensatory changes in response to this deficiency. To test this hypothesis, we studied the ba...

journal_title：Journal of neurochemistry

authors： Simon JR,Yu H,Richter JA,Vasko MR,Ghetti B

更新日期：1991-11-01 00:00:00

abstract：:The extracellular concentrations of amino acids in the hippocampal CA1 field and striatum of conscious freely moving rats were monitored simultaneously by in vivo brain microdialysis using HPLC with electrochemical detection. Under basal conditions, aspartate, glutamate, glutamine, glycine, taurine, and alanine were d...

journal_title：Journal of neurochemistry

authors： Shibanoki S,Kogure M,Sugahara M,Ishikawa K

更新日期：1993-11-01 00:00:00

abstract：:PCR was used to isolate identical partial cDNA clones encoding a serotonin 5-HT3 receptor subunit from rat nodose and superior cervical ganglia. The amino acid sequence predicted from these clones, extending from the putative transmembrane domain I to the stop codon, demonstrated a 93% homology with the 5-HT3 receptor...

journal_title：Journal of neurochemistry

authors： Miquel MC,Emerit MB,Gingrich JA,Nosjean A,Hamon M,el Mestikawy S

更新日期：1995-08-01 00:00:00

abstract：:The modulation by adenosine analogues and endogenous adenosine of the electrically evoked release of [3H]acetylcholine ([3H]ACh) was compared in subslices of the three areas of the rat hippocampus (CA1, CA3, and dentate gyrus). The mixed A1/A2 agonist 2-chloroadenosine (CADO; 2-10 microM) inhibited, in a concentration...

journal_title：Journal of neurochemistry

authors： Cunha RA,Milusheva E,Vizi ES,Ribeiro JA,Sebastião AM

更新日期：1994-07-01 00:00:00

abstract：:Post-ischemic inflammation is an essential step in the progression of ischemic stroke. This review focuses on the function of infiltrating immune cells, macrophages, and T cells, in ischemic brain injury. The brain is a sterile organ; however, the activation of Toll-like receptor (TLR) 2 and TLR4 is pivotal in the beg...

journal_title：Journal of neurochemistry

authors： Shichita T,Ago T,Kamouchi M,Kitazono T,Yoshimura A,Ooboshi H

更新日期：2012-11-01 00:00:00

abstract：:This study presents the initial characterization of transgenic mice with mutations in a primary zinc-binding residue (H80), either alone or with a G93A mutation. H80G;G93A superoxide dismutase 1 (SOD1) transgenic mice developed paralysis with motor neuron loss, and ubiquitin inclusion-type rather than mitochondrial va...

journal_title：Journal of neurochemistry

authors： Son M,Srikanth U,Puttaparthi K,Luther C,Elliott JL

更新日期：2011-09-01 00:00:00

abstract：:Intracellular calcium ions regulate the structure and functions of cytoskeletal proteins. On the other hand, recent studies have shown that the cytoskeleton, and actin filaments in particular, can modulate calcium influx through plasma membrane ligand- and voltage-gated channels. We now report that calcium release fro...

journal_title：Journal of neurochemistry

authors： Wang Y,Mattson MP,Furukawa K

更新日期：2002-08-01 00:00:00

abstract：:The prescribed drugs for treatment of cognitive deficits in Alzheimer's disease (AD) patients are regarded as symptomatic drugs. Effective disease modifying therapies are not yet prescribed in AD patients. Three major hallmarks of AD (e.g. cholinergic hypofunction, Aβ and tau neuropathologies) are closely linked raisi...

journal_title：Journal of neurochemistry

authors： Fisher A

更新日期：2012-01-01 00:00:00

abstract：:Ras-related GTPases of the Rho family, such as RhoA and RhoB, are well-characterised mediators of morphological change in peripheral tissues via their effects on the actin cytoskeleton. We tested the hypothesis that Rho family GTPases are involved in synaptic transmission in the CA1 region of the hippocampus. We show ...

journal_title：Journal of neurochemistry

authors： O'Kane EM,Stone TW,Morris BJ

更新日期：2003-12-01 00:00:00

abstract：:Excitotoxicity and defects in neuronal energy metabolism have both been implicated in the pathogenesis of neurodegenerative disease. These two mechanisms may be linked through the NMDA receptor, activation of which is dependent on neuronal membrane potential. Because the ability to maintain membrane potential is depen...

journal_title：Journal of neurochemistry

authors： Greene JG,Porter RH,Eller RV,Greenamyre JT

更新日期：1993-09-01 00:00:00

abstract：:The presence of the biologically uncommon D-aspartic acid (D-aspartate) in human brain white matter has been previously reported. The earlier study has now been expanded to include D/L-aspartate ratios from 67 normal brains. The data show that the D-aspartate content increases rapidly from 1 year to approximately 35 y...

journal_title：Journal of neurochemistry

authors： Man EH,Fisher GH,Payan IL,Cadilla-Perezrios R,Garcia NM,Chemburkar R,Arends G,Frey WH 2nd

更新日期：1987-02-01 00:00:00

abstract：:Variations occurring in cortical nitric oxide (NO) release were analysed with a voltametric method in rats (i) placed in control conditions, (ii) while being paradoxical sleep deprived (PSD), or (iii) recovering from a PSD. Activities of neuronal (nNOS) and inducible (iNOS) NO-synthases as well as nNOS expression were...

journal_title：Journal of neurochemistry

authors： Clément P,Sarda N,Cespuglio R,Gharib A

更新日期：2004-08-01 00:00:00

abstract：:Glutathione (GSH) and GSH-related enzymes constitute the most important defense system that protects cells from free radical, radiotherapy, and chemotherapy attacks. In this study, we aim to explore the potential role and regulatory mechanism of the GSH redox cycle in drug resistance in glioblastoma multiforme (GBM) c...

journal_title：Journal of neurochemistry

authors： Zhu Z,Du S,Du Y,Ren J,Ying G,Yan Z

更新日期：2018-01-01 00:00:00

abstract：:The present study aims to investigate the role of extracellular glutamate and NMDA receptor stimulation in the neuronal death induced by a transient exposure to H2O2 of cultured neurons originating from mouse cerebral cortex. Most of the neuronal loss following a transient exposure to H2O2 of cortical neurons results ...

journal_title：Journal of neurochemistry

authors： Mailly F,Marin P,Israël M,Glowinski J,Prémont J

更新日期：1999-09-01 00:00:00

abstract：:It is well established that chronic nicotine treatment produces a dose-dependent increase in high-affinity L-[3H]nicotine binding. This increase may be due to chronic desensitization of the receptor. Sophisticated kinetic analyses of high-affinity nicotine binding to rat brain have demonstrated that the association ra...

journal_title：Journal of neurochemistry

authors： Bhat RV,Marks MJ,Collins AC

更新日期：1994-02-01 00:00:00

abstract：:The normal cellular prion protein (PrP(C)) is a glycoprotein with two highly conserved potential N-linked glycosylation sites. All prion diseases, whether inherited, infectious or sporadic, are believed to share the same pathogenic mechanism that is based on the conversion of the normal cellular prion protein (PrP(C))...

journal_title：Journal of neurochemistry

authors： Goh AX,Li C,Sy MS,Wong BS

更新日期：2007-02-01 00:00:00

abstract：:The protein B-50 is dephosphorylated in rat cortical synaptic plasma membranes (SPM) by protein phosphatase type 1 and 2A (PP-1 and PP-2A)-like activities. The present studies further demonstrate that B-50 is dephosphorylated not only by a spontaneously active PP-1-like enzyme, but also by a latent form after pretreat...

journal_title：Journal of neurochemistry

authors： Han YF,Wang W,Schlender KK,Ganjeizadeh M,Dokas LA

更新日期：1992-07-01 00:00:00

abstract：:Studies in continuously cultured cells have established that familial Alzheimer's disease (FAD) mutant presenilin 1 (PS1) delays exit of the amyloid precursor protein (APP) from the trans-Golgi network (TGN). Here we report the first description of PS1-regulated APP trafficking in cerebral neurons in culture and in vi...

journal_title：Journal of neurochemistry

authors： Gandy S,Zhang YW,Ikin A,Schmidt SD,Bogush A,Levy E,Sheffield R,Nixon RA,Liao FF,Mathews PM,Xu H,Ehrlich ME

更新日期：2007-08-01 00:00:00

abstract：:Kindling induces long-term adaptations in neuronal function that lead to a decreased threshold for induction of seizures. In the present study, the influence of amygdala kindling on levels of mRNA for the immediate-early genes (IEGs) c-fos, c-jun, and NGF1-A were examined both before and after an acute electroconvulsi...

journal_title：Journal of neurochemistry

authors： Duman RS,Craig JS,Winston SM,Deutch AY,Hernandez TD

更新日期：1992-11-01 00:00:00

abstract：:Brain homogenate, cerebral microvessels, and endothelial cells (ECs) were prepared from 15-18-week-old human fetuses and analyzed biochemically for the presence of elements of the cholinergic system [acetylcholinesterase (AChE), choline acetyltransferase (ChAT), and butyrylcholinesterase]. The ECs were cultured, and t...

journal_title：Journal of neurochemistry

authors： Kasa P,Pakaski M,Joó F,Lajtha A

更新日期：1991-06-01 00:00:00

abstract：:Chandipura virus (CHPV; genus Vesiculovirus, family Rhabdoviridae) induces neuronal death through the Fas-mediated extrinsic apoptosis pathway. What propels this apoptosis remains unclear, although oxysterols have been reported to be key players in neurodegeneration. In our study of CHPV-infected brain samples, we obs...

journal_title：Journal of neurochemistry

authors： Ghosh S,Mukherjee S,Basu A

更新日期：2015-10-01 00:00:00

abstract：:Cytokines have been suggested to be involved in the cross talk between the immune and the nervous systems, under normal and pathological conditions. For example, the cytokine interleukin-2 was suggested to be involved in response to CNS trauma and spontaneous regeneration. Here, we examined whether mammalian CNS has a...

journal_title：Journal of neurochemistry

authors： Eizenberg O,Faber-Elman A,Lotan M,Schwartz M

更新日期：1995-05-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor function and eventual death as a result of degeneration of motor neurons in the spinal cord and brain. The discovery of mutations in SOD1, the gene encoding the antioxidant enzyme Cu/Zn-superoxide dismutase (C...

journal_title：Journal of neurochemistry

authors： Flanagan SW,Anderson RD,Ross MA,Oberley LW

更新日期：2002-04-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is involved in many aspects of neuronal biology and hippocampal physiology. Status epilepticus (SE) is a condition in which prolonged seizures lead to neuronal degeneration. SE-induced in rodents serves as a model of Temporal Lobe Epilepsy with hippocampal sclerosis, the most f...

journal_title：Journal of neurochemistry

authors： Unsain N,Montroull LE,Mascó DH

更新日期：2009-10-01 00:00:00

abstract：:The NMDA receptor/channel has been shown to be inhibited by ethanol in the clinically relevant range 25-100 mM. We studied heteromeric assemblies (NR1b/NR2) of the NMDA receptor, expressed in oocytes, to address three questions regarding this inhibition, and discovered the following: (1) The inhibition was nearly equi...

journal_title：Journal of neurochemistry

authors： Chu B,Anantharam V,Treistman SN

更新日期：1995-07-01 00:00:00

abstract：:We report the distribution of choline acetyltransferase (ChAT) activity in the laminae of the rat olfactory tubercle. Within its posterior medical portion, the tubercle contains three parallel histological laminae that can be separated by cutting tangential sections from frozen tissue. ChAT was measured in homogenates...

journal_title：Journal of neurochemistry

authors： Gordon CR,Krieger NR

更新日期：1983-01-01 00:00:00

abstract：:Several cholinesterase inhibitors used in the treatment of Alzheimer's disease (AD) have been shown to interact with an allosteric site on the nicotinic acetylcholine receptor (nAChR). A possible linkage between the phosphorylation state of tau, the major component of paired helical filaments found in AD brain, and st...

journal_title：Journal of neurochemistry

authors： Hellström-Lindahl E,Moore H,Nordberg A

更新日期：2000-02-01 00:00:00

abstract：:Water-soluble iron, and manganese(III) complexes of corroles and porphyrins were examined with regard to their neuroprotective/neurorescue activities by using various neuronal cytotoxic models of oxidative and nitrative stress. The present study demonstrates that the metallocorroles significantly protect human neurobl...

journal_title：Journal of neurochemistry

authors： Kupershmidt L,Okun Z,Amit T,Mandel S,Saltsman I,Mahammed A,Bar-Am O,Gross Z,Youdim MB

更新日期：2010-04-01 00:00:00

abstract：:[3H]Spiroperidol binding to homogenates of rat striatum is saturable and shows either monophasic or biphasic saturation isotherms under specified conditions. In poorly washed membrane fragment preparations, saturation isotherms of [3H]spiroperidol binding are monophasic, revealing an apparently homogeneous set of site...

journal_title：Journal of neurochemistry

authors： Andorn AC,Maguire ME

更新日期：1980-11-01 00:00:00